octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Agius L and Alberti KG | Regulation of flux through pyruvate dehydrogenase and pyruvate carboxylase in rat hepatocytes. Effects of fatty acids and glucagon. | 1985 | Eur. J. Biochem. | pmid:3932072 |
Bjorge SM and Baillie TA | Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933498 |
Veerkamp JH et al. | Interaction of short-chain and branched-chain fatty acids and their carnitine and CoA esters and of various metabolites and agents with branched-chain 2-oxo acid oxidation in rat muscle and liver mitochondria. | 1985 | Int. J. Biochem. | pmid:3934010 |
Chan K et al. | An improved gas liquid chromatographic assay for plasma valproic acid concentrations in mentally handicapped epileptic children. | 1985 | Methods Find Exp Clin Pharmacol | pmid:3937004 |
Stanisz J et al. | Serum factors that stimulate fatty acid oxidation: physiological specificity. | 1986 | J. Cell. Physiol. | pmid:3944194 |
Zieve L et al. | Ammonia, octanoate and a mercaptan depress regeneration of normal rat liver after partial hepatectomy. | 1985 Jan-Feb | Hepatology | pmid:3967863 |
Noy N and Zakim D | Substrate specificity of fatty-acyl-CoA ligase in liver microsomes. | 1985 | Biochim. Biophys. Acta | pmid:3970953 |
Ferris CF et al. | Alcohol and fatty acid stimulation of neurotensin release from rat small intestine. | 1985 | Endocrinology | pmid:3971900 |
Germán JC et al. | [Solvent effects on cholesterol calculi: an in vitro study using octanoic acid, glycerol monooctanate, sodium cholate, heparin and ursodeoxycholic acid]. | 1985 | Rev Esp Enferm Apar Dig | pmid:3975461 |
Maddaiah VT | Ammonium inhibition of fatty acid oxidation in rat liver mitochondria. A possible cause of fatty liver in Reye's syndrome and urea cycle defects. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977937 |
Haas R et al. | Salicylate-induced loose coupling: protonmotive force measurements. | 1985 | Biochem. Pharmacol. | pmid:3977963 |
Taylor WM et al. | Effect of depolarizing concentrations of potassium on calcium uptake and metabolism in rat liver. | 1985 | FEBS Lett. | pmid:3979569 |
Duée PH et al. | Development and regulation of ketogenesis in isolated hepatocytes from newborn rabbits. | 1985 | Reprod Nutr Dev | pmid:3992001 |
Lee SM et al. | Prevention of the metabolic effects of 2-tetradecylglycidate by octanoic acid in the genetically diabetic mouse (db/db). | 1985 | Biochem Med | pmid:3994695 |
Sabbagh E et al. | 3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria. | 1985 | J. Biol. Chem. | pmid:3997873 |
Maublant JC et al. | Effects of grisorixin on the distribution of thallium-201 and on the oxidative metabolism in cultured myocardial cells. | 1985 | J. Nucl. Med. | pmid:3998852 |
Bougnères PF et al. | Medium-chain acyl-CoA dehydrogenase deficiency in two siblings with a Reye-like syndrome. | 1985 | J. Pediatr. | pmid:3998948 |
Roe CR et al. | Diagnostic and therapeutic implications of medium-chain acylcarnitines in the medium-chain acyl-coA dehydrogenase deficiency. | 1985 | Pediatr. Res. | pmid:4000772 |
McCandless DW | Octanoic acid-induced coma and reticular formation energy metabolism. | 1985 | Brain Res. | pmid:4005536 |
Rowley H and Collins RC | [1-14C]Octanoate: a fast functional marker of brain activity. | 1985 | Brain Res. | pmid:4005560 |
Phillips JW et al. | Some unexplained features of hepatic ethanol oxidation. | 1985 Jan-Feb | Alcohol | pmid:4015838 |
Brandes R et al. | The specificity of triacylglycerol synthesis for medium-chain fatty acids in rat and human adipose preparations. | 1985 | Biochim. Biophys. Acta | pmid:4027259 |
Drewes LR and Leino RL | Neuron-specific mitochondrial degeneration induced by hyperammonemia and octanoic acidemia. | 1985 | Brain Res. | pmid:4027650 |
Duran M et al. | Octanoic acidemia and octanoylcarnitine excretion with dicarboxylic aciduria due to defective oxidation of medium-chain fatty acids. | 1985 | J. Pediatr. | pmid:4032135 |
Wolf HP and Engel DW | Decrease of fatty acid oxidation, ketogenesis and gluconeogenesis in isolated perfused rat liver by phenylalkyl oxirane carboxylate (B 807-27) due to inhibition of CPT I (EC 2.3.1.21). | 1985 | Eur. J. Biochem. | pmid:4038486 |
Hütter JF et al. | Effect of fatty acid oxidation on efficiency of energy production in rat heart. | 1985 | Am. J. Physiol. | pmid:4051011 |
Lutz WH et al. | Inhibition of citrulline synthesis by octanoate and its modulation by adenine nucleotides. | 1985 | Biochem Med | pmid:4052056 |
Strieleman PJ et al. | Fatty acid activation of the reconstituted brown adipose tissue mitochondria uncoupling protein. | 1985 | J. Biol. Chem. | pmid:4055740 |
Nelis HJ et al. | Chromatographic determination of N-acetyl-DL-tryptophan and octanoic acid in human albumin solutions. | 1985 | J. Chromatogr. | pmid:4055947 |
Zieve L et al. | Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat. | 1985 | J. Lab. Clin. Med. | pmid:4056569 |
Duran M et al. | Octanoylglucuronide excretion in patients with a defective oxidation of medium-chain fatty acids. | 1985 | Clin. Chim. Acta | pmid:4064333 |
Plomp PJ et al. | Mechanism of the stimulation of respiration by fatty acids in rat liver. | 1985 | FEBS Lett. | pmid:4065340 |
MacDonald ML et al. | Aversion of the cat to dietary medium-chain triglycerides and caprylic acid. | 1985 | Physiol. Behav. | pmid:4070410 |
Taguchi S | [Acidosis tolerance of fetal metabolism--comparative studies on isolated perfused adult, fetal and neonatal livers]. | 1985 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:4086906 |
Dube VE et al. | Caprylate-dependent auto-anti-e. | 1977 | Vox Sang. | pmid:412322 |
Harwood JL et al. | Fat metabolism in higher plants. Beta-hydroxylation of fatty acids by a soluble preparation from maturing avocado mesocarp. | 1972 | Biochem. J. | pmid:4144293 |
Ring J et al. | Anaphylactoid reactions to infusions of plasma protein and human serum albumin. Role of aggregated proteins and of stabilizers added during production. | 1979 | Clin. Allergy | pmid:421339 |
Dhopeshwarkar GA and Subramanian C | Lipogenesis in the developing brain: utilization of radioactive leucine, isoleucine, octanoic acid and beta-hydroxybutyric acid. | 1979 | Lipids | pmid:423709 |
Hainaut J et al. | Differentiation of antilymphocytic antibodies by analytical ion exchange chromatography: the effect of caprylic acid. | 1974 | Biomedicine | pmid:4433656 |
Tanner GA et al. | Excretion of phenol red by the Necturus kidney. | 1979 | Am. J. Physiol. | pmid:443381 |
Miller TB | Cardiac performance of isolated perfused hearts from alloxan diabetic rats. | 1979 | Am. J. Physiol. | pmid:443443 |
Debeer LJ et al. | Effects of octanoate and oleate on energy metabolism in the perfused rat liver. | 1974 | Eur. J. Biochem. | pmid:4434997 |
Lemieux G et al. | Effect of fluoroacetate on the inhibitory action of ketone bodies and fatty acids on renal ammoniagenesis. | 1979 | Am. J. Physiol. | pmid:464062 |
Strong CR and Dils R | Fatty acid biosynthesis in rabbit mammary gland during pregnancy and early lactation. | 1972 | Biochem. J. | pmid:4643704 |
Sheikh MI | Renal handling of phenol red. I. A comparative study on the accumulation of phenol red and p-aminohippurate in rabbit kidney tubules in vitro. | 1972 | J. Physiol. (Lond.) | pmid:4647268 |
Aurousseau B and de Groot L | [Effect of caprylic acid on metabolism of other fatty acids in the growing rat]. | 1972 | Ann Biol Anim Biochim Biophys | pmid:4667618 |
Kabara JJ et al. | Fatty acids and derivatives as antimicrobial agents. | 1972 | Antimicrob. Agents Chemother. | pmid:4670656 |
Spydevold O | The effect of octanoate and palmitate on the metabolism of valine in perfused hindquarter of rat. | 1979 | Eur. J. Biochem. | pmid:467425 |
Morrow RJ et al. | Functional utilization of palmitate, octanoate, and glucose by the isolated rat heart. | 1973 | Proc. Soc. Exp. Biol. Med. | pmid:4683244 |
Stewart HB et al. | Intermediates in fatty acid oxidation. | 1973 | Biochem. J. | pmid:4722901 |
Wilson MB | Control of phosphoenolpyruvate synthesis in guinea-pig mitochondria. | 1973 | Biochem. J. | pmid:4724589 |
Groot PH and Hülsmann WC | The activation and oxidation of octanoate and palmitate by rat skeletal muscle mitochondria. | 1973 | Biochim. Biophys. Acta | pmid:4741907 |
Trimble ME | Transport and metabolism of octanoate by the perfused rat kidney. | 1979 | Am. J. Physiol. | pmid:474762 |
Boveris A and Chance B | The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. | 1973 | Biochem. J. | pmid:4749271 |
Turakulov IaKh et al. | [Caprylate oxidation and ketone body concentration in the cardiac muscle of rabbits with thyrotoxicosis]. | 1973 | Biull Eksp Biol Med | pmid:4778684 |
Bach A et al. | Octanoate metabolism in the isolated perfused rat liver. I. Methodology and preliminary results. | 1973 | Arch Sci Physiol (Paris) | pmid:4780669 |
Abidov AA and Isaev EI | [The effect of strophanthin on caprylic acid oxidation in cardiac muscle in adrenaline myocarditis]. | 1973 May-Jun | Farmakol Toksikol | pmid:4788489 |
Allary M and Saint-Blancard J | [Use of sodium caprylate for the separation of plasma proteins]. | 1973 Jul-Aug | Ann Pharm Fr | pmid:4793461 |
Staeffen J et al. | [Coma induced in Macaca mulatta by intravenous sodium octanoate. Polygraphic study]. | 1973 | C. R. Seances Soc. Biol. Fil. | pmid:4803135 |
Borbola J et al. | Effects of octanoate on the electrical activity of Purkinje fibres. | 1974 | Experientia | pmid:4824600 |
Glick MR et al. | Glucose and octanoate utilization by isolated adult rat heart cells. | 1974 | Life Sci. | pmid:4829540 |
Fischer JH et al. | Free fatty acid and glucose metabolism during hypothermic perfusion of canine kidneys. | 1979 | Eur Surg Res | pmid:488147 |
Andersen JM and Dietschy JM | Absolute rates of cholesterol synthesis in extrahepatic tissues measured with 3H-labeled water and 14C-labeled substrates. | 1979 | J. Lipid Res. | pmid:490050 |
Campillo JE et al. | Effect of oleic and octanoic acids on glucose-induced insulin release in vitro. | 1979 | Diabete Metab | pmid:499632 |
Sallee VL et al. | Determination of unidirectional uptake rates for lipids across the intestinal brush border. | 1972 | J. Lipid Res. | pmid:5016300 |
Paquet RJ et al. | Effects of thiamine deficiency and octanoate administration, in vivo, on gluconeogenesis in rat kidney slices and on amino acid profile in rat liver. | 1972 | Proc. Soc. Exp. Biol. Med. | pmid:5039394 |
Valdivia MM et al. | [Effect of octanoic acid on the insulin secretion in response to glucose in vitro (author's transl)]. | 1979 | Rev. Esp. Fisiol. | pmid:504776 |
Bach A et al. | Octanoate metabolism in the isolated perfused rat liver. II. Comparison with a long chain fatty acid. | 1975 | Arch. Int. Physiol. Biochim. | pmid:50825 |
Abidov AA et al. | [Strophantin K action on caprylate oxidation in the myocardium]. | 1971 Sep-Oct | Farmakol Toksikol | pmid:5151251 |
Skrede S and Slaattelid O | Fatty acid metabolism during hypothermic perfusion of the isolated dog kidney. | 1979 | Scand. J. Clin. Lab. Invest. | pmid:531496 |
Schröder K et al. | [Energy metabolism of the rat renal cortex, as measured by incubation in various substrates]. | 1979 | Acta Biol. Med. Ger. | pmid:543370 |
Clark SB | The uptake of oleic acid by rat small intestine: a comparison of methodologies. | 1971 | J. Lipid Res. | pmid:5542704 |
McGarry JD and Foster DW | The regulation of ketogenesis from octanoic acid. The role of the tricarboxylic acid cycle and fatty acid synthesis. | 1971 | J. Biol. Chem. | pmid:5543682 |
Brodersen R and Hansen P | Bilirubin displacing effect of stabilizers added to injectable preparations of human serum albumin. | 1977 | Acta Paediatr Scand | pmid:557276 |
Trauner DA and Huttenlocher PR | Short chain fatty acid-induced central hyperventilation in rabbits. | 1978 | Neurology | pmid:567765 |
Katoh K and Tsuda T | Effects of acetylcholine and short-chain fatty acids on acinar cells of the exocrine pancreas in sheep. | 1984 | J. Physiol. (Lond.) | pmid:6084059 |
Martin-Sanz P et al. | Long-chain fatty acids and their acyl-CoA esters cause the translocation of phosphatidate phosphohydrolase from the cytosolic to the microsomal fraction of rat liver. | 1984 | FEBS Lett. | pmid:6090213 |
Sundin U et al. | Thyroid-catecholamine interactions in isolated rat brown adipocytes. | 1984 | Metab. Clin. Exp. | pmid:6092828 |
Baraldi M et al. | Toxins in hepatic encephalopathy: the role of the synergistic effect of ammonia, mercaptans and short chain fatty acids. | 1984 | Arch. Toxicol. Suppl. | pmid:6097201 |
Henze K et al. | The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts. | 1981 | Biochim. Biophys. Acta | pmid:6118180 |
Rofe AM and Williamson DH | Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia. | 1983 | Biochem. J. | pmid:6135420 |
Pfadenhauer EH et al. | Identification of the metabolites of erythro-9-(2-hydroxy-3-nonyl)hypoxanthine from laboratory animals. | 1984 May-Jun | Drug Metab. Dispos. | pmid:6145553 |
Sánchez-Serrano D et al. | Enhancement of ouabain arrhythmias by fatty acids. | 1980 | J. Cardiovasc. Pharmacol. | pmid:6156330 |
Trimble ME et al. | Fatty acid transport and metabolism in the isolated perfused rat kidney. | 1977 Oct 23-26 | Curr Probl Clin Biochem | pmid:616371 |
Lemieux G et al. | Relationship between the renal metabolism of glutamine, fatty acids and ketone bodies. | 1977 Oct 23-26 | Curr Probl Clin Biochem | pmid:616372 |
Grill V | Nutrient-induced priming of insulin and glucagon secretion. Effects of alpha-ketoisocaproic acid. | 1982 | Endocrinology | pmid:6173206 |
Guddat W and Hillger K | A heat polyethylene glycol procedure as an alternative method for plasmafractionation. | 1982 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:6187637 |
Claycomb WC et al. | Culture of the terminally differentiated ventricular cardiac muscle cell. Characterization of exogenous substrate oxidation and the adenylate cyclase system. | 1984 | FEBS Lett. | pmid:6201398 |
Rabinowitz JL et al. | Sources of serum [14C]-octanoate in cirrhosis of the liver and hepatic encephalopathy. | 1978 | J. Lab. Clin. Med. | pmid:621424 |
Seydoux J et al. | Brown adipose tissue metabolism in streptozotocin-diabetic rats. | 1983 | Endocrinology | pmid:6223804 |
Trauner DA | Regional cerebral Na+K+ ATPase activity following octanoate administration. | 1980 | Pediatr. Res. | pmid:6250122 |
Kinnula VL and Hassinen I | Effect of chronic hypoxia on hepatic triacylglycerol concentration and mitochondrial fatty acid oxidizing capacity in liver and heart. | 1978 | Acta Physiol. Scand. | pmid:626089 |
Burns AH and Reddy WJ | Effect of ouabain on exogenous substrate oxidation by isolated cardiac myocytes. | 1981 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6267674 |
Müller MJ et al. | Effect of thyroid state on ketogenic capacity of the isolated perfused liver of starved rats. | 1981 | Biochim. Biophys. Acta | pmid:6275888 |
Assimacopoulos-Jeannet F et al. | Alterations of brown adipose tissue in genetically obese (ob/ob) mice. II. Studies of beta-adrenergic receptors and fatty acid degradation. | 1982 | Endocrinology | pmid:6276135 |
Seydoux J et al. | Impaired metabolic response to nerve stimulation in brown adipose tissue of hypothyroid rats. | 1982 | Mol. Cell. Endocrinol. | pmid:6276252 |
Salesse R et al. | Modulation of adenylate cyclase activity by the physical state of pigeon erythrocyte membrane. 1. Parallel drug-induced changes in the bilayer fluidity and adenylate cyclase activity. | 1982 | Biochemistry | pmid:6282308 |
Nosek TM and Crosland MB | Calcium-dependent proteolysis in neural tissue is activated at physiologic intracellular Ca2+ levels and inhibited by some anticonvulsants. | 1983 | J. Neurobiol. | pmid:6298363 |
Geppert EF and Elstein KH | Short-term regulation of fatty acid synthesis in isolated alveolar type II cells from adult rat lung. Effects of free fatty acids and hormones. | 1983 | Exp. Lung Res. | pmid:6305647 |
Skrede S et al. | Coenzyme A in dog kidneys during hypothermic perfusion. | 1983 | Cryobiology | pmid:6309478 |