N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kinscherf R et al. | Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent. | 1998 | FASEB J. | pmid:9535218 |
Cuvillier O et al. | Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. | 1998 | J. Biol. Chem. | pmid:9446602 |
Sakai T et al. | Effects of alpha- and beta-galactosylated C2-ceramides on the immune system. | 1998 | J. Med. Chem. | pmid:9484513 |
Simon CG and Gear AR | Membrane-destabilizing properties of C2-ceramide may be responsible for its ability to inhibit platelet aggregation. | 1998 | Biochemistry | pmid:9485333 |
Monney L et al. | Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis. | 1998 | Eur. J. Biochem. | pmid:9492297 |
Tanabe F et al. | Ceramide promotes calpain-mediated proteolysis of protein kinase C beta in murine polymorphonuclear leukocytes. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9439623 |
Harada-Shiba M et al. | Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. | 1998 | J. Biol. Chem. | pmid:9545302 |
Foghi A et al. | Fas-induced apoptosis in rat thecal/interstitial cells signals through sphingomyelin-ceramide pathway. | 1998 | Endocrinology | pmid:9528992 |
Takeda H et al. | Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts. | 1998 | FEBS Lett. | pmid:9490019 |
Flores I et al. | Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. | 1998 | J. Immunol. | pmid:9531315 |
Veldman RJ et al. | Metabolism and apoptotic properties of elevated ceramide in HT29rev cells. | 1998 | Biochem. J. | pmid:9531498 |
Iwasaki-Bessho Y et al. | Decreased phospholipase D (PLD) activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT. | 1998 | J. Invest. Dermatol. | pmid:9540978 |
Lawler JF et al. | Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. | 1998 | J. Biol. Chem. | pmid:9478955 |
Reunanen N et al. | Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways. | 1998 | J. Biol. Chem. | pmid:9478967 |
Kim BC and Kim JH | Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway. | 1998 | Biochem. J. | pmid:9480923 |
Hashizume T et al. | Different effects of cell-permeable ceramide analogs on platelet activation. | 1998 | Biochem. Mol. Biol. Int. | pmid:9556209 |
Kirtikara K et al. | An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis. | 1998 | Mol. Cell. Biochem. | pmid:9562240 |
Pfau JC et al. | A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. | 1998 | Cell. Immunol. | pmid:9665757 |
Galvan V and Roizman B | Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9520470 |
Kishida E et al. | Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis. | 1998 | Biochim. Biophys. Acta | pmid:9555103 |
Xia P et al. | Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9826677 |
Lauricella M et al. | Increased cyclin E level in retinoblastoma cells during programmed cell death. | 1998 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:9874510 |
Ibitayo AI et al. | Src kinase and PI 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle. | 1998 | Am. J. Physiol. | pmid:9756500 |
Mutoh T et al. | Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells. | 1998 | J. Biol. Chem. | pmid:9748278 |
Cartus T et al. | Distribution of protein phosphatases type 1 and 2A in RINm5F cells. | 1998 | Regul. Pept. | pmid:9809799 |
Mizushima N et al. | Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells. | 1998 | Ann. Rheum. Dis. | pmid:9797556 |
Birt DF et al. | Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine. | 1998 | Nutr Cancer | pmid:9770723 |
Ji L et al. | Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells. | 1998 | Arch. Biochem. Biophys. | pmid:9799567 |
Lakics V and Vogel SN | Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages. | 1998 | J. Immunol. | pmid:9725248 |
Lian JP et al. | Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils. | 1998 | J. Immunol. | pmid:9780215 |
Zheng T et al. | C2-ceramide attenuates prostaglandin F2alpha-induced vasoconstriction and elevation of [Ca2+]i in canine cerebral vascular smooth muscle. | 1998 | Neurosci. Lett. | pmid:9853716 |
Hama-Inaba H et al. | Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiation. | 1998 | Mutat. Res. | pmid:9726009 |
Durrieu F et al. | Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes. | 1998 | Exp. Cell Res. | pmid:9596989 |
Yorek MA et al. | Effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells. | 1998 | Am. J. Physiol. | pmid:9458713 |
Ghahremani M et al. | Activation of Fas ligand/receptor system kills ovarian cancer cell lines by an apoptotic mechanism. | 1998 | Gynecol. Oncol. | pmid:9740705 |
Centeno F et al. | Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons. | 1998 | Neuroreport | pmid:9926873 |
Escargueil-Blanc I et al. | Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells. | 1998 | J. Biol. Chem. | pmid:9765267 |
Johns DG et al. | The role of the endothelium in ceramide-induced vasodilation. | 1998 | Eur. J. Pharmacol. | pmid:9671089 |
Ragg SJ et al. | The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937. | 1998 | J. Immunol. | pmid:9686602 |
Ichinose Y et al. | Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects. | 1998 | J. Lab. Clin. Med. | pmid:9605105 |
Canova C et al. | Epigenetic control of programmed cell death: inhibition by 5-azacytidine of 1,25-dihydroxyvitamin D3-induced programmed cell death in C6.9 glioma cells. | 1998 | Mech. Ageing Dev. | pmid:9593321 |
Boland MP and O'Neill LA | Ceramide activates NFkappaB by inducing the processing of p105. | 1998 | J. Biol. Chem. | pmid:9624136 |
Zhou H et al. | Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. | 1998 | J. Biol. Chem. | pmid:9632728 |
Jaffrézou JP et al. | Positive feedback control of neutral sphingomyelinase activity by ceramide. | 1998 | FASEB J. | pmid:9707172 |
Summers SA et al. | Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. | 1998 | Mol. Cell. Biol. | pmid:9710629 |
Hartfield PJ et al. | Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells. | 1998 | J. Neurochem. | pmid:9648862 |
Zhang J et al. | Regulation of membrane release in apoptosis. | 1998 | Biochem. J. | pmid:9716508 |
Patel M | Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic. | 1998 | J. Neurochem. | pmid:9721731 |
Galadari S et al. | Purification and characterization of ceramide-activated protein phosphatases. | 1998 | Biochemistry | pmid:9698369 |
Hershberger PA et al. | In vitro thymocyte maturation is associated with reduced cellular susceptibility to Fas-mediated apoptosis. | 1998 | Cell. Immunol. | pmid:9636691 |
Alesse E et al. | The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering. | 1998 | Cell Death Differ. | pmid:10200487 |
Wang P and Bitar KN | Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27. | 1998 | Am. J. Physiol. | pmid:9843784 |
Soeda S et al. | Tumor necrosis factor-alpha-induced release of plasminogen activator inhibitor-1 from human umbilical vein endothelial cells: involvement of intracellular ceramide signaling event. | 1998 | Biochim. Biophys. Acta | pmid:9824663 |
Pörn-Ares MI et al. | Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609. | 1997 | Exp. Cell Res. | pmid:9281351 |
Whitman SP et al. | Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation. | 1997 | J. Biol. Chem. | pmid:9295281 |
Kimura T et al. | Inhibition of TSH-induced hydrogen peroxide production by TNF-alpha through a sphingomyelinase signaling pathway. | 1997 | Am. J. Physiol. | pmid:9316456 |
Chmura SJ et al. | Loss of ceramide production confers resistance to radiation-induced apoptosis. | 1997 | Cancer Res. | pmid:9102212 |
Larocca JN et al. | Induction of oligodendrocyte apoptosis by C2-ceramide. | 1997 | Neurochem. Res. | pmid:9130266 |
Gill ZP et al. | Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner. | 1997 | J. Biol. Chem. | pmid:9325280 |
Nakabo Y and Pabst MJ | C2-ceramide and C6-ceramide inhibited priming for enhanced release of superoxide in monocytes, but had no effect on the killing of leukaemic cells by monocytes. | 1997 | Immunology | pmid:9176098 |
Wieder T et al. | Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. | 1997 | FEBS Lett. | pmid:9271217 |
Xie H and Johnson GV | Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. | 1997 | J. Neurochem. | pmid:9282924 |
Manev H and Cagnoli CM | Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common? | 1997 | Neurochem. Int. | pmid:9220452 |
Keane RW et al. | Activation of CPP32 during apoptosis of neurons and astrocytes. | 1997 | J. Neurosci. Res. | pmid:9130145 |
Separovic D et al. | Ceramide generation in response to photodynamic treatment of L5178Y mouse lymphoma cells. | 1997 | Cancer Res. | pmid:9135014 |
GarcÃa-Ruiz C et al. | Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. | 1997 | J. Biol. Chem. | pmid:9111045 |
Baker A et al. | Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. | 1997 | Cancer Res. | pmid:9371519 |
Suchard SJ et al. | Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes. | 1997 | Blood | pmid:9058737 |
Kuo ML et al. | Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells. | 1997 | Biochem. J. | pmid:9581540 |
Bielawska AE et al. | Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. | 1997 | Am. J. Pathol. | pmid:9358751 |
Lozanski G et al. | The sphingomyelin-ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not alpha-fibrinogen. | 1997 | Biochem. J. | pmid:9359864 |
Gudz TI et al. | Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. | 1997 | J. Biol. Chem. | pmid:9305864 |
Mattson MP et al. | Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. | 1997 | J. Neurosci. Res. | pmid:9335256 |
Bártová E et al. | Apoptotic damage of DNA in human leukaemic HL-60 cells treated with C2-ceramide was detected after G1 blockade of the cell cycle. | 1997 | Physiol Res | pmid:9727507 |
Shinkai M et al. | Inhibitory action of sphingosine or ceramide on amylase secretion from isolated rat pancreatic acini. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9196062 |
Shirahama T et al. | Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression. | 1997 | FEBS Lett. | pmid:9141489 |
Herrmann JL et al. | Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells. | 1997 | Exp. Cell Res. | pmid:9260915 |
Kozawa O et al. | Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. | 1997 | J. Biol. Chem. | pmid:9312119 |
Degnan BM et al. | Sphingomyelinase inhibits in vitro Leydig cell function. | 1996 May-Jun | Ann. Clin. Lab. Sci. | pmid:8726216 |
Lee TC et al. | Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels. | 1996 | J. Biol. Chem. | pmid:8550561 |
Orlati S et al. | Sphingosine-induced inhibition of capacitative calcium influx in CFPAC-1 cells. | 1996 | Cell Calcium | pmid:8955554 |
Verheij M et al. | Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. | 1996 | Nature | pmid:8598911 |
Nickels JT and Broach JR | A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. | 1996 | Genes Dev. | pmid:8600023 |
Welsh N | Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. | 1996 | J. Biol. Chem. | pmid:8626526 |
Wiesner DA and Dawson G | Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. | 1996 | J. Neurochem. | pmid:8627293 |
Latinis KM and Koretzky GA | Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. | 1996 | Blood | pmid:8562955 |
Abe A et al. | A novel enzyme that catalyzes the esterification of N-acetylsphingosine. Metabolism of C2-ceramides. | 1996 | J. Biol. Chem. | pmid:8662981 |
Mizushima N et al. | Ceramide induces apoptosis via CPP32 activation. | 1996 | FEBS Lett. | pmid:8898109 |
Kuroki J et al. | Cell-permeable ceramide inhibits the growth of B lymphoma Raji cells lacking TNF-alpha-receptors by inducing G0/G1 arrest but not apoptosis: a new model for dissecting cell-cycle arrest and apoptosis. | 1996 | Leukemia | pmid:8946936 |
Kaipia A et al. | Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. | 1996 | Endocrinology | pmid:8895358 |
Chmura SJ et al. | Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231. | 1996 | Adv. Exp. Med. Biol. | pmid:8910670 |
Metz RJ et al. | Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A. | 1996 | Invasion Metastasis | pmid:9371227 |
Cuvillier O et al. | Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. | 1996 | Nature | pmid:8657285 |
Wong K et al. | N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx. | 1995 | J. Biol. Chem. | pmid:7852386 |
Law B and Rossie S | The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide. | 1995 | J. Biol. Chem. | pmid:7759536 |
Ridgway ND | Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide. | 1995 | Biochim. Biophys. Acta | pmid:7742354 |
Jones MJ and Murray AW | Evidence that ceramide selectively inhibits protein kinase C-alpha translocation and modulates bradykinin activation of phospholipase D. | 1995 | J. Biol. Chem. | pmid:7890607 |
Jäättelä M et al. | Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. | 1995 | Oncogene | pmid:7540278 |
Liu R et al. | Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7677781 |
Kiss Z and Deli E | Preferential inhibition of phorbol ester-induced hydrolysis of phosphatidylethanolamine by N-acetylsphingosine in NIH 3T3 fibroblasts. | 1995 | FEBS Lett. | pmid:7781767 |