octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Meeuwse P et al. | Modeling lipid accumulation in oleaginous fungi in chemostat cultures. II: Validation of the chemostat model using yeast culture data from literature. | 2011 | Bioprocess Biosyst Eng | pmid:21516366 |
Makino T et al. | Semisynthesis of human ghrelin: condensation of a Boc-protected recombinant peptide with a synthetic O-acylated fragment. | 2005 | Biopolymers | pmid:16049959 |
Shrake A et al. | Thermal stabilization of human albumin by medium- and short-chain n-alkyl fatty acid anions. | 2006 | Biopolymers | pmid:16273515 |
Etzerodt T et al. | Selective acylation enhances membrane charge sensitivity of the antimicrobial peptide mastoparan-x. | 2011 | Biophys. J. | pmid:21244836 |
Gordon DJ et al. | Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel. | 2004 | Biophys. J. | pmid:14695285 |
Liu MJ and Pollack GM | Pharmacokinetics and pharmacodynamics of valproate analogs in rats. II. Pharmacokinetics of octanoic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid. | 1993 | Biopharm Drug Dispos | pmid:8499583 |
Guo H et al. | Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. | 2013 | Bioorg. Med. Chem. Lett. | pmid:24018188 |
Sawatani Y et al. | Sequence-specific DNA binding by long hairpin pyrrole-imidazole polyamides containing an 8-amino-3,6-dioxaoctanoic acid unit. | 2016 | Bioorg. Med. Chem. | pmid:27301681 |
Grossauer J et al. | The peptide hormone ghrelin binds to membrane-mimetics via its octanoyl chain and an adjacent phenylalanine. | 2010 | Bioorg. Med. Chem. | pmid:20621491 |
Koda Y et al. | Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides. | 2008 | Bioorg. Med. Chem. | pmid:18468445 |
Cao B et al. | 19F NMR studies of tryptophan/serum albumin binding. | 2003 | Bioorg. Med. Chem. | pmid:12467709 |
Hainaut J et al. | Differentiation of antilymphocytic antibodies by analytical ion exchange chromatography: the effect of caprylic acid. | 1974 | Biomedicine | pmid:4433656 |
Nakajima K et al. | Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells. | 2016 | Biomed. Res. | pmid:28003581 |
Kuhara T et al. | Identification and quantification of octanoyl glucuronide in the urine of children who ingested medium-chain triglycerides. | 1986 | Biomed. Environ. Mass Spectrom. | pmid:2948585 |
Santa T et al. | Synthesis of benzofurazan derivatization reagents for carboxylic acids in liquid chromatography/electrospray ionization-tandem mass spectrometry. | 2007 | Biomed. Chromatogr. | pmid:17590866 |
Haufe CC et al. | Development and regulation of hepatocellular fatty acid synthesis towards term: studies in isolated fetal rat hepatocytes. | 1990 | Biomed. Biochim. Acta | pmid:2177982 |
Kössler F et al. | Depressive effects of free fatty acids on the development of tension in different muscle types. | 1986 | Biomed. Biochim. Acta | pmid:2938577 |
Schönfeld P et al. | Influence of octanoate on the rate of oxidative phosphorylation and the associated extramitochondrial ATP/ADP ratios studied with isolated rat liver mitochondria oxidizing pyruvate. | 1984 | Biomed. Biochim. Acta | pmid:6525184 |
Letko G and Halangk W | Effect of improved hydrogen supply on energy state, ureogenesis and gluconeogenesis in isolated hepatocytes. | 1986 | Biomed. Biochim. Acta | pmid:3707550 |
Alva-Murillo N et al. | Effects of sodium octanoate on innate immune response of mammary epithelial cells during Staphylococcus aureus internalization. | 2013 | Biomed Res Int | pmid:23509807 |
Hazer DB et al. | Synthesis of microbial elastomers based on soybean oily acids. Biocompatibility studies. | 2009 | Biomed Mater | pmid:19498224 |
Ou W et al. | Biodegradable block poly(ester-urethane)s based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymers. | 2011 | Biomaterials | pmid:21310479 |
Kubies D et al. | Microdomain structure in polylactide-block-poly(ethylene oxide) copolymer films. | 2000 | Biomaterials | pmid:10674818 |
Pan J et al. | Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol). | 2009 | Biomaterials | pmid:19230967 |
Patel SK et al. | Prediction of the solubility of cucurbitacin drugs in self-associating poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate epsilon-caprolactone) block copolymer with different tacticities using molecular dynamics simulation. | 2010 | Biomaterials | pmid:19796808 |
Zhou S et al. | Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system. | 2003 | Biomaterials | pmid:12809785 |
Cai Q et al. | Synthesis and characterization of biodegradable polylactide-grafted dextran and its application as compatilizer. | 2003 | Biomaterials | pmid:12809784 |
Corbin PS et al. | Biocompatible polyester macroligands: new subunits for the assembly of star-shaped polymers with luminescent and cleavable metal cores. | 2001 | Biomacromolecules | pmid:11749177 |
Cheng Y et al. | Thermally controlled release of anticancer drug from self-assembled γ-substituted amphiphilic poly(ε-caprolactone) micellar nanoparticles. | 2012 | Biomacromolecules | pmid:22681332 |
Wang CH et al. | Extended release of bevacizumab by thermosensitive biodegradable and biocompatible hydrogel. | 2012 | Biomacromolecules | pmid:22145634 |
Randriamahefa S et al. | Fourier transform infrared spectroscopy for screening and quantifying production of PHAs by Pseudomonas grown on sodium octanoate. | 2003 Jul-Aug | Biomacromolecules | pmid:12857097 |
Rai R et al. | Poly-3-hydroxyoctanoate P(3HO), a medium chain length polyhydroxyalkanoate homopolymer from Pseudomonas mendocina. | 2011 | Biomacromolecules | pmid:21561067 |
Hartmann R et al. | Simultaneous biosynthesis of two copolymers in Pseudomonas putida GPo1 using a two-stage continuous culture system. | 2010 | Biomacromolecules | pmid:20459087 |
Mahmud A et al. | Self-associating poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer for the solubilization of STAT-3 inhibitor cucurbitacin I. | 2009 | Biomacromolecules | pmid:19175305 |
Karanikolopoulos N et al. | Poly(DL-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate): synthesis, characterization, micellization behavior in aqueous solutions, and encapsulation of the hydrophobic drug dipyridamole. | 2010 | Biomacromolecules | pmid:20041661 |
Buwalda SJ et al. | Influence of amide versus ester linkages on the properties of eight-armed PEG-PLA star block copolymer hydrogels. | 2010 | Biomacromolecules | pmid:19938809 |
Wang YC et al. | Thermoresponsive block copolymers of poly(ethylene glycol) and polyphosphoester: thermo-induced self-assembly, biocompatibility, and hydrolytic degradation. | 2009 | Biomacromolecules | pmid:19133835 |
Du JZ et al. | Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers. | 2007 | Biomacromolecules | pmid:17902689 |
Tsuji H et al. | Novel preparation method for poly(L-lactide)-based block copolymers: extended chain crystallites as a solid-state macro-coinitiator. | 2007 | Biomacromolecules | pmid:17432901 |
Haynes D et al. | In situ copolyesters containing poly(L-lactide) and poly(hydroxyalkanoate) units. | 2007 | Biomacromolecules | pmid:17371065 |
Dai XH et al. | Supramolecular Polypseudorotaxanes composed of star-shaped porphyrin-cored poly(epsilon-caprolactone) and alpha-cyclodextrin. | 2006 | Biomacromolecules | pmid:17154484 |
Gerhardt WW et al. | Functional lactide monomers: methodology and polymerization. | 2006 | Biomacromolecules | pmid:16768392 |
Jiang X et al. | Biosynthesis and properties of medium-chain-length polyhydroxyalkanoates with enriched content of the dominant monomer. | 2012 | Biomacromolecules | pmid:22871146 |
Kricheldorf HR and Rost S | Copolymerizations of epsilon-caprolactone and glycolide-a comparison of tin(II)octanoate and bismuth(III)subsalicylate as initiators. | Biomacromolecules | pmid:15877351 | |
Qiu X et al. | Hydroxyapatite surface modified by L-lactic acid and its subsequent grafting polymerization of L-lactide. | Biomacromolecules | pmid:15877333 | |
Dobrzynski P et al. | Structure-property relationships of copolymers obtained by ring-opening polymerization of glycolide and epsilon-caprolactone. Part 1. Synthesis and characterization. | Biomacromolecules | pmid:15638556 | |
Hu Y et al. | Degradation behavior of poly(epsilon-caprolactone)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles in aqueous solution. | Biomacromolecules | pmid:15360284 | |
Sanguanchaipaiwong V et al. | Biosynthesis of natural-synthetic hybrid copolymers: polyhydroxyoctanoate-diethylene glycol. | Biomacromolecules | pmid:15003032 | |
Gorenflo V et al. | Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties. | 2001 | Biomacromolecules | pmid:11749154 |
Ba C et al. | Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks. | Biomacromolecules | pmid:14606915 | |
Gomes FM et al. | Immobilization of lipase on chitin and its use in nonconventional biocatalysis. | 2004 Jan-Feb | Biomacromolecules | pmid:14715003 |
Choi MH et al. | First-order kinetics analysis of monomer composition dependent polyhydroxyalkanoic acid degradation in Pseudomonas spp. | Biomacromolecules | pmid:12625741 | |
Green PR et al. | Formation of short chain length/medium chain length polyhydroxyalkanoate copolymers by fatty acid beta-oxidation inhibited Ralstonia eutropha. | 2002 Jan-Feb | Biomacromolecules | pmid:11866575 |
Barnette D et al. | Pathogen safety profile of a 10% IgG preparation manufactured using a depth filtration-modified process. | 2012 | Biologicals | pmid:22579294 |
Solano S et al. | Low pH formulation of whole IgG antivenom: impact on quality, safety, neutralizing potency and viral inactivation. | 2012 | Biologicals | pmid:22266304 |
Johnston A et al. | Low pH, caprylate incubation as a second viral inactivation step in the manufacture of albumin. Parametric and validation studies. | 2003 | Biologicals | pmid:12935811 |
Estrada R et al. | Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows. | 2010 | Biologicals | pmid:20833066 |
Segura A et al. | Assessment of the impact of solvent/detergent treatment on the quality and potency of a whole IgG equine antivenom. | 2009 | Biologicals | pmid:19540775 |
Stucki M et al. | Investigations of prion and virus safety of a new liquid IVIG product. | 2008 | Biologicals | pmid:18337119 |
Mpandi M et al. | Partitioning and inactivation of viruses by the caprylic acid precipitation followed by a terminal pasteurization in the manufacturing process of horse immunoglobulins. | 2007 | Biologicals | pmid:17470396 |
Burnouf T et al. | Assessment of viral inactivation during pH 3.3 pepsin digestion and caprylic acid treatment of antivenoms. | 2007 | Biologicals | pmid:17363271 |
Simsiriwong P et al. | A study on the use of caprylic acid and ammonium sulfate in combination for the fractionation of equine antivenom F(ab')(2). | 2012 | Biologicals | pmid:22704919 |
Burnouf T et al. | Assessment of the viral safety of antivenoms fractionated from equine plasma. | 2004 | Biologicals | pmid:15536042 |
Herrera M et al. | Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production. | 2009 | Biologicals | pmid:19375941 |
Athavale M et al. | Validation of a simple, rapid and cost effective method for the estimation of caprylic acid and sodium caprylate from biological products using NEFA-C kit. | 2010 | Biologicals | pmid:19919899 |
GarcÃa M et al. | Effect of preservatives on IgG aggregation, complement-activating effect and hypotensive activity of horse polyvalent antivenom used in snakebite envenomation. | 2002 | Biologicals | pmid:12127316 |
Korneyeva M et al. | Enveloped virus inactivation by caprylate: a robust alternative to solvent-detergent treatment in plasma derived intermediates. | 2002 | Biologicals | pmid:12127317 |
Dichtelmüller H et al. | Inactivation of lipid enveloped viruses by octanoic Acid treatment of immunoglobulin solution. | 2002 | Biologicals | pmid:12127315 |
Kuge Y et al. | [1-11C]Octanoate as a PET tracer for studying ischemic stroke: evaluation in a canine model of thromboembolic stroke with positron emission tomography. | 2000 | Biol. Pharm. Bull. | pmid:10963308 |
Tokudome Y and Otsuka M | Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats. | 2012 | Biol. Pharm. Bull. | pmid:22975500 |
Uchida M and Shimizu K | 13C-acetic acid is more sensitive than 13C-octanoic acid for evaluating gastric emptying of liquid enteral nutrient formula by breath test in conscious rats. | 2007 | Biol. Pharm. Bull. | pmid:17329843 |
Pahl-Wostl C and Seelig J | Ketogenesis in the living rat followed by 13C-NMR spectroscopy. Infusion of [1,3-13C]octanoate. | 1987 | Biol. Chem. Hoppe-Seyler | pmid:3593540 |
Lemmen C et al. | Utilization of medium-chain triglycerides and octanoic acid by cultured human fibroblasts and lymphoblasts. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:3242549 |
Küster J et al. | Modulation of the sympathetic nerve action on carbohydrate and ketone body metabolism by fatty acids, glucagon und insulin in perfused rat liver. | 1989 | Biol. Chem. Hoppe-Seyler | pmid:2692615 |
Kundu S and Roy D | Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation. | 2010 | Bioinformation | pmid:20978606 |
Kumar S | Comparative modeling and molecular docking of orphan human CYP4V2 protein with fatty acid substrates: Insights into substrate specificity. | 2011 | Bioinformation | pmid:22355237 |
Nagata J et al. | Effects of structured lipids containing eicosapentaenoic or docosahexaenoic acid and caprylic acid on serum and liver lipid profiles in rats. | 2004 | Biofactors | pmid:15630273 |
Goussen C et al. | Biological Safety of a Highly Purified 10% Liquid Intravenous Immunoglobulin Preparation from Human Plasma. | 2017 | BioDrugs | pmid:28508264 |
van Ginkel CG et al. | Substrate specificity of a long-chain alkylamine-degrading Pseudomonas sp isolated from activated sludge. | 2008 | Biodegradation | pmid:17492358 |
Pochapsky SS et al. | Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents. | 1990 Jul-Aug | Bioconjug. Chem. | pmid:2096916 |
Salesse R et al. | [Intensity and anisotropy decays measurement of perylene in pigeon erythrocyte membrane. Comparison with an isotropic viscous medium (author's transl)]. | 1981 Nov-Dec | Biochimie | pmid:7332761 |
Pérez-Diaz J et al. | Preparation and metabolic characterization of isolated rat lung cells. | 1977 | Biochimie | pmid:195638 |
Brass EP and Garrity MJ | Modulation of prostaglandin E2 catabolism and action by fuel substrates in rat hepatocytes. | 1989 | Biochim. Biophys. Acta | pmid:2912505 |
Lemarié F et al. | Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration. | 2016 | Biochim. Biophys. Acta | pmid:27317984 |
Bartels PD and Sestoft L | Thyroid hormone-induced changes in gluconeogenesis and ketogenesis in perfused rat liver. | 1980 | Biochim. Biophys. Acta | pmid:7448206 |
Arakawa T and Kita Y | Stabilizing effects of caprylate and acetyltryptophanate on heat-induced aggregation of bovine serum albumin. | 2000 | Biochim. Biophys. Acta | pmid:10862953 |
Kohlwein SD and Paltauf F | Uptake of fatty acids by the yeasts, Saccharomyces uvarum and Saccharomycopsis lipolytica. | 1984 | Biochim. Biophys. Acta | pmid:6696936 |
Schönfeld P et al. | On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:3196710 |
Wilson TA et al. | Structured triglycerides containing caprylic (8:0) and oleic (18:1) fatty acids reduce blood cholesterol concentrations and aortic cholesterol accumulation in hamsters. | 2006 | Biochim. Biophys. Acta | pmid:16580874 |
Gambert S et al. | Regulation of intermediary metabolism in rat cardiac myocyte by extracellular glycerol. | 2005 | Biochim. Biophys. Acta | pmid:16153888 |
Henze K et al. | The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts. | 1981 | Biochim. Biophys. Acta | pmid:6118180 |
González-Manchón C et al. | Control of gluconeogenesis: role of fatty acids in the alpha-adrenergic response. | 1988 | Biochim. Biophys. Acta | pmid:3191164 |
Redondo O et al. | Comparative kinetic study of lipases A and B from Candida rugosa in the hydrolysis of lipid p-nitrophenyl esters in mixed micelles with Triton X-100. | 1995 | Biochim. Biophys. Acta | pmid:7827103 |
Martinelle M and Hult K | Kinetics of acyl transfer reactions in organic media catalysed by Candida antarctica lipase B. | 1995 | Biochim. Biophys. Acta | pmid:7669809 |
Hulsmann WC et al. | Imminent ischemia in normal and hypertrophic Langendorff rat hearts; effects of fatty acids and superoxide dismutase monitored by NADH surface fluorescence. | 1993 | Biochim. Biophys. Acta | pmid:8318552 |
Kato T et al. | Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11). | 2010 | Biochim. Biophys. Acta | pmid:20398791 |
Brandes R et al. | The specificity of triacylglycerol synthesis for medium-chain fatty acids in rat and human adipose preparations. | 1985 | Biochim. Biophys. Acta | pmid:4027259 |
Salesse R and Garnier J | Effects of drugs on pigeon erythrocyte membrane and asymmetric control or adenylate cyclase by the lipid bilayer. | 1979 | Biochim. Biophys. Acta | pmid:222319 |
Bohnensack R and Fritz S | Stimulation of alanine metabolism by ammonia in the perfused rat liver. Quantitative analysis by means of a mathematical model. | 1991 | Biochim. Biophys. Acta | pmid:2009283 |
Babu E et al. | Role of human organic anion transporter 4 in the transport of ochratoxin A. | 2002 | Biochim. Biophys. Acta | pmid:12063169 |