octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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BROWN GW et al. | The oxidative metabolic pattern of mouse hepatoma C954 as studied with C14-labeled acetates, propionate, octanoate, and glucose. | 1956 | Cancer Res. | pmid:13343123 |
REES ED and KLINE DL | Metabolism of octanoate by fatty liver slices. | 1957 | Am. J. Physiol. | pmid:13470069 |
LOSSOW WJ and CHAIKOFF IL | Secretion of intravenously administered tripalmitin-1-C14 and octanoate-1-C14 into milk by the lactating rat. | 1958 | J. Biol. Chem. | pmid:13502382 |
Prip-Buus C et al. | Evidence for an impaired long-chain fatty acid oxidation and ketogenesis in Fao hepatoma cells. | 1992 | Eur. J. Biochem. | pmid:1356769 |
Berger M et al. | Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. | 1976 | Biochem. J. | pmid:136249 |
Kristev A et al. | Effects of the medium chain octanoic fatty acid on the contractile activity of vascular smooth muscle tissues. | 1992 | Folia Med (Plovdiv) | pmid:1364081 |
Favre-Bulle O et al. | Bioconversion of n-octane to octanoic acid by a recombinant Escherichia coli cultured in a two-liquid phase bioreactor. | 1991 | Biotechnology (N.Y.) | pmid:1367010 |
DIANZANI MU and MARINARI U | The octanoate oxidation by mitochondria from faty livers. | 1961 | Biochim. Biophys. Acta | pmid:13722612 |
Kim CS et al. | Octanoic acid produces accumulation of monoamine acidic metabolites in the brain: interaction with organic anion transport at the choroid plexus. | 1992 | J. Neurochem. | pmid:1372345 |
Ohkubo Y et al. | Presence and properties of acyl coenzyme A synthetase for medium-chain fatty acids in rat intestinal mucosa. | 1992 | Digestion | pmid:1386328 |
BROADBENT JL | Importance of calcium in the actions of some drugs that stimulate the isolated hypodynamic frog heart. | 1962 | Br J Pharmacol Chemother | pmid:13873208 |
GLENN JL et al. | Rare-earth fatty liver. I. Octanoate oxidation and energy production. | 1962 | Biochim. Biophys. Acta | pmid:13899206 |
GEHRIG RF and KNIGHT SG | Fatty acid oxidation by spores of Penicillium roqueforti. | 1963 | Appl Microbiol | pmid:13947000 |
Noctor TA et al. | Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. | 1992 | J. Chromatogr. | pmid:1400761 |
Scholte HR et al. | Assessment of deficiencies of fatty acyl-CoA dehydrogenases in fibroblasts, muscle and liver. | 1992 | J. Inherit. Metab. Dis. | pmid:1405467 |
BROADBENT JL | THE INTERACTION OF SOME STIMULANT AND DEPRESSANT DRUGS ON THE FROG HEART. | 1963 | Br J Pharmacol Chemother | pmid:14066153 |
ADAMS JN et al. | EFFECTS OF SODIUM CAPRYLATE ON CANDIDA ALBICANS. I. INFLUENCE OF CONCENTRATION ON ULTRASTRUCTURE. | 1963 | J. Bacteriol. | pmid:14066435 |
PAYNE WJ and BANNISTER ER | EFFECTS OF SODIUM CAPRYLATE ON CANDIDA ALBICANS. II. INFLUENCE OF VARIOUS CONCENTRATIONS ON BIOCHEMICAL CHANGES. | 1963 | J. Bacteriol. | pmid:14066436 |
SMITH JA and DELUCA HF | STRUCTURAL CHANGES IN ISOLATED LIVER MITOCHONDRIA OF RATS DURING ESSENTIAL FATTY ACID DEFICIENCY. | 1964 | J. Cell Biol. | pmid:14154491 |
SCHWABE AD et al. | OCTANOIC ACID ABSORPTION AND OXIDATION IN HUMANS. | 1964 | J Appl Physiol | pmid:14155309 |
Porter DJ | Binding of 2-acetylpyridine-5-[(2-chloroanilino)thiocarbonyl] thiocarbonohydrazone (BW348U87) to human serum albumin. | 1992 | Biochem. Pharmacol. | pmid:1417962 |
KUSUNOSE M et al. | ENZYMATIC OMEGA-OXIDATION OF FATTY ACIDS. I. PRODUCTS OF OCTANOATE, DECONATE, AND LAURATE OXIDATION. | 1964 | J. Biol. Chem. | pmid:14189868 |
Boulanger Y et al. | 13C and 1H NMR study of the metabolic degradation of 4-pentenoate in different dog nephron segments. | 1992 | Magn Reson Med | pmid:1435217 |
Hu H et al. | Ethanol and oleate inhibition of alpha-ketoisovalerate and 3-hydroxyisobutyrate metabolism by isolated hepatocytes. | 1992 | Arch. Biochem. Biophys. | pmid:1444452 |
Clore JN et al. | Evidence for dissociation of gluconeogenesis stimulated by non-esterified fatty acids and changes in fructose 2,6-bisphosphate in cultured rat hepatocytes. | 1992 | Biochem. J. | pmid:1445259 |
Nash RA et al. | The possibility of lidocaine ion pair absorption through excised hairless mouse skin. | 1992 | Skin Pharmacol. | pmid:1445706 |
Bradt BM et al. | Documentation of idiotypic cascade after Lym-1 radioimmunotherapy in a patient with non-Hodgkin's lymphoma: basis for extended survival? | 2003 | Clin. Cancer Res. | pmid:14506201 |
Margolles Cabrales I et al. | Influence of Fatty acids on foaming properties of cider. | 2003 | J. Agric. Food Chem. | pmid:14518961 |
Sarnatskaya VV et al. | Extraction of uraemic toxins with activated carbon restores the functional properties of albumin. | 2003 | Nephron Physiol | pmid:14520007 |
Lai CY and Cronan JE | Beta-ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis. | 2003 | J. Biol. Chem. | pmid:14523010 |
Miele L et al. | Hepatic mitochondrial beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13C-octanoate breath test. | 2003 | Am. J. Gastroenterol. | pmid:14572600 |
Osborn-Barnes HT and Akoh CC | Copper-catalyzed oxidation of a structured lipid-based emulsion containing alpha-tocopherol and citric acid: influence of pH and NaCl. | 2003 | J. Agric. Food Chem. | pmid:14582985 |
Osborn-Barnes HT and Akoh CC | Effects of alpha-tocopherol, beta-carotene, and soy isoflavones on lipid oxidation of structured lipid-based emulsions. | 2003 | J. Agric. Food Chem. | pmid:14582986 |
Sakaki K and Itoh N | Optical resolution of racemic 2-hydroxy octanoic acid by lipase-catalyzed hydrolysis in a biphasic membrane reactor. | 2003 | Biotechnol. Lett. | pmid:14584912 |
Jaeggi JJ et al. | Hard ewe's milk cheese manufactured from milk of three different groups of somatic cell counts. | 2003 | J. Dairy Sci. | pmid:14594225 |
Kamita SG et al. | Juvenile hormone (JH) esterase: why are you so JH specific? | 2003 | Insect Biochem. Mol. Biol. | pmid:14599498 |
Chew CG et al. | Simultaneous 13C/14C dual isotope breath test measurement of gastric emptying of solid and liquid in normal subjects and patients: comparison with scintigraphy. | 2003 | Nucl Med Rev Cent East Eur | pmid:14600930 |
Raweerith R and Ratanabanangkoon K | Fractionation of equine antivenom using caprylic acid precipitation in combination with cationic ion-exchange chromatography. | 2003 | J. Immunol. Methods | pmid:14604541 |
Ba C et al. | Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks. | Biomacromolecules | pmid:14606915 | |
Gorna K and Gogolewski S | Preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes. | 2003 | J Biomed Mater Res A | pmid:14613229 |
Erol E et al. | Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice. | 2004 | FASEB J. | pmid:14656998 |
Symonds EL et al. | Relation between pancreatic lipase activity and gastric emptying rate in children with cystic fibrosis. | 2003 | J. Pediatr. | pmid:14657826 |
Pantazaki AA et al. | Polyhydroxyalkanoate (PHA) biosynthesis in Thermus thermophilus: purification and biochemical properties of PHA synthase. | 2003 | Mol. Cell. Biochem. | pmid:14674696 |
Gordon DJ et al. | Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel. | 2004 | Biophys. J. | pmid:14695285 |
Zhao X et al. | Assembly of the covalent linkage between lipoic acid and its cognate enzymes. | 2003 | Chem. Biol. | pmid:14700636 |
Leite-Moreira AF et al. | Modulation of the positive inotropic effect of pyruvate by energetic substrate availability. | 2003 | Acta Cardiol | pmid:14713177 |
Sarnelli G et al. | Symptom patterns and pathophysiological mechanisms in dyspeptic patients with and without Helicobacter pylori. | 2003 | Dig. Dis. Sci. | pmid:14714606 |
Gomes FM et al. | Immobilization of lipase on chitin and its use in nonconventional biocatalysis. | 2004 Jan-Feb | Biomacromolecules | pmid:14715003 |
Araneda RC et al. | A pharmacological profile of the aldehyde receptor repertoire in rat olfactory epithelium. | 2004 | J. Physiol. (Lond.) | pmid:14724183 |
Dimas DA et al. | Effect of several factors on the mechanical properties of pressure-sensitive adhesives used in transdermal therapeutic systems. | 2000 | AAPS PharmSciTech | pmid:14727849 |
Jones PM et al. | Effects of odd-numbered medium-chain fatty acids on the accumulation of long-chain 3-hydroxy-fatty acids in long-chain L-3-hydroxyacyl CoA dehydrogenase and mitochondrial trifunctional protein deficient skin fibroblasts. | 2004 | Mol. Genet. Metab. | pmid:14741189 |
COHEN R and PERSKY M | Sodium caprylate treatment for thrusii. | 1951 | Arch Pediatr | pmid:14800560 |
COHEN R | Four new fungicides for Coccidioides immitis: 1. Sodium caprylate. 2. Ethyl vanillate 3. Fradicin. 4. Thiolutin. | 1951 | Arch Pediatr | pmid:14847786 |
ALELLA A | [Protective action of sodium caprylate on protein denaturation]. | 1951 Jan-Feb | Boll. Soc. Ital. Biol. Sper. | pmid:14848275 |
HIRSCH HM and WALLACE GI | The octanoxidase system of Streptomyces aureofaciens. | 1951 | Rev Can Biol | pmid:14865337 |
Wood WF | Volatile components in metatarsal glands of sika deer, Cervus nippon. | 2003 | J. Chem. Ecol. | pmid:14969359 |
Takenouchi T et al. | Co-treatment with dexamethasone and octanoate induces adipogenesis in 3T3-L1 cells. | 2004 | Cell Biol. Int. | pmid:14984747 |
Welters HJ et al. | Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. | 2004 | FEBS Lett. | pmid:14988006 |
Derlacz RA et al. | Amino-acid-dependent, differential effects of ethanol on glucose production in rabbit kidney-cortex tubules. | Alcohol Alcohol. | pmid:14998823 | |
Sanguanchaipaiwong V et al. | Biosynthesis of natural-synthetic hybrid copolymers: polyhydroxyoctanoate-diethylene glycol. | Biomacromolecules | pmid:15003032 | |
Cortezzo DE et al. | Analysis of the action of compounds that inhibit the germination of spores of Bacillus species. | 2004 | J. Appl. Microbiol. | pmid:15012811 |
Corson TW et al. | Cell-type specific regulation of calreticulin and Bcl-2 expression by mood stabilizer drugs. | 2004 | Eur Neuropsychopharmacol | pmid:15013030 |
Wang ZY and Zhang Q | [Study on pulmonary delivery of peptide drugs in rats: effects of absorption enhancers on cellular membrane fluidity]. | 2003 | Yao Xue Xue Bao | pmid:15040095 |
Littlechild JA et al. | Hyperthermophilic dehydrogenase enzymes. | 2004 | Biochem. Soc. Trans. | pmid:15046583 |
Olsen H et al. | Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro. | 2004 | BMC Clin Pharmacol | pmid:15046641 |
Marounek M et al. | Susceptibility of Escherichia coli to C2-C18 fatty acids. | 2003 | Folia Microbiol. (Praha) | pmid:15058184 |
Pohl J et al. | Long-chain fatty acid uptake into adipocytes depends on lipid raft function. | 2004 | Biochemistry | pmid:15065861 |
Liu K et al. | Effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents. | 2004 | World J. Gastroenterol. | pmid:15069720 |
Gwak HS et al. | Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers. | 2004 | Drug Dev Ind Pharm | pmid:15089053 |
Wang X et al. | A self-contained 48-well fatty acid oxidation assay. | 2004 | Assay Drug Dev Technol | pmid:15090211 |
Lei T et al. | Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation. | 2004 | Obes. Res. | pmid:15090627 |
Varshney M et al. | Pluronic microemulsions as nanoreservoirs for extraction of bupivacaine from normal saline. | 2004 | J. Am. Chem. Soc. | pmid:15099093 |
Suzuki T et al. | Analysis of anal secretions from phlaeothripine thrips. | 2004 | J. Chem. Ecol. | pmid:15112732 |
Giri AV et al. | A novel medium for the enhanced cell growth and production of prodigiosin from Serratia marcescens isolated from soil. | 2004 | BMC Microbiol. | pmid:15113456 |
Katoh K et al. | Saturated fatty acids suppress adrenocorticotropic hormone (ACTH) release from rat anterior pituitary cells in vitro. | 2004 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:15123208 |
Djordjevic L et al. | Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. | 2004 | Int J Pharm | pmid:15129969 |
Attygalle AB et al. | Defensive chemicals of two species of Trachypachus Motschulski. | 2004 | J. Chem. Ecol. | pmid:15139309 |
Jackson SJ et al. | Use of isotopically labelled octanoic acid to assess the effect of meal size on gastric emptying. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15150821 |
Annamalai T et al. | In vitro inactivation of Escherichia coli O157:H7 in bovine rumen fluid by caprylic acid. | 2004 | J. Food Prot. | pmid:15151222 |
Cardoso DR et al. | Comparison between cachaça and rum using pattern recognition methods. | 2004 | J. Agric. Food Chem. | pmid:15161210 |
Campbell SE et al. | A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. | 2004 | J. Biol. Chem. | pmid:15161924 |
Jackson SJ et al. | Delayed gastric emptying in the obese: an assessment using the non-invasive (13)C-octanoic acid breath test. | 2004 | Diabetes Obes Metab | pmid:15171750 |
Van Immerseel F et al. | Medium-chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enterica serovar Enteritidis. | 2004 | Appl. Environ. Microbiol. | pmid:15184160 |
Skrivanová E et al. | In vitro effect of C2-C18 fatty acids on Salmonellas. | 2004 | Folia Microbiol. (Praha) | pmid:15227798 |
Sogorb MA et al. | Hydrolysis of carbaryl by human serum albumin. | 2004 | Arch. Toxicol. | pmid:15235763 |
Ohta K et al. | Separation and conductimetric detection of C1-C7 aliphatic monocarboxylic acids and C1-C7 aliphatic monoamines on unfunctionized polymethacrylate resin columns. | 2004 | J Chromatogr A | pmid:15250420 |
Remington KM et al. | Inactivation of West Nile virus, vaccinia virus and viral surrogates for relevant and emergent viral pathogens in plasma-derived products. | 2004 | Vox Sang. | pmid:15260817 |
Keel TR et al. | AFM studies of the crystallization and habit modification of an excipient material, adipic acid. | 2004 | Int J Pharm | pmid:15265558 |
Hoffmann N and Rehm BH | Regulation of polyhydroxyalkanoate biosynthesis in Pseudomonas putida and Pseudomonas aeruginosa. | 2004 | FEMS Microbiol. Lett. | pmid:15268931 |
Albrecht M et al. | Preparation of tripeptide-bridged dicatechol ligands and their macrocyclic molybdenum(VI) complexes: fixation of the RGD sequence and the WKY sequence of urotensin ii in a cyclic conformation. | 2004 | Chemistry | pmid:15281149 |
Bourreau J et al. | Gastric emptying rate is inversely related to body weight in dog breeds of different sizes. | 2004 | J. Nutr. | pmid:15284397 |
Cho YA and Gwak HS | Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers. | 2004 | Drug Dev Ind Pharm | pmid:15285328 |
González Moreno PA et al. | Production of structured lipids by acidolysis of an EPA-enriched fish oil and caprylic acid in a packed bed reactor: analysis of three different operation modes. | 2004 Jul-Aug | Biotechnol. Prog. | pmid:15296428 |
Minderhoud IM et al. | Gastric emptying of a solid meal starts during meal ingestion: combined study using 13C-octanoic acid breath test and Doppler ultrasonography. Absence of a lag phase in 13C-octanoic acid breath test. | 2004 | Digestion | pmid:15297778 |
Li Z and Huang L | Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(D,L-lactide-co-4-hydroxy-L-proline). | 2004 | J Control Release | pmid:15312999 |
Khuwijitjaru P et al. | Preparation of finely dispersed O/W emulsion from fatty acid solubilized in subcritical water. | 2004 | J Colloid Interface Sci | pmid:15313654 |
El Hafidi M et al. | Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15331379 |
Pêgo AP et al. | Physical properties of high molecular weight 1,3-trimethylene carbonate and D,L-lactide copolymers. | 2003 | J Mater Sci Mater Med | pmid:15348396 |
Yam PS et al. | Effect of body size on gastric emptying using the 13C-octanoic acid breath test. | 2004 | J Small Anim Pract | pmid:15352406 |
Kim HW et al. | The effect of vehicles and pressure sensitive adhesives on the percutaneous absorption of quercetin through the hairless mouse skin. | 2004 | Arch. Pharm. Res. | pmid:15357005 |