| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Neuronal Ceroid-Lipofuscinoses | D009472 | 5 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mansfield PJ et al. | Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. | 2002 | Blood | pmid:11830497 |
| Shou J et al. | Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. | 2002 | Oncogene | pmid:11840333 |
| Kondo T et al. | Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis. | 2002 | Mol. Pharmacol. | pmid:11854443 |
| Chang YT et al. | The synthesis and biological characterization of a ceramide library. | 2002 | J. Am. Chem. Soc. | pmid:11866590 |
| Mei J et al. | C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes. | 2002 | Diabetes | pmid:11872660 |
| Itakura A et al. | Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor. | 2002 | Exp. Hematol. | pmid:11882365 |
| Mora A et al. | Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. | 2002 | Cell. Signal. | pmid:11897496 |
| Hanna AN et al. | Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance. | 2001 | Adv. Exp. Med. Biol. | pmid:11900368 |
| Kim HJ and Lee KJ | Heat shock and ceramide have different apoptotic pathways in radiation induced fibrosarcoma (RIF) cells. | 2002 | Mol. Cell. Biochem. | pmid:11936839 |
| Calcerrada MC et al. | Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes. | 2002 | FEBS Lett. | pmid:11943182 |
| Bitar KN | HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11960785 |
| Siskind LJ et al. | Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. | 2002 | J. Biol. Chem. | pmid:12006562 |
| Gurunathan S et al. | t-SNARE phosphorylation regulates endocytosis in yeast. | 2002 | Mol. Biol. Cell | pmid:12006655 |
| Kondo T et al. | Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase. | 2002 | Cell Death Differ. | pmid:12032677 |
| Kim DS et al. | Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. | 2002 | Cell. Signal. | pmid:12034359 |
| Sprott KM et al. | Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide. | 2002 | Biochem. J. | pmid:12071851 |
| Perks CM et al. | A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074574 |
| Perks CM et al. | Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074575 |
| Mansfield PJ et al. | Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. | 2002 | J. Lab. Clin. Med. | pmid:12080323 |
| Mallick S et al. | Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | 2002 | J. Biosci. | pmid:12089473 |