| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Neuronal Ceroid-Lipofuscinoses | D009472 | 5 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hollander MC et al. | Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. | 2001 | Int. J. Cancer | pmid:11241327 |
| Hajduch E et al. | Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. | 2001 | Diabetologia | pmid:11270673 |
| Frago LM et al. | Short-chain ceramide regulates hepatic methionine adenosyltransferase expression. | 2001 | J. Hepatol. | pmid:11281546 |
| Spyridopoulos I et al. | Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells. | 2001 | Cardiovasc. Res. | pmid:11282082 |
| Huang C et al. | Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation. | 2001 | FASEB J. | pmid:11292685 |
| Furuya K et al. | Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia. | 2001 | J. Cereb. Blood Flow Metab. | pmid:11295877 |
| Kim DS et al. | Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells. | 2001 | Pigment Cell Res. | pmid:11310790 |
| Hsu YW et al. | Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors. | 2001 | J. Immunol. | pmid:11313375 |
| Zhang DX et al. | Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. | 2001 | Circ. Res. | pmid:11325875 |
| Vitale N et al. | Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. | 2001 | EMBO J. | pmid:11350931 |
| Sabatini M et al. | Effects of ceramide on aggrecanase activity in rabbit articular cartilage. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11355886 |
| Belichenko I et al. | Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. | 2001 | Arch. Biochem. Biophys. | pmid:11368515 |
| Won JS et al. | Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases. | 2001 | Brain Res. | pmid:11382404 |
| Pinton P et al. | The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. | 2001 | EMBO J. | pmid:11387204 |
| Gupta N et al. | Angiostatin effects on endothelial cells mediated by ceramide and RhoA. | 2001 | EMBO Rep. | pmid:11415988 |
| Willaime S et al. | Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. | 2001 | Eur. J. Neurosci. | pmid:11422444 |
| Cabrero A et al. | Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. | 2001 | Biochim. Biophys. Acta | pmid:11470240 |
| Pacher P and Hajnóczky G | Propagation of the apoptotic signal by mitochondrial waves. | 2001 | EMBO J. | pmid:11483514 |
| Ghosh Choudhury G et al. | Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11527425 |
| Wagenknecht B et al. | C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis. | 2001 | Cell Death Differ. | pmid:11536010 |