N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Kim DK et al. | NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide. | 2001 | Free Radic. Biol. Med. | pmid:11182527 |
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Bulanova E et al. | The IL-15R alpha chain signals through association with Syk in human B cells. | 2001 | J. Immunol. | pmid:11714793 |
Edsall LC et al. | Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. | 2001 | J. Neurochem. | pmid:11238741 |
Hollander MC et al. | Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. | 2001 | Int. J. Cancer | pmid:11241327 |
Yang MS et al. | Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia. | 2001 | Neurosci. Lett. | pmid:11567796 |
Stratford S et al. | Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation. | 2001 | Biochem. J. | pmid:11171115 |
Chen CC et al. | Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. | 2001 | Mol. Pharmacol. | pmid:11179444 |
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Sabatini M et al. | Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623638 |
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Liu J et al. | Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10644522 |
Schürmann A et al. | p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. | 2000 | Mol. Cell. Biol. | pmid:10611223 |
Di Nardo A et al. | Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes. | 2000 | Br. J. Dermatol. | pmid:10971319 |
Klapisz E et al. | Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2). | 2000 | J. Lipid Res. | pmid:11013311 |
Jiang Z et al. | Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. | 2000 | Cell. Mol. Life Sci. | pmid:10961348 |
Pahlavani MA and Vargas DM | The effect of a ceramide analog, N-acetylsphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats. | 2000 | Immunopharmacology | pmid:10996032 |
Hirokawa M et al. | Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10997557 |
Müller-Wieprecht V et al. | Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor alpha and 1 alpha, 25-dihydroxyvitamin D(3). | 2000 | Arch. Dermatol. Res. | pmid:11000289 |
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