octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Camarasa C et al. | Phenotypic landscape of Saccharomyces cerevisiae during wine fermentation: evidence for origin-dependent metabolic traits. | 2011 | PLoS ONE | pmid:21949874 |
Carlsson MA et al. | Odour maps in the brain of butterflies with divergent host-plant preferences. | 2011 | PLoS ONE | pmid:21901154 |
Brilli F et al. | Detection of plant volatiles after leaf wounding and darkening by proton transfer reaction "time-of-flight" mass spectrometry (PTR-TOF). | 2011 | PLoS ONE | pmid:21637822 |
Paul D et al. | Proteome and membrane fatty acid analyses on Oligotropha carboxidovorans OM5 grown under chemolithoautotrophic and heterotrophic conditions. | 2011 | PLoS ONE | pmid:21386900 |
Xu W et al. | Odorant-binding proteins of the malaria mosquito Anopheles funestus sensu stricto. | 2010 | PLoS ONE | pmid:21042539 |
Bao F et al. | New cobalt-mediated radical polymerization (CMRP) of methyl methacrylate initiated by two single-component dinuclear β-diketone cobalt (II) catalysts. | 2010 | PLoS ONE | pmid:21049027 |
Guo J et al. | Characterization of a novel esterase Rv0045c from Mycobacterium tuberculosis. | 2010 | PLoS ONE | pmid:20957207 |
Pérez D et al. | A novel halophilic lipase, LipBL, showing high efficiency in the production of eicosapentaenoic acid (EPA). | 2011 | PLoS ONE | pmid:21853111 |
Buglino JA and Resh MD | Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. | 2010 | PLoS ONE | pmid:20585641 |
Hauser PV et al. | Novel siRNA delivery system to target podocytes in vivo. | 2010 | PLoS ONE | pmid:20209128 |
Wang DB et al. | Detection of B. anthracis spores and vegetative cells with the same monoclonal antibodies. | 2009 | PLoS ONE | pmid:19915677 |
Can Güven S and Laska M | Olfactory sensitivity and odor structure-activity relationships for aliphatic carboxylic acids in CD-1 mice. | 2012 | PLoS ONE | pmid:22479594 |
Prpich AM et al. | Tension at the surface: which phase is more important, liquid or vapor? | 2009 | PLoS ONE | pmid:20011532 |
Brault G et al. | Isolation and characterization of EstC, a new cold-active esterase from Streptomyces coelicolor A3(2). | 2012 | PLoS ONE | pmid:22396747 |
Brisse S et al. | Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. | 2009 | PLoS ONE | pmid:19319196 |
Zelano C et al. | A specialized odor memory buffer in primary olfactory cortex. | 2009 | PLoS ONE | pmid:19305509 |
Eagle RA et al. | Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G. | 2009 | PLoS ONE | pmid:19223974 |
Takahashi K et al. | Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism. | 2009 | PLoS ONE | pmid:19119319 |
González-Mas MC et al. | Comparative analysis of the volatile fraction of fruit juice from different Citrus species. | 2011 | PLoS ONE | pmid:21818287 |
Berna AZ et al. | Bio-benchmarking of electronic nose sensors. | 2009 | PLoS ONE | pmid:19641604 |
Murzyn A et al. | Capric acid secreted by S. boulardii inhibits C. albicans filamentous growth, adhesion and biofilm formation. | 2010 | PLoS ONE | pmid:20706577 |
Spring S et al. | The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov. | 2009 | PLoS ONE | pmid:19287491 |
Janssen S et al. | Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. | 2012 | PLoS ONE | pmid:22768248 |
Gumel AM et al. | Biosynthesis and characterization of polyhydroxyalkanoates copolymers produced by Pseudomonas putida Bet001 isolated from palm oil mill effluent. | 2012 | PLoS ONE | pmid:23028854 |
Liberato MV et al. | Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists. | 2012 | PLoS ONE | pmid:22649490 |
Li J et al. | Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma xenografts. | 2012 | PLoS ONE | pmid:22529899 |
Liang QH et al. | Ghrelin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the ERK pathway. | 2012 | PLoS ONE | pmid:22514603 |
Lin HV et al. | Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. | 2012 | PLoS ONE | pmid:22506074 |
Jin M et al. | A rapid subtractive immunization method to prepare discriminatory monoclonal antibodies for food E. coli O157:H7 contamination. | 2012 | PLoS ONE | pmid:22347466 |
Lemarié F et al. | Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat. | 2015 | PLoS ONE | pmid:26196391 |
Arora T et al. | Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission. | 2015 | PLoS ONE | pmid:25946120 |
Takatani-Nakase T et al. | Transcutaneous immunization system using a hydrotropic formulation induces a potent antigen-specific antibody response. | 2012 | PLoS ONE | pmid:23110149 |
Caballero E et al. | Potential use of avocado oil on structured lipids MLM-type production catalysed by commercial immobilised lipases. | 2014 | PLoS ONE | pmid:25248107 |
Librán-Pérez M et al. | Oleic acid and octanoic acid sensing capacity in rainbow trout Oncorhynchus mykiss is direct in hypothalamus and Brockmann bodies. | 2013 | PLoS ONE | pmid:23533628 |
Paulsen SJ et al. | Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion. | 2014 | PLoS ONE | pmid:24520357 |
Nair DR et al. | Two functionally distinctive phosphopantetheinyl transferases from amoeba Dictyostelium discoideum. | 2011 | PLoS ONE | pmid:21931666 |
Wexler-Cohen Y and Shai Y | Membrane-anchored HIV-1 N-heptad repeat peptides are highly potent cell fusion inhibitors via an altered mode of action. | 2009 | PLoS Pathog. | pmid:19593361 |
Günther S et al. | Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum. | 2007 | PLoS Pathog. | pmid:18069893 |
Vavricka CJ et al. | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. | 2011 | PLoS Pathog. | pmid:22028647 |
Rosiak J and Olejniczak J | [Polymer materials for biomedical use obtained by radiation methods. IV. The therapeutic system for local release of prostaglandins]. | 1989 | Polim Med | pmid:2641404 |
Solis de Los Santos F et al. | Caprylic acid supplemented in feed reduces enteric Campylobacter jejuni colonization in ten-day-old broiler chickens. | 2008 | Poult. Sci. | pmid:18340004 |
Bhanushali JK et al. | Simple method to purify chicken immunoglobulin G. | 1994 | Poult. Sci. | pmid:7937478 |
Hughes RJ et al. | A method for collecting breath samples from individual chickens for analysis of 13CO(2), H(2), and CH(4). | 2008 | Poult. Sci. | pmid:18753448 |
Metcalf JH et al. | Water administration of the medium-chain fatty acid caprylic acid produced variable efficacy against enteric Campylobacter colonization in broilers. | 2011 | Poult. Sci. | pmid:21248350 |
Kollanoor-Johny A et al. | Caprylic acid reduces Salmonella Enteritidis populations in various segments of digestive tract and internal organs of 3- and 6-week-old broiler chickens, therapeutically. | 2012 | Poult. Sci. | pmid:22700516 |
Solis de los Santos F et al. | The natural feed additive caprylic acid decreases Campylobacter jejuni colonization in market-aged broiler chickens. | 2009 | Poult. Sci. | pmid:19096058 |
Tien ES et al. | Examination of Ligand-Dependent Coactivator Recruitment by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha). | 2006 | PPAR Res | pmid:17259669 |
Allison F et al. | The oxidation of octanoic acid by cultured amniotic fluid cells: the effect of cell type and passage number. | 1988 | Prenat. Diagn. | pmid:3405975 |
Bennett MJ et al. | Prenatal diagnosis of medium-chain acyl-coenzyme A dehydrogenase deficiency. | 1987 | Prenat. Diagn. | pmid:3575262 |
Habeeb AF and Francis RD | Preparation of human immunoglobulin by caprylic acid precipitation. | 1984 | Prep. Biochem. | pmid:6718324 |
Omura T | Recollection of the early years of the research on cytochrome P450. | 2011 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:22156409 |
Pösö AR and Mortimore GE | Requirement for alanine in the amino acid control of deprivation-induced protein degradation in liver. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6589593 |
Jenkins DL and Griffith OW | Antiketogenic and hypoglycemic effects of aminocarnitine and acylaminocarnitines. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3455765 |
Gutierrez JA et al. | Ghrelin octanoylation mediated by an orphan lipid transferase. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18443287 |
Merritt ME et al. | Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18056642 |
Pi-Sunyer FX | Effect of long- and medium-chain fatty acids on insulin secretion from pieces of rat pancreas. | 1975 | Proc. Soc. Exp. Biol. Med. | pmid:1144459 |
Paquet RJ et al. | Effects of thiamine deficiency and octanoate administration, in vivo, on gluconeogenesis in rat kidney slices and on amino acid profile in rat liver. | 1972 | Proc. Soc. Exp. Biol. Med. | pmid:5039394 |
Morrow RJ et al. | Functional utilization of palmitate, octanoate, and glucose by the isolated rat heart. | 1973 | Proc. Soc. Exp. Biol. Med. | pmid:4683244 |
Maragoudakis ME et al. | Metabolism of octanoate and its effect on glucose and palmitate utilization by isolated fat cells. | 1975 | Proc. Soc. Exp. Biol. Med. | pmid:236573 |
McDonough KH and Spitzer JJ | Effects of hypoxia and reoxygenation on adult rat heart cell metabolism. | 1983 | Proc. Soc. Exp. Biol. Med. | pmid:6412237 |
Socała K et al. | Role of the adenosine system and glucose restriction in the acute anticonvulsant effect of caprylic acid in the 6 Hz psychomotor seizure test in mice. | 2015 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:25455587 |
Wlaź P et al. | Acute anticonvulsant effects of capric acid in seizure tests in mice. | 2015 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:25445478 |
Leovey EM and Andersen NH | Molecular basis of prostaglandin potency. II. Proton NMR studies of the conformation of prostaglandin F2alpha. | 1975 | Prostaglandins | pmid:1215541 |
Midelfort KS et al. | Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin. | 2013 | Protein Eng. Des. Sel. | pmid:23012440 |
Raza S et al. | Enantioselectivity in Candida antarctica lipase B: a molecular dynamics study. | 2001 | Protein Sci. | pmid:11266619 |
Kim DJ et al. | Structural basis of octanoic acid recognition by lipoate-protein ligase B. | 2008 | Proteins | pmid:18076036 |
Hlongwane C et al. | Comparative quantitative fatty acid analysis of triacylglycerols using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and gas chromatography. | 2001 | Rapid Commun. Mass Spectrom. | pmid:11675670 |
Parshintsev J et al. | Desorption atmospheric pressure photoionization high-resolution mass spectrometry: a complementary approach for the chemical analysis of atmospheric aerosols. | 2015 | Rapid Commun. Mass Spectrom. | pmid:26395607 |
Jackson SJ et al. | Use of isotopically labelled octanoic acid to assess the effect of meal size on gastric emptying. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15150821 |
Nebbioso A et al. | Limitations of electrospray ionization in the analysis of a heterogeneous mixture of naturally occurring hydrophilic and hydrophobic compounds. | 2010 | Rapid Commun. Mass Spectrom. | pmid:20941764 |
Bluck LJ et al. | Measurement of gastric emptying in man using deuterated octanoic acid. | 2002 | Rapid Commun. Mass Spectrom. | pmid:11754258 |
Ma J et al. | Effects of cefaclor on gastric emptying and cholecystokinin release in healthy humans. | 2010 | Regul. Pept. | pmid:19914303 |
Duée PH et al. | Development and regulation of ketogenesis in isolated hepatocytes from newborn rabbits. | 1985 | Reprod Nutr Dev | pmid:3992001 |
Aurousseau B et al. | [Effect of the replacement of a part of the tallow in a milk supply with tricaprylin or coconut oil on the use of energy and nitrogen by the preruminant calf]. | 1984 | Reprod Nutr Dev | pmid:6729239 |
O'Brien M et al. | Ghrelin in the human myometrium. | 2010 | Reprod. Biol. Endocrinol. | pmid:20509935 |
Mitkov D et al. | On octanoic acid-induced hyperventilation--implications for hepatic encephalopathy and Reye's syndrome. | 1989 | Res Exp Med (Berl) | pmid:2813970 |
Burns AH and Reddy WJ | Effect of ouabain on exogenous substrate oxidation by isolated cardiac myocytes. | 1981 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6267674 |
Derr RF and Draves K | Methanethiol metabolism in the rat. | 1983 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6407074 |
Schmeisch AP et al. | The role of hemodynamics in the action of diltiazem on hepatic fatty acid metabolism. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:10342914 |
Wyse CA et al. | A comparison of the rate of recovery of 13CO2 in exhaled breath with 2H in body water following ingestion of [2H/13C]octanoic acid in a dog. | 2003 | Res. Vet. Sci. | pmid:12589736 |
Wyse CA et al. | The(13)C-octanoic acid breath test for detection of effects of meal composition on the rate of solid-phase gastric emptying in ponies. | 2001 | Res. Vet. Sci. | pmid:11666152 |
Kojima M and Kangawa K | Ghrelin: from gene to physiological function. | 2010 | Results Probl Cell Differ | pmid:19859676 |
Angelos MG et al. | Glucose, insulin and potassium (GIK) during reperfusion mediates improved myocardial bioenergetics. | 2002 | Resuscitation | pmid:12458070 |
Auriol S et al. | Safety of medium-chain triglycerides used as an intraocular tamponading agent in an experimental vitrectomy model rabbit. | 2013 | Retina (Philadelphia, Pa.) | pmid:22902566 |
Novaretti MC and Dinardo CL | Immunoglobulin: production, mechanisms of action and formulations. | 2011 | Rev Bras Hematol Hemoter | pmid:23049343 |
HIRSCH HM and WALLACE GI | The octanoxidase system of Streptomyces aureofaciens. | 1951 | Rev Can Biol | pmid:14865337 |
Germán JC et al. | [Solvent effects on cholesterol calculi: an in vitro study using octanoic acid, glycerol monooctanate, sodium cholate, heparin and ursodeoxycholic acid]. | 1985 | Rev Esp Enferm Apar Dig | pmid:3975461 |
Sfarti C et al. | [Prevalence of delayed gastric emptying of solids in functional dyspepsia and its relationship to symptoms]. | 2009 Oct-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:20191871 |
González A et al. | [Applications of stable isotopes in biomedical sciences]. | 1998 Apr-Jun | Rev Med Univ Navarra | pmid:10420942 |
González A et al. | [Studying of gastric emptying for solids and liquids by means of using stable isotopes]. | 1998 Apr-Jun | Rev Med Univ Navarra | pmid:10420944 |
Leite-Moreira AF et al. | Modulation of myocardial function by pyruvate. | 2002 | Rev Port Cardiol | pmid:12090129 |
Valdivia MM et al. | [Effect of octanoic acid on the insulin secretion in response to glucose in vitro (author's transl)]. | 1979 | Rev. Esp. Fisiol. | pmid:504776 |
Rosario P and Medina JM | Effect of gluconeogenic substrates on ketogenesis in isolated rat hepatocytes. I. Effect of glycerol. | 1980 | Rev. Esp. Fisiol. | pmid:7221165 |
Rosario P and Medina JM | Antiketogenic effect of gluconeogenic substrates. II. Effect of pyruvate. | 1981 | Rev. Esp. Fisiol. | pmid:7244329 |
Guimbretiere J et al. | [A further case of albumin auto-agglutination in a blood donor]. | 1976 | Rev. Fr. Transfus. Immunohematol. | pmid:824703 |
Reuge C | [Enzymatic determination of caprylates in protein preparations]. | 1982 | Rev. Fr. Transfus. Immunohematol. | pmid:7163732 |
Blatrix C et al. | [Properties of and information about a new preparation of immunoglobulins (IgGAM) enriched in IgA and IgM]. | 1977 | Rev. Fr. Transfus. Immunohematol. | pmid:918496 |
Lambin P and Debbia M | [IgG4 levels in polyvalent immunoglobulins and immunoglobulins prepared by precipitation with caprylic acid]. | 1986 Oct-Nov | Rev. Fr. Transfus. Immunohematol. | pmid:3576044 |
Andres T et al. | Brain edema in acute liver failure. Insight from experimental studies. | 1990 | Rev. Invest. Clin. | pmid:19256151 |
Skrede S and Slaattelid O | Fatty acid metabolism during hypothermic perfusion of the isolated dog kidney. | 1979 | Scand. J. Clin. Lab. Invest. | pmid:531496 |