octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Christensen E et al. | Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. | 1989 | Biochim. Biophys. Acta | pmid:2752017 |
Sumbilla CM et al. | Comparison of the oxidation of glutamine, glucose, ketone bodies and fatty acids by human diploid fibroblasts. | 1981 | Biochim. Biophys. Acta | pmid:7272339 |
Einarsson R | The binding of 1-anilino-8-naphthalenesulfonate, heparin, salicylate and caprylate by human antithrombin III. | 1976 | Biochim. Biophys. Acta | pmid:974107 |
Brass EP and Garrity MJ | Modulation of prostaglandin E2 catabolism and action by fuel substrates in rat hepatocytes. | 1989 | Biochim. Biophys. Acta | pmid:2912505 |
Lemarié F et al. | Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration. | 2016 | Biochim. Biophys. Acta | pmid:27317984 |
Bartels PD and Sestoft L | Thyroid hormone-induced changes in gluconeogenesis and ketogenesis in perfused rat liver. | 1980 | Biochim. Biophys. Acta | pmid:7448206 |
Sundqvist KE et al. | Effect of acetate and octanoate on tricarboxylic acid cycle metabolite disposal during propionate oxidation in the perfused rat heart. | 1984 | Biochim. Biophys. Acta | pmid:6487652 |
Ayuso MS et al. | Interrelation between gluconeogenesis and hepatic protein synthesis. | 1986 | Biochim. Biophys. Acta | pmid:3015233 |
Tachibana S et al. | Octanoate reduces very low-density lipoprotein secretion by decreasing the synthesis of apolipoprotein B in primary cultures of chicken hepatocytes. | 2005 | Biochim. Biophys. Acta | pmid:16226916 |
Arakawa T and Kita Y | Stabilizing effects of caprylate and acetyltryptophanate on heat-induced aggregation of bovine serum albumin. | 2000 | Biochim. Biophys. Acta | pmid:10862953 |
Merrill AR et al. | Effects of exogenous fatty acids on calcium uptake by brush-border membrane vesicles from rabbit small intestine. | 1986 | Biochim. Biophys. Acta | pmid:3081028 |
Veerkamp JH et al. | An accurate and sensitive assay of [14C]octanoate oxidation and its application on tissue homogenates and fibroblasts. | 1986 | Biochim. Biophys. Acta | pmid:3081042 |
GLENN JL et al. | Rare-earth fatty liver. I. Octanoate oxidation and energy production. | 1962 | Biochim. Biophys. Acta | pmid:13899206 |
Barron JT et al. | Effect of serum albumin on vascular smooth muscle metabolism. | 2000 | Biochim. Biophys. Acta | pmid:10924897 |
DIANZANI MU and MARINARI U | The octanoate oxidation by mitochondria from faty livers. | 1961 | Biochim. Biophys. Acta | pmid:13722612 |
Kohlwein SD and Paltauf F | Uptake of fatty acids by the yeasts, Saccharomyces uvarum and Saccharomycopsis lipolytica. | 1984 | Biochim. Biophys. Acta | pmid:6696936 |
Herold G et al. | Cholesterol synthesis and esterification in cultured intestinal mucosa. Evidence for compartmentation. | 1984 | Biochim. Biophys. Acta | pmid:6567470 |
Schönfeld P et al. | On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:3196710 |
Wilson TA et al. | Structured triglycerides containing caprylic (8:0) and oleic (18:1) fatty acids reduce blood cholesterol concentrations and aortic cholesterol accumulation in hamsters. | 2006 | Biochim. Biophys. Acta | pmid:16580874 |
Gambert S et al. | Regulation of intermediary metabolism in rat cardiac myocyte by extracellular glycerol. | 2005 | Biochim. Biophys. Acta | pmid:16153888 |
Cheng Y and Hauton D | Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase. | 2008 | Biochim. Biophys. Acta | pmid:18722549 |
Henze K et al. | The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts. | 1981 | Biochim. Biophys. Acta | pmid:6118180 |
Müller MJ et al. | Effect of thyroid state on ketogenic capacity of the isolated perfused liver of starved rats. | 1981 | Biochim. Biophys. Acta | pmid:6275888 |
González-Manchón C et al. | Control of gluconeogenesis: role of fatty acids in the alpha-adrenergic response. | 1988 | Biochim. Biophys. Acta | pmid:3191164 |
Anraku M et al. | Stabilizing mechanisms in commercial albumin preparations: octanoate and N-acetyl-L-tryptophanate protect human serum albumin against heat and oxidative stress. | 2004 | Biochim. Biophys. Acta | pmid:15450846 |
Redondo O et al. | Comparative kinetic study of lipases A and B from Candida rugosa in the hydrolysis of lipid p-nitrophenyl esters in mixed micelles with Triton X-100. | 1995 | Biochim. Biophys. Acta | pmid:7827103 |
Martinelle M and Hult K | Kinetics of acyl transfer reactions in organic media catalysed by Candida antarctica lipase B. | 1995 | Biochim. Biophys. Acta | pmid:7669809 |
Hulsmann WC et al. | Imminent ischemia in normal and hypertrophic Langendorff rat hearts; effects of fatty acids and superoxide dismutase monitored by NADH surface fluorescence. | 1993 | Biochim. Biophys. Acta | pmid:8318552 |
Viegas CA et al. | Regulation of the expression of the H(+)-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae. | 1994 | Biochim. Biophys. Acta | pmid:8286419 |
Murphy MG et al. | Abnormalities in hepatic fatty-acid metabolism in a surfactant/influenza B virus mouse model for acute encephalopathy. | 1996 | Biochim. Biophys. Acta | pmid:8611661 |
Decagny B et al. | 1H-NMR on line monitoring of water activity during lipase catalysed esterification. | 1998 | Biochim. Biophys. Acta | pmid:9748540 |
Kato T et al. | Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11). | 2010 | Biochim. Biophys. Acta | pmid:20398791 |
Noy N and Zakim D | Substrate specificity of fatty-acyl-CoA ligase in liver microsomes. | 1985 | Biochim. Biophys. Acta | pmid:3970953 |
Brandes R et al. | The specificity of triacylglycerol synthesis for medium-chain fatty acids in rat and human adipose preparations. | 1985 | Biochim. Biophys. Acta | pmid:4027259 |
Thennarasu S et al. | Antimicrobial activity and membrane selective interactions of a synthetic lipopeptide MSI-843. | 2005 | Biochim. Biophys. Acta | pmid:15904663 |
González-Manchón C et al. | Ca2(+)-fatty acid interaction in the control of hepatic gluconeogenesis. | 1990 | Biochim. Biophys. Acta | pmid:2310772 |
Evtodienko VY et al. | Effect of the alkyl chain length of monocarboxylic acid on the permeation through bilayer lipid membranes. | 1996 | Biochim. Biophys. Acta | pmid:8664324 |
Salesse R and Garnier J | Effects of drugs on pigeon erythrocyte membrane and asymmetric control or adenylate cyclase by the lipid bilayer. | 1979 | Biochim. Biophys. Acta | pmid:222319 |
Latipää PM et al. | Regulation of fatty acid oxidation in heart muscle. Effects of pyruvate and dichloroacetate. | 1983 | Biochim. Biophys. Acta | pmid:6849964 |
Magliano P et al. | Repercussion of a deficiency in mitochondrial ß-oxidation on the carbon flux of short-chain fatty acids to the peroxisomal ß-oxidation cycle in Aspergillus nidulans. | 2010 | Biochim. Biophys. Acta | pmid:20736083 |
el Alaoui-Talibi Z and Moravec J | Carnitine transport and exogenous palmitate oxidation in chronically volume-overloaded rat hearts. | 1989 | Biochim. Biophys. Acta | pmid:2499353 |
Shimshoni JA et al. | Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. | 2011 | Biochim. Biophys. Acta | pmid:21184843 |
Nomura T et al. | Effects of octanoate and acetate upon hepatic glycolysis and lipogenesis. | 1983 | Biochim. Biophys. Acta | pmid:6317044 |
Babu E et al. | Role of human organic anion transporter 4 in the transport of ochratoxin A. | 2002 | Biochim. Biophys. Acta | pmid:12063169 |
Kawai A et al. | Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions. | 2017 | Biochim Biophys Acta Proteins Proteom | pmid:28473296 |
Zwiebel FM et al. | Role of pyruvate transporter in the regulation of the pyruvate dehydrogenase multienzyme complex in perfused rat liver. | 1982 | Biochemistry | pmid:7074018 |
Miller JR et al. | Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. | 2000 | Biochemistry | pmid:11106496 |
Lo YC et al. | Substrate specificities of Escherichia coli thioesterase I/protease I/lysophospholipase L1 are governed by its switch loop movement. | 2005 | Biochemistry | pmid:15697222 |
Mao LF et al. | Hepatic beta-oxidation of 3-phenylpropionic acid and the stereospecific dehydration of (R)- and (S)-3-hydroxy-3-phenylpropionyl-CoA by different enoyl-CoA hydratases. | 1994 | Biochemistry | pmid:8136368 |
Hsieh CH et al. | The Enigmatic P450 Decarboxylase OleT Is Capable of, but Evolved To Frustrate, Oxygen Rebound Chemistry. | 2017 | Biochemistry | pmid:28603981 |