| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Hemorrhage | D006470 | 15 associated lipids |
| Hepatic Encephalopathy | D006501 | 9 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hepatorenal Syndrome | D006530 | 1 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hypertension, Portal | D006975 | 12 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Infant, Newborn, Diseases | D007232 | 9 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
octanoic acid
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
Cross Reference
Introduction
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with octanoic acid?
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with octanoic acid
PubChem Associated disorders and diseases
What pathways are associated with octanoic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with octanoic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with octanoic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with octanoic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with octanoic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with octanoic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with octanoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wright TC et al. | Inhibition of fatty acid synthesis in bovine mammary homogenate by palmitic acid is not a detergent effect. | 2002 | J. Dairy Sci. | pmid:11949869 |
| Giesy JG et al. | Effect of dose of calcium salts of conjugated linoleic acid (CLA) on percentage and fatty acid content of milk fat in midlactation holstein cows. | 2002 | J. Dairy Sci. | pmid:12214995 |
| Dimenna GP and Emery RS | Palmitate and octanoate metabolism in bovine mammary tissue. | 1981 | J. Dairy Sci. | pmid:7264015 |
| Nair MK et al. | Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens. | 2005 | J. Dairy Sci. | pmid:16162522 |
| van Zijderveld SM et al. | Dietary inclusion of diallyl disulfide, yucca powder, calcium fumarate, an extruded linseed product, or medium-chain fatty acids does not affect methane production in lactating dairy cows. | 2011 | J. Dairy Sci. | pmid:21605778 |
| Guidry AJ and O'Brien CN | A method for measuring specific antibodies in bovine lacteal secretions during the nonlactating period. | 1996 | J. Dairy Sci. | pmid:8792284 |
| Tomita GM et al. | Antigenic crossreactivity and lipopolysaccharide neutralization properties of bovine immunoglobulin G. | 1995 | J. Dairy Sci. | pmid:8675757 |
| Jaeggi JJ et al. | Hard ewe's milk cheese manufactured from milk of three different groups of somatic cell counts. | 2003 | J. Dairy Sci. | pmid:14594225 |
| Morrill KM et al. | Estimate of serum immunoglobulin G concentration using refractometry with or without caprylic acid fractionation. | 2013 | J. Dairy Sci. | pmid:23664346 |
| Fonseca CR et al. | Storage of refrigerated raw goat milk affecting the quality of whole milk powder. | 2013 | J. Dairy Sci. | pmid:23664351 |
| Mills JK et al. | The effects of feeding medium-chain triglycerides on the growth, insulin responsiveness, and body composition of Holstein calves from birth to 85 kg of body weight. | 2010 | J. Dairy Sci. | pmid:20723699 |
| Yonezawa T et al. | Octanoate stimulates cytosolic triacylglycerol accumulation and CD36 mRNA expression but inhibits acetyl coenzyme A carboxylase activity in primary cultured bovine mammary epithelial cells. | 2004 | J. Dairy Res. | pmid:15605705 |
| Lord DL et al. | Comparison of capillary pressure relationships of organic liquid-water systems containing an organic acid or base. | 2005 | J. Contam. Hydrol. | pmid:15763355 |
| Du J et al. | Molecular basis of P450 OleT: an investigation of substrate binding mechanism and major pathways. | 2017 | J. Comput. Aided Mol. Des. | pmid:28342136 |
| Katoh K et al. | Octanoate increases cytosolic Ca2+ concentration and membrane conductance in ovine pancreatic acinar cells. | 1996 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:8923746 |
| Croce A et al. | Effect of infliximab on the glycosylation of IgG of patients with rheumatoid arthritis. | 2007 | J. Clin. Lab. Anal. | pmid:17847113 |
| Planelles D et al. | A new, fast, and simple DNA extraction method for HLA and VNTR genotyping by PCR amplification. | 1996 | J. Clin. Lab. Anal. | pmid:8731498 |
| Demaugre F et al. | Infantile form of carnitine palmitoyltransferase II deficiency with hepatomuscular symptoms and sudden death. Physiopathological approach to carnitine palmitoyltransferase II deficiencies. | 1991 | J. Clin. Invest. | pmid:1999498 |
| Tonsgard JH et al. | Binding of straight-chain saturated dicarboxylic acids to albumin. | 1988 | J. Clin. Invest. | pmid:3183053 |
| Amendt BA and Rhead WJ | The multiple acyl-coenzyme A dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria. Mitochondrial fatty acid oxidation, acyl-coenzyme A dehydrogenase, and electron transfer flavoprotein activities in fibroblasts. | 1986 | J. Clin. Invest. | pmid:3722376 |
| Matsuzaki K et al. | Inhibition of cortical collecting tubule chloride transport by organic acids. | 1988 | J. Clin. Invest. | pmid:3392216 |
| Sidossis LS et al. | Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. | 1996 | J. Clin. Invest. | pmid:8941640 |
| Zhou YP and Grill VE | Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. | 1994 | J. Clin. Invest. | pmid:8113418 |
| Voller B et al. | Dose-escalation study of octanoic acid in patients with essential tremor. | 2016 | J. Clin. Invest. | pmid:26927672 |
| Dickman R et al. | A novel continuous breath test versus scintigraphy for gastric emptying rate measurement. | 2011 | J. Clin. Gastroenterol. | pmid:20495467 |
| Kanamoto N et al. | Substantial production of ghrelin by a human medullary thyroid carcinoma cell line. | 2001 | J. Clin. Endocrinol. Metab. | pmid:11600575 |
| Beglinger S et al. | Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion. | 2010 | J. Clin. Endocrinol. Metab. | pmid:19837920 |
| Nass R et al. | The level of circulating octanoate does not predict ghrelin O-acyl transferase (GOAT)-mediated acylation of ghrelin during fasting. | 2015 | J. Clin. Endocrinol. Metab. | pmid:25337923 |
| Hayball PJ et al. | Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7894686 |
| Mu H and Høy CE | Application of atmospheric pressure chemical ionization liquid chromatography-mass spectrometry in identification of lymph triacylglycerols. | 2000 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11087085 |
| Kulik W et al. | Improved use of the [13C]octanoic acid breath test as intra-individual parameter to study the effect of a prokinetic drug on gastric emptying in preterm infants with oral feeding intolerance. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11204215 |
| Simon-Colin C et al. | Development of a three-steps derivatization assay for the localization of double bond in monounsaturated monomers of poly-beta-hydroxyalkanoates by GC-MS. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22717557 |
| Endo M et al. | In vitro probe acylcarnitine profiling assay using cultured fibroblasts and electrospray ionization tandem mass spectrometry predicts severity of patients with glutaric aciduria type 2. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20392676 |
| Tavares V et al. | Determination of dimenhydrinate in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a relative bioavailability study. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17442639 |
| Isidorov VA et al. | Gas chromatographic-mass spectrometric investigation of volatile and extractable compounds of crude royal jelly. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22245368 |
| Tsaconas C et al. | Gas chromatographic-mass spectrometric assessment of the pharmacokinetics of amineptine and its main metabolite in volunteers with liver impairment. | 1989 | J. Chromatogr. | pmid:2722999 |
| Noctor TA et al. | Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. | 1992 | J. Chromatogr. | pmid:1400761 |
| Nelis HJ et al. | Chromatographic determination of N-acetyl-DL-tryptophan and octanoic acid in human albumin solutions. | 1985 | J. Chromatogr. | pmid:4055947 |
| Abbott FS et al. | Valproic acid analysis in saliva and serum using selected ion monitoring (electron ionization) of the tert.-butyldimethylsilyl derivatives. | 1982 | J. Chromatogr. | pmid:6801067 |
| Lee YC and Johnson JH | Determination of sodium caprylate in plasma volume expanders by gas chromatography. | 1986 | J. Chromatogr. | pmid:2426293 |
| Arimoto K et al. | Abnormal 13C-fatty acid breath tests in patients treated with valproic acid. | 1988 | J. Child Neurol. | pmid:3143757 |
| Pierre PS et al. | Differences in volatile profiles of turnip plants subjected to single and dual herbivory above- and belowground. | 2011 | J. Chem. Ecol. | pmid:21448706 |
| Vinson SB et al. | Nest liquid resources of several cavity nesting bees in the genus Centris and the identification of a preservative, levulinic acid. | 2006 | J. Chem. Ecol. | pmid:16902822 |
| Mukabana WR et al. | A novel synthetic odorant blend for trapping of malaria and other African mosquito species. | 2012 | J. Chem. Ecol. | pmid:22426893 |
| Attygalle AB et al. | Defensive chemicals of two species of Trachypachus Motschulski. | 2004 | J. Chem. Ecol. | pmid:15139309 |
| Smallegange RC et al. | The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto. | 2009 | J. Chem. Ecol. | pmid:19626371 |
| Hall DR et al. | Identification of components of male-produced pheromone of coffee white stemborer, Xylotrechus quadripes. | 2006 | J. Chem. Ecol. | pmid:16525878 |
| Suzuki T et al. | Analysis of anal secretions from phlaeothripine thrips. | 2004 | J. Chem. Ecol. | pmid:15112732 |
| Wood WF | Volatile components in metatarsal glands of sika deer, Cervus nippon. | 2003 | J. Chem. Ecol. | pmid:14969359 |
| Mori S et al. | Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. | 2003 | J. Cereb. Blood Flow Metab. | pmid:12679720 |
| Stanisz J et al. | Serum factors that stimulate fatty acid oxidation: physiological specificity. | 1986 | J. Cell. Physiol. | pmid:3944194 |
| SMITH JA and DELUCA HF | STRUCTURAL CHANGES IN ISOLATED LIVER MITOCHONDRIA OF RATS DURING ESSENTIAL FATTY ACID DEFICIENCY. | 1964 | J. Cell Biol. | pmid:14154491 |
| Sánchez-Serrano D et al. | Enhancement of ouabain arrhythmias by fatty acids. | 1980 | J. Cardiovasc. Pharmacol. | pmid:6156330 |
| Buclin T et al. | Bioavailability and biological efficacy of a new oral formulation of salmon calcitonin in healthy volunteers. | 2002 | J. Bone Miner. Res. | pmid:12162502 |
| Russell RA et al. | Production and use of deuterated polyhydroxyoctanoate in structural studies of PHO inclusions. | 2007 | J. Biotechnol. | pmid:17555837 |
| Lomborg CJ et al. | At-line determination of octanoic acid in cultivation broth--an electronic tongue (ET) feasibility study. | 2008 | J. Biotechnol. | pmid:17996321 |
| Choi MH et al. | Metabolic relationship between polyhydroxyalkanoic acid and rhamnolipid synthesis in Pseudomonas aeruginosa: comparative ¹³C NMR analysis of the products in wild-type and mutants. | 2011 | J. Biotechnol. | pmid:21029757 |
| Vikbjerg AF et al. | Synthesis of structured phospholipids by immobilized phospholipase A2 catalyzed acidolysis. | 2007 | J. Biotechnol. | pmid:17150274 |
| Chen YJ et al. | Production and characterization of medium-chain-length polyhydroxyalkanoates by Pseudomonas mosselii TO7. | 2014 | J. Biosci. Bioeng. | pmid:24630613 |
| Maeda A et al. | Characterization of novel cholesterol esterase from Trichoderma sp. AS59 with high ability to synthesize steryl esters. | 2008 | J. Biosci. Bioeng. | pmid:18499049 |
| Furukawa K et al. | Increased ethyl caproate production by inositol limitation in Saccharomyces cerevisiae. | 2003 | J. Biosci. Bioeng. | pmid:16233438 |
| Okamoto K et al. | Production of gamma-lactones by the brown-rot basidiomycete Piptoporus soloniensis. | 2002 | J. Biosci. Bioeng. | pmid:16233291 |
| Comar JF et al. | Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations. | 2010 | J. Biomed. Sci. | pmid:20055990 |
| Mazarro R et al. | Copolymerization of D,L-lactide and glycolide in supercritical carbon dioxide with zinc octoate as catalyst. | 2008 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:17854066 |
| Gurvitz A | Identification of the Leishmania major proteins LmjF07.0430, LmjF07.0440, and LmjF27.2440 as components of fatty acid synthase II. | 2009 | J. Biomed. Biotechnol. | pmid:20145708 |
| Chen R et al. | Chemiluminescent nanomicelles for imaging hydrogen peroxide and self-therapy in photodynamic therapy. | 2011 | J. Biomed. Biotechnol. | pmid:21765637 |
| Martin JD et al. | Structure and membrane affinity of new amphiphilic siderophores produced by Ochrobactrum sp. SP18. | 2006 | J. Biol. Inorg. Chem. | pmid:16791646 |
| Mao LF et al. | Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid. | 1992 | J. Biol. Chem. | pmid:1737769 |
| Deng S et al. | Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver. | 2009 | J. Biol. Chem. | pmid:19666922 |
| May ME et al. | Mechanism of the stimulation of branched chain oxoacid oxidation in liver by carnitine. | 1980 | J. Biol. Chem. | pmid:7410370 |
| Taylor SI et al. | Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio. | 1975 | J. Biol. Chem. | pmid:1116996 |
| Hansford RG and Johnson RN | The steady state concentrations of coenzyme A-SH and coenzyme A thioester, citrate, and isocitrate during tricarboxylate cycle oxidations in rabbit heart mitochondria. | 1975 | J. Biol. Chem. | pmid:1194259 |
| Jomain-Baum M and Hanson RW | Regulation of hepatic gluconeogenesis in the guinea pig by fatty acids and ammonia. | 1975 | J. Biol. Chem. | pmid:1194271 |
| Fulks RM et al. | Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. | 1975 | J. Biol. Chem. | pmid:1141208 |
| Vidal H et al. | Inhibition of glucose oxidation by vasoactive intestinal peptide in isolated rat enterocytes. | 1988 | J. Biol. Chem. | pmid:3132456 |
| Shrake A and Ross PD | Biphasic denaturation of human albumin due to ligand redistribution during unfolding. | 1988 | J. Biol. Chem. | pmid:3170588 |
| Connolly E and Nedergaard J | Beta-adrenergic modulation of Ca2+ uptake by isolated brown adipocytes. Possible involvement of mitochondria. | 1988 | J. Biol. Chem. | pmid:2839496 |
| Kaiya H et al. | Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. | 2001 | J. Biol. Chem. | pmid:11546772 |
| Campbell SE et al. | A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. | 2004 | J. Biol. Chem. | pmid:15161924 |
| Lysiak W et al. | Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria. | 1988 | J. Biol. Chem. | pmid:3335535 |
| Mortimore GE et al. | Modulation of the amino acid control of hepatic protein degradation by caloric deprivation. Two modes of alanine co-regulation. | 1988 | J. Biol. Chem. | pmid:3264284 |
| Cistola DP et al. | Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. I. The filling of individual fatty acid binding sites. | 1987 | J. Biol. Chem. | pmid:3611099 |
| Cistola DP et al. | Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. II. Electrostatic interactions in individual fatty acid binding sites. | 1987 | J. Biol. Chem. | pmid:3611100 |
| GEYER RP et al. | Metabolism of emulsified trilaurin (-C1400-) and octanoic acid (-C1400-) by rat tissue slices. | 1949 | J. Biol. Chem. | pmid:18139198 |
| Zhang Y et al. | Nonhomogeneous labeling of liver extra-mitochondrial acetyl-CoA. Implications for the probing of lipogenic acetyl-CoA via drug acetylation and for the production of acetate by the liver. | 1994 | J. Biol. Chem. | pmid:8157628 |
| Morris TW et al. | Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product. | 1994 | J. Biol. Chem. | pmid:8206909 |
| Beaumont NJ et al. | Ghrelin can bind to a species of high density lipoprotein associated with paraoxonase. | 2003 | J. Biol. Chem. | pmid:12531885 |
| Gao J and Serrero G | Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. | 1999 | J. Biol. Chem. | pmid:10358026 |
| Kawaguchi T et al. | Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. | 2002 | J. Biol. Chem. | pmid:11724780 |
| Li RL et al. | Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. | 2012 | J. Biol. Chem. | pmid:22474325 |
| Paul HS and Adibi SA | Mechanism of increased conversion of branched chain keto acid dehydrogenase from inactive to active form by a medium chain fatty acid (octanoate) in skeletal muscle. | 1992 | J. Biol. Chem. | pmid:1597456 |
| Nobes CD et al. | The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes. | 1990 | J. Biol. Chem. | pmid:2376580 |
| LOSSOW WJ and CHAIKOFF IL | Secretion of intravenously administered tripalmitin-1-C14 and octanoate-1-C14 into milk by the lactating rat. | 1958 | J. Biol. Chem. | pmid:13502382 |
| LOSSOW WJ et al. | The action of insulin in sparing fatty acid oxidation: a study with palmitic acid-1-C14 and octanoate-1-C14. | 1956 | J. Biol. Chem. | pmid:13331942 |
| Mayorek N and Bar-Tana J | Medium chain fatty acids as specific substrates for diglyceride acyltransferase in cultured hepatocytes. | 1983 | J. Biol. Chem. | pmid:6853505 |
| GEYER RP et al. | Effect of pyruvate on octanoate metabolism as influenced by potassium and lithium. | 1953 | J. Biol. Chem. | pmid:13084632 |
| CRANDALL DI et al. | Studies of acetoacetate formation with labeled carbon; the conversion of zeta-(C7)-labeled octanoate to acetoacetate. | 1949 | J. Biol. Chem. | pmid:15393802 |
| LORBER V et al. | Conversion of octanoic acid to rat liver glycogen, studied with C14, C13-labeled octanoate. | 1949 | J. Biol. Chem. | pmid:15393766 |
| Hiltunen JK et al. | Mitochondrial fatty acid synthesis type II: more than just fatty acids. | 2009 | J. Biol. Chem. | pmid:19028688 |
| VESTLING CS and KAUFMAN S | The oxidation of octanoate by normal and leucemic mouse liver homogenates. | 1946 | J. Biol. Chem. | pmid:21001223 |