| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Neuropathies | D003929 | 5 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Dumping Syndrome | D004377 | 1 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Flatulence | D005414 | 1 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Giardiasis | D005873 | 3 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Hemorrhage | D006470 | 15 associated lipids |
| Hepatic Encephalopathy | D006501 | 9 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hepatorenal Syndrome | D006530 | 1 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hypertension, Portal | D006975 | 12 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Infant, Newborn, Diseases | D007232 | 9 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
octanoic acid
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
Cross Reference
Introduction
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with octanoic acid?
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with octanoic acid
PubChem Associated disorders and diseases
What pathways are associated with octanoic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with octanoic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with octanoic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with octanoic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with octanoic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with octanoic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with octanoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grossauer J et al. | The peptide hormone ghrelin binds to membrane-mimetics via its octanoyl chain and an adjacent phenylalanine. | 2010 | Bioorg. Med. Chem. | pmid:20621491 |
| Koda Y et al. | Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides. | 2008 | Bioorg. Med. Chem. | pmid:18468445 |
| Cao B et al. | 19F NMR studies of tryptophan/serum albumin binding. | 2003 | Bioorg. Med. Chem. | pmid:12467709 |
| Guo H et al. | Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. | 2013 | Bioorg. Med. Chem. Lett. | pmid:24018188 |
| Liu MJ and Pollack GM | Pharmacokinetics and pharmacodynamics of valproate analogs in rats. II. Pharmacokinetics of octanoic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid. | 1993 | Biopharm Drug Dispos | pmid:8499583 |
| Etzerodt T et al. | Selective acylation enhances membrane charge sensitivity of the antimicrobial peptide mastoparan-x. | 2011 | Biophys. J. | pmid:21244836 |
| Gordon DJ et al. | Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel. | 2004 | Biophys. J. | pmid:14695285 |
| Makino T et al. | Semisynthesis of human ghrelin: condensation of a Boc-protected recombinant peptide with a synthetic O-acylated fragment. | 2005 | Biopolymers | pmid:16049959 |
| Shrake A et al. | Thermal stabilization of human albumin by medium- and short-chain n-alkyl fatty acid anions. | 2006 | Biopolymers | pmid:16273515 |
| Meeuwse P et al. | Modeling lipid accumulation in oleaginous fungi in chemostat cultures. II: Validation of the chemostat model using yeast culture data from literature. | 2011 | Bioprocess Biosyst Eng | pmid:21516366 |
| Tahir MN et al. | Stability of lipase immobilized on O-pentynyl dextran. | 2012 | Bioprocess Biosyst Eng | pmid:21932061 |
| Cai L et al. | Enhanced production of medium-chain-length polyhydroxyalkanoates (PHA) by PHA depolymerase knockout mutant of Pseudomonas putida KT2442. | 2009 | Bioresour. Technol. | pmid:19103481 |
| Ahmed EH et al. | An alkaline lipase from organic solvent tolerant Acinetobacter sp. EH28: Application for ethyl caprylate synthesis. | 2010 | Bioresour. Technol. | pmid:20096565 |
| Sun SY et al. | Novel minor lipase from Rhizopus chinensis during solid-state fermentation: biochemical characterization and its esterification potential for ester synthesis. | 2009 | Bioresour. Technol. | pmid:19157870 |
| Jian J et al. | Metabolic engineering for microbial production of polyhydroxyalkanoates consisting of high 3-hydroxyhexanoate content by recombinant Aeromonas hydrophila. | 2010 | Bioresour. Technol. | pmid:20236821 |
| Oztürk T et al. | Production of medium-chain triacylglycerols from corn oil: optimization by response surface methodology. | 2010 | Bioresour. Technol. | pmid:20576567 |
| Kobayashi M et al. | Retarding activity of 6-O-acyl-D-alloses against plant growth. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20057117 |
| Kuribayashi T et al. | Analysis of free fatty acids in sake by an enzymatic method and its application for estimating ethyl caproate and selecting yeast with high productivity of the ester. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22313771 |
| Murota K et al. | Inhibitory effect of monoacylglycerol on fatty acid uptake into rat intestinal epithelial cells. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11471752 |
| Sugihara A et al. | Purification and characterization of a novel cholesterol esterase from Pseudomonas aeruginosa, with its application to cleaning lipid-stained contact lenses. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12506971 |
| Shapiro IM et al. | Studies of nucleotides of growth-plate cartilage: evidence linking changes in cellular metabolism with cartilage calcification. | 1983 | Biosci. Rep. | pmid:6871381 |
| Baum G et al. | Clarification of ascites fluid. | 1991 | BioTechniques | pmid:1651092 |
| Kateja N et al. | Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow inversion reactor (CFIR). | 2016 | Biotechnol J | pmid:27447837 |
| Zinn M et al. | Growth and accumulation dynamics of poly(3-hydroxyalkanoate) (PHA) in Pseudomonas putida GPo1 cultivated in continuous culture under transient feed conditions. | 2011 | Biotechnol J | pmid:21751398 |
| Grellet S et al. | An associated process for the purification of immuno globulin G, catalase, superoxide dismutase and albumin from haemolysed human placenta blood. | 2001 | Biotechnol. Appl. Biochem. | pmid:11730480 |
| Cabrera-Crespo J et al. | Albumin purification from human placenta. | 2000 | Biotechnol. Appl. Biochem. | pmid:10744954 |
| Morais V and Massaldi H | A model mechanism for protein precipitation by caprylic acid: application to plasma purification. | 2012 Jan-Feb | Biotechnol. Appl. Biochem. | pmid:22332745 |
| Besada-Lombana PB et al. | Engineering Saccharomyces cerevisiae fatty acid composition for increased tolerance to octanoic acid. | 2017 | Biotechnol. Bioeng. | pmid:28294288 |
| Holstein MA et al. | Mobile phase modifier effects in multimodal cation exchange chromatography. | 2012 | Biotechnol. Bioeng. | pmid:21898370 |
| Flores MV et al. | The nature of fatty acid modifies the equilibrium position in the esterification catalyzed by lipase. | 2000 | Biotechnol. Bioeng. | pmid:10620267 |
| Hacking MA et al. | Lipase and esterase-catalyzed acylation of hetero-substituted nitrogen nucleophiles in water and organic solvents. | 2000 | Biotechnol. Bioeng. | pmid:10699875 |
| Larroche C and Gros JB | Batch and continuous 2-heptanone production by Ca-alginate/Eudragit RL entrapped spores of Penicillium roquefortii. | 1989 | Biotechnol. Bioeng. | pmid:18588048 |
| Brodsky Y et al. | Caprylic acid precipitation method for impurity reduction: an alternative to conventional chromatography for monoclonal antibody purification. | 2012 | Biotechnol. Bioeng. | pmid:22549395 |
| Hartmann R et al. | Tailor-made olefinic medium-chain-length poly[(R)-3-hydroxyalkanoates] by Pseudomonas putida GPo1: batch versus chemostat production. | 2006 | Biotechnol. Bioeng. | pmid:16255038 |
| Rothen SA et al. | Biotransformation of octane by E. coli HB101[pGEc47] on defined medium: octanoate production and product inhibition. | 1998 | Biotechnol. Bioeng. | pmid:10099269 |
| Kwon MA et al. | Synthesis activity-based zymography for detection of lipases and esterases. | 2011 | Biotechnol. Lett. | pmid:21120585 |
| Sakaki K and Itoh N | Optical resolution of racemic 2-hydroxy octanoic acid by lipase-catalyzed hydrolysis in a biphasic membrane reactor. | 2003 | Biotechnol. Lett. | pmid:14584912 |
| Ji JH et al. | Optimization of octanoic acid and sulfur donor concentrations for lipoic acid production by Pseudomonas reptilivora. | 2008 | Biotechnol. Lett. | pmid:18575810 |
| Vikbjerg AF et al. | Lipase-catalyzed acyl exchange of soybean phosphatidylcholine in n-Hexane: a critical evaluation of both acyl incorporation and product recovery. | 2005 Mar-Apr | Biotechnol. Prog. | pmid:15801777 |
| Vargas M et al. | Purification of IgG and albumin from human plasma by aqueous two phase system fractionation. | 2012 | Biotechnol. Prog. | pmid:22619188 |
| González Moreno PA et al. | Production of structured lipids by acidolysis of an EPA-enriched fish oil and caprylic acid in a packed bed reactor: analysis of three different operation modes. | 2004 Jul-Aug | Biotechnol. Prog. | pmid:15296428 |
| Boushaba R et al. | Kinetics of whole serum and prepurified IgG digestion by pepsin for F(ab')2 manufacture. | Biotechnol. Prog. | pmid:12892479 | |
| Favre-Bulle O et al. | Bioconversion of n-octane to octanoic acid by a recombinant Escherichia coli cultured in a two-liquid phase bioreactor. | 1991 | Biotechnology (N.Y.) | pmid:1367010 |
| Turakulov IaKh et al. | [Caprylate oxidation and ketone body concentration in the cardiac muscle of rabbits with thyrotoxicosis]. | 1973 | Biull Eksp Biol Med | pmid:4778684 |
| Kaiya H et al. | Ghrelin-like peptide with fatty acid modification and O-glycosylation in the red stingray, Dasyatis akajei. | 2009 | BMC Biochem. | pmid:20003394 |
| Satish Kumar V et al. | Optimization based automated curation of metabolic reconstructions. | 2007 | BMC Bioinformatics | pmid:17584497 |
| Yang B et al. | Prevention of post-surgical abdominal adhesions by a novel biodegradable thermosensitive PECE hydrogel. | 2010 | BMC Biotechnol. | pmid:20825683 |
| Gong CY et al. | In vitro drug release behavior from a novel thermosensitive composite hydrogel based on Pluronic f127 and poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) copolymer. | 2009 | BMC Biotechnol. | pmid:19210779 |
| Le Meur S et al. | Production of medium-chain-length polyhydroxyalkanoates by sequential feeding of xylose and octanoic acid in engineered Pseudomonas putida KT2440. | 2012 | BMC Biotechnol. | pmid:22913372 |
| Graef RR et al. | Isolation of a highly thermal stable lama single domain antibody specific for Staphylococcus aureus enterotoxin B. | 2011 | BMC Biotechnol. | pmid:21933444 |
| Wang Y et al. | 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice. | 2010 | BMC Cancer | pmid:20678220 |
| Olsen H et al. | Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro. | 2004 | BMC Clin Pharmacol | pmid:15046641 |
| Ong VY and Tan BK | Novel phytoandrogens and lipidic augmenters from Eucommia ulmoides. | 2007 | BMC Complement Altern Med | pmid:17261169 |
| Marcet-Houben M et al. | Phylogenomics of the oxidative phosphorylation in fungi reveals extensive gene duplication followed by functional divergence. | 2009 | BMC Evol. Biol. | pmid:20025735 |
| Mizrahi M et al. | Dumping syndrome following nissen fundoplication in an adult patient diagnosed by continuous online 13C/12C monitoring of ¹³C-Octanoic acid breath test "a case report". | 2011 | BMC Gastroenterol | pmid:21929798 |
| Nóbrega AC et al. | Dyspeptic symptoms and delayed gastric emptying of solids in patients with inactive Crohn's disease. | 2012 | BMC Gastroenterol | pmid:23216812 |
| Rossouw D et al. | Linking gene regulation and the exo-metabolome: a comparative transcriptomics approach to identify genes that impact on the production of volatile aroma compounds in yeast. | 2008 | BMC Genomics | pmid:18990252 |
| Johansson H et al. | A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests. | 2011 | BMC Genomics | pmid:21824406 |
| Henderson ST and Poirier J | Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study. | 2011 | BMC Med. Genet. | pmid:21992747 |
| Ren Q et al. | Influence of growth stage on activities of polyhydroxyalkanoate (PHA) polymerase and PHA depolymerase in Pseudomonas putida U. | 2010 | BMC Microbiol. | pmid:20937103 |
| Kemmer D et al. | Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis. | 2009 | BMC Microbiol. | pmid:19144191 |
| Giri AV et al. | A novel medium for the enhanced cell growth and production of prodigiosin from Serratia marcescens isolated from soil. | 2004 | BMC Microbiol. | pmid:15113456 |
| Gallis JL et al. | Decrease in oxidative phosphorylation yield in presence of butyrate in perfused liver isolated from fed rats. | 2007 | BMC Physiol. | pmid:17725817 |
| MacGowan GA et al. | High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibition. | 2001 | BMC Physiol. | pmid:11553322 |
| Zulak KG et al. | Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures. | 2008 | BMC Plant Biol. | pmid:18211706 |
| Fang X et al. | Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosis. | 2010 | BMC Syst Biol | pmid:21092312 |
| Nogales J et al. | A genome-scale metabolic reconstruction of Pseudomonas putida KT2440: iJN746 as a cell factory. | 2008 | BMC Syst Biol | pmid:18793442 |
| ALELLA A | [Protective action of sodium caprylate on protein denaturation]. | 1951 Jan-Feb | Boll. Soc. Ital. Biol. Sper. | pmid:14848275 |
| Hämmerle SP et al. | The single dose pharmacokinetic profile of a novel oral human parathyroid hormone formulation in healthy postmenopausal women. | 2012 | Bone | pmid:22289659 |
| Van Hoogdalem EJ et al. | Rate-controlled rectal absorption enhancement of cefoxitin by co-administration of sodium salicylate or sodium octanoate in healthy volunteers. | 1989 | Br J Clin Pharmacol | pmid:2706190 |
| BROADBENT JL | THE INTERACTION OF SOME STIMULANT AND DEPRESSANT DRUGS ON THE FROG HEART. | 1963 | Br J Pharmacol Chemother | pmid:14066153 |
| BROADBENT JL | Importance of calcium in the actions of some drugs that stimulate the isolated hypodynamic frog heart. | 1962 | Br J Pharmacol Chemother | pmid:13873208 |
| Grill V and Qvigstad E | Fatty acids and insulin secretion. | 2000 | Br. J. Nutr. | pmid:10889796 |
| Mochizuki K et al. | Fatty acids in component of milk enhance the expression of the cAMP-response-element-binding-protein-binding protein (CBP)/p300 gene in developing rats. | 2008 | Br. J. Nutr. | pmid:17916272 |
| Gil-Campos M et al. | Ghrelin: a hormone regulating food intake and energy homeostasis. | 2006 | Br. J. Nutr. | pmid:16923214 |
| Hoshimoto A et al. | Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. | 2002 | Br. J. Pharmacol. | pmid:12010777 |
| Wang JP and Kim IH | Effect of caprylic acid and Yucca schidigera extract on production performance, egg quality, blood characteristics, and excreta microflora in laying hens. | 2011 | Br. Poult. Sci. | pmid:22221237 |
| Mabayo RT et al. | Improvement of dietary protein utilisation in chicks by medium chain triglyceride. | 1993 | Br. Poult. Sci. | pmid:8467393 |
| Zinnanti WJ et al. | Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease. | 2009 | Brain | pmid:19293241 |
| Reis de Assis D et al. | Inhibition of energy metabolism in cerebral cortex of young rats by the medium-chain fatty acids accumulating in MCAD deficiency. | 2004 | Brain Res. | pmid:15567346 |
| Kim CS et al. | L-carnitine: therapeutic strategy for metabolic encephalopathy. | 1984 | Brain Res. | pmid:6478235 |
| Trusk TC and Stein EA | Effects of heroin and cocaine on brain activity in rats using [1-14C]octanoate as a fast functional tracer. | 1988 | Brain Res. | pmid:3345450 |
| McCandless DW | Octanoic acid-induced coma and reticular formation energy metabolism. | 1985 | Brain Res. | pmid:4005536 |
| Rowley H and Collins RC | [1-14C]Octanoate: a fast functional marker of brain activity. | 1985 | Brain Res. | pmid:4005560 |
| Schuck PF et al. | Evidence that the major metabolites accumulating in medium-chain acyl-CoA dehydrogenase deficiency disturb mitochondrial energy homeostasis in rat brain. | 2009 | Brain Res. | pmid:19703432 |
| Takenaka T et al. | Fatty acids as an energy source for the operation of axoplasmic transport. | 2003 | Brain Res. | pmid:12711076 |
| Drewes LR and Leino RL | Neuron-specific mitochondrial degeneration induced by hyperammonemia and octanoic acidemia. | 1985 | Brain Res. | pmid:4027650 |
| Kim CS et al. | L-Carnitine prevents mitochondrial damage induced by octanoic acid in the rat choroid plexus. | 1990 | Brain Res. | pmid:1964833 |
| Tanaka K et al. | Isolation of bovine plasma albumin by liquid chromatography and its polymerization for use in immunohematology. | 2001 | Braz. J. Med. Biol. Res. | pmid:11471035 |
| Constantin J et al. | Octanoate transport in the isolated, perfused rat liver. | 1989 | Braz. J. Med. Biol. Res. | pmid:2667669 |
| Bell FP | Di(2-ethylhexyl)adipate (DEHA): effect on plasma lipids and hepatic cholesterolgenesis in the rat. | 1984 | Bull Environ Contam Toxicol | pmid:6697017 |
| KEENEY EL | Sodium caprylate; a new and effective treatment for moniliasis of the skin and mucous membranes. | 1946 | Bull Johns Hopkins Hosp | pmid:20984783 |
| KEENEY EL and AJELLO L | Sodium caprylate; a new and effective treatment for dermatomycosis of the feet. | 1945 | Bull Johns Hopkins Hosp | pmid:21011144 |
| Ademola-Majekodunmi FO et al. | Incidence of snakebites in Kaltungo, Gombe State and the efficacy of a new highly purified monovalent antivenom in treating snakebite patients from January 2009 to December 2010. | 2012 | Bull Soc Pathol Exot | pmid:22851309 |
| Remy-Heintz N and Bali JP | [Demonstration of glycoprotein antigens associated with stomach tumors]. | 1985 | C. R. Seances Soc. Biol. Fil. | pmid:2935234 |
| Staeffen J et al. | [Coma induced in Macaca mulatta by intravenous sodium octanoate. Polygraphic study]. | 1973 | C. R. Seances Soc. Biol. Fil. | pmid:4803135 |
| Cheema-Dhadli S and Halperin ML | Effect of palmitoyl-CoA and beta-oxidation of fatty acids on the kinetics of mitochondrial citrate transporter. | 1976 | Can. J. Biochem. | pmid:1260499 |
| Sharma PK et al. | Kinetics of medium-chain-length polyhydroxyalkanoate production by a novel isolate of Pseudomonas putida LS46. | 2012 | Can. J. Microbiol. | pmid:22804681 |
| Bardi L et al. | Esterase activity and release of ethyl esters of medium-chain fatty acids by Saccharomyces cerevisiae during anaerobic growth. | 1998 | Can. J. Microbiol. | pmid:10347863 |
| Daniels T et al. | Effects of valproic acid on cardiac metabolism. | 2004 | Can. J. Physiol. Pharmacol. | pmid:15573154 |