octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ishii-Iwamoto EL et al. | Effects of norepinephrine on the metabolism of fatty acids with different chain lengths in the perfused rat liver. | 2000 | Mol. Cell. Biochem. | pmid:10821418 |
Awan MM et al. | Mechanisms whereby glucose deprivation triggers metabolic preconditioning in the isolated rat heart. | 2000 | Mol. Cell. Biochem. | pmid:11055554 |
Pantazaki AA et al. | Polyhydroxyalkanoate (PHA) biosynthesis in Thermus thermophilus: purification and biochemical properties of PHA synthase. | 2003 | Mol. Cell. Biochem. | pmid:14674696 |
Abdel-aleem S et al. | Regulation of carbohydrate and fatty acid utilization by L-carnitine during cardiac development and hypoxia. | 1998 | Mol. Cell. Biochem. | pmid:9546635 |
Scaini G et al. | Toxicity of octanoate and decanoate in rat peripheral tissues: evidence of bioenergetic dysfunction and oxidative damage induction in liver and skeletal muscle. | 2012 | Mol. Cell. Biochem. | pmid:22015654 |
Leverve X et al. | Oxidative phosphorylation in intact hepatocytes: quantitative characterization of the mechanisms of change in efficiency and cellular consequences. | 1998 | Mol. Cell. Biochem. | pmid:9746312 |
Elliott KR and Pogson CI | Preparation and characterization of isolated parenchymal cells from guinea pig liver. | 1977 | Mol. Cell. Biochem. | pmid:196181 |
Tissier C et al. | Substrate dependence of the postischemic cardiomyocyte recovery: dissociation between functional, metabolic and injury markers. | 2005 | Mol. Cell. Biochem. | pmid:16013439 |
Coort SL et al. | Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake. | 2002 | Mol. Cell. Biochem. | pmid:12479588 |
Salesse R and Garnier J | Adenylate cyclase and membrane fluidity. The repressor hypothesis. | 1984 | Mol. Cell. Biochem. | pmid:6323963 |
Morita YS and Englund PT | Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate. | 2001 | Mol. Biochem. Parasitol. | pmid:11420102 |
Puchowicz MA et al. | Oxidative phosphorylation analysis: assessing the integrated functional activity of human skeletal muscle mitochondria--case studies. | 2004 | Mitochondrion | pmid:16120399 |
Caviglia GP et al. | Gastric emptying and related symptoms in patients treated with buspirone, amitriptyline or clebopride: a "real world" study by 13C-octanoic Acid Breath Test. | 2017 | Minerva Med. | pmid:28707862 |
Andreev LV and Temnov AV | [Determination of the specificity of microbial esterases in vivo]. | 1976 Jan-Feb | Mikrobiologiia | pmid:940489 |
Goh YS and Tan IK | Polyhydroxyalkanoate production by antarctic soil bacteria isolated from Casey Station and Signy Island. | 2012 | Microbiol. Res. | pmid:21945102 |
Park S et al. | Development of sandwich enzyme-linked immunosorbent assay for the detection of Cronobacter muytjensii (formerly called Enterobacter sakazakii). | 2012 | Microbiol. Immunol. | pmid:22519814 |
Ren Q et al. | Overexpression and characterization of medium-chain-length polyhydroxyalkanoate granule bound polymerases from Pseudomonas putida GPo1. | 2009 | Microb. Cell Fact. | pmid:19925642 |
Kang CH et al. | A novel family VII esterase with industrial potential from compost metagenomic library. | 2011 | Microb. Cell Fact. | pmid:21619698 |
JunGang L et al. | Cloning and biochemical characterization of a novel lipolytic gene from activated sludge metagenome, and its gene product. | 2010 | Microb. Cell Fact. | pmid:21054894 |
Gómez-Pastor R et al. | Reduction of oxidative cellular damage by overexpression of the thioredoxin TRX2 gene improves yield and quality of wine yeast dry active biomass. | 2010 | Microb. Cell Fact. | pmid:20152017 |
Zhang T and Han WJ | Gene cloning and characterization of a novel esterase from activated sludge metagenome. | 2009 | Microb. Cell Fact. | pmid:20028524 |
Li G et al. | Molecular cloning and characterization of a novel pyrethroid-hydrolyzing esterase originating from the Metagenome. | 2008 | Microb. Cell Fact. | pmid:19116015 |
Wang Q et al. | Complete PHB mobilization in Escherichia coli enhances the stress tolerance: a potential biotechnological application. | 2009 | Microb. Cell Fact. | pmid:19719845 |
Poblete-Castro I et al. | The metabolic response of P. putida KT2442 producing high levels of polyhydroxyalkanoate under single- and multiple-nutrient-limited growth: highlights from a multi-level omics approach. | 2012 | Microb. Cell Fact. | pmid:22433058 |
Follonier S et al. | A reduction in growth rate of Pseudomonas putida KT2442 counteracts productivity advances in medium-chain-length polyhydroxyalkanoate production from gluconate. | 2011 | Microb. Cell Fact. | pmid:21513516 |
Singh M et al. | Bacillus subtilis as potential producer for polyhydroxyalkanoates. | 2009 | Microb. Cell Fact. | pmid:19619289 |
Peng Q et al. | A novel esterase gene cloned from a metagenomic library from neritic sediments of the South China Sea. | 2011 | Microb. Cell Fact. | pmid:22067554 |
Yu WL et al. | Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae. | 2011 | Microb. Cell Fact. | pmid:22047615 |
Wittgens A et al. | Growth independent rhamnolipid production from glucose using the non-pathogenic Pseudomonas putida KT2440. | 2011 | Microb. Cell Fact. | pmid:21999513 |
Fan X et al. | Identification and characterization of a novel thermostable pyrethroid-hydrolyzing enzyme isolated through metagenomic approach. | 2012 | Microb. Cell Fact. | pmid:22409882 |
Iwahashi H | High performance liquid chromatography/electron spin resonance/mass spectrometry analyses of lipid-derived radicals. | 2008 | Methods Mol. Biol. | pmid:19082939 |
Cho W and Shen Z | Efficient immobilization of phospholipase A2. | 1999 | Methods Mol. Biol. | pmid:9918031 |
Page M and Thorpe R | IgG purification. | 1998 | Methods Mol. Biol. | pmid:9664367 |
Page M and Thorpe R | Purification of monoclonal antibodies. | 1998 | Methods Mol. Biol. | pmid:9664368 |
Grodzki AC and Berenstein E | Antibody purification: ammonium sulfate fractionation or gel filtration. | 2010 | Methods Mol. Biol. | pmid:20012814 |
Morais V et al. | Immunoglobulin purification by caprylic acid. | 2014 | Methods Mol. Biol. | pmid:24648074 |
Chan K et al. | An improved gas liquid chromatographic assay for plasma valproic acid concentrations in mentally handicapped epileptic children. | 1985 | Methods Find Exp Clin Pharmacol | pmid:3937004 |
Ariyasu H et al. | Transgenic mice overexpressing ghrelin or ghrelin analog. | 2012 | Meth. Enzymol. | pmid:22975065 |
Kaiya H et al. | Determination of nonmammalian ghrelin. | 2012 | Meth. Enzymol. | pmid:22975047 |
Kojima M et al. | Purification of rat and human ghrelins. | 2012 | Meth. Enzymol. | pmid:22975045 |
Schwarzmann G et al. | Using biotinylated gangliosides to study their distribution and traffic in cells by immunoelectron microscopy. | 2000 | Meth. Enzymol. | pmid:11070901 |
Gutierrez JA et al. | From ghrelin to ghrelin's O-acyl transferase. | 2012 | Meth. Enzymol. | pmid:22975051 |
Ohgusu H et al. | Enzymatic characterization of GOAT, ghrelin O-acyltransferase. | 2012 | Meth. Enzymol. | pmid:22975052 |
Matsumoto N and Nakazato M | Clinical application of ghrelin for chronic respiratory diseases. | 2012 | Meth. Enzymol. | pmid:22975067 |
Royce LA et al. | Evolution for exogenous octanoic acid tolerance improves carboxylic acid production and membrane integrity. | 2015 | Metab. Eng. | pmid:25839166 |
Wang L et al. | Octanoylated ghrelin attenuates angiogenesis induced by oxLDL in human coronary artery endothelial cells via the GHSR1a-mediated NF-κB pathway. | 2015 | Metab. Clin. Exp. | pmid:26277200 |
Carnielli VP et al. | Conversion of octanoic acid into long-chain saturated fatty acids in premature infants fed a formula containing medium-chain triglycerides. | 1994 | Metab. Clin. Exp. | pmid:7934982 |
MartÃn-Requero A et al. | Reciprocal changes in gluconeogenesis and ureagenesis induced by fatty acid oxidation. | 1993 | Metab. Clin. Exp. | pmid:8246772 |
Hong J et al. | The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: studies in vitro. | 2005 | Metab. Clin. Exp. | pmid:16154432 |
Winiarska K et al. | Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules. | 2003 | Metab. Clin. Exp. | pmid:12800101 |