| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bourbon NA et al. | Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. | 2002 | J. Biol. Chem. | pmid:11723139 |
| Itakura A et al. | Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor. | 2002 | Exp. Hematol. | pmid:11882365 |
| Chang YT et al. | The synthesis and biological characterization of a ceramide library. | 2002 | J. Am. Chem. Soc. | pmid:11866590 |
| Mei J et al. | C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes. | 2002 | Diabetes | pmid:11872660 |
| Kondo T et al. | Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis. | 2002 | Mol. Pharmacol. | pmid:11854443 |
| Shou J et al. | Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. | 2002 | Oncogene | pmid:11840333 |
| Mora A et al. | Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. | 2002 | Cell. Signal. | pmid:11897496 |
| Kralik SF et al. | Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. | 2002 | Endocrinology | pmid:11751589 |
| Abousalham A et al. | Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin-Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor. | 2002 | Biochem. J. | pmid:11802796 |
| Deng J et al. | Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis. | 2002 | Oncogene | pmid:11791175 |
| Colombaioni L et al. | Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells. | 2002 | Neurochem. Int. | pmid:11792463 |
| Cabrero A et al. | Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells. | 2002 | J. Biol. Chem. | pmid:11792699 |
| Montes LR et al. | Membrane restructuring via ceramide results in enhanced solute efflux. | 2002 | J. Biol. Chem. | pmid:11796726 |
| Czyborra P et al. | Transient relaxation of rat mesenteric microvessels by ceramides. | 2002 | Br. J. Pharmacol. | pmid:11815377 |
| Mansfield PJ et al. | Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. | 2002 | Blood | pmid:11830497 |
| Phillips DC et al. | Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. | 2002 | Arch. Biochem. Biophys. | pmid:12392710 |
| Conway EM et al. | Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. | 2002 | Gastroenterology | pmid:12145814 |
| Toman RE et al. | Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. | 2002 | J. Neurosci. Res. | pmid:12111862 |
| Todaro M et al. | High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells. | 2002 | J. Cell. Biochem. | pmid:12112027 |
| Hearps AC et al. | Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. | 2002 | Apoptosis | pmid:12207171 |
| Gómez Del Pulgar T et al. | Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. | 2002 | J. Biol. Chem. | pmid:12133838 |
| Poppe M et al. | Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. | 2002 | J. Neurochem. | pmid:12153473 |
| Soltys CL et al. | Phosphorylation of cardiac protein kinase B is regulated by palmitate. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12181135 |
| Decraene C et al. | Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays. | 2002 | Genome Biol. | pmid:12186649 |
| Gurunathan S et al. | t-SNARE phosphorylation regulates endocytosis in yeast. | 2002 | Mol. Biol. Cell | pmid:12006655 |
| Kim HJ and Lee KJ | Heat shock and ceramide have different apoptotic pathways in radiation induced fibrosarcoma (RIF) cells. | 2002 | Mol. Cell. Biochem. | pmid:11936839 |
| Calcerrada MC et al. | Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes. | 2002 | FEBS Lett. | pmid:11943182 |
| Bitar KN | HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11960785 |
| Perks CM et al. | A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074574 |
| Perks CM et al. | Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074575 |
| Shin CY et al. | C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase. | 2002 | Cell. Signal. | pmid:12220618 |
| De Stefanis D et al. | Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. | 2002 | Biol. Chem. | pmid:12222689 |
| Ramos B et al. | Inhibition of CTP:phosphocholine cytidylyltransferase by C(2)-ceramide and its relationship to apoptosis. | 2002 | Mol. Pharmacol. | pmid:12391269 |
| Colligan PB et al. | Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes. | 2002 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:12643441 |
| Kumar Mangalam A et al. | Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway. | 2002 | Cell. Immunol. | pmid:12473262 |
| Movsesyan VA et al. | Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437970 |
| Rapizzi E et al. | Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. | 2002 | J. Cell Biol. | pmid:12438411 |
| Siskind LJ et al. | Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. | 2002 | J. Biol. Chem. | pmid:12006562 |
| Kim DS et al. | Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. | 2002 | Cell. Signal. | pmid:12034359 |
| Mallick S et al. | Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | 2002 | J. Biosci. | pmid:12089473 |
| Kozawa O et al. | Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. | 2002 | Cell. Signal. | pmid:12359305 |
| Shklyaev SS et al. | Involvement of wild-type p53 in radiation-induced c-Jun N-terminal kinase activation in human thyroid cells. | 2001 Jul-Aug | Anticancer Res. | pmid:11724323 |
| Ktitorova OV et al. | [Relationship between the induction of MDR1, a multidrug resistance gene in tumor cells, and apoptosis]. | 2001 Jul-Aug | Ontogenez | pmid:11573427 |
| Hanna AN et al. | Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase. | 2001 | Mol. Biol. Cell | pmid:11694593 |
| Schmelz EM et al. | Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. | 2001 | Cancer Res. | pmid:11559543 |
| Ghosh Choudhury G et al. | Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11527425 |
| Belichenko I et al. | Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. | 2001 | Arch. Biochem. Biophys. | pmid:11368515 |
| Willaime S et al. | Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. | 2001 | Eur. J. Neurosci. | pmid:11422444 |
| Won JS et al. | Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases. | 2001 | Brain Res. | pmid:11382404 |
| Pinton P et al. | The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. | 2001 | EMBO J. | pmid:11387204 |