N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Melanoma D008545 69 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
pmid:
Zhang TH et al. Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases. 2007 Acta Pharmacol. Sin. pmid:17303009
Hanna AN et al. Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance. 2001 Adv. Exp. Med. Biol. pmid:11900368
Chik CL et al. Ceramide inhibits L-type calcium channel currents in rat pinealocytes. 1999 Adv. Exp. Med. Biol. pmid:10810500
Chmura SJ et al. Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231. 1996 Adv. Exp. Med. Biol. pmid:8910670
Bielawska AE et al. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. 1997 Am. J. Pathol. pmid:9358751
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Wang P and Bitar KN Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27. 1998 Am. J. Physiol. pmid:9843784
Bitar KN HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction. 2002 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11960785
Soltys CL et al. Phosphorylation of cardiac protein kinase B is regulated by palmitate. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12181135
Liu SJ and Kennedy RH Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12730052
Sparkman L et al. Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16183668
Liu J et al. Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide. 2000 Am. J. Physiol., Cell Physiol. pmid:10644522
Kawano Y et al. Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells. 2001 Am. J. Reprod. Immunol. pmid:11775008
Chan C and Goldkorn T Ceramide path in human lung cell death. 2000 Am. J. Respir. Cell Mol. Biol. pmid:10745027
Graf C et al. A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. 2009 Anal. Biochem. pmid:18831956
Degnan BM et al. Sphingomyelinase inhibits in vitro Leydig cell function. 1996 May-Jun Ann. Clin. Lab. Sci. pmid:8726216