N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Retinoblastoma D012175 12 associated lipids
Parkinson Disease D010300 53 associated lipids
Neuronal Ceroid-Lipofuscinoses D009472 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
Ahn EH and Schroeder JJ Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide. 2010 Anticancer Res. pmid:20683027
Lu CY et al. Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway. 2010 J. Nutr. Biochem. pmid:19427778
Nakao S et al. C2-ceramide inhibits the prostaglandin E2-induced accumulation of cAMP in human gingival fibroblasts. 2010 Biomed. Res. pmid:20460737
Arboleda G et al. Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death. 2010 Neurotoxicology pmid:20696185
Abrahan CE et al. Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. 2010 Invest. Ophthalmol. Vis. Sci. pmid:19797232
Chen JY et al. Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. 2010 Life Sci. pmid:20624405
Lee YG et al. Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147. 2010 Immunobiology pmid:19576658
Ferrari D et al. Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. 2010 Biochem. Biophys. Res. Commun. pmid:19941832
Raucci FJ et al. Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes. 2010 Cardiovasc. Res. pmid:20008476
Galluzzi L et al. miR-181a and miR-630 regulate cisplatin-induced cancer cell death. 2010 Cancer Res. pmid:20145152