| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Neuronal Ceroid-Lipofuscinoses | D009472 | 5 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
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|---|---|---|---|---|
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| Galluzzi L et al. | miR-181a and miR-630 regulate cisplatin-induced cancer cell death. | 2010 | Cancer Res. | pmid:20145152 |
| Martins I et al. | Chemotherapy induces ATP release from tumor cells. | 2009 | Cell Cycle | pmid:19855167 |
| Jeng JY et al. | Functional modulation of mitochondria by eicosapentaenoic acid provides protection against ceramide toxicity to C6 glioma cells. | 2009 | J. Agric. Food Chem. | pmid:19921818 |
| Fontés G et al. | Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. | 2009 | Diabetes | pmid:19502418 |
| Kang JH et al. | Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency. | 2009 | Bioorg. Med. Chem. | pmid:19171486 |
| Graf C et al. | A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. | 2009 | Anal. Biochem. | pmid:18831956 |
| Furuchi T et al. | Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells. | 2009 | Arch. Biochem. Biophys. | pmid:19720044 |
| Masgrau R et al. | BM88/Cend1 regulates stimuli-induced intracellular calcium mobilization. | 2009 | Neuropharmacology | pmid:19061903 |
| Gubern A et al. | Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2. | 2009 | J. Biol. Chem. | pmid:19117952 |
| Wang J et al. | Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells. | 2009 | Biomed. Environ. Sci. | pmid:19462692 |
| Li R et al. | Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. | 2009 | J. Neurochem. | pmid:19558454 |
| Lin YC et al. | Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19435666 |
| Chien CC et al. | Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis. | 2009 | J. Cell. Physiol. | pmid:18932216 |
| de Castro e Paula LA and Hansen PJ | Ceramide inhibits development and cytokinesis and induces apoptosis in preimplantation bovine embryos. | 2008 | Mol. Reprod. Dev. | pmid:18157869 |
| Miñano A et al. | C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3. | 2008 | J. Neurosci. Res. | pmid:18311838 |
| Zhokhov SS et al. | Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage. | 2008 | Cell Death Differ. | pmid:18323863 |
| Chen CL et al. | Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. | 2008 | Blood | pmid:18270325 |
| Elner SG et al. | Retinal flavoprotein autofluorescence as a measure of retinal health. | 2008 | Trans Am Ophthalmol Soc | pmid:19277237 |
| Zhang X et al. | [Mitochondrial changes in apoptosis of HT-29 cells induced by C2-ceramide]. | 2008 | Wei Sheng Yan Jiu | pmid:19069652 |