N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Melanoma D008545 69 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with N-acetylsphingosine?

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What functions are associated with N-acetylsphingosine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
Falluel-Morel A et al. Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. 2004 J. Neurochem. pmid:15569266
Jones EL et al. The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer. 2004 Int J Hyperthermia pmid:15764345
Murase T et al. Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa. 2004 J. Reprod. Dev. pmid:15647619
Pilane CM and LaBelle EF NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. 2004 J. Cell. Physiol. pmid:15040013
Shayman JA et al. A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity. 2004 Glycoconj. J. pmid:14973367
Blázquez C et al. Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. 2004 Cancer Res. pmid:15313899
Dawson G et al. Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death. 2004 J. Neurochem. pmid:15189346
Mansfield PJ et al. Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes. 2004 Blood pmid:14615385
Kong JY and Rabkin SW Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate. 2003 Arch. Biochem. Biophys. pmid:12667483
Willaime-Morawek S et al. C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. 2003 Neuroscience pmid:12770554
Shikata K et al. Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells. 2003 Bioorg. Med. Chem. Lett. pmid:12639542
Shack S et al. Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. 2003 Mol. Cell. Biol. pmid:12640124
Cotteret S et al. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. 2003 Mol. Cell. Biol. pmid:12897128
Scorrano L et al. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. 2003 Science pmid:12624178
Shikata K et al. Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells. 2003 Bioorg. Med. Chem. pmid:12788346
Koide N et al. C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt. 2003 J. Endotoxin Res. pmid:12803880
Siskind LJ et al. Enlargement and contracture of C2-ceramide channels. 2003 Biophys. J. pmid:12944273
Maedler K et al. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. 2003 Diabetes pmid:12606514
Stoica BA et al. Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. 2003 Mol. Cell. Neurosci. pmid:12691738
Liu SJ and Kennedy RH Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12730052
Wang XQ et al. Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. 2003 J. Cell. Sci. pmid:12679386
Itoh M et al. Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. 2003 Clin. Cancer Res. pmid:12538495
Darios F et al. Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. 2003 J. Neurochem. pmid:12562509
Ito M Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. 2003 Biochem. Biophys. Res. Commun. pmid:12565900
Cho YH et al. Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages. 2003 Mol. Pharmacol. pmid:12606757
Upham BL et al. Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis. 2003 Cancer Lett. pmid:12609706
Mikati MA et al. Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. 2003 Epilepsia pmid:12614382
Prinetti A et al. Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells. 2003 J. Biol. Chem. pmid:12486134
Iwai K et al. Ceramide increases oxidative damage due to inhibition of catalase by caspase-3-dependent proteolysis in HL-60 cell apoptosis. 2003 J. Biol. Chem. pmid:12511568
Sreenivasan Y et al. Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation. 2003 Oncogene pmid:12853972
Amati F et al. Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies. 2003 Cell Biochem. Funct. pmid:12910480
Witting SR et al. Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. 2003 J. Biol. Chem. pmid:12890677
Ramos B et al. Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells. 2003 Mol. Pharmacol. pmid:12869656
Latorre E et al. Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide. 2003 Eur. J. Biochem. pmid:12492473
Fillet M et al. Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity. 2003 Biochem. Pharmacol. pmid:12754099
Hunsperger EA and Wilcox CL Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures. 2003 J. Neurovirol. pmid:12775421
Yakushiji K et al. Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance. 2003 Exp. Cell Res. pmid:12749866
Perks CM et al. Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells. 2003 Hum. Reprod. pmid:14645190
Enomoto A et al. Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4. 2003 Int. J. Radiat. Biol. pmid:14555342
Gentil B et al. Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells. 2003 Mol. Cell. Biochem. pmid:14674699
Pascual M et al. Ceramide pathways modulate ethanol-induced cell death in astrocytes. 2003 J. Neurochem. pmid:14713309
Kralik SF et al. Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. 2002 Endocrinology pmid:11751589
Abousalham A et al. Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin-Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor. 2002 Biochem. J. pmid:11802796
Deng J et al. Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis. 2002 Oncogene pmid:11791175
Colombaioni L et al. Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells. 2002 Neurochem. Int. pmid:11792463
Phillips DC et al. Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. 2002 Arch. Biochem. Biophys. pmid:12392710
Soltys CL et al. Phosphorylation of cardiac protein kinase B is regulated by palmitate. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12181135
Decraene C et al. Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays. 2002 Genome Biol. pmid:12186649
Kim DS et al. Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. 2002 Cell. Signal. pmid:12034359
Kozawa O et al. Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. 2002 Cell. Signal. pmid:12359305