octanoic acid

octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.

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Introduction

To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with octanoic acid?

octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with octanoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Hemorrhage D006470 15 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hepatorenal Syndrome D006530 1 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypertension, Portal D006975 12 associated lipids
Hypothyroidism D007037 32 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Inflammation D007249 119 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with octanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with octanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with octanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with octanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with octanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with octanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with octanoic acid

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Authors Title Published Journal PubMed Link
Marchington DR et al. Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat cardiac myocytes. 1990 Biochem. J. pmid:2158309
Kragh-Hansen U Effects of aliphatic fatty acids on the binding of Phenol Red to human serum albumin. 1981 Biochem. J. pmid:7316975
Bauché F et al. 2-Mercaptoacetate administration depresses the beta-oxidation pathway through an inhibition of long-chain acyl-CoA dehydrogenase activity. 1981 Biochem. J. pmid:7317017
Hansford RG Lipid oxidation by heart mitochondria from young adult and senescent rats. 1978 Biochem. J. pmid:637843
Berne C The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies. 1975 Biochem. J. pmid:776173
Buxton DB et al. Regulatory effects of fatty acids on decarboxylation of leucine and 4-methyl-2-oxopentanoate in the perfused rat heart. 1984 Biochem. J. pmid:6477487
Felix R and Fleisch H Increase in fatty acid oxidation in calvaria cells cultured with diphosphonates. 1981 Biochem. J. pmid:6458286
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Iwahashi H Some polyphenols inhibit the formation of pentyl radical and octanoic acid radical in the reaction mixture of linoleic acid hydroperoxide with ferrous ions. 2000 Biochem. J. pmid:10677343
Watford M et al. The regulation of glutamine and ketone-body metabolism in the small intestine of the long-term (40-day) streptozotocin-diabetic rat. 1987 Biochem. J. pmid:3473986
Even PC et al. Defective regulation of energy metabolism in mdx-mouse skeletal muscles. 1994 Biochem. J. pmid:7999003
Dieuaide M et al. Effects of glucose starvation on the oxidation of fatty acids by maize root tip mitochondria and peroxisomes: evidence for mitochondrial fatty acid beta-oxidation and acyl-CoA dehydrogenase activity in a higher plant. 1993 Biochem. J. pmid:8250843
Lin X et al. Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets. 1996 Biochem. J. pmid:8761477
Sibille B et al. The mitochondrial consequences of uncoupling intact cells depend on the nature of the exogenous substrate. 2001 Biochem. J. pmid:11256968
Harwood JL et al. Fat metabolism in higher plants. Beta-hydroxylation of fatty acids by a soluble preparation from maturing avocado mesocarp. 1972 Biochem. J. pmid:4144293
Ledden DJ et al. Characterization of fragments of human albumin purified by Cibacron blue F3GA affinity chromatography. 1982 Biochem. J. pmid:6814424
Reed WD et al. A double-isotope method for the measurement of ketone-body turnover in the rat. Effect of L-alanine. 1984 Biochem. J. pmid:6721850
Marchington DR et al. Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat hepatocytes. 1989 Biochem. J. pmid:2539088
Clore JN et al. Evidence for dissociation of gluconeogenesis stimulated by non-esterified fatty acids and changes in fructose 2,6-bisphosphate in cultured rat hepatocytes. 1992 Biochem. J. pmid:1445259