octanoic acid

octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.

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Introduction

To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with octanoic acid?

octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with octanoic acid

MeSH term MeSH ID Detail
REM Sleep Behavior Disorder D020187 1 associated lipids
Flatulence D005414 1 associated lipids
Dumping Syndrome D004377 1 associated lipids
Snake Bites D012909 1 associated lipids
Chickenpox D002644 1 associated lipids
Esophageal Motility Disorders D015154 1 associated lipids
Severe Acute Respiratory Syndrome D045169 1 associated lipids
Chylothorax D002916 1 associated lipids
Hepatorenal Syndrome D006530 1 associated lipids
Prion Diseases D017096 2 associated lipids
Essential Tremor D020329 2 associated lipids
Gastroparesis D018589 2 associated lipids
Giardiasis D005873 3 associated lipids
Malocclusion D008310 3 associated lipids
Blind Loop Syndrome D001765 3 associated lipids
Drug-Related Side Effects and Adverse Reactions D064420 3 associated lipids
Coccidiosis D003048 3 associated lipids
Gallstones D042882 3 associated lipids
Schistosomiasis D012552 4 associated lipids
Urinary Incontinence D014549 4 associated lipids
Chest Pain D002637 4 associated lipids
Intracranial Hypertension D019586 4 associated lipids
Dyspepsia D004415 5 associated lipids
Liver Failure D017093 5 associated lipids
Asthenia D001247 5 associated lipids
Diabetic Neuropathies D003929 5 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Jaundice, Neonatal D007567 7 associated lipids
Stomach Diseases D013272 7 associated lipids
Chronic Disease D002908 7 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Amyotrophic Lateral Sclerosis D000690 11 associated lipids
Hypertension, Portal D006975 12 associated lipids
Crohn Disease D003424 12 associated lipids
Biliary Fistula D001658 13 associated lipids
Campylobacter Infections D002169 13 associated lipids
Critical Illness D016638 13 associated lipids
Reye Syndrome D012202 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Hemorrhage D006470 15 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Poultry Diseases D011201 21 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Endotoxemia D019446 27 associated lipids
Obesity D009765 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Diarrhea D003967 32 associated lipids
Hypothyroidism D007037 32 associated lipids
Memory Disorders D008569 33 associated lipids
Epilepsy D004827 35 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Starvation D013217 47 associated lipids
Parkinson Disease D010300 53 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Seizures D012640 87 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Insulin Resistance D007333 99 associated lipids
Glioma D005910 112 associated lipids
Inflammation D007249 119 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with octanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with octanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with octanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with octanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with octanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with octanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with octanoic acid

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Authors Title Published Journal PubMed Link
Mao LF et al. Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid. 1992 J. Biol. Chem. pmid:1737769
Roncero C and Goodridge AG Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. 1992 J. Biol. Chem. pmid:1634532
Wanders RJ and Ijlst L Fatty acid beta-oxidation in leukocytes from control subjects and medium-chain acyl-CoA dehydrogenase deficient patients. 1992 Biochim. Biophys. Acta pmid:1737072
Kristev A et al. Effects of the medium chain octanoic fatty acid on the contractile activity of vascular smooth muscle tissues. 1992 Folia Med (Plovdiv) pmid:1364081
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Ghoos YF et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. 1993 Gastroenterology pmid:8500721
Consoli A et al. Limitations in the use of [2-14C]acetate for measuring gluconeogenesis in vivo. 1993 Diabetes pmid:8482430
Hayden MA et al. Biosynthesis of lipoic acid: characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33-lip9. 1993 Biochemistry pmid:8466915
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Ben Cheikh R et al. Control of oxidative metabolism in volume-overloaded rat hearts: effects of different lipid substrates. 1994 Am. J. Physiol. pmid:8203607
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Morris TW et al. Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product. 1994 J. Biol. Chem. pmid:8206909
Viegas CA et al. Regulation of the expression of the H(+)-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae. 1994 Biochim. Biophys. Acta pmid:8286419
Odle J et al. Emulsification and fatty acid chain length affect the kinetics of [14C]-medium-chain triacylglycerol utilization by neonatal piglets. 1994 J. Nutr. pmid:8283298
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