octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Carlsson MA et al. | Odour maps in the brain of butterflies with divergent host-plant preferences. | 2011 | PLoS ONE | pmid:21901154 |
Paul D et al. | Proteome and membrane fatty acid analyses on Oligotropha carboxidovorans OM5 grown under chemolithoautotrophic and heterotrophic conditions. | 2011 | PLoS ONE | pmid:21386900 |
Xu W et al. | Odorant-binding proteins of the malaria mosquito Anopheles funestus sensu stricto. | 2010 | PLoS ONE | pmid:21042539 |
Bao F et al. | New cobalt-mediated radical polymerization (CMRP) of methyl methacrylate initiated by two single-component dinuclear β-diketone cobalt (II) catalysts. | 2010 | PLoS ONE | pmid:21049027 |
Guo J et al. | Characterization of a novel esterase Rv0045c from Mycobacterium tuberculosis. | 2010 | PLoS ONE | pmid:20957207 |
Pérez D et al. | A novel halophilic lipase, LipBL, showing high efficiency in the production of eicosapentaenoic acid (EPA). | 2011 | PLoS ONE | pmid:21853111 |
Buglino JA and Resh MD | Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. | 2010 | PLoS ONE | pmid:20585641 |
Wang DB et al. | Detection of B. anthracis spores and vegetative cells with the same monoclonal antibodies. | 2009 | PLoS ONE | pmid:19915677 |
Can Güven S and Laska M | Olfactory sensitivity and odor structure-activity relationships for aliphatic carboxylic acids in CD-1 mice. | 2012 | PLoS ONE | pmid:22479594 |
Prpich AM et al. | Tension at the surface: which phase is more important, liquid or vapor? | 2009 | PLoS ONE | pmid:20011532 |
Brault G et al. | Isolation and characterization of EstC, a new cold-active esterase from Streptomyces coelicolor A3(2). | 2012 | PLoS ONE | pmid:22396747 |
Zelano C et al. | A specialized odor memory buffer in primary olfactory cortex. | 2009 | PLoS ONE | pmid:19305509 |
Eagle RA et al. | Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G. | 2009 | PLoS ONE | pmid:19223974 |
Takahashi K et al. | Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism. | 2009 | PLoS ONE | pmid:19119319 |
González-Mas MC et al. | Comparative analysis of the volatile fraction of fruit juice from different Citrus species. | 2011 | PLoS ONE | pmid:21818287 |
Spring S et al. | The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov. | 2009 | PLoS ONE | pmid:19287491 |
Janssen S et al. | Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. | 2012 | PLoS ONE | pmid:22768248 |
Gumel AM et al. | Biosynthesis and characterization of polyhydroxyalkanoates copolymers produced by Pseudomonas putida Bet001 isolated from palm oil mill effluent. | 2012 | PLoS ONE | pmid:23028854 |
Liang QH et al. | Ghrelin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the ERK pathway. | 2012 | PLoS ONE | pmid:22514603 |
Lin HV et al. | Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. | 2012 | PLoS ONE | pmid:22506074 |
Lemarié F et al. | Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat. | 2015 | PLoS ONE | pmid:26196391 |
Arora T et al. | Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission. | 2015 | PLoS ONE | pmid:25946120 |
Takatani-Nakase T et al. | Transcutaneous immunization system using a hydrotropic formulation induces a potent antigen-specific antibody response. | 2012 | PLoS ONE | pmid:23110149 |
Librán-Pérez M et al. | Oleic acid and octanoic acid sensing capacity in rainbow trout Oncorhynchus mykiss is direct in hypothalamus and Brockmann bodies. | 2013 | PLoS ONE | pmid:23533628 |
Nair DR et al. | Two functionally distinctive phosphopantetheinyl transferases from amoeba Dictyostelium discoideum. | 2011 | PLoS ONE | pmid:21931666 |
Casewell NR et al. | Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom. | 2010 | PLoS Negl Trop Dis | pmid:21049058 |
Abubakar IS et al. | Randomised controlled double-blind non-inferiority trial of two antivenoms for saw-scaled or carpet viper (Echis ocellatus) envenoming in Nigeria. | 2010 | PLoS Negl Trop Dis | pmid:20668549 |
Vargas M et al. | Preclinical evaluation of caprylic acid-fractionated IgG antivenom for the treatment of Taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea. | 2011 | PLoS Negl Trop Dis | pmid:21610854 |
Brown NI | Consequences of neglect: analysis of the sub-Saharan African snake antivenom market and the global context. | 2012 | PLoS Negl Trop Dis | pmid:22679521 |
El-Ekiaby M et al. | Minipool caprylic acid fractionation of plasma using disposable equipment: a practical method to enhance immunoglobulin supply in developing countries. | 2015 | PLoS Negl Trop Dis | pmid:25719558 |
de Silva HA et al. | Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. | 2011 | PLoS Med. | pmid:21572992 |
Saft C et al. | No evidence of impaired gastric emptying in early Huntington's Disease. | 2011 | PLoS Curr | pmid:22130331 |
Gross L | Can a taste for poison drive speciation? | 2007 | PLoS Biol. | pmid:20076673 |
Matsuo T et al. | Odorant-binding proteins OBP57d and OBP57e affect taste perception and host-plant preference in Drosophila sechellia. | 2007 | PLoS Biol. | pmid:17456006 |
Eren E et al. | Substrate specificity within a family of outer membrane carboxylate channels. | 2012 | PLoS Biol. | pmid:22272184 |
Won HS et al. | Mechanism of action of Brazilin on gluconeogenesis in isolated rat hepatocytes. | 2004 | Planta Med. | pmid:15368663 |
Crane J et al. | Triacylglycerols determine the unusual storage physiology of Cuphea seed. | 2003 | Planta | pmid:12743824 |
Wiberg E et al. | The distribution of caprylate, caprate and laurate in lipids from developing and mature seeds of transgenic Brassica napus L. | 2000 | Planta | pmid:11219581 |
Lawo NC et al. | The volatile metabolome of grapevine roots: first insights into the metabolic response upon phylloxera attack. | 2011 | Plant Physiol. Biochem. | pmid:21764593 |
Vincenzini MT et al. | The Effects of Octanoate and Oleate on Isocitrate Lyase Activity during the Germination of Pinus pinea Seeds. | 1973 | Plant Physiol. | pmid:16658603 |
Waltenberger B et al. | Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine. | 2011 | Phytomedicine | pmid:20851587 |
Corona-Castañeda B et al. | Modulators of antibiotic activity from Ipomoea murucoides. | 2013 | Phytochemistry | pmid:23920226 |
Jambor de Sousa UL et al. | Caprylic acid infusion acts in the liver to decrease food intake in rats. | 2006 | Physiol. Behav. | pmid:16360711 |
Librán-Pérez M et al. | Central administration of oleate or octanoate activates hypothalamic fatty acid sensing and inhibits food intake in rainbow trout. | 2014 | Physiol. Behav. | pmid:24631300 |
Jambor de Sousa UL et al. | Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats. | 2006 | Physiol. Behav. | pmid:16890966 |
MacDonald ML et al. | Aversion of the cat to dietary medium-chain triglycerides and caprylic acid. | 1985 | Physiol. Behav. | pmid:4070410 |
Hiraoka T et al. | Effects of oral stimulation with fats on the cephalic phase of pancreatic enzyme secretion in esophagostomized rats. | 2003 | Physiol. Behav. | pmid:12954413 |
Gann VK and Hardin CD | Acetate or octanoate increases glycogenolysis in smooth muscle as determined by 13C-NMR. | 1997 | Physiol Chem Phys Med NMR | pmid:9353955 |
Polácek H et al. | Study of cough in anaesthetized cats with experimental pulmonary oedema. | 1986 | Physiol Bohemoslov | pmid:2950532 |
Pereira RF et al. | What drives the precipitation of long-chain calcium carboxylates (soaps) in aqueous solution? | 2012 | Phys Chem Chem Phys | pmid:22513819 |
Dzikovski B et al. | Multifrequency ESR study of spin-labeled molecules in inclusion compounds with cyclodextrins. | 2009 | Phys Chem Chem Phys | pmid:19639141 |
Coenen MJ et al. | Polymorphism in porphyrin monolayers: the relation between adsorption configuration and molecular conformation. | 2013 | Phys Chem Chem Phys | pmid:23620134 |
Lala AK and Koppaka V | Transverse location of new fluorene based depth dependent fluorescent probes in membranes--quenching studies with 9,10-dibromostearic acid. | 1989 | Photochem. Photobiol. | pmid:2772065 |
Latere DJ et al. | Spontaneously self-assembled micelles from poly(ethylene glycol)-b-poly(epsilon-caprolactone-co-trimethylene carbonate) for drug solubilization. | 2008 | Pharmazie | pmid:18444514 |
Mahadevia PJ | The pocketbook: Pharmacoeconomic issues related to intravenous immunoglobulin therapy. | 2005 | Pharmacotherapy | pmid:16229680 |
Chen CY et al. | Ghrelin gene products and the regulation of food intake and gut motility. | 2009 | Pharmacol. Rev. | pmid:20038570 |
Trusk TC and Stein EA | Effect of heroin-conditioned auditory stimuli on cerebral functional activity in rats. | 1988 | Pharmacol. Biochem. Behav. | pmid:3227045 |
Horisawa E et al. | Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit. | 2002 | Pharm. Res. | pmid:12033371 |
Chuang VT and Otagiri M | How do fatty acids cause allosteric binding of drugs to human serum albumin? | 2002 | Pharm. Res. | pmid:12425462 |
Yanai S et al. | Antitumor effect of arterial administration of a medium-chain triglyceride solution of an angiogenesis inhibitor, TNP-470, in rabbits bearing VX-2 carcinoma. | 1995 | Pharm. Res. | pmid:7479548 |
Goodwin D et al. | Stability, permeability and growth-inhibitory properties of gonadotropin-releasing hormone liposaccharides. | 2015 | Pharm. Res. | pmid:25407542 |
Tomita M et al. | Enhancement of colonic drug absorption by the paracellular permeation route. | 1988 | Pharm. Res. | pmid:3244645 |
Constantinides PP et al. | Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation. | 1996 | Pharm. Res. | pmid:8932438 |
Tomita M et al. | Enhancement of colonic drug absorption by the transcellular permeation route. | 1988 | Pharm. Res. | pmid:3247289 |
Cheruvallath VK et al. | The effect of octanoic acid on the binding of the enantiomers of ibuprofen and naproxen to human serum albumin: a chromatographic implication. | 1996 | Pharm. Res. | pmid:8668670 |
Sawada T et al. | Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate. | 1991 | Pharm. Res. | pmid:1798671 |
Prajapati HN et al. | A comparative evaluation of mono-, di- and triglyceride of medium chain fatty acids by lipid/surfactant/water phase diagram, solubility determination and dispersion testing for application in pharmaceutical dosage form development. | 2012 | Pharm. Res. | pmid:21861203 |
Olivier JC et al. | Synthesis of pegylated immunonanoparticles. | 2002 | Pharm. Res. | pmid:12240939 |
Dixit RP and Nagarsenker MS | Dry adsorbed emulsion of simvastatin: optimization and in vivo advantage. | 2007 | Pharm Dev Technol | pmid:17963150 |
Parrilla R et al. | Use of endogenous triglycerides to support gluconeogenesis in the perfused isolated rat liver. | 1976 | Pflugers Arch. | pmid:1033522 |
Bünger R et al. | Energy utilization and pyruvate as determinants of pyruvate dehydrogenase in norepinephrine-stimulated heart. | 1983 | Pflugers Arch. | pmid:6878010 |
Caffier G et al. | The influence of free fatty acids on functional properties of isolated skeletal muscles. Octanoate action on membrane resistance. | 1980 | Pflugers Arch. | pmid:6966791 |
Athéa Y et al. | Mitochondrial and energetic cardiac phenotype in hypothyroid rat. Relevance to heart failure. | 2007 | Pflugers Arch. | pmid:17638011 |
Seydoux J et al. | Functional disconnection of brown adipose tissue in hypothalamic obesity in rats. | 1981 | Pflugers Arch. | pmid:7195549 |
Andolfi A et al. | Bioactive and structural metabolites of pseudomonas and burkholderia species causal agents of cultivated mushrooms diseases. | 2008 | Perspect Medicin Chem | pmid:19787100 |
Maes BD et al. | Gastric emptying in renal failure patients using the 13C-octanoic acid breath test: facts and artifacts. | 2002 Nov-Dec | Perit Dial Int | pmid:12556082 |
Satou M et al. | Understanding the functional significance of ghrelin processing and degradation. | 2011 | Peptides | pmid:21763742 |
Yahashi S et al. | GHRP-6 mimics ghrelin-induced stimulation of food intake and suppression of locomotor activity in goldfish. | 2012 | Peptides | pmid:22349352 |
Rucinski M et al. | Evidence suggesting that ghrelin O-acyl transferase inhibitor acts at the hypothalamus to inhibit hypothalamo-pituitary-adrenocortical axis function in the rat. | 2012 | Peptides | pmid:22543218 |
Ishida Y et al. | Identification of ghrelin in the house musk shrew (Suncus murinus): cDNA cloning, peptide purification and tissue distribution. | 2009 | Peptides | pmid:19428777 |
Miura T et al. | Purification and properties of ghrelin from the intestine of the goldfish, Carassius auratus. | 2009 | Peptides | pmid:19150635 |
Kojima M and Kangawa K | The discovery of ghrelin: with a little luck and great passion. Preface. | 2011 | Peptides | pmid:22027335 |
Wang J et al. | Pharmacokinetics, toxicity of nasal cilia and immunomodulating effects in Sprague-Dawley rats following intranasal delivery of thymopentin with or without absorption enhancers. | 2006 | Peptides | pmid:16242213 |
Sulkers EJ et al. | Quantitation of oxidation of medium-chain triglycerides in preterm infants. | 1989 | Pediatr. Res. | pmid:2797943 |
Jones PM et al. | Accumulation of 3-hydroxy-fatty acids in the culture medium of long-chain L-3-hydroxyacyl CoA dehydrogenase (LCHAD) and mitochondrial trifunctional protein-deficient skin fibroblasts: implications for medium chain triglyceride dietary treatment of LCHAD deficiency. | 2003 | Pediatr. Res. | pmid:12621125 |
Trauner DA and Adams H | Intracranial pressure elevations during octanoate infusion in rabbits: an experimental model of Reye's syndrome. | 1981 | Pediatr. Res. | pmid:7267183 |
Nakajima T et al. | The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency. | 1997 | Pediatr. Res. | pmid:9212045 |
Whyte RK et al. | Excretion of dicarboxylic and omega-1 hydroxy fatty acids by low birth weight infants fed with medium-chain triglycerides. | 1986 | Pediatr. Res. | pmid:3080726 |
Trauner DA | Regional cerebral Na+K+ ATPase activity following octanoate administration. | 1980 | Pediatr. Res. | pmid:6250122 |
Yoshida Y et al. | Effect of salicylic acid on mitochondrial-peroxisomal fatty acid catabolism. | 1988 | Pediatr. Res. | pmid:3353181 |
Roe CR et al. | Diagnostic and therapeutic implications of medium-chain acylcarnitines in the medium-chain acyl-coA dehydrogenase deficiency. | 1985 | Pediatr. Res. | pmid:4000772 |
Dombrowski GJ and Swiatek KR | Lactate genesis by rat liver and muscle during development. | 1991 | Pediatr. Res. | pmid:1956716 |
Trauner DA and Garrett RS | Effect of octanoate injection on rat blood-brain barrier. | 1985 Jan-Feb | Pediatr. Neurol. | pmid:3880386 |
Trauner DA and de la Torre JC | Effect of octanoate on blood-brain barrier permeability using L-dopa as a marker. | 1985 Jul-Aug | Pediatr. Neurol. | pmid:3880408 |
Trice JE and Trauner DA | Alterations in serum glucose and hepatic glycogen concentrations during octanoate administration in rabbits. | 1985 Sep-Oct | Pediatr. Neurol. | pmid:3880415 |
Trauner DA and Adams HR | Effects of therapeutic agents in a rabbit model of Reye syndrome. | 1987 May-Jun | Pediatr. Neurol. | pmid:3508061 |
Massaldi H and Morais V | Evolution of endotoxin contamination during production of a therapeutic serum. | 2007 Sep-Oct | PDA J Pharm Sci Technol | pmid:18047176 |
Tezikov EB et al. | [Effect of beta-hydroxybutyrate and caprylic acid on function of isolated rat heart in alcoholic intoxication and in the post-intoxication period]. | 1993 May-Jun | Patol Fiziol Eksp Ter | pmid:8058394 |
Müller T | Levodopa/carbidopa and entacapone in the treatment of Parkinson's disease: efficacy, safety and patient preference. | 2009 | Patient Prefer Adherence | pmid:19936145 |
Webb T | Identification of interference affecting the gas-liquid chromatography analysis of valproic acid in quality control material. | 1986 | Pathology | pmid:3097616 |