octanoic acid

octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.

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Introduction

To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with octanoic acid?

octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with octanoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Hemorrhage D006470 15 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hepatorenal Syndrome D006530 1 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypertension, Portal D006975 12 associated lipids
Hypothyroidism D007037 32 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Inflammation D007249 119 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with octanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with octanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with octanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with octanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with octanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with octanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with octanoic acid

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Authors Title Published Journal PubMed Link
Pohl J et al. Long-chain fatty acid uptake into adipocytes depends on lipid raft function. 2004 Biochemistry pmid:15065861
Li W et al. Reconstitution of the M13 major coat protein and its transmembrane peptide segment on a DNA template. 2007 Biochemistry pmid:17595059
Jiang Y et al. The soluble acyl-acyl carrier protein synthetase of Vibrio harveyi B392 is a member of the medium chain acyl-CoA synthetase family. 2006 Biochemistry pmid:16906759
Hayden MA et al. Biosynthesis of lipoic acid: characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33-lip9. 1993 Biochemistry pmid:8466915
White RH Stable isotope studies on the biosynthesis of lipoic acid in Escherichia coli. 1980 Biochemistry pmid:6766313
Kawai A et al. Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions. 2017 Biochim Biophys Acta Proteins Proteom pmid:28473296
Sumbilla CM et al. Comparison of the oxidation of glutamine, glucose, ketone bodies and fatty acids by human diploid fibroblasts. 1981 Biochim. Biophys. Acta pmid:7272339
Einarsson R The binding of 1-anilino-8-naphthalenesulfonate, heparin, salicylate and caprylate by human antithrombin III. 1976 Biochim. Biophys. Acta pmid:974107
Sundqvist KE et al. Effect of acetate and octanoate on tricarboxylic acid cycle metabolite disposal during propionate oxidation in the perfused rat heart. 1984 Biochim. Biophys. Acta pmid:6487652
Merrill AR et al. Effects of exogenous fatty acids on calcium uptake by brush-border membrane vesicles from rabbit small intestine. 1986 Biochim. Biophys. Acta pmid:3081028
Veerkamp JH et al. An accurate and sensitive assay of [14C]octanoate oxidation and its application on tissue homogenates and fibroblasts. 1986 Biochim. Biophys. Acta pmid:3081042
Barron JT et al. Effect of serum albumin on vascular smooth muscle metabolism. 2000 Biochim. Biophys. Acta pmid:10924897
Herold G et al. Cholesterol synthesis and esterification in cultured intestinal mucosa. Evidence for compartmentation. 1984 Biochim. Biophys. Acta pmid:6567470
Müller MJ et al. Effect of thyroid state on ketogenic capacity of the isolated perfused liver of starved rats. 1981 Biochim. Biophys. Acta pmid:6275888
Anraku M et al. Stabilizing mechanisms in commercial albumin preparations: octanoate and N-acetyl-L-tryptophanate protect human serum albumin against heat and oxidative stress. 2004 Biochim. Biophys. Acta pmid:15450846
Viegas CA et al. Regulation of the expression of the H(+)-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae. 1994 Biochim. Biophys. Acta pmid:8286419
Murphy MG et al. Abnormalities in hepatic fatty-acid metabolism in a surfactant/influenza B virus mouse model for acute encephalopathy. 1996 Biochim. Biophys. Acta pmid:8611661
González-Manchón C et al. Ca2(+)-fatty acid interaction in the control of hepatic gluconeogenesis. 1990 Biochim. Biophys. Acta pmid:2310772
Shimshoni JA et al. Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. 2011 Biochim. Biophys. Acta pmid:21184843
Nomura T et al. Effects of octanoate and acetate upon hepatic glycolysis and lipogenesis. 1983 Biochim. Biophys. Acta pmid:6317044