octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Sutton DG et al. | Validation of the 13C-octanoic acid breath test for measurement of equine gastric emptying rate of solids using radioscintigraphy. | 2003 | Equine Vet. J. | pmid:12553459 |
Wyse CA et al. | Assessment of the rate of solid-phase gastric emptying in ponies by means of the 13C-octanoic acid breath test: a preliminary study. | 2001 | Equine Vet. J. | pmid:11266071 |
Khabbush A et al. | Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium-chain triglyceride ketogenic diet. | 2017 | Epilepsia | pmid:28682459 |
RodrÃguez A et al. | Synthesis of 2-monoacylglycerols and structured triacylglycerols rich in polyunsaturated fatty acids by enzyme catalyzed reactions. | 2012 | Enzyme Microb. Technol. | pmid:22759534 |
Tao Y et al. | Enhancing trimethylolpropane esters synthesis through lipase immobilized on surface hydrophobic modified support and appropriate substrate feeding methods. | 2014 | Enzyme Microb. Technol. | pmid:24731826 |
Zhang JH et al. | High-throughput screening of B factor saturation mutated Rhizomucor miehei lipase thermostability based on synthetic reaction. | 2012 | Enzyme Microb. Technol. | pmid:22500900 |
Knight VK et al. | Biotransformation of 3,5-dibromo-4-hydroxybenzonitrile under denitrifying, Fe(III)-reducing, sulfidogenic, and methanogenic conditions. | 2003 | Environ. Toxicol. Chem. | pmid:12627640 |
Walser T et al. | Prospective environmental life cycle assessment of nanosilver T-shirts. | 2011 | Environ. Sci. Technol. | pmid:21506582 |
Hsu HL and Demond AH | Influence of organic acid and organic base interactions on interfacial properties in NAPL--water systems. | 2007 | Environ. Sci. Technol. | pmid:17328200 |
Escapa IF et al. | The polyhydroxyalkanoate metabolism controls carbon and energy spillage in Pseudomonas putida. | 2012 | Environ. Microbiol. | pmid:22225632 |
Obeso JI et al. | The loss of function of PhaC1 is a survival mechanism that counteracts the stress caused by the overproduction of poly-3-hydroxyalkanoates in Pseudomonas putidaΔfadBA. | 2015 | Environ. Microbiol. | pmid:25627209 |
Genser B et al. | Within- and between-group regression for improving the robustness of causal claims in cross-sectional analysis. | 2015 | Environ Health | pmid:26159541 |
Schenk J et al. | Treatment of choledocholithiasis using the transpapillary perfusion technique. | 1980 | Endoscopy | pmid:7428727 |
De Vriese C et al. | Ghrelin interacts with human plasma lipoproteins. | 2007 | Endocrinology | pmid:17289852 |
Satou M et al. | Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium. | 2010 | Endocrinology | pmid:20685872 |
Silavin SL et al. | Reevaluation of the effects of cytochalasins on steroidogenesis: studies on hamster granulosa cells. | 1984 | Endocrinology | pmid:6592092 |
Nishi Y et al. | Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. | 2005 | Endocrinology | pmid:15677766 |
Grill V | Nutrient-induced priming of insulin and glucagon secretion. Effects of alpha-ketoisocaproic acid. | 1982 | Endocrinology | pmid:6173206 |
Seydoux J et al. | Brown adipose tissue metabolism in streptozotocin-diabetic rats. | 1983 | Endocrinology | pmid:6223804 |
Assimacopoulos-Jeannet F et al. | Alterations of brown adipose tissue in genetically obese (ob/ob) mice. II. Studies of beta-adrenergic receptors and fatty acid degradation. | 1982 | Endocrinology | pmid:6276135 |
Ferris CF et al. | Alcohol and fatty acid stimulation of neurotensin release from rat small intestine. | 1985 | Endocrinology | pmid:3971900 |
Grill V et al. | Multiple abnormalities in insulin responses to nonglucose nutrients in neonatally streptozotocin diabetic rats. | 1991 | Endocrinology | pmid:1706269 |
Kaiya H et al. | Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout. | 2003 | Endocrinology | pmid:12970156 |
Hamel FG et al. | In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters. | 2003 | Endocrinology | pmid:12746301 |
Phillips PS et al. | Myotoxic reactions to lipid-lowering therapy are associated with altered oxidation of fatty acids. | 2009 | Endocrine | pmid:19051066 |
Lim CT et al. | The expression of ghrelin O-acyltransferase (GOAT) in human tissues. | 2011 | Endocr. J. | pmid:21646729 |
Crawford MJ et al. | Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast. | 2006 | EMBO J. | pmid:16778769 |
Clifton JG et al. | Proteomic characterization of plasma-derived clotting factor VIII-von Willebrand factor concentrates. | 2009 | Electrophoresis | pmid:19768705 |
Schenk J et al. | [Irrigation treatment of concrements in the common bile duct with octanoate (Capmul 8210) (author's transl)]. | 1980 | Dtsch. Med. Wochenschr. | pmid:7408673 |
Smits NG et al. | Development of a flow cytometric immunoassay for recombinant bovine somatotropin-induced antibodies in serum of dairy cows. | 2012 | Drug Test Anal | pmid:21964757 |
Yamamoto A et al. | Enhanced permeability of phenylalanyl-glycine (Phe-Gly) across the intestinal membranes by chemical modification with various fatty acids. | 2003 | Drug Metab. Pharmacokinet. | pmid:15618716 |
Bjorge SM and Baillie TA | Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations. | 1991 Jul-Aug | Drug Metab. Dispos. | pmid:1680661 |
Pfadenhauer EH et al. | Identification of the metabolites of erythro-9-(2-hydroxy-3-nonyl)hypoxanthine from laboratory animals. | 1984 May-Jun | Drug Metab. Dispos. | pmid:6145553 |
Visarius TM et al. | Thiodiglycolic acid is excreted by humans receiving ifosfamide and inhibits mitochondrial function in rats. | 1998 | Drug Metab. Dispos. | pmid:9492379 |
Kuypers DR et al. | The rate of gastric emptying determines the timing but not the extent of oral tacrolimus absorption: simultaneous measurement of drug exposure and gastric emptying by carbon-14-octanoic acid breath test in stable renal allograft recipients. | 2004 | Drug Metab. Dispos. | pmid:15383495 |
Li C et al. | Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. | 2003 | Drug Metab. Dispos. | pmid:12756204 |
Morris AP et al. | Synthesis of haloperidol prodrugs and their hydrolysis by porcine liver esterase. | 2008 | Drug Metab Lett | pmid:19356105 |
Ryu JK and Yoo SD | Preparation and evaluation of bicyclol microemulsions for enhanced oral bioavailability. | 2012 | Drug Dev Ind Pharm | pmid:22283588 |
Karakatsani M et al. | The effect of permeation enhancers on the viscosity and the release profile of transdermal hydroxypropyl methylcellulose gel formulations containing diltiazem HCl. | 2010 | Drug Dev Ind Pharm | pmid:20545504 |
Chen X et al. | Preparation and characterization of PEG-modified polyurethane pressure-sensitive adhesives for transdermal drug delivery. | 2009 | Drug Dev Ind Pharm | pmid:19514985 |
Jung SY et al. | Formulation and evaluation of ubidecarenone transdermal delivery systems. | 2009 | Drug Dev Ind Pharm | pmid:19365779 |
Hossain MA et al. | Effect of vehicle systems, pH and enhancers on the permeation of highly lipophilic aripiprazole from Carbopol 971P gel systems across human cadaver skin. | 2012 | Drug Dev Ind Pharm | pmid:22067044 |
Cho CW et al. | Development of the ambroxol gels for enhanced transdermal delivery. | 2008 | Drug Dev Ind Pharm | pmid:18363149 |
Whang J and Gwak H | Effects of amines on percutaneous absorption of alendronate. | 2011 | Drug Dev Ind Pharm | pmid:21126206 |
Choi JS and Shin SC | Preparation and evaluation of pranoprofen gel for percutaneous administration. | 2007 | Drug Dev Ind Pharm | pmid:17192247 |
Gwak HS et al. | Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers. | 2004 | Drug Dev Ind Pharm | pmid:15089053 |
Cho YA and Gwak HS | Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers. | 2004 | Drug Dev Ind Pharm | pmid:15285328 |
Matsumoto Y et al. | Rectal absorption enhancement of gentamicin in rabbits from hollow type suppositories by sodium salicylate or sodium caprylate. | 1989 | Drug Des. Deliv. | pmid:2490276 |
Mohanty AK et al. | Etoposide-loaded biodegradable amphiphilic methoxy (poly ethylene glycol) and poly (epsilon caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy. | 2010 | Drug Deliv | pmid:20370380 |
Choi A et al. | Pharmacokinetic characteristics of formulated alendronate transdermal delivery systems in rats and humans. | 2010 | Drug Deliv | pmid:20214414 |
Librán-Pérez M et al. | Effects of insulin treatment on the response to oleate and octanoate of food intake and fatty acid-sensing systems in rainbow trout. | 2015 | Domest. Anim. Endocrinol. | pmid:26226227 |
Chang P et al. | The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. | 2012 | Dis Model Mech | pmid:21876211 |
Schmidt-Wilcke HA et al. | Effect of fatty acids on the stimulated gastric secretion in man. | 1975 | Digestion | pmid:1201821 |
Toepfer M et al. | Noninvasive (13)C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis. | 1999 Nov-Dec | Digestion | pmid:10545728 |
Minderhoud IM et al. | Gastric emptying of a solid meal starts during meal ingestion: combined study using 13C-octanoic acid breath test and Doppler ultrasonography. Absence of a lag phase in 13C-octanoic acid breath test. | 2004 | Digestion | pmid:15297778 |
Ohkubo Y et al. | Presence and properties of acyl coenzyme A synthetase for medium-chain fatty acids in rat intestinal mucosa. | 1992 | Digestion | pmid:1386328 |
Bluck LJ et al. | Bayesian hierarchical methods to interpret the (13)C-octanoic acid breath test for gastric emptying. | 2011 | Digestion | pmid:21042021 |
Vessey DA | Isolation and preliminary characterization of the medium-chain fatty acid:CoA ligase responsible for activation of short- and medium-chain fatty acids in colonic mucosa from swine. | 2001 | Dig. Dis. Sci. | pmid:11281196 |
Duan LP et al. | Influence of cisapride on gastric emptying of solids and liquids monitored by 13C breath tests. | 1995 | Dig. Dis. Sci. | pmid:7587790 |
Yoshioka M et al. | Malabsorption of long-chain fatty acid in cholera toxin-induced secretory diarrhea. | 1986 | Dig. Dis. Sci. | pmid:3698768 |
Sanaka M et al. | Is the time for absorption and oxidation of 13c-octanoate really negligible in the gastric emptying breath test? | 2006 | Dig. Dis. Sci. | pmid:17120146 |
Maes BD et al. | Gastric emptying rate of solids in patients with nonulcer dyspepsia. | 1997 | Dig. Dis. Sci. | pmid:9201077 |
Punkkinen J et al. | Measuring gastric emptying: comparison of 13C-octanoic acid breath test and scintigraphy. | 2006 | Dig. Dis. Sci. | pmid:16534667 |
Sarnelli G et al. | Symptom patterns and pathophysiological mechanisms in dyspeptic patients with and without Helicobacter pylori. | 2003 | Dig. Dis. Sci. | pmid:14714606 |
Perri F et al. | Gastric emptying and Helicobacter pylori infection in duodenal ulcer disease. | 1996 | Dig. Dis. Sci. | pmid:8617116 |
Shalev T et al. | Evaluation of the 13C-octanoate breath test as a surrogate marker of liver damage in animal models. | 2010 | Dig. Dis. Sci. | pmid:19731033 |
Gonlachanvit S et al. | Effect of meal size and test duration on gastric emptying and gastric myoelectrical activity as determined with simultaneous [13C]octanoate breath test and electrogastrography in normal subjects using a muffin meal. | 2001 | Dig. Dis. Sci. | pmid:11768254 |
Bromer MQ et al. | Simultaneous measurement of gastric emptying with a simple muffin meal using [13C]octanoate breath test and scintigraphy in normal subjects and patients with dyspeptic symptoms. | 2002 | Dig. Dis. Sci. | pmid:12141833 |
Foschi D et al. | Effects of intramural administration of Botulinum Toxin A on gastric emptying and eating capacity in obese patients. | 2008 | Dig Liver Dis | pmid:18420471 |
Perri F et al. | (13)C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer): Toward standardization for testing gastric emptying of solids. | 2010 | Dig Liver Dis | pmid:20116352 |
Bianchi M and Capurso L | Effects of guar gum, ispaghula and microcrystalline cellulose on abdominal symptoms, gastric emptying, orocaecal transit time and gas production in healthy volunteers. | 2002 | Dig Liver Dis | pmid:12408456 |
Jackson SJ et al. | Delayed gastric emptying in the obese: an assessment using the non-invasive (13)C-octanoic acid breath test. | 2004 | Diabetes Obes Metab | pmid:15171750 |
Tesfaye S et al. | Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. | 2010 | Diabetes Care | pmid:20876709 |
Aiston S et al. | Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase. | 2003 | Diabetes | pmid:12765941 |
Oberhaensli RD et al. | Effect of norepinephrine on ketogenesis, fatty acid oxidation, and esterification in isolated rat hepatocytes. | 1985 | Diabetes | pmid:2862086 |
Padmalayam I et al. | Lipoic acid synthase (LASY): a novel role in inflammation, mitochondrial function, and insulin resistance. | 2009 | Diabetes | pmid:19074983 |
Fulgencio JP et al. | Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats. | 1996 | Diabetes | pmid:8866561 |
Satapati S et al. | Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism. | 2008 | Diabetes | pmid:18469201 |
Gómez-Valadés AG et al. | Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice. | 2008 | Diabetes | pmid:18443203 |
Alcázar O et al. | Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid. | 1997 | Diabetes | pmid:9200650 |
Athéa Y et al. | AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function. | 2007 | Diabetes | pmid:17327449 |
Consoli A et al. | Limitations in the use of [2-14C]acetate for measuring gluconeogenesis in vivo. | 1993 | Diabetes | pmid:8482430 |
Page KA et al. | Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. | 2009 | Diabetes | pmid:19223595 |
Briaud I et al. | Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. | 2001 | Diabetes | pmid:11272142 |
Campillo JE et al. | Effect of oleic and octanoic acids on glucose-induced insulin release in vitro. | 1979 | Diabete Metab | pmid:499632 |
Malewiak MI et al. | Oleate metabolism and endogenous triacylglycerol hydrolysis in isolated hepatocytes from rats fed a high-fat diet. | 1988 May-Jun | Diabete Metab | pmid:3410152 |
Ikemura K et al. | Design of a new, multi-purpose, light-curing adhesive comprising a silane coupling agent, acidic adhesive monomers and dithiooctanoate monomers for bonding to varied metal and dental ceramic materials. | 2011 | Dent Mater J | pmid:21778601 |
Ikemura K et al. | Effect of the combination of dithiooctanoate monomers and acidic adhesive monomers on adhesion to precious metals, precious metal alloys and non-precious metal alloys. | 2011 | Dent Mater J | pmid:21778614 |
Ikemura K et al. | Effects of a newly designed HEMA-free, multi-purpose, single-bottle, self-etching adhesive on bonding to dental hard tissues, zirconia-based ceramics, and gold alloy. | 2011 | Dent Mater J | pmid:21946481 |
Ikemura K et al. | Design of a metal primer containing a dithiooctanoate monomer and a phosphonic acid monomer for bonding of prosthetic light-curing resin composite to gold, dental precious and non-precious metal alloys. | 2011 | Dent Mater J | pmid:21597216 |
Ayvalı T et al. | One-pot synthesis of colloidally robust rhodium(0) nanoparticles and their catalytic activity in the dehydrogenation of ammonia-borane for chemical hydrogen storage. | 2011 | Dalton Trans | pmid:21373677 |
Sibille B et al. | 2,4 Dinitrophenol-uncoupling effect on delta psi in living hepatocytes depends on reducing-equivalent supply. | 1998 | Cytometry | pmid:9627223 |
Coronado MA et al. | Structural Insights into Substrate Binding of Brown Spider Venom Class II Phospholipases D. | 2015 | Curr. Protein Pept. Sci. | pmid:25961401 |
Cai T et al. | Degradation of bromoxynil octanoate by strain Acinetobacter sp. XB2 isolated from contaminated soil. | 2011 | Curr. Microbiol. | pmid:21674164 |
López NI et al. | Pseudomonas extremaustralis sp. nov., a Poly(3-hydroxybutyrate) producer isolated from an antarctic environment. | 2009 | Curr. Microbiol. | pmid:19688380 |
Ayub ND et al. | A polyhydroxybutyrate-producing Pseudomonas sp. isolated from Antarctic environments with high stress resistance. | 2004 | Curr. Microbiol. | pmid:15386099 |
Trimble ME et al. | Fatty acid transport and metabolism in the isolated perfused rat kidney. | 1977 Oct 23-26 | Curr Probl Clin Biochem | pmid:616371 |
Lemieux G et al. | Relationship between the renal metabolism of glutamine, fatty acids and ketone bodies. | 1977 Oct 23-26 | Curr Probl Clin Biochem | pmid:616372 |
Maricic MJ | Oral calcitonin. | 2012 | Curr Osteoporos Rep | pmid:22281725 |
Kojima M and Kangawa K | Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract. | 2002 | Curr Opin Pharmacol | pmid:12482728 |