N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kumar Mangalam A et al. | Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway. | 2002 | Cell. Immunol. | pmid:12473262 |
Prinetti A et al. | Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells. | 2003 | J. Biol. Chem. | pmid:12486134 |
Latorre E et al. | Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide. | 2003 | Eur. J. Biochem. | pmid:12492473 |
Condrescu M et al. | Cellular regulation of sodium-calcium exchange. | 2002 | Ann. N. Y. Acad. Sci. | pmid:12502564 |
Iwai K et al. | Ceramide increases oxidative damage due to inhibition of catalase by caspase-3-dependent proteolysis in HL-60 cell apoptosis. | 2003 | J. Biol. Chem. | pmid:12511568 |
Itoh M et al. | Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. | 2003 | Clin. Cancer Res. | pmid:12538495 |
Darios F et al. | Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. | 2003 | J. Neurochem. | pmid:12562509 |
Ito M | Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565900 |
Maedler K et al. | Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. | 2003 | Diabetes | pmid:12606514 |
Cho YH et al. | Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages. | 2003 | Mol. Pharmacol. | pmid:12606757 |
Upham BL et al. | Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis. | 2003 | Cancer Lett. | pmid:12609706 |
Mikati MA et al. | Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. | 2003 | Epilepsia | pmid:12614382 |
Scorrano L et al. | BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. | 2003 | Science | pmid:12624178 |
Shikata K et al. | Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639542 |
Shack S et al. | Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. | 2003 | Mol. Cell. Biol. | pmid:12640124 |
Colligan PB et al. | Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes. | 2002 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:12643441 |
Kong JY and Rabkin SW | Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate. | 2003 | Arch. Biochem. Biophys. | pmid:12667483 |
Wang XQ et al. | Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. | 2003 | J. Cell. Sci. | pmid:12679386 |
Stoica BA et al. | Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. | 2003 | Mol. Cell. Neurosci. | pmid:12691738 |
Liu SJ and Kennedy RH | Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12730052 |
Yakushiji K et al. | Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance. | 2003 | Exp. Cell Res. | pmid:12749866 |
Fillet M et al. | Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity. | 2003 | Biochem. Pharmacol. | pmid:12754099 |
Willaime-Morawek S et al. | C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. | 2003 | Neuroscience | pmid:12770554 |
Hunsperger EA and Wilcox CL | Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures. | 2003 | J. Neurovirol. | pmid:12775421 |
Shikata K et al. | Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells. | 2003 | Bioorg. Med. Chem. | pmid:12788346 |
Koide N et al. | C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt. | 2003 | J. Endotoxin Res. | pmid:12803880 |
Sreenivasan Y et al. | Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation. | 2003 | Oncogene | pmid:12853972 |
Ramos B et al. | Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells. | 2003 | Mol. Pharmacol. | pmid:12869656 |
Witting SR et al. | Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. | 2003 | J. Biol. Chem. | pmid:12890677 |
Cotteret S et al. | p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. | 2003 | Mol. Cell. Biol. | pmid:12897128 |
Amati F et al. | Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies. | 2003 | Cell Biochem. Funct. | pmid:12910480 |
Siskind LJ et al. | Enlargement and contracture of C2-ceramide channels. | 2003 | Biophys. J. | pmid:12944273 |
Enomoto A et al. | Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4. | 2003 | Int. J. Radiat. Biol. | pmid:14555342 |
Mansfield PJ et al. | Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes. | 2004 | Blood | pmid:14615385 |
Perks CM et al. | Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells. | 2003 | Hum. Reprod. | pmid:14645190 |
Gentil B et al. | Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells. | 2003 | Mol. Cell. Biochem. | pmid:14674699 |
Niiro H et al. | (3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells. | 2004 | Bioorg. Med. Chem. | pmid:14697769 |
Pascual M et al. | Ceramide pathways modulate ethanol-induced cell death in astrocytes. | 2003 | J. Neurochem. | pmid:14713309 |
Kiss Z and Deli E | Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts. | 1992 | Biochem. J. | pmid:1472000 |
Fernandez S et al. | Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. | 2004 | J. Immunol. | pmid:14764735 |
Shayman JA et al. | A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity. | 2004 | Glycoconj. J. | pmid:14973367 |
Pilane CM and LaBelle EF | NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. | 2004 | J. Cell. Physiol. | pmid:15040013 |
Park IN et al. | Ceramide negatively regulates glutathione S-transferase gene transactivation via repression of hepatic nuclear factor-1 that is degraded by the ubiquitin proteasome system. | 2004 | Mol. Pharmacol. | pmid:15155840 |
Schultz A and Larsson C | Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms. | 2004 | J. Neurochem. | pmid:15189345 |
Dawson G et al. | Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death. | 2004 | J. Neurochem. | pmid:15189346 |
Daido S et al. | Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. | 2004 | Cancer Res. | pmid:15205343 |
Perks CM et al. | Prolactin acts as a potent survival factor for human breast cancer cell lines. | 2004 | Br. J. Cancer | pmid:15213724 |
Hatano M et al. | Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells. | 2004 | J. Neurosurg. | pmid:15255262 |
Blázquez C et al. | Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. | 2004 | Cancer Res. | pmid:15313899 |
Park IN et al. | Ceramide, an apoptotic rheostat, inhibits CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 activation: the role in glutathione S-transferase A2 gene repression. | 2004 | Drug Metab. Dispos. | pmid:15319326 |