octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kingsley-Hickman PB et al. | 31P NMR measurement of mitochondrial uncoupling in isolated rat hearts. | 1990 | J. Biol. Chem. | pmid:2136855 |
Mao LF et al. | Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid. | 1992 | J. Biol. Chem. | pmid:1737769 |
Deng S et al. | Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver. | 2009 | J. Biol. Chem. | pmid:19666922 |
May ME et al. | Mechanism of the stimulation of branched chain oxoacid oxidation in liver by carnitine. | 1980 | J. Biol. Chem. | pmid:7410370 |
Qahwash IM et al. | Site-specific effects of peptide lipidation on beta-amyloid aggregation and cytotoxicity. | 2007 | J. Biol. Chem. | pmid:17693400 |
Taylor SI et al. | Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio. | 1975 | J. Biol. Chem. | pmid:1116996 |
Hansford RG and Johnson RN | The steady state concentrations of coenzyme A-SH and coenzyme A thioester, citrate, and isocitrate during tricarboxylate cycle oxidations in rabbit heart mitochondria. | 1975 | J. Biol. Chem. | pmid:1194259 |
Jomain-Baum M and Hanson RW | Regulation of hepatic gluconeogenesis in the guinea pig by fatty acids and ammonia. | 1975 | J. Biol. Chem. | pmid:1194271 |
Fulks RM et al. | Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. | 1975 | J. Biol. Chem. | pmid:1141208 |
Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
Vidal H et al. | Inhibition of glucose oxidation by vasoactive intestinal peptide in isolated rat enterocytes. | 1988 | J. Biol. Chem. | pmid:3132456 |
Shrake A and Ross PD | Biphasic denaturation of human albumin due to ligand redistribution during unfolding. | 1988 | J. Biol. Chem. | pmid:3170588 |
Connolly E and Nedergaard J | Beta-adrenergic modulation of Ca2+ uptake by isolated brown adipocytes. Possible involvement of mitochondria. | 1988 | J. Biol. Chem. | pmid:2839496 |
Bian F et al. | Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate. | 2005 | J. Biol. Chem. | pmid:15611129 |
Kaiya H et al. | Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. | 2001 | J. Biol. Chem. | pmid:11546772 |
Campbell SE et al. | A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. | 2004 | J. Biol. Chem. | pmid:15161924 |
Lysiak W et al. | Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria. | 1988 | J. Biol. Chem. | pmid:3335535 |
Mortimore GE et al. | Modulation of the amino acid control of hepatic protein degradation by caloric deprivation. Two modes of alanine co-regulation. | 1988 | J. Biol. Chem. | pmid:3264284 |
Cistola DP et al. | Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. I. The filling of individual fatty acid binding sites. | 1987 | J. Biol. Chem. | pmid:3611099 |
Cistola DP et al. | Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. II. Electrostatic interactions in individual fatty acid binding sites. | 1987 | J. Biol. Chem. | pmid:3611100 |
GEYER RP et al. | Metabolism of emulsified trilaurin (-C1400-) and octanoic acid (-C1400-) by rat tissue slices. | 1949 | J. Biol. Chem. | pmid:18139198 |
Stephens JL et al. | Mitochondrial fatty acid synthesis in Trypanosoma brucei. | 2007 | J. Biol. Chem. | pmid:17166831 |
Zhang Y et al. | Nonhomogeneous labeling of liver extra-mitochondrial acetyl-CoA. Implications for the probing of lipogenic acetyl-CoA via drug acetylation and for the production of acetate by the liver. | 1994 | J. Biol. Chem. | pmid:8157628 |
Morris TW et al. | Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product. | 1994 | J. Biol. Chem. | pmid:8206909 |
Sabbagh E et al. | 3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria. | 1985 | J. Biol. Chem. | pmid:3997873 |
Beaumont NJ et al. | Ghrelin can bind to a species of high density lipoprotein associated with paraoxonase. | 2003 | J. Biol. Chem. | pmid:12531885 |
Gao J and Serrero G | Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. | 1999 | J. Biol. Chem. | pmid:10358026 |
Kawaguchi T et al. | Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. | 2002 | J. Biol. Chem. | pmid:11724780 |
Li RL et al. | Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. | 2012 | J. Biol. Chem. | pmid:22474325 |
Strieleman PJ et al. | Fatty acid activation of the reconstituted brown adipose tissue mitochondria uncoupling protein. | 1985 | J. Biol. Chem. | pmid:4055740 |
Abumrad NA et al. | Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. | 1984 | J. Biol. Chem. | pmid:6746632 |
Paul HS and Adibi SA | Mechanism of increased conversion of branched chain keto acid dehydrogenase from inactive to active form by a medium chain fatty acid (octanoate) in skeletal muscle. | 1992 | J. Biol. Chem. | pmid:1597456 |
KUSUNOSE M et al. | ENZYMATIC OMEGA-OXIDATION OF FATTY ACIDS. I. PRODUCTS OF OCTANOATE, DECONATE, AND LAURATE OXIDATION. | 1964 | J. Biol. Chem. | pmid:14189868 |
Nobes CD et al. | The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes. | 1990 | J. Biol. Chem. | pmid:2376580 |
LOSSOW WJ and CHAIKOFF IL | Secretion of intravenously administered tripalmitin-1-C14 and octanoate-1-C14 into milk by the lactating rat. | 1958 | J. Biol. Chem. | pmid:13502382 |
Vidal H et al. | Vasoactive intestinal peptide stimulates long-chain fatty acid oxidation and inhibits acetyl-coenzyme A carboxylase activity in isolated rat enterocytes. | 1989 | J. Biol. Chem. | pmid:2564395 |
LOSSOW WJ et al. | The action of insulin in sparing fatty acid oxidation: a study with palmitic acid-1-C14 and octanoate-1-C14. | 1956 | J. Biol. Chem. | pmid:13331942 |
Mayorek N and Bar-Tana J | Medium chain fatty acids as specific substrates for diglyceride acyltransferase in cultured hepatocytes. | 1983 | J. Biol. Chem. | pmid:6853505 |
GEYER RP et al. | Effect of pyruvate on octanoate metabolism as influenced by potassium and lithium. | 1953 | J. Biol. Chem. | pmid:13084632 |
CRANDALL DI et al. | Studies of acetoacetate formation with labeled carbon; the conversion of zeta-(C7)-labeled octanoate to acetoacetate. | 1949 | J. Biol. Chem. | pmid:15393802 |
LORBER V et al. | Conversion of octanoic acid to rat liver glycogen, studied with C14, C13-labeled octanoate. | 1949 | J. Biol. Chem. | pmid:15393766 |
Hiltunen JK et al. | Mitochondrial fatty acid synthesis type II: more than just fatty acids. | 2009 | J. Biol. Chem. | pmid:19028688 |
VESTLING CS and KAUFMAN S | The oxidation of octanoate by normal and leucemic mouse liver homogenates. | 1946 | J. Biol. Chem. | pmid:21001223 |
Martin JD et al. | Structure and membrane affinity of new amphiphilic siderophores produced by Ochrobactrum sp. SP18. | 2006 | J. Biol. Inorg. Chem. | pmid:16791646 |
Gurvitz A | Identification of the Leishmania major proteins LmjF07.0430, LmjF07.0440, and LmjF27.2440 as components of fatty acid synthase II. | 2009 | J. Biomed. Biotechnol. | pmid:20145708 |
Chen R et al. | Chemiluminescent nanomicelles for imaging hydrogen peroxide and self-therapy in photodynamic therapy. | 2011 | J. Biomed. Biotechnol. | pmid:21765637 |
Mazarro R et al. | Copolymerization of D,L-lactide and glycolide in supercritical carbon dioxide with zinc octoate as catalyst. | 2008 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:17854066 |
Comar JF et al. | Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations. | 2010 | J. Biomed. Sci. | pmid:20055990 |
Chen YJ et al. | Production and characterization of medium-chain-length polyhydroxyalkanoates by Pseudomonas mosselii TO7. | 2014 | J. Biosci. Bioeng. | pmid:24630613 |
Maeda A et al. | Characterization of novel cholesterol esterase from Trichoderma sp. AS59 with high ability to synthesize steryl esters. | 2008 | J. Biosci. Bioeng. | pmid:18499049 |
Furukawa K et al. | Increased ethyl caproate production by inositol limitation in Saccharomyces cerevisiae. | 2003 | J. Biosci. Bioeng. | pmid:16233438 |
Okamoto K et al. | Production of gamma-lactones by the brown-rot basidiomycete Piptoporus soloniensis. | 2002 | J. Biosci. Bioeng. | pmid:16233291 |
Russell RA et al. | Production and use of deuterated polyhydroxyoctanoate in structural studies of PHO inclusions. | 2007 | J. Biotechnol. | pmid:17555837 |
Lomborg CJ et al. | At-line determination of octanoic acid in cultivation broth--an electronic tongue (ET) feasibility study. | 2008 | J. Biotechnol. | pmid:17996321 |
Choi MH et al. | Metabolic relationship between polyhydroxyalkanoic acid and rhamnolipid synthesis in Pseudomonas aeruginosa: comparative ¹³C NMR analysis of the products in wild-type and mutants. | 2011 | J. Biotechnol. | pmid:21029757 |
Vikbjerg AF et al. | Synthesis of structured phospholipids by immobilized phospholipase A2 catalyzed acidolysis. | 2007 | J. Biotechnol. | pmid:17150274 |
Buclin T et al. | Bioavailability and biological efficacy of a new oral formulation of salmon calcitonin in healthy volunteers. | 2002 | J. Bone Miner. Res. | pmid:12162502 |
Sánchez-Serrano D et al. | Enhancement of ouabain arrhythmias by fatty acids. | 1980 | J. Cardiovasc. Pharmacol. | pmid:6156330 |
SMITH JA and DELUCA HF | STRUCTURAL CHANGES IN ISOLATED LIVER MITOCHONDRIA OF RATS DURING ESSENTIAL FATTY ACID DEFICIENCY. | 1964 | J. Cell Biol. | pmid:14154491 |
Stanisz J et al. | Serum factors that stimulate fatty acid oxidation: physiological specificity. | 1986 | J. Cell. Physiol. | pmid:3944194 |
Mori S et al. | Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. | 2003 | J. Cereb. Blood Flow Metab. | pmid:12679720 |
Pierre PS et al. | Differences in volatile profiles of turnip plants subjected to single and dual herbivory above- and belowground. | 2011 | J. Chem. Ecol. | pmid:21448706 |
Vinson SB et al. | Nest liquid resources of several cavity nesting bees in the genus Centris and the identification of a preservative, levulinic acid. | 2006 | J. Chem. Ecol. | pmid:16902822 |
Mukabana WR et al. | A novel synthetic odorant blend for trapping of malaria and other African mosquito species. | 2012 | J. Chem. Ecol. | pmid:22426893 |
Attygalle AB et al. | Defensive chemicals of two species of Trachypachus Motschulski. | 2004 | J. Chem. Ecol. | pmid:15139309 |
Smallegange RC et al. | The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto. | 2009 | J. Chem. Ecol. | pmid:19626371 |
Hall DR et al. | Identification of components of male-produced pheromone of coffee white stemborer, Xylotrechus quadripes. | 2006 | J. Chem. Ecol. | pmid:16525878 |
Suzuki T et al. | Analysis of anal secretions from phlaeothripine thrips. | 2004 | J. Chem. Ecol. | pmid:15112732 |
Wood WF | Volatile components in metatarsal glands of sika deer, Cervus nippon. | 2003 | J. Chem. Ecol. | pmid:14969359 |
Arimoto K et al. | Abnormal 13C-fatty acid breath tests in patients treated with valproic acid. | 1988 | J. Child Neurol. | pmid:3143757 |
Tsaconas C et al. | Gas chromatographic-mass spectrometric assessment of the pharmacokinetics of amineptine and its main metabolite in volunteers with liver impairment. | 1989 | J. Chromatogr. | pmid:2722999 |
Noctor TA et al. | Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. | 1992 | J. Chromatogr. | pmid:1400761 |
Nelis HJ et al. | Chromatographic determination of N-acetyl-DL-tryptophan and octanoic acid in human albumin solutions. | 1985 | J. Chromatogr. | pmid:4055947 |
Abbott FS et al. | Valproic acid analysis in saliva and serum using selected ion monitoring (electron ionization) of the tert.-butyldimethylsilyl derivatives. | 1982 | J. Chromatogr. | pmid:6801067 |
Lee YC and Johnson JH | Determination of sodium caprylate in plasma volume expanders by gas chromatography. | 1986 | J. Chromatogr. | pmid:2426293 |
Simon-Colin C et al. | Development of a three-steps derivatization assay for the localization of double bond in monounsaturated monomers of poly-beta-hydroxyalkanoates by GC-MS. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22717557 |
Endo M et al. | In vitro probe acylcarnitine profiling assay using cultured fibroblasts and electrospray ionization tandem mass spectrometry predicts severity of patients with glutaric aciduria type 2. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20392676 |
Tavares V et al. | Determination of dimenhydrinate in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a relative bioavailability study. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17442639 |
Isidorov VA et al. | Gas chromatographic-mass spectrometric investigation of volatile and extractable compounds of crude royal jelly. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22245368 |
Mu H and Høy CE | Application of atmospheric pressure chemical ionization liquid chromatography-mass spectrometry in identification of lymph triacylglycerols. | 2000 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11087085 |
Kulik W et al. | Improved use of the [13C]octanoic acid breath test as intra-individual parameter to study the effect of a prokinetic drug on gastric emptying in preterm infants with oral feeding intolerance. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11204215 |
Hayball PJ et al. | Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7894686 |
Kanamoto N et al. | Substantial production of ghrelin by a human medullary thyroid carcinoma cell line. | 2001 | J. Clin. Endocrinol. Metab. | pmid:11600575 |
Beglinger S et al. | Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion. | 2010 | J. Clin. Endocrinol. Metab. | pmid:19837920 |
Nass R et al. | The level of circulating octanoate does not predict ghrelin O-acyl transferase (GOAT)-mediated acylation of ghrelin during fasting. | 2015 | J. Clin. Endocrinol. Metab. | pmid:25337923 |
Dickman R et al. | A novel continuous breath test versus scintigraphy for gastric emptying rate measurement. | 2011 | J. Clin. Gastroenterol. | pmid:20495467 |
Demaugre F et al. | Infantile form of carnitine palmitoyltransferase II deficiency with hepatomuscular symptoms and sudden death. Physiopathological approach to carnitine palmitoyltransferase II deficiencies. | 1991 | J. Clin. Invest. | pmid:1999498 |
Tonsgard JH et al. | Binding of straight-chain saturated dicarboxylic acids to albumin. | 1988 | J. Clin. Invest. | pmid:3183053 |
Amendt BA and Rhead WJ | The multiple acyl-coenzyme A dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria. Mitochondrial fatty acid oxidation, acyl-coenzyme A dehydrogenase, and electron transfer flavoprotein activities in fibroblasts. | 1986 | J. Clin. Invest. | pmid:3722376 |
Matsuzaki K et al. | Inhibition of cortical collecting tubule chloride transport by organic acids. | 1988 | J. Clin. Invest. | pmid:3392216 |
Sidossis LS et al. | Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. | 1996 | J. Clin. Invest. | pmid:8941640 |
Zhou YP and Grill VE | Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. | 1994 | J. Clin. Invest. | pmid:8113418 |
Voller B et al. | Dose-escalation study of octanoic acid in patients with essential tremor. | 2016 | J. Clin. Invest. | pmid:26927672 |
Croce A et al. | Effect of infliximab on the glycosylation of IgG of patients with rheumatoid arthritis. | 2007 | J. Clin. Lab. Anal. | pmid:17847113 |
Planelles D et al. | A new, fast, and simple DNA extraction method for HLA and VNTR genotyping by PCR amplification. | 1996 | J. Clin. Lab. Anal. | pmid:8731498 |
Katoh K et al. | Octanoate increases cytosolic Ca2+ concentration and membrane conductance in ovine pancreatic acinar cells. | 1996 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:8923746 |
Du J et al. | Molecular basis of P450 OleT: an investigation of substrate binding mechanism and major pathways. | 2017 | J. Comput. Aided Mol. Des. | pmid:28342136 |
Lord DL et al. | Comparison of capillary pressure relationships of organic liquid-water systems containing an organic acid or base. | 2005 | J. Contam. Hydrol. | pmid:15763355 |
Yonezawa T et al. | Octanoate stimulates cytosolic triacylglycerol accumulation and CD36 mRNA expression but inhibits acetyl coenzyme A carboxylase activity in primary cultured bovine mammary epithelial cells. | 2004 | J. Dairy Res. | pmid:15605705 |
Mills JK et al. | The effects of feeding medium-chain triglycerides on the growth, insulin responsiveness, and body composition of Holstein calves from birth to 85 kg of body weight. | 2010 | J. Dairy Sci. | pmid:20723699 |