Bianchi K et al. |
Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha. |
2006 |
Cell Death Differ. |
pmid:16239931
|
Kolettas E et al. |
Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response. |
2006 |
Arch. Biochem. Biophys. |
pmid:16297852
|
Detre C et al. |
Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration. |
2006 |
Cell. Signal. |
pmid:16099142
|
Rath GM et al. |
Thrombospondin-1 C-terminal-derived peptide protects thyroid cells from ceramide-induced apoptosis through the adenylyl cyclase pathway. |
2006 |
Int. J. Biochem. Cell Biol. |
pmid:16971166
|
Ghering AB and Davidson WS |
Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I. |
2006 |
J. Lipid Res. |
pmid:16990644
|
Kniep B et al. |
9-O-acetyl GD3 protects tumor cells from apoptosis. |
2006 |
Int. J. Cancer |
pmid:16432837
|
Hughes PJ et al. |
Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. |
2006 |
J. Cell. Biochem. |
pmid:16178010
|
Sparkman L et al. |
Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. |
2006 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:16183668
|
Zhang XF et al. |
Apoptosis of human colon carcinoma HT-29 cells induced by ceramide. |
2006 |
World J. Gastroenterol. |
pmid:16773715
|
Gibanova NV et al. |
Protective effect of the hexapeptide TGENHR on the TNF-induced death of HL-60 cells. |
2006 Sep-Oct |
Dokl. Biochem. Biophys. |
pmid:17286111
|
Arboleda G et al. |
Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells. |
2007 |
Neurosci. Lett. |
pmid:17573191
|
Adachi T et al. |
Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. |
2007 |
Biochem. Biophys. Res. Commun. |
pmid:17511962
|
Kim S et al. |
Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide. |
2007 |
Bioorg. Med. Chem. Lett. |
pmid:17561396
|
Arboleda G et al. |
Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. |
2007 |
Eur. J. Neurosci. |
pmid:17561816
|
Zhang J et al. |
Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms. |
2007 |
J. Vasc. Surg. |
pmid:17350784
|
Abe A et al. |
The acylation of lipophilic alcohols by lysosomal phospholipase A2. |
2007 |
J. Lipid Res. |
pmid:17626977
|
JeBailey L et al. |
Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. |
2007 |
Diabetes |
pmid:17259384
|
Yang LX et al. |
[Association between murine double minute 2 expression and AngII and ceramide induced endothelial cells apoptosis]. |
2007 |
Zhonghua Xin Xue Guan Bing Za Zhi |
pmid:18206046
|
Van Overloop H et al. |
On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. |
2007 |
Biol. Chem. |
pmid:17338639
|
Stoeck A et al. |
L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. |
2007 |
Gynecol. Oncol. |
pmid:17030349
|
Ulrich S et al. |
De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity. |
2007 |
Biochem. Pharmacol. |
pmid:17521618
|
Samadi A |
Ceramide-induced cell death in lens epithelial cells. |
2007 |
Mol. Vis. |
pmid:17893663
|
Wang J et al. |
Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. |
2007 |
World J. Gastroenterol. |
pmid:17373752
|
Zhang TH et al. |
Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases. |
2007 |
Acta Pharmacol. Sin. |
pmid:17303009
|
de Castro e Paula LA and Hansen PJ |
Ceramide inhibits development and cytokinesis and induces apoptosis in preimplantation bovine embryos. |
2008 |
Mol. Reprod. Dev. |
pmid:18157869
|
Miñano A et al. |
C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3. |
2008 |
J. Neurosci. Res. |
pmid:18311838
|
Zhokhov SS et al. |
Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage. |
2008 |
Cell Death Differ. |
pmid:18323863
|
Nicol GD |
Nerve growth factor, sphingomyelins, and sensitization in sensory neurons. |
2008 |
Sheng Li Xue Bao |
pmid:18958367
|
Lim JY et al. |
Investigation on C2-ceramide complexes with transition metal ions using electrospray ionization tandem mass spectrometry. |
2008 |
Eur J Mass Spectrom (Chichester, Eng) |
pmid:18493098
|
Chen CL et al. |
Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. |
2008 |
Blood |
pmid:18270325
|
Elner SG et al. |
Retinal flavoprotein autofluorescence as a measure of retinal health. |
2008 |
Trans Am Ophthalmol Soc |
pmid:19277237
|
Zhang X et al. |
[Mitochondrial changes in apoptosis of HT-29 cells induced by C2-ceramide]. |
2008 |
Wei Sheng Yan Jiu |
pmid:19069652
|
Martins I et al. |
Chemotherapy induces ATP release from tumor cells. |
2009 |
Cell Cycle |
pmid:19855167
|
Jeng JY et al. |
Functional modulation of mitochondria by eicosapentaenoic acid provides protection against ceramide toxicity to C6 glioma cells. |
2009 |
J. Agric. Food Chem. |
pmid:19921818
|
Fontés G et al. |
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. |
2009 |
Diabetes |
pmid:19502418
|
Kang JH et al. |
Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency. |
2009 |
Bioorg. Med. Chem. |
pmid:19171486
|
Graf C et al. |
A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. |
2009 |
Anal. Biochem. |
pmid:18831956
|
Furuchi T et al. |
Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells. |
2009 |
Arch. Biochem. Biophys. |
pmid:19720044
|
Masgrau R et al. |
BM88/Cend1 regulates stimuli-induced intracellular calcium mobilization. |
2009 |
Neuropharmacology |
pmid:19061903
|
Gubern A et al. |
Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2. |
2009 |
J. Biol. Chem. |
pmid:19117952
|
Wang J et al. |
Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells. |
2009 |
Biomed. Environ. Sci. |
pmid:19462692
|
Li R et al. |
Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. |
2009 |
J. Neurochem. |
pmid:19558454
|
Lin YC et al. |
Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons. |
2009 |
Bioorg. Med. Chem. Lett. |
pmid:19435666
|
Chien CC et al. |
Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis. |
2009 |
J. Cell. Physiol. |
pmid:18932216
|
Ahn EH and Schroeder JJ |
Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide. |
2010 |
Anticancer Res. |
pmid:20683027
|
Lu CY et al. |
Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway. |
2010 |
J. Nutr. Biochem. |
pmid:19427778
|
Nakao S et al. |
C2-ceramide inhibits the prostaglandin E2-induced accumulation of cAMP in human gingival fibroblasts. |
2010 |
Biomed. Res. |
pmid:20460737
|
Arboleda G et al. |
Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death. |
2010 |
Neurotoxicology |
pmid:20696185
|
Abrahan CE et al. |
Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. |
2010 |
Invest. Ophthalmol. Vis. Sci. |
pmid:19797232
|
Chen JY et al. |
Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. |
2010 |
Life Sci. |
pmid:20624405
|
Lee YG et al. |
Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147. |
2010 |
Immunobiology |
pmid:19576658
|
Ferrari D et al. |
Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:19941832
|
Raucci FJ et al. |
Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes. |
2010 |
Cardiovasc. Res. |
pmid:20008476
|
Yoon BS et al. |
Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal. |
2010 |
Stem Cells |
pmid:20306465
|
Pozuelo-Rubio M |
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. |
2010 |
FEBS J. |
pmid:20618440
|
Galluzzi L et al. |
miR-181a and miR-630 regulate cisplatin-induced cancer cell death. |
2010 |
Cancer Res. |
pmid:20145152
|
Du WW et al. |
Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy. |
2011 |
PLoS ONE |
pmid:22096483
|
Kalo D and Roth Z |
Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes. |
2011 |
Reprod. Fertil. Dev. |
pmid:21871207
|
El Btaouri H et al. |
Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells. |
2011 |
Biochim. Biophys. Acta |
pmid:21333695
|
Pozuelo-Rubio M |
Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase. |
2011 |
Cell Death Differ. |
pmid:20885446
|
Kowluru A |
Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches. |
2011 |
Biochem. Pharmacol. |
pmid:21300027
|
Kazutaka S et al. |
Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor α and interleukin 1α: interaction with follicle-stimulating hormone/adenosine 3',5'-cyclic phosphate signalling. |
2011 |
Mol. Cell. Endocrinol. |
pmid:21256182
|
Park JY et al. |
Ceramide induces apoptosis via caspase-dependent and caspase-independent pathways in mesenchymal stem cells derived from human adipose tissue. |
2011 |
Arch. Toxicol. |
pmid:21259059
|
Li R and Reiser G |
Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death. |
2011 |
J. Neurochem. |
pmid:21615407
|
Cheng YL et al. |
Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli. |
2011 |
Biochem. Biophys. Res. Commun. |
pmid:21821001
|
Zhang X et al. |
Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis. |
2012 |
Eur. J. Pharmacol. |
pmid:22296759
|
Li R et al. |
[Effect of ceramide on GSTA1 in Caco-2 cells]. |
2012 |
Yao Xue Xue Bao |
pmid:22993865
|
Sabirzhanov B et al. |
Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. |
2012 |
J. Neurochem. |
pmid:22909049
|
Sánchez-Mora RM et al. |
PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway. |
2012 |
J. Mol. Neurosci. |
pmid:22212487
|
Li R et al. |
Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity. |
2012 |
Neurochem. Int. |
pmid:22414529
|
Kim SK et al. |
Palmitate induces RIP1-dependent necrosis in RAW 264.7 cells. |
2012 |
Atherosclerosis |
pmid:23084711
|
Xiao Q et al. |
Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia. |
2012 |
J. Neurosci. |
pmid:23015448
|
Taniguchi M et al. |
Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway. |
2012 |
J. Biol. Chem. |
pmid:23035115
|
Kue CS et al. |
C6-ceramide enhances Interleukin-12-mediated T helper type 1 cell responses through a cyclooxygenase-2-dependent pathway. |
2012 |
Immunobiology |
pmid:22112438
|
Chiu TT et al. |
Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance. |
2013 |
J. Biol. Chem. |
pmid:23640896
|
Lee JT et al. |
Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway. |
2013 |
Prog. Neuropsychopharmacol. Biol. Psychiatry |
pmid:23665108
|
Luther JA et al. |
Neurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanism. |
2013 |
J. Neurophysiol. |
pmid:23114219
|
Chen WF et al. |
Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets. |
2013 |
Haematologica |
pmid:23065519
|
Iwayama H and Ueda N |
Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells. |
2013 |
Mol. Cell. Biochem. |
pmid:23543151
|
Taheripak G et al. |
Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells. |
2013 |
Free Radic. Biol. Med. |
pmid:24120971
|
Li H et al. |
Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. |
2013 |
Cell Death Dis |
pmid:24091673
|
Pacheco A et al. |
C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. |
2013 |
PLoS ONE |
pmid:24040213
|
Guo L et al. |
Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development. |
2013 |
Theriogenology |
pmid:23731666
|
Dekker MJ et al. |
Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. |
2013 |
Atherosclerosis |
pmid:23466071
|
Weil BR and Canty JM |
Ceramide signaling in the coronary microcirculation: a double-edged sword? |
2014 |
Circ. Res. |
pmid:25124322
|
Freed JK et al. |
Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation. |
2014 |
Circ. Res. |
pmid:24920698
|
Zhu W et al. |
C2-ceramide induces cell death and protective autophagy in head and neck squamous cell carcinoma cells. |
2014 |
Int J Mol Sci |
pmid:24566153
|
Tan KB et al. |
Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia. |
2014 |
Nanomedicine (Lond) |
pmid:24294981
|
Leanza L et al. |
Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines. |
2014 |
Curr. Pharm. Des. |
pmid:23701546
|
Hsieh CT et al. |
Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle. |
2014 |
Cell. Signal. |
pmid:24650522
|
Costanzi E et al. |
Hypermethylation contributes to down-regulation of lysosomal β-hexosaminidase α subunit in prostate cancer cells. |
2014 |
Biochimie |
pmid:24389457
|
Rojas-Charry L et al. |
Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. |
2014 |
Neurotoxicology |
pmid:24792327
|
Huang Y et al. |
[Ceramide participates in cell programmed death induced by Type II anti-CD20 mAb]. |
2015 |
Zhong Nan Da Xue Xue Bao Yi Xue Ban |
pmid:26739069
|
Ogiso H et al. |
Analysis of lipid-composition changes in plasma membrane microdomains. |
2015 |
J. Lipid Res. |
pmid:26116739
|
Wehinger S et al. |
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells. |
2015 |
Biochim. Biophys. Acta |
pmid:25572853
|
Jaramillo-Gómez J et al. |
Overexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy. |
2015 |
Neurosci. Lett. |
pmid:26222260
|
Zhu Z et al. |
Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria. |
2015 |
Brain Res. |
pmid:25998538
|
Di Bartolomeo S et al. |
Differential apoptotic effect and metabolism of N-acetylsphingosine and N-hexanoylsphingosine in CHP-100 human neurotumor cells. |
2015 |
Biochem. Biophys. Res. Commun. |
pmid:25656578
|
Scholl A et al. |
Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. |
2016 |
Oncotarget |
pmid:27556861
|
Wang Y et al. |
Acid sphingomyelinase mediates 50-Hz magnetic field-induced EGF receptor clustering on lipid raft. |
2016 |
J. Recept. Signal Transduct. Res. |
pmid:26915736
|