octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Thomas JD et al. | The carboxylic and amino acid chemoreception niche of Bulinus rohlfsi (Clessin), the snail host of Schistosoma haematobium. | 1985 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2865079 |
Oberhaensli RD et al. | Effect of norepinephrine on ketogenesis, fatty acid oxidation, and esterification in isolated rat hepatocytes. | 1985 | Diabetes | pmid:2862086 |
Carr C and Morrison DC | Mechanism of polymyxin B-mediated lysis of lipopolysaccharide-treated erythrocytes. | 1985 | Infect. Immun. | pmid:2989182 |
Remy-Heintz N and Bali JP | [Demonstration of glycoprotein antigens associated with stomach tumors]. | 1985 | C. R. Seances Soc. Biol. Fil. | pmid:2935234 |
Komura S and Kurahashi K | Biosynthesis of polymyxin E by a cell-free enzyme system. IV. Acylation of enzyme-bound L-2,4-diaminobutyric acid. | 1985 | J. Biochem. | pmid:3861608 |
Bjorge SM and Baillie TA | Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933498 |
Schmidt FH et al. | A new inhibitor of the long-chain fatty acid transfer across the mitochondrial membrane: 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304). | 1985 | Life Sci. | pmid:3917523 |
Eanes WF et al. | Targeted selection experiments and enzyme polymorphism: negative evidence for octanoate selection at the G6PD locus in Drosophila melanogaster. | 1985 | Genetics | pmid:3918918 |
Agius L and Alberti KG | Regulation of flux through pyruvate dehydrogenase and pyruvate carboxylase in rat hepatocytes. Effects of fatty acids and glucagon. | 1985 | Eur. J. Biochem. | pmid:3932072 |
Veerkamp JH et al. | Interaction of short-chain and branched-chain fatty acids and their carnitine and CoA esters and of various metabolites and agents with branched-chain 2-oxo acid oxidation in rat muscle and liver mitochondria. | 1985 | Int. J. Biochem. | pmid:3934010 |
Duée PH et al. | Development and regulation of ketogenesis in isolated hepatocytes from newborn rabbits. | 1985 | Reprod Nutr Dev | pmid:3992001 |
Lee SM et al. | Prevention of the metabolic effects of 2-tetradecylglycidate by octanoic acid in the genetically diabetic mouse (db/db). | 1985 | Biochem Med | pmid:3994695 |
Sabbagh E et al. | 3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria. | 1985 | J. Biol. Chem. | pmid:3997873 |
Maublant JC et al. | Effects of grisorixin on the distribution of thallium-201 and on the oxidative metabolism in cultured myocardial cells. | 1985 | J. Nucl. Med. | pmid:3998852 |
Bougnères PF et al. | Medium-chain acyl-CoA dehydrogenase deficiency in two siblings with a Reye-like syndrome. | 1985 | J. Pediatr. | pmid:3998948 |
Roe CR et al. | Diagnostic and therapeutic implications of medium-chain acylcarnitines in the medium-chain acyl-coA dehydrogenase deficiency. | 1985 | Pediatr. Res. | pmid:4000772 |
McCandless DW | Octanoic acid-induced coma and reticular formation energy metabolism. | 1985 | Brain Res. | pmid:4005536 |
Rowley H and Collins RC | [1-14C]Octanoate: a fast functional marker of brain activity. | 1985 | Brain Res. | pmid:4005560 |
Noy N and Zakim D | Substrate specificity of fatty-acyl-CoA ligase in liver microsomes. | 1985 | Biochim. Biophys. Acta | pmid:3970953 |
Germán JC et al. | [Solvent effects on cholesterol calculi: an in vitro study using octanoic acid, glycerol monooctanate, sodium cholate, heparin and ursodeoxycholic acid]. | 1985 | Rev Esp Enferm Apar Dig | pmid:3975461 |
Maddaiah VT | Ammonium inhibition of fatty acid oxidation in rat liver mitochondria. A possible cause of fatty liver in Reye's syndrome and urea cycle defects. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977937 |
Haas R et al. | Salicylate-induced loose coupling: protonmotive force measurements. | 1985 | Biochem. Pharmacol. | pmid:3977963 |
Taylor WM et al. | Effect of depolarizing concentrations of potassium on calcium uptake and metabolism in rat liver. | 1985 | FEBS Lett. | pmid:3979569 |
Brandes R et al. | The specificity of triacylglycerol synthesis for medium-chain fatty acids in rat and human adipose preparations. | 1985 | Biochim. Biophys. Acta | pmid:4027259 |
Drewes LR and Leino RL | Neuron-specific mitochondrial degeneration induced by hyperammonemia and octanoic acidemia. | 1985 | Brain Res. | pmid:4027650 |
Duran M et al. | Octanoic acidemia and octanoylcarnitine excretion with dicarboxylic aciduria due to defective oxidation of medium-chain fatty acids. | 1985 | J. Pediatr. | pmid:4032135 |
Ferris CF et al. | Alcohol and fatty acid stimulation of neurotensin release from rat small intestine. | 1985 | Endocrinology | pmid:3971900 |
Wolf HP and Engel DW | Decrease of fatty acid oxidation, ketogenesis and gluconeogenesis in isolated perfused rat liver by phenylalkyl oxirane carboxylate (B 807-27) due to inhibition of CPT I (EC 2.3.1.21). | 1985 | Eur. J. Biochem. | pmid:4038486 |
Hütter JF et al. | Effect of fatty acid oxidation on efficiency of energy production in rat heart. | 1985 | Am. J. Physiol. | pmid:4051011 |
Lutz WH et al. | Inhibition of citrulline synthesis by octanoate and its modulation by adenine nucleotides. | 1985 | Biochem Med | pmid:4052056 |
Strieleman PJ et al. | Fatty acid activation of the reconstituted brown adipose tissue mitochondria uncoupling protein. | 1985 | J. Biol. Chem. | pmid:4055740 |
Nelis HJ et al. | Chromatographic determination of N-acetyl-DL-tryptophan and octanoic acid in human albumin solutions. | 1985 | J. Chromatogr. | pmid:4055947 |
Zieve L et al. | Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat. | 1985 | J. Lab. Clin. Med. | pmid:4056569 |
Plomp PJ et al. | Mechanism of the stimulation of respiration by fatty acids in rat liver. | 1985 | FEBS Lett. | pmid:4065340 |
MacDonald ML et al. | Aversion of the cat to dietary medium-chain triglycerides and caprylic acid. | 1985 | Physiol. Behav. | pmid:4070410 |
Taguchi S | [Acidosis tolerance of fetal metabolism--comparative studies on isolated perfused adult, fetal and neonatal livers]. | 1985 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:4086906 |
Duran M et al. | Octanoylglucuronide excretion in patients with a defective oxidation of medium-chain fatty acids. | 1985 | Clin. Chim. Acta | pmid:4064333 |
Trauner DA and Garrett RS | Effect of octanoate injection on rat blood-brain barrier. | 1985 Jan-Feb | Pediatr. Neurol. | pmid:3880386 |
Phillips JW et al. | Some unexplained features of hepatic ethanol oxidation. | 1985 Jan-Feb | Alcohol | pmid:4015838 |
Zieve L et al. | Ammonia, octanoate and a mercaptan depress regeneration of normal rat liver after partial hepatectomy. | 1985 Jan-Feb | Hepatology | pmid:3967863 |
Trauner DA and de la Torre JC | Effect of octanoate on blood-brain barrier permeability using L-dopa as a marker. | 1985 Jul-Aug | Pediatr. Neurol. | pmid:3880408 |
Trice JE and Trauner DA | Alterations in serum glucose and hepatic glycogen concentrations during octanoate administration in rabbits. | 1985 Sep-Oct | Pediatr. Neurol. | pmid:3880415 |
Harris RA et al. | Regulation of branched-chain alpha-ketoacid dehydrogenase complex by covalent modification. | 1986 | Adv. Enzyme Regul. | pmid:3028049 |
Lysiak W et al. | Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria. | 1986 | J. Biol. Chem. | pmid:3759988 |
Higaki K et al. | Effect of medium-chain glycerides (MGK) on the intestinal absorption and the hepatobiliary transport of bromthymol blue. | 1986 | J. Pharmacobio-dyn. | pmid:3761141 |
Fatania HR et al. | Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n-octanoate. | 1986 | Biochem. J. | pmid:3707545 |
Letko G and Halangk W | Effect of improved hydrogen supply on energy state, ureogenesis and gluconeogenesis in isolated hepatocytes. | 1986 | Biomed. Biochim. Acta | pmid:3707550 |
Okita M et al. | Plasma level of branched chain alpha-amino acids following its alpha-keto acid administration to rats. | 1986 | J. Nutr. Sci. Vitaminol. | pmid:3712111 |
Matsumura T et al. | O2 uptake in periportal and pericentral regions of liver lobule in perfused liver. | 1986 | Am. J. Physiol. | pmid:3717341 |
Kössler F and Nasledov GA | Effects of Na-octanoate on potassium contractures in normal and denervated frog tonic fibres. | 1986 | Gen. Physiol. Biophys. | pmid:2433184 |