octanoic acid

octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.

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Introduction

To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with octanoic acid?

octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with octanoic acid

MeSH term MeSH ID Detail
Biliary Fistula D001658 13 associated lipids
Campylobacter Infections D002169 13 associated lipids
Hypertension, Portal D006975 12 associated lipids
Amyotrophic Lateral Sclerosis D000690 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Diabetic Neuropathies D003929 5 associated lipids
Critical Illness D016638 13 associated lipids
Endotoxemia D019446 27 associated lipids
Memory Disorders D008569 33 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Liver Failure D017093 5 associated lipids
Chickenpox D002644 1 associated lipids
Chylothorax D002916 1 associated lipids
Gastroparesis D018589 2 associated lipids
Gallstones D042882 3 associated lipids
Dyspepsia D004415 5 associated lipids
Snake Bites D012909 1 associated lipids
Prion Diseases D017096 2 associated lipids
Asthenia D001247 5 associated lipids
Esophageal Motility Disorders D015154 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with octanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with octanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with octanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with octanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with octanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with octanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with octanoic acid

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Authors Title Published Journal PubMed Link
Miller TB Cardiac performance of isolated perfused hearts from alloxan diabetic rats. 1979 Am. J. Physiol. pmid:443443
Vinay P et al. Effect of fatty acids on renal ammoniagenesis in in vivo and in vitro studies. 1976 Am. J. Physiol. pmid:970471
Burns AH and Reddy WJ Amino acid stimulation of oxygen and substrate utilization by cardiac myocytes. 1978 Am. J. Physiol. pmid:727249
Patel TB Effect of sulfonylureas on hepatic fatty acid oxidation. 1986 Am. J. Physiol. pmid:3090894
Lemieux G et al. Glutamine synthetase and glutamyltransferase in the kidney of man, dog, and rat. 1976 Am. J. Physiol. pmid:10736
REES ED and KLINE DL Metabolism of octanoate by fatty liver slices. 1957 Am. J. Physiol. pmid:13470069
Matsumura T et al. O2 uptake in periportal and pericentral regions of liver lobule in perfused liver. 1986 Am. J. Physiol. pmid:3717341
Sidossis LS et al. Regulation of fatty acid oxidation in untrained vs. trained men during exercise. 1998 Am. J. Physiol. pmid:9530135
Adams SH and Odle J Plasma beta-hydroxybutyrate after octanoate challenge: attenuated ketogenic capacity in neonatal swine. 1993 Am. J. Physiol. pmid:8238444
Beaufrere B et al. Apparent decreased oxidation and turnover of leucine during infusion of medium-chain triglycerides. 1985 Am. J. Physiol. pmid:3895976
Barron JT et al. Substrate-dependent alteration in O2 consumption and energy metabolism in vascular smooth muscle. 1996 Am. J. Physiol. pmid:8764234
Bonen A et al. Palmitate transport and fatty acid transporters in red and white muscles. 1998 Am. J. Physiol. pmid:9725814
Morand C et al. Fatty acids are potent modulators of lactate utilization in isolated hepatocytes from fed rats. 1993 Am. J. Physiol. pmid:8498503
Werner JC et al. Fatty acid and glucose utilization in isolated, working newborn pig hearts. 1983 Am. J. Physiol. pmid:6849379
Witters LA and Trasko CS Regulation of hepatic free fatty acid metabolism by glucagon and insulin. 1979 Am. J. Physiol. pmid:157075
Bielefeld DR et al. Altered sensitivity of chronic diabetic rat heart to calcium. 1983 Am. J. Physiol. pmid:6362427
Trimble ME Transport and metabolism of octanoate by the perfused rat kidney. 1979 Am. J. Physiol. pmid:474762
Lemieux G et al. Effect of fluoroacetate on the inhibitory action of ketone bodies and fatty acids on renal ammoniagenesis. 1979 Am. J. Physiol. pmid:464062
Odessey R and Chace KV Utilization of endogenous lipid, glycogen, and protein by rabbit aorta. 1982 Am. J. Physiol. pmid:7091374
Tanner GA et al. Excretion of phenol red by the Necturus kidney. 1979 Am. J. Physiol. pmid:443381