octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Maes BD et al. | Gastric emptying rate of solids in patients with nonulcer dyspepsia. | 1997 | Dig. Dis. Sci. | pmid:9201077 |
Pakula R et al. | Biosynthesis of medium-chain triacylglycerols and phospholipids by HepG-2 cells. | 1997 | Lipids | pmid:9168455 |
Cave AC et al. | A model of anoxic preconditioning in the isolated rat cardiac myocyte. Importance of adenosine and insulin. | 1996 May-Jun | Basic Res. Cardiol. | pmid:8831940 |
Yang H et al. | Enhancing the stereoselectivity and activity of Candida species lipase in organic solvent by noncovalent enzyme modification. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8958099 |
Castel MA et al. | The antibodies causing thyroid stimulating hormone-binding inhibition (TSH-BI) are not responsible for the specific inhibition of gonadal steroidogenesis by Graves' sera. | 1996 | J. Reprod. Immunol. | pmid:8920164 |
Katoh K et al. | Octanoate increases cytosolic Ca2+ concentration and membrane conductance in ovine pancreatic acinar cells. | 1996 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:8923746 |
Guthy E | Enteric-coated fish oil in Crohn's disease. | 1996 | N. Engl. J. Med. | pmid:8927072 |
Bojes HK and Thurman RG | Potent peroxisome proliferators inhibit beta-oxidation in the isolated perfused rat liver. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8887448 |
Sidossis LS et al. | Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. | 1996 | J. Clin. Invest. | pmid:8941640 |
Veereman-Wauters G et al. | The 13C-octanoic acid breath test: a noninvasive technique to assess gastric emptying in preterm infants. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8856575 |
Fulgencio JP et al. | Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats. | 1996 | Diabetes | pmid:8866561 |
Amin D et al. | 1-Hydroxy-3-(methylpentylamino)-propylidene-1,1-bisphosphonic acid as a potent inhibitor of squalene synthase. | 1996 | Arzneimittelforschung | pmid:9125274 |
Constantinides PP et al. | Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation. | 1996 | Pharm. Res. | pmid:8932438 |
Kuge Y et al. | [1-11C]octanoate as a potential PET tracer for studying glial functions: PET evaluation in rats and cats. | 1996 | Nucl. Med. Biol. | pmid:9004290 |
Yamazaki S et al. | Uptake of radioactive octanoate in astrocytoma cells: basic studies for application of [11C]octanoate as a PET tracer. | 1996 | Ann Nucl Med | pmid:9006724 |
Trotter PJ et al. | Fatty acid uptake by Caco-2 human intestinal cells. | 1996 | J. Lipid Res. | pmid:9026531 |
Kalogeris TJ et al. | Intestinal synthesis and lymphatic secretion of apolipoprotein A-IV vary with chain length of intestinally infused fatty acids in rats. | 1996 | J. Nutr. | pmid:8914941 |
Murphy MG et al. | Abnormalities in hepatic fatty-acid metabolism in a surfactant/influenza B virus mouse model for acute encephalopathy. | 1996 | Biochim. Biophys. Acta | pmid:8611661 |
Perri F et al. | Gastric emptying and Helicobacter pylori infection in duodenal ulcer disease. | 1996 | Dig. Dis. Sci. | pmid:8617116 |
Lin X et al. | Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets. | 1996 | Biochem. J. | pmid:8761477 |
Barron JT et al. | Substrate-dependent alteration in O2 consumption and energy metabolism in vascular smooth muscle. | 1996 | Am. J. Physiol. | pmid:8764234 |
Petschow BW et al. | Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids. | 1996 | Antimicrob. Agents Chemother. | pmid:8834870 |
Priestman DA et al. | Pyruvate inhibition of pyruvate dehydrogenase kinase. Effects of progressive starvation and hyperthyroidism in vivo, and of dibutyryl cyclic AMP and fatty acids in cultured cardiac myocytes. | 1996 | FEBS Lett. | pmid:8814284 |
Guidry AJ and O'Brien CN | A method for measuring specific antibodies in bovine lacteal secretions during the nonlactating period. | 1996 | J. Dairy Sci. | pmid:8792284 |
Zhou YP et al. | Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism. | 1996 | Metab. Clin. Exp. | pmid:8769356 |
Sherrington EJ et al. | Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736816 |
Cheruvallath VK et al. | The effect of octanoic acid on the binding of the enantiomers of ibuprofen and naproxen to human serum albumin: a chromatographic implication. | 1996 | Pharm. Res. | pmid:8668670 |
Planelles D et al. | A new, fast, and simple DNA extraction method for HLA and VNTR genotyping by PCR amplification. | 1996 | J. Clin. Lab. Anal. | pmid:8731498 |
Evtodienko VY et al. | Effect of the alkyl chain length of monocarboxylic acid on the permeation through bilayer lipid membranes. | 1996 | Biochim. Biophys. Acta | pmid:8664324 |
Büllesbach EE and Schwabe C | Structural contribution of the A-chain loop in relaxin. | 1995 Sep-Oct | Int. J. Pept. Protein Res. | pmid:8537177 |
Yanai S et al. | Antitumor effect of arterial administration of a medium-chain triglyceride solution of an angiogenesis inhibitor, TNP-470, in rabbits bearing VX-2 carcinoma. | 1995 | Pharm. Res. | pmid:7479548 |
Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
Sibille B et al. | Octanoate affects 2,4-dinitrophenol uncoupling in intact isolated rat hepatocytes. | 1995 | Eur. J. Biochem. | pmid:7635161 |
Nagatsugi F et al. | 18F-labeled octanoates as potential agents for cerebral fatty acid studies. The influence of 4-substitution and the fluorine position on biodistribution. | 1995 | Chem. Pharm. Bull. | pmid:7600614 |
Onkenhout W et al. | Identification and quantification of intermediates of unsaturated fatty acid metabolism in plasma of patients with fatty acid oxidation disorders. | 1995 | Clin. Chem. | pmid:7586519 |
Duan LP et al. | Influence of cisapride on gastric emptying of solids and liquids monitored by 13C breath tests. | 1995 | Dig. Dis. Sci. | pmid:7587790 |
Grekin RJ et al. | Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension. | 1995 | Hypertension | pmid:7607723 |
Morris TW et al. | Lipoic acid metabolism in Escherichia coli: the lplA and lipB genes define redundant pathways for ligation of lipoyl groups to apoprotein. | 1995 | J. Bacteriol. | pmid:8002607 |
Redondo O et al. | Comparative kinetic study of lipases A and B from Candida rugosa in the hydrolysis of lipid p-nitrophenyl esters in mixed micelles with Triton X-100. | 1995 | Biochim. Biophys. Acta | pmid:7827103 |
Maes BD et al. | Influence of octreotide on the gastric emptying of solids and liquids in normal healthy subjects. | 1995 | Aliment. Pharmacol. Ther. | pmid:7766738 |
Martinelle M and Hult K | Kinetics of acyl transfer reactions in organic media catalysed by Candida antarctica lipase B. | 1995 | Biochim. Biophys. Acta | pmid:7669809 |
Svendsen L et al. | Development and comparison of purification strategies for chicken antibodies from egg yolk. | 1995 | Lab. Anim. Sci. | pmid:7752622 |
Pfaffenbach B et al. | [Non-invasive 13C octanoic acid breath test for measuring stomach emptying of a solid test meal--correlation with scintigraphy in diabetic patients and reproducibility in healthy probands]. | 1995 | Z Gastroenterol | pmid:7754644 |
Fryer LG et al. | The long-term regulation of skeletal muscle pyruvate dehydrogenase kinase by dietary lipid is dependent on fatty acid composition. | 1995 | Eur. J. Biochem. | pmid:7758471 |
Godet MC et al. | Inclusion/exclusion of fatty acids in amylose complexes as a function of the fatty acid chain length. | 1995 | Int. J. Biol. Macromol. | pmid:8789347 |
Tomita GM et al. | Antigenic crossreactivity and lipopolysaccharide neutralization properties of bovine immunoglobulin G. | 1995 | J. Dairy Sci. | pmid:8675757 |
Kuge Y et al. | Brain uptake and metabolism of [1-11C]octanoate in rats: pharmacokinetic basis for its application as a radiopharmaceutical for studying brain fatty acid metabolism. | 1995 | Ann Nucl Med | pmid:8534586 |
Lamas JA et al. | Caprylic acid, a medium chain saturated fatty acid, inhibits the sodium inward current in neuroglioma (NG108-15) cells. | 1995 | Neurosci. Lett. | pmid:8552316 |
Morand C et al. | Importance of the modulation of glycolysis in the control of lactate metabolism by fatty acids in isolated hepatocytes from fed rats. | 1994 | Arch. Biochem. Biophys. | pmid:8135535 |
Hayball PJ et al. | Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7894686 |
McLaren RD et al. | The use of caprylic acid for the extraction of the immunoglobulin fraction from egg yolk of chickens immunised with ovine alpha-lactalbumin. | 1994 | J. Immunol. Methods | pmid:7822824 |
Carnielli VP et al. | Conversion of octanoic acid into long-chain saturated fatty acids in premature infants fed a formula containing medium-chain triglycerides. | 1994 | Metab. Clin. Exp. | pmid:7934982 |
Bhanushali JK et al. | Simple method to purify chicken immunoglobulin G. | 1994 | Poult. Sci. | pmid:7937478 |
Even PC et al. | Defective regulation of energy metabolism in mdx-mouse skeletal muscles. | 1994 | Biochem. J. | pmid:7999003 |
Boles RG et al. | Biochemical diagnosis of fatty acid oxidation disorders by metabolite analysis of postmortem liver. | 1994 | Hum. Pathol. | pmid:8056418 |
Kenyon MA and Hamilton JA | 13C NMR studies of the binding of medium-chain fatty acids to human serum albumin. | 1994 | J. Lipid Res. | pmid:8014580 |
Rojas G et al. | Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production. | 1994 | Toxicon | pmid:8016856 |
Gavva SR et al. | A 13C isotopomer n.m.r. method for monitoring incomplete beta-oxidation of fatty acids in intact tissue. | 1994 | Biochem. J. | pmid:7980454 |
Zhou YP and Grill VE | Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. | 1994 | J. Clin. Invest. | pmid:8113418 |
Jakobs BS et al. | Beta-oxidation of fatty acids in cultured human skin fibroblasts devoid of the capacity for oxidative phosphorylation. | 1994 | Biochim. Biophys. Acta | pmid:8123680 |
Mao LF et al. | Hepatic beta-oxidation of 3-phenylpropionic acid and the stereospecific dehydration of (R)- and (S)-3-hydroxy-3-phenylpropionyl-CoA by different enoyl-CoA hydratases. | 1994 | Biochemistry | pmid:8136368 |
Bennett MJ et al. | Population screening for medium-chain acyl-CoA dehydrogenase deficiency: analysis of medium-chain fatty acids and acylglycines in blood spots. | 1994 | Ann. Clin. Biochem. | pmid:8154855 |
Zhang Y et al. | Nonhomogeneous labeling of liver extra-mitochondrial acetyl-CoA. Implications for the probing of lipogenic acetyl-CoA via drug acetylation and for the production of acetate by the liver. | 1994 | J. Biol. Chem. | pmid:8157628 |
Herold G et al. | HDL3-mediated cholesterol efflux from cultured enterocytes: the role of apoproteins A-I and A-II. | 1994 | Lipids | pmid:7869853 |
Jensen RG et al. | Fatty acid and positional selectivities of gastric lipase from premature human infants: in vitro studies. | 1994 | Lipids | pmid:8090065 |
Ben Cheikh R et al. | Control of oxidative metabolism in volume-overloaded rat hearts: effects of different lipid substrates. | 1994 | Am. J. Physiol. | pmid:8203607 |
Jensen MM et al. | Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. | 1994 | Ann. Nutr. Metab. | pmid:8067685 |
Morris TW et al. | Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product. | 1994 | J. Biol. Chem. | pmid:8206909 |
Viegas CA et al. | Regulation of the expression of the H(+)-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae. | 1994 | Biochim. Biophys. Acta | pmid:8286419 |
Odle J et al. | Emulsification and fatty acid chain length affect the kinetics of [14C]-medium-chain triacylglycerol utilization by neonatal piglets. | 1994 | J. Nutr. | pmid:8283298 |
Riehle M and Bereiter-Hahn J | Ouabain and digitoxin as modulators of chick embryo cardiomyocyte energy metabolism. | 1994 | Arzneimittelforschung | pmid:7945537 |
Schepkin V et al. | NMR study of lipoic acid binding to bovine serum albumin. | 1994 | Biochem. Mol. Biol. Int. | pmid:7987256 |
Tsai CS and al-Kassim LS | Multifunctional activities of pickerel liver alcohol dehydrogenase. | 1993 Sep-Oct | Biochem. Cell Biol. | pmid:8192894 |
Fitzsimmons ME and Anders MW | Fatty acid beta-oxidation-dependent bioactivation of halogenated thiaalkanoic acids in isolated rat hepatocytes. | 1993 Sep-Oct | Chem. Res. Toxicol. | pmid:8292744 |
Tezikov EB et al. | [Effect of beta-hydroxybutyrate and caprylic acid on function of isolated rat heart in alcoholic intoxication and in the post-intoxication period]. | 1993 May-Jun | Patol Fiziol Eksp Ter | pmid:8058394 |
Hennes MM et al. | Mechanism of free fatty acid effects on hepatocyte insulin receptor binding and processing. | 1993 | Obes. Res. | pmid:16353347 |
SeñarÃs RM et al. | Effects of free fatty acids on somatostatin secretion, content and mRNA levels in cortical and hypothalamic fetal rat neurones in monolayer culture. | 1993 | J. Mol. Endocrinol. | pmid:8097916 |
Alvarez CV et al. | Regulation of prothymosin alpha mRNA levels in rat pituitary tumor cells. | 1993 | Neuroendocrinology | pmid:8232763 |
Adams SH and Odle J | Plasma beta-hydroxybutyrate after octanoate challenge: attenuated ketogenic capacity in neonatal swine. | 1993 | Am. J. Physiol. | pmid:8238444 |
Massolini G et al. | Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases. | 1993 | Biochem. Pharmacol. | pmid:8216380 |
Mitkov D | The role of the octanoic fatty acid in the pathogenesis of the metabolic alkalosis in experimental liver failure. | 1993 | Folia Med (Plovdiv) | pmid:8194797 |
Hulsmann WC et al. | Imminent ischemia in normal and hypertrophic Langendorff rat hearts; effects of fatty acids and superoxide dismutase monitored by NADH surface fluorescence. | 1993 | Biochim. Biophys. Acta | pmid:8318552 |
Geelen MJ and Schmitz MG | The role of citrate in the regulation of hepatic fatty acid synthesis by insulin and glucagon. | 1993 | Horm. Metab. Res. | pmid:7903266 |
Miura S et al. | Increased proliferative response of lymphocytes from intestinal lymph during long chain fatty acid absorption. | 1993 | Immunology | pmid:8436400 |
MartÃn-Requero A et al. | Reciprocal changes in gluconeogenesis and ureagenesis induced by fatty acid oxidation. | 1993 | Metab. Clin. Exp. | pmid:8246772 |
Grolier P and Elcombe CR | In vitro inhibition of carnitine acyltransferase activity in mitochondria from rat and mouse liver by a diethylhexylphthalate metabolite. | 1993 | Biochem. Pharmacol. | pmid:8452557 |
Wieland TM et al. | Utilization of medium-chain triglycerides by neonatal pigs: effects of emulsification and dose delivered. | 1993 | J. Anim. Sci. | pmid:8349513 |
Hoffmann GF et al. | Physiology and pathophysiology of organic acids in cerebrospinal fluid. | 1993 | J. Inherit. Metab. Dis. | pmid:8412012 |
Dieuaide M et al. | Effects of glucose starvation on the oxidation of fatty acids by maize root tip mitochondria and peroxisomes: evidence for mitochondrial fatty acid beta-oxidation and acyl-CoA dehydrogenase activity in a higher plant. | 1993 | Biochem. J. | pmid:8250843 |
Reed KE and Cronan JE | Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes. | 1993 | J. Bacteriol. | pmid:8444795 |
Vandenvelde C et al. | Suppression of the inhibitory effect of denatured albumin on the polymerase chain reaction by sodium octanoate: application to routine clinical detection of hepatitis B virus at its infectivity threshold in serum. | 1993 | J. Virol. Methods | pmid:8514843 |
Morand C et al. | Fatty acids are potent modulators of lactate utilization in isolated hepatocytes from fed rats. | 1993 | Am. J. Physiol. | pmid:8498503 |
Liu MJ and Pollack GM | Pharmacokinetics and pharmacodynamics of valproate analogs in rats. II. Pharmacokinetics of octanoic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid. | 1993 | Biopharm Drug Dispos | pmid:8499583 |
Ghoos YF et al. | Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. | 1993 | Gastroenterology | pmid:8500721 |
Consoli A et al. | Limitations in the use of [2-14C]acetate for measuring gluconeogenesis in vivo. | 1993 | Diabetes | pmid:8482430 |
Hayden MA et al. | Biosynthesis of lipoic acid: characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33-lip9. | 1993 | Biochemistry | pmid:8466915 |
Mabayo RT et al. | Improvement of dietary protein utilisation in chicks by medium chain triglyceride. | 1993 | Br. Poult. Sci. | pmid:8467393 |
Giron D et al. | Analysis of mono-, di- and triglycerides in pharmaceutical excipients by capillary supercritical fluid chromatography. | 1992 Oct-Dec | J Pharm Biomed Anal | pmid:1298389 |
Scholte HR et al. | Assessment of deficiencies of fatty acyl-CoA dehydrogenases in fibroblasts, muscle and liver. | 1992 | J. Inherit. Metab. Dis. | pmid:1405467 |
Porter DJ | Binding of 2-acetylpyridine-5-[(2-chloroanilino)thiocarbonyl] thiocarbonohydrazone (BW348U87) to human serum albumin. | 1992 | Biochem. Pharmacol. | pmid:1417962 |