octanoic acid

octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.

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Introduction

To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with octanoic acid?

octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with octanoic acid

MeSH term MeSH ID Detail
Intracranial Hypertension D019586 4 associated lipids
Schistosomiasis D012552 4 associated lipids
Liver Failure D017093 5 associated lipids
Asthenia D001247 5 associated lipids
Diabetic Neuropathies D003929 5 associated lipids
Dyspepsia D004415 5 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Stomach Diseases D013272 7 associated lipids
Jaundice, Neonatal D007567 7 associated lipids
Chronic Disease D002908 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with octanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with octanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with octanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with octanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with octanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with octanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with octanoic acid

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Authors Title Published Journal PubMed Link
Torres-Guzmán R et al. Substrate specificity of penicillin acylase from Streptomyces lavendulae. 2002 Biochem. Biophys. Res. Commun. pmid:11855830
Nakajima I et al. Growth arrest by octanoate is required for porcine preadipocyte differentiation. 2003 Biochem. Biophys. Res. Commun. pmid:12963048
Yamato M et al. Exogenous administration of octanoic acid accelerates octanoylated ghrelin production in the proventriculus of neonatal chicks. 2005 Biochem. Biophys. Res. Commun. pmid:15953586
Ohgusu H et al. Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor. 2009 Biochem. Biophys. Res. Commun. pmid:19501572
Jones PM et al. Medium-chain fatty acids undergo elongation before beta-oxidation in fibroblasts. 2006 Biochem. Biophys. Res. Commun. pmid:16750167
Bjorge SM and Baillie TA Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid. 1985 Biochem. Biophys. Res. Commun. pmid:3933498
Maddaiah VT Ammonium inhibition of fatty acid oxidation in rat liver mitochondria. A possible cause of fatty liver in Reye's syndrome and urea cycle defects. 1985 Biochem. Biophys. Res. Commun. pmid:3977937
Hosoda H et al. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. 2000 Biochem. Biophys. Res. Commun. pmid:11162448
Shanado Y et al. Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach. 2004 Biochem. Biophys. Res. Commun. pmid:15555596
Matsumoto M et al. Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides. 2001 Biochem. Biophys. Res. Commun. pmid:11549267
Olivieri MC and Botelho LH Synergistic inhibition of hepatic ketogenesis in the presence of insulin and a cAMP antagonist. 1989 Biochem. Biophys. Res. Commun. pmid:2539126
Oettl K et al. An apparent decrease in cholesterol biosynthesis in peroxisomal-defective Chinese hamster ovary cells is related to impaired mitochondrial oxidation. 2003 Biochem. Biophys. Res. Commun. pmid:12767923
Lee SM et al. Prevention of the metabolic effects of 2-tetradecylglycidate by octanoic acid in the genetically diabetic mouse (db/db). 1985 Biochem Med pmid:3994695
Lutz WH et al. Inhibition of citrulline synthesis by octanoate and its modulation by adenine nucleotides. 1985 Biochem Med pmid:4052056
Böhles H et al. The influence of i.v. MCT and carnitine on the excretion of dicarboxylic acids. 1988 Beitr Infusionther Klin Ernahr pmid:3132147
Wang Z and Zhang Q [Study on pulmonary delivery system of salmon calcitonin in rats]. 2003 Beijing Da Xue Xue Bao pmid:12914259
Amlou M et al. Genetic analysis of Drosophila sechellia specialization: oviposition behavior toward the major aliphatic acids of its host plant. 1998 Behav. Genet. pmid:9926614
Rösen P et al. Myocardial performance and metabolism in non-ketotic, diabetic rat hearts: myocardial function and metabolism in vivo and in the isolated perfused heart under the influence of insulin and octanoate. 1986 Nov-Dec Basic Res. Cardiol. pmid:3545178
Cave AC et al. A model of anoxic preconditioning in the isolated rat cardiac myocyte. Importance of adenosine and insulin. 1996 May-Jun Basic Res. Cardiol. pmid:8831940
Mathiesen L et al. Transport of benzo[alpha]pyrene in the dually perfused human placenta perfusion model: effect of albumin in the perfusion medium. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19508462