octanoic acid

octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.

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Introduction

To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with octanoic acid?

octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with octanoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Stomach Diseases D013272 7 associated lipids
Inflammation D007249 119 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypothyroidism D007037 32 associated lipids
Kidney Diseases D007674 29 associated lipids
Glioma D005910 112 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Obesity D009765 29 associated lipids
Hemorrhage D006470 15 associated lipids
Malocclusion D008310 3 associated lipids
Per page 10 20 50 100 | Total 73

PubChem Associated disorders and diseases

What pathways are associated with octanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with octanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with octanoic acid?


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Function Cross reference Weighted score Related literatures

What lipids are associated with octanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with octanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with octanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with octanoic acid

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Authors Title Published Journal PubMed Link
Parameswaran M and Arinze IJ Phosphoenolpyruvate synthesis by fetal guinea-pig liver mitochondria. 1981 Biochim. Biophys. Acta pmid:7225415
Christensen E et al. Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. 1989 Biochim. Biophys. Acta pmid:2752017
Einarsson R The binding of 1-anilino-8-naphthalenesulfonate, heparin, salicylate and caprylate by human antithrombin III. 1976 Biochim. Biophys. Acta pmid:974107
Mannaerts GP et al. Hepatic fatty acid oxidation and ketogenesis after clofibrate treatment. 1978 Biochim. Biophys. Acta pmid:656451
Brass EP and Garrity MJ Modulation of prostaglandin E2 catabolism and action by fuel substrates in rat hepatocytes. 1989 Biochim. Biophys. Acta pmid:2912505
Lemarié F et al. Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration. 2016 Biochim. Biophys. Acta pmid:27317984
Bartels PD and Sestoft L Thyroid hormone-induced changes in gluconeogenesis and ketogenesis in perfused rat liver. 1980 Biochim. Biophys. Acta pmid:7448206
Ayuso MS et al. Interrelation between gluconeogenesis and hepatic protein synthesis. 1986 Biochim. Biophys. Acta pmid:3015233
Martínez Izquierdo JA et al. Fatty acid-glucose interaction in the control of protein synthesis by isolated rat lung cells. 1983 Biochim. Biophys. Acta pmid:6615881
Merrill AR et al. Effects of exogenous fatty acids on calcium uptake by brush-border membrane vesicles from rabbit small intestine. 1986 Biochim. Biophys. Acta pmid:3081028
Veerkamp JH et al. An accurate and sensitive assay of [14C]octanoate oxidation and its application on tissue homogenates and fibroblasts. 1986 Biochim. Biophys. Acta pmid:3081042
Kohlwein SD and Paltauf F Uptake of fatty acids by the yeasts, Saccharomyces uvarum and Saccharomycopsis lipolytica. 1984 Biochim. Biophys. Acta pmid:6696936
McDonough KH et al. Effects of oxygen radicals on substrate oxidation by cardiac myocytes. 1987 Biochim. Biophys. Acta pmid:2822138
Groot PH and Hülsmann WC The activation and oxidation of octanoate and palmitate by rat skeletal muscle mitochondria. 1973 Biochim. Biophys. Acta pmid:4741907
Barron JT et al. Oxidation of acetate and octanoate and its relation to glucose metabolism in contracting porcine carotid artery. 1997 Biochim. Biophys. Acta pmid:9452767
Wilson TA et al. Structured triglycerides containing caprylic (8:0) and oleic (18:1) fatty acids reduce blood cholesterol concentrations and aortic cholesterol accumulation in hamsters. 2006 Biochim. Biophys. Acta pmid:16580874
Henze K et al. The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts. 1981 Biochim. Biophys. Acta pmid:6118180
Jakobs BS et al. Beta-oxidation of fatty acids in cultured human skin fibroblasts devoid of the capacity for oxidative phosphorylation. 1994 Biochim. Biophys. Acta pmid:8123680
Redondo O et al. Comparative kinetic study of lipases A and B from Candida rugosa in the hydrolysis of lipid p-nitrophenyl esters in mixed micelles with Triton X-100. 1995 Biochim. Biophys. Acta pmid:7827103
Martinelle M and Hult K Kinetics of acyl transfer reactions in organic media catalysed by Candida antarctica lipase B. 1995 Biochim. Biophys. Acta pmid:7669809
Kato T et al. Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11). 2010 Biochim. Biophys. Acta pmid:20398791
Wanders RJ and Ijlst L Fatty acid beta-oxidation in leukocytes from control subjects and medium-chain acyl-CoA dehydrogenase deficient patients. 1992 Biochim. Biophys. Acta pmid:1737072
Matsuki H et al. Specific and non-specific binding of long-chain fatty acids to firefly luciferase: cutoff at octanoate. 1999 Biochim. Biophys. Acta pmid:9878713
Apel CL et al. Self-assembled vesicles of monocarboxylic acids and alcohols: conditions for stability and for the encapsulation of biopolymers. 2002 Biochim. Biophys. Acta pmid:11825583
González-Manchón C et al. Ca2(+)-fatty acid interaction in the control of hepatic gluconeogenesis. 1990 Biochim. Biophys. Acta pmid:2310772
Zabłocki K et al. The inhibitory effect of octanoate, palmitate and oleate on glucose formation in rabbit kidney tubules. 1983 Biochim. Biophys. Acta pmid:6838901
Latipää PM et al. Regulation of fatty acid oxidation in heart muscle. Effects of pyruvate and dichloroacetate. 1983 Biochim. Biophys. Acta pmid:6849964
Babu E et al. Role of human organic anion transporter 4 in the transport of ochratoxin A. 2002 Biochim. Biophys. Acta pmid:12063169
Salesse R et al. [Intensity and anisotropy decays measurement of perylene in pigeon erythrocyte membrane. Comparison with an isotropic viscous medium (author's transl)]. 1981 Nov-Dec Biochimie pmid:7332761
Pérez-Diaz J et al. Preparation and metabolic characterization of isolated rat lung cells. 1977 Biochimie pmid:195638
Pochapsky SS et al. Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents. 1990 Jul-Aug Bioconjug. Chem. pmid:2096916
van Ginkel CG et al. Substrate specificity of a long-chain alkylamine-degrading Pseudomonas sp isolated from activated sludge. 2008 Biodegradation pmid:17492358
Goussen C et al. Biological Safety of a Highly Purified 10% Liquid Intravenous Immunoglobulin Preparation from Human Plasma. 2017 BioDrugs pmid:28508264
Nagata J et al. Effects of structured lipids containing eicosapentaenoic or docosahexaenoic acid and caprylic acid on serum and liver lipid profiles in rats. 2004 Biofactors pmid:15630273
Kundu S and Roy D Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation. 2010 Bioinformation pmid:20978606
Kumar S Comparative modeling and molecular docking of orphan human CYP4V2 protein with fatty acid substrates: Insights into substrate specificity. 2011 Bioinformation pmid:22355237
Pahl-Wostl C and Seelig J Ketogenesis in the living rat followed by 13C-NMR spectroscopy. Infusion of [1,3-13C]octanoate. 1987 Biol. Chem. Hoppe-Seyler pmid:3593540
Lemmen C et al. Utilization of medium-chain triglycerides and octanoic acid by cultured human fibroblasts and lymphoblasts. 1988 Biol. Chem. Hoppe-Seyler pmid:3242549
Küster J et al. Modulation of the sympathetic nerve action on carbohydrate and ketone body metabolism by fatty acids, glucagon und insulin in perfused rat liver. 1989 Biol. Chem. Hoppe-Seyler pmid:2692615
Kuge Y et al. [1-11C]Octanoate as a PET tracer for studying ischemic stroke: evaluation in a canine model of thromboembolic stroke with positron emission tomography. 2000 Biol. Pharm. Bull. pmid:10963308
Tokudome Y and Otsuka M Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats. 2012 Biol. Pharm. Bull. pmid:22975500
Uchida M and Shimizu K 13C-acetic acid is more sensitive than 13C-octanoic acid for evaluating gastric emptying of liquid enteral nutrient formula by breath test in conscious rats. 2007 Biol. Pharm. Bull. pmid:17329843
Barnette D et al. Pathogen safety profile of a 10% IgG preparation manufactured using a depth filtration-modified process. 2012 Biologicals pmid:22579294
Solano S et al. Low pH formulation of whole IgG antivenom: impact on quality, safety, neutralizing potency and viral inactivation. 2012 Biologicals pmid:22266304
Johnston A et al. Low pH, caprylate incubation as a second viral inactivation step in the manufacture of albumin. Parametric and validation studies. 2003 Biologicals pmid:12935811
Estrada R et al. Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows. 2010 Biologicals pmid:20833066
Segura A et al. Assessment of the impact of solvent/detergent treatment on the quality and potency of a whole IgG equine antivenom. 2009 Biologicals pmid:19540775
Stucki M et al. Investigations of prion and virus safety of a new liquid IVIG product. 2008 Biologicals pmid:18337119
Mpandi M et al. Partitioning and inactivation of viruses by the caprylic acid precipitation followed by a terminal pasteurization in the manufacturing process of horse immunoglobulins. 2007 Biologicals pmid:17470396
Burnouf T et al. Assessment of viral inactivation during pH 3.3 pepsin digestion and caprylic acid treatment of antivenoms. 2007 Biologicals pmid:17363271
Simsiriwong P et al. A study on the use of caprylic acid and ammonium sulfate in combination for the fractionation of equine antivenom F(ab')(2). 2012 Biologicals pmid:22704919
Burnouf T et al. Assessment of the viral safety of antivenoms fractionated from equine plasma. 2004 Biologicals pmid:15536042
Herrera M et al. Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production. 2009 Biologicals pmid:19375941
Athavale M et al. Validation of a simple, rapid and cost effective method for the estimation of caprylic acid and sodium caprylate from biological products using NEFA-C kit. 2010 Biologicals pmid:19919899
García M et al. Effect of preservatives on IgG aggregation, complement-activating effect and hypotensive activity of horse polyvalent antivenom used in snakebite envenomation. 2002 Biologicals pmid:12127316
Korneyeva M et al. Enveloped virus inactivation by caprylate: a robust alternative to solvent-detergent treatment in plasma derived intermediates. 2002 Biologicals pmid:12127317
Dichtelmüller H et al. Inactivation of lipid enveloped viruses by octanoic Acid treatment of immunoglobulin solution. 2002 Biologicals pmid:12127315
Corbin PS et al. Biocompatible polyester macroligands: new subunits for the assembly of star-shaped polymers with luminescent and cleavable metal cores. 2001 Biomacromolecules pmid:11749177
Cheng Y et al. Thermally controlled release of anticancer drug from self-assembled γ-substituted amphiphilic poly(ε-caprolactone) micellar nanoparticles. 2012 Biomacromolecules pmid:22681332
Wang CH et al. Extended release of bevacizumab by thermosensitive biodegradable and biocompatible hydrogel. 2012 Biomacromolecules pmid:22145634
Randriamahefa S et al. Fourier transform infrared spectroscopy for screening and quantifying production of PHAs by Pseudomonas grown on sodium octanoate. 2003 Jul-Aug Biomacromolecules pmid:12857097
Rai R et al. Poly-3-hydroxyoctanoate P(3HO), a medium chain length polyhydroxyalkanoate homopolymer from Pseudomonas mendocina. 2011 Biomacromolecules pmid:21561067
Hartmann R et al. Simultaneous biosynthesis of two copolymers in Pseudomonas putida GPo1 using a two-stage continuous culture system. 2010 Biomacromolecules pmid:20459087
Mahmud A et al. Self-associating poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer for the solubilization of STAT-3 inhibitor cucurbitacin I. 2009 Biomacromolecules pmid:19175305
Karanikolopoulos N et al. Poly(DL-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate): synthesis, characterization, micellization behavior in aqueous solutions, and encapsulation of the hydrophobic drug dipyridamole. 2010 Biomacromolecules pmid:20041661
Buwalda SJ et al. Influence of amide versus ester linkages on the properties of eight-armed PEG-PLA star block copolymer hydrogels. 2010 Biomacromolecules pmid:19938809
Wang YC et al. Thermoresponsive block copolymers of poly(ethylene glycol) and polyphosphoester: thermo-induced self-assembly, biocompatibility, and hydrolytic degradation. 2009 Biomacromolecules pmid:19133835
Du JZ et al. Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers. 2007 Biomacromolecules pmid:17902689
Tsuji H et al. Novel preparation method for poly(L-lactide)-based block copolymers: extended chain crystallites as a solid-state macro-coinitiator. 2007 Biomacromolecules pmid:17432901
Haynes D et al. In situ copolyesters containing poly(L-lactide) and poly(hydroxyalkanoate) units. 2007 Biomacromolecules pmid:17371065
Dai XH et al. Supramolecular Polypseudorotaxanes composed of star-shaped porphyrin-cored poly(epsilon-caprolactone) and alpha-cyclodextrin. 2006 Biomacromolecules pmid:17154484
Gerhardt WW et al. Functional lactide monomers: methodology and polymerization. 2006 Biomacromolecules pmid:16768392
Jiang X et al. Biosynthesis and properties of medium-chain-length polyhydroxyalkanoates with enriched content of the dominant monomer. 2012 Biomacromolecules pmid:22871146
Kricheldorf HR and Rost S Copolymerizations of epsilon-caprolactone and glycolide-a comparison of tin(II)octanoate and bismuth(III)subsalicylate as initiators. Biomacromolecules pmid:15877351
Qiu X et al. Hydroxyapatite surface modified by L-lactic acid and its subsequent grafting polymerization of L-lactide. Biomacromolecules pmid:15877333
Dobrzynski P et al. Structure-property relationships of copolymers obtained by ring-opening polymerization of glycolide and epsilon-caprolactone. Part 1. Synthesis and characterization. Biomacromolecules pmid:15638556
Hu Y et al. Degradation behavior of poly(epsilon-caprolactone)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles in aqueous solution. Biomacromolecules pmid:15360284
Sanguanchaipaiwong V et al. Biosynthesis of natural-synthetic hybrid copolymers: polyhydroxyoctanoate-diethylene glycol. Biomacromolecules pmid:15003032
Gorenflo V et al. Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties. 2001 Biomacromolecules pmid:11749154
Ba C et al. Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks. Biomacromolecules pmid:14606915
Gomes FM et al. Immobilization of lipase on chitin and its use in nonconventional biocatalysis. 2004 Jan-Feb Biomacromolecules pmid:14715003
Choi MH et al. First-order kinetics analysis of monomer composition dependent polyhydroxyalkanoic acid degradation in Pseudomonas spp. Biomacromolecules pmid:12625741
Green PR et al. Formation of short chain length/medium chain length polyhydroxyalkanoate copolymers by fatty acid beta-oxidation inhibited Ralstonia eutropha. 2002 Jan-Feb Biomacromolecules pmid:11866575
Ou W et al. Biodegradable block poly(ester-urethane)s based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymers. 2011 Biomaterials pmid:21310479
Kubies D et al. Microdomain structure in polylactide-block-poly(ethylene oxide) copolymer films. 2000 Biomaterials pmid:10674818
Pan J et al. Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol). 2009 Biomaterials pmid:19230967
Patel SK et al. Prediction of the solubility of cucurbitacin drugs in self-associating poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate epsilon-caprolactone) block copolymer with different tacticities using molecular dynamics simulation. 2010 Biomaterials pmid:19796808
Zhou S et al. Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system. 2003 Biomaterials pmid:12809785
Cai Q et al. Synthesis and characterization of biodegradable polylactide-grafted dextran and its application as compatilizer. 2003 Biomaterials pmid:12809784
Hazer DB et al. Synthesis of microbial elastomers based on soybean oily acids. Biocompatibility studies. 2009 Biomed Mater pmid:19498224
Alva-Murillo N et al. Effects of sodium octanoate on innate immune response of mammary epithelial cells during Staphylococcus aureus internalization. 2013 Biomed Res Int pmid:23509807
Haufe CC et al. Development and regulation of hepatocellular fatty acid synthesis towards term: studies in isolated fetal rat hepatocytes. 1990 Biomed. Biochim. Acta pmid:2177982
Kössler F et al. Depressive effects of free fatty acids on the development of tension in different muscle types. 1986 Biomed. Biochim. Acta pmid:2938577
Schönfeld P et al. Influence of octanoate on the rate of oxidative phosphorylation and the associated extramitochondrial ATP/ADP ratios studied with isolated rat liver mitochondria oxidizing pyruvate. 1984 Biomed. Biochim. Acta pmid:6525184
Letko G and Halangk W Effect of improved hydrogen supply on energy state, ureogenesis and gluconeogenesis in isolated hepatocytes. 1986 Biomed. Biochim. Acta pmid:3707550
Santa T et al. Synthesis of benzofurazan derivatization reagents for carboxylic acids in liquid chromatography/electrospray ionization-tandem mass spectrometry. 2007 Biomed. Chromatogr. pmid:17590866
Kuhara T et al. Identification and quantification of octanoyl glucuronide in the urine of children who ingested medium-chain triglycerides. 1986 Biomed. Environ. Mass Spectrom. pmid:2948585
Nakajima K et al. Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells. 2016 Biomed. Res. pmid:28003581
Hainaut J et al. Differentiation of antilymphocytic antibodies by analytical ion exchange chromatography: the effect of caprylic acid. 1974 Biomedicine pmid:4433656
Koda Y et al. Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides. 2008 Bioorg. Med. Chem. pmid:18468445