N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Cabrero A et al. | Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. | 2001 | Biochim. Biophys. Acta | pmid:11470240 |
Wehinger S et al. | Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells. | 2015 | Biochim. Biophys. Acta | pmid:25572853 |
Ogura M and Handa S | Induction of apoptosis by novel synthesized acylamides of human lymphocytes. | 2000 | Biochim. Biophys. Acta | pmid:10601700 |
Ridgway ND | Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide. | 1995 | Biochim. Biophys. Acta | pmid:7742354 |
Ito A et al. | Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells. | 1999 | Biochim. Biophys. Acta | pmid:10590315 |
Kishida E et al. | Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis. | 1998 | Biochim. Biophys. Acta | pmid:9555103 |
El Btaouri H et al. | Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells. | 2011 | Biochim. Biophys. Acta | pmid:21333695 |
Chen JS et al. | Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells. | 2000 | Biochim. Biophys. Acta | pmid:11082532 |
Soeda S et al. | Tumor necrosis factor-alpha-induced release of plasminogen activator inhibitor-1 from human umbilical vein endothelial cells: involvement of intracellular ceramide signaling event. | 1998 | Biochim. Biophys. Acta | pmid:9824663 |
Costanzi E et al. | Hypermethylation contributes to down-regulation of lysosomal β-hexosaminidase α subunit in prostate cancer cells. | 2014 | Biochimie | pmid:24389457 |
Townley HE et al. | Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner. | 2005 | Biol. Chem. | pmid:15843160 |
Van Overloop H et al. | On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | 2007 | Biol. Chem. | pmid:17338639 |
De Stefanis D et al. | Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. | 2002 | Biol. Chem. | pmid:12222689 |
Soboloff J et al. | Acyl chain length-specific ceramide-induced changes in intracellular Ca2+ concentration and progesterone production are not regulated by tumor necrosis factor alpha in hen granulosa cells. | 1999 | Biol. Reprod. | pmid:9915989 |
Wang J et al. | Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells. | 2009 | Biomed. Environ. Sci. | pmid:19462692 |
Nakao S et al. | C2-ceramide inhibits the prostaglandin E2-induced accumulation of cAMP in human gingival fibroblasts. | 2010 | Biomed. Res. | pmid:20460737 |
Shikata K et al. | Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells. | 2003 | Bioorg. Med. Chem. | pmid:12788346 |
Niiro H et al. | (3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells. | 2004 | Bioorg. Med. Chem. | pmid:14697769 |
Kang JH et al. | Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency. | 2009 | Bioorg. Med. Chem. | pmid:19171486 |
Kim S et al. | Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17561396 |