octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Choi YH et al. | Lipoic acid suppresses compound 48/80-induced anaphylaxis-like reaction. | 2010 | Anat Cell Biol | pmid:21267406 |
Bailly-Chouriberry L et al. | Detection of secondary biomarker of met-eGH as a strategy to screen for somatotropin misuse in horseracing. | 2008 | Analyst | pmid:18227952 |
Meng Y et al. | Role of counteranions in polymeric ionic liquid-based solid-phase microextraction coatings for the selective extraction of polar compounds. | 2011 | Anal. Chim. Acta | pmid:21277416 |
Rodrigues F et al. | Development of a dynamic headspace solid-phase microextraction procedure coupled to GC-qMSD for evaluation the chemical profile in alcoholic beverages. | 2008 | Anal. Chim. Acta | pmid:18243877 |
Kragh-Hansen U et al. | Rate-of-dialysis technique: theoretical and practical aspects. | 2005 | Anal. Biochem. | pmid:15802140 |
Bryant P et al. | The activity of a thermostable lipoyl synthase from Sulfolobus solfataricus with a synthetic octanoyl substrate. | 2006 | Anal. Biochem. | pmid:16500612 |
Jones JG et al. | Determination of acetyl-CoA enrichment in rat heart and skeletal muscle by 1H nuclear magnetic resonance analysis of glutamate in tissue extracts. | 1997 | Anal. Biochem. | pmid:9212871 |
Kunz D et al. | Flow cytometric detection of mitochondrial dysfunction in subpopulations of human mononuclear cells. | 1997 | Anal. Biochem. | pmid:9073359 |
Hjelmeland LM et al. | A new class of nonionic detergents with a gluconamide polar group. | 1983 | Anal. Biochem. | pmid:6869837 |
Zhu L et al. | Simultaneous sampling of volatile and non-volatile analytes in beer for fast fingerprinting by extractive electrospray ionization mass spectrometry. | 2010 | Anal Bioanal Chem | pmid:20644917 |
Dietrich B et al. | Synthesis, characterization, and high-performance liquid chromatographic evaluation of C14 stationary phases containing branched and unbranched alkyl groups. | 2008 | Anal Bioanal Chem | pmid:18506426 |
Takahashi H et al. | Metabolomics approach for determining growth-specific metabolites based on Fourier transform ion cyclotron resonance mass spectrometry. | 2008 | Anal Bioanal Chem | pmid:18560811 |
Eggink M et al. | Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA. | 2010 | Anal Bioanal Chem | pmid:20238107 |
Yamamoto K et al. | An LC method for monitoring medium-chain fatty acid permeation through CaCo-2 cell monolayers. | 2009 | Anal Bioanal Chem | pmid:19641905 |
Urquiza M et al. | α-Helix peptides designed from EBV-gH protein display higher antigenicity and induction of monocyte apoptosis than the native peptide. | 2010 | Amino Acids | pmid:20473772 |
McLellan J et al. | Comparison of the carbon 13-labeled octanoic acid breath test and ultrasonography for assessment of gastric emptying of a semisolid meal in dogs. | 2004 | Am. J. Vet. Res. | pmid:15566095 |
Wyse CA et al. | Use of the 13C-octanoic acid breath test for assessment of solid-phase gastric emptying in dogs. | 2001 | Am. J. Vet. Res. | pmid:11763185 |
Valipe SR et al. | In vitro antimicrobial properties of caprylic acid, monocaprylin, and sodium caprylate against Dermatophilus congolensis. | 2011 | Am. J. Vet. Res. | pmid:21355735 |
Battiprolu PK et al. | Sex differences in energy metabolism and performance of teleost cardiac tissue. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17038442 |
Richards JG et al. | Palmitate movement across red and white muscle membranes of rainbow trout. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12969874 |
El Hafidi M et al. | Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15331379 |
Librán-Pérez M et al. | Evidence of a metabolic fatty acid-sensing system in the hypothalamus and Brockmann bodies of rainbow trout: implications in food intake regulation. | 2012 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:22496361 |
Sallam HS et al. | Mechanisms of burn-induced impairment in gastric slow waves and emptying in rats. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20427716 |
Darling RA et al. | Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24760994 |
Degen L et al. | Effect of CCK-1 receptor blockade on ghrelin and PYY secretion in men. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17138722 |
Barron JT and Gu L | Energetic effects of adenosine on vascular smooth muscle. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644580 |
Panchal AR et al. | Partitioning of pyruvate between oxidation and anaplerosis in swine hearts. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11045976 |
Longnus SL et al. | Regulation of myocardial fatty acid oxidation by substrate supply. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11557544 |
Allard MF et al. | AMPK and metabolic adaptation by the heart to pressure overload. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16920812 |
Labarthe F et al. | Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15550523 |
Vincent G et al. | Differential modulation of citrate synthesis and release by fatty acids in perfused working rat hearts. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12933348 |
Kajimoto M et al. | Differential effects of octanoate and heptanoate on myocardial metabolism during extracorporeal membrane oxygenation in an infant swine model. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26232235 |
Kajimoto M et al. | Effects of continuous triiodothyronine infusion on the tricarboxylic acid cycle in the normal immature swine heart under extracorporeal membrane oxygenation in vivo. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24531815 |
Jørgensen J and Mortensen PB | Substrate utilization by intestinal mucosal tissue strips from patients with inflammatory bowel disease. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11447021 |
Mizutani M et al. | Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pH. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20501445 |
Vincent G et al. | Citrate release by perfused rat hearts: a window on mitochondrial cataplerosis. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10780941 |
Kim JY et al. | Lipid oxidation is reduced in obese human skeletal muscle. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:11052958 |
Benthem L et al. | Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:11093916 |
Bezaire V et al. | Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16219667 |
Cha BS et al. | Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARgamma agonists. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15727952 |
Sakata I et al. | Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19401456 |
Tham E et al. | Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19240252 |
Hommelberg PP et al. | Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18957619 |
Bando M et al. | Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22114024 |
Turcotte LP et al. | High carbohydrate availability increases LCFA uptake and decreases LCFA oxidation in perfused muscle. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11739099 |
Vinay P et al. | Effect of fatty acids on renal ammoniagenesis in in vivo and in vitro studies. | 1976 | Am. J. Physiol. | pmid:970471 |
Burns AH and Reddy WJ | Amino acid stimulation of oxygen and substrate utilization by cardiac myocytes. | 1978 | Am. J. Physiol. | pmid:727249 |
Azain MJ and Ontko JA | An explanation for decreased ketogenesis in the liver of the obese Zucker rat. | 1989 | Am. J. Physiol. | pmid:2552844 |
Witters LA and Trasko CS | Regulation of hepatic free fatty acid metabolism by glucagon and insulin. | 1979 | Am. J. Physiol. | pmid:157075 |
Bielefeld DR et al. | Altered sensitivity of chronic diabetic rat heart to calcium. | 1983 | Am. J. Physiol. | pmid:6362427 |