octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Allard MF et al. | AMPK and metabolic adaptation by the heart to pressure overload. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16920812 |
Kajimoto M et al. | Differential effects of octanoate and heptanoate on myocardial metabolism during extracorporeal membrane oxygenation in an infant swine model. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26232235 |
Kajimoto M et al. | Effects of continuous triiodothyronine infusion on the tricarboxylic acid cycle in the normal immature swine heart under extracorporeal membrane oxygenation in vivo. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24531815 |
Jørgensen J and Mortensen PB | Substrate utilization by intestinal mucosal tissue strips from patients with inflammatory bowel disease. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11447021 |
Mizutani M et al. | Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pH. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20501445 |
Vincent G et al. | Citrate release by perfused rat hearts: a window on mitochondrial cataplerosis. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10780941 |
Kim JY et al. | Lipid oxidation is reduced in obese human skeletal muscle. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:11052958 |
Benthem L et al. | Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:11093916 |
Bezaire V et al. | Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16219667 |
Cha BS et al. | Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARgamma agonists. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15727952 |
Sakata I et al. | Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19401456 |
Tham E et al. | Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19240252 |
Hommelberg PP et al. | Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18957619 |
Bando M et al. | Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22114024 |
Turcotte LP et al. | High carbohydrate availability increases LCFA uptake and decreases LCFA oxidation in perfused muscle. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11739099 |
Miller TB | Cardiac performance of isolated perfused hearts from alloxan diabetic rats. | 1979 | Am. J. Physiol. | pmid:443443 |
Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
Nutting CW et al. | Vasorelaxant effects of short chain fatty acid salts in rat caudal artery. | 1991 | Am. J. Physiol. | pmid:1877681 |
Ben Cheikh R et al. | Control of oxidative metabolism in volume-overloaded rat hearts: effects of different lipid substrates. | 1994 | Am. J. Physiol. | pmid:8203607 |
ChacÃn J et al. | Role of fatty acid oxidation in mechanism of action of gastric secretagogues. | 1980 | Am. J. Physiol. | pmid:6768310 |