octanoic acid

octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.

Cross Reference

Introduction

To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with octanoic acid?

octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with octanoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Hemorrhage D006470 15 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hepatorenal Syndrome D006530 1 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypertension, Portal D006975 12 associated lipids
Hypothyroidism D007037 32 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 73

PubChem Associated disorders and diseases

What pathways are associated with octanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with octanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with octanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with octanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with octanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with octanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with octanoic acid

Download all related citations
Per page 10 20 50 100 | Total 2110
Authors Title Published Journal PubMed Link
Kingsley-Hickman PB et al. 31P NMR measurement of mitochondrial uncoupling in isolated rat hearts. 1990 J. Biol. Chem. pmid:2136855
Gimeno RE et al. Characterization of a heart-specific fatty acid transport protein. 2003 J. Biol. Chem. pmid:12556534
Waymack PP et al. Studies on the activation and inactivation of the branched chain alpha-keto acid dehydrogenase in the perfused rat heart. 1980 J. Biol. Chem. pmid:7430101
Mao LF et al. Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid. 1992 J. Biol. Chem. pmid:1737769
May ME et al. Mechanism of the stimulation of branched chain oxoacid oxidation in liver by carnitine. 1980 J. Biol. Chem. pmid:7410370
Qahwash IM et al. Site-specific effects of peptide lipidation on beta-amyloid aggregation and cytotoxicity. 2007 J. Biol. Chem. pmid:17693400
Otto DA Relationship of the ATP/ADP ratio to the site of octanoate activation. 1984 J. Biol. Chem. pmid:6715356
Massillon D et al. Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. 2003 J. Biol. Chem. pmid:12915406
Vidal H et al. Inhibition of glucose oxidation by vasoactive intestinal peptide in isolated rat enterocytes. 1988 J. Biol. Chem. pmid:3132456
Jordanova R et al. The highly abundant protein Ag-lbp55 from Ascaridia galli represents a novel type of lipid-binding proteins. 2005 J. Biol. Chem. pmid:16210327
Heaney-Kieras J and King TP Limited pepsin digestion of human plasma albumin. 1977 J. Biol. Chem. pmid:325004
Roncero C and Goodridge AG Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. 1992 J. Biol. Chem. pmid:1634532
Lysiak W et al. Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria. 1986 J. Biol. Chem. pmid:3759988
Gueguen V et al. Fatty acid and lipoic acid biosynthesis in higher plant mitochondria. 2000 J. Biol. Chem. pmid:10671542
McGarry JD and Foster DW The regulation of ketogenesis from octanoic acid. The role of the tricarboxylic acid cycle and fatty acid synthesis. 1971 J. Biol. Chem. pmid:5543682
Stoddart CA et al. Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice. 2008 J. Biol. Chem. pmid:18809675
Cistola DP et al. Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. I. The filling of individual fatty acid binding sites. 1987 J. Biol. Chem. pmid:3611099
Cistola DP et al. Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. II. Electrostatic interactions in individual fatty acid binding sites. 1987 J. Biol. Chem. pmid:3611100
GEYER RP et al. Metabolism of emulsified trilaurin (-C1400-) and octanoic acid (-C1400-) by rat tissue slices. 1949 J. Biol. Chem. pmid:18139198
Stephens JL et al. Mitochondrial fatty acid synthesis in Trypanosoma brucei. 2007 J. Biol. Chem. pmid:17166831
Connolly E et al. Norepinephrine-induced Na+ influx in brown adipocytes is cyclic AMP-mediated. 1986 J. Biol. Chem. pmid:3021738
Sabbagh E et al. 3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria. 1985 J. Biol. Chem. pmid:3997873
Lai CY and Cronan JE Beta-ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis. 2003 J. Biol. Chem. pmid:14523010
Gao J and Serrero G Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. 1999 J. Biol. Chem. pmid:10358026
Guy JE et al. Crystal structure of a class XIB phospholipase A2 (PLA2): rice (oryza sativa) isoform-2 pla2 and an octanoate complex. 2009 J. Biol. Chem. pmid:19457861
Fujino T et al. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. 2001 J. Biol. Chem. pmid:11470804
Frederich M and Balschi JA The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart. 2002 J. Biol. Chem. pmid:11707445
KUSUNOSE M et al. ENZYMATIC OMEGA-OXIDATION OF FATTY ACIDS. I. PRODUCTS OF OCTANOATE, DECONATE, AND LAURATE OXIDATION. 1964 J. Biol. Chem. pmid:14189868
LOSSOW WJ and CHAIKOFF IL Secretion of intravenously administered tripalmitin-1-C14 and octanoate-1-C14 into milk by the lactating rat. 1958 J. Biol. Chem. pmid:13502382
Derbocio AM et al. The action of zymosan on octanoate transport and metabolism in the isolated perfused rat liver. 2009 May-Jun J. Biochem. Mol. Toxicol. pmid:19526564
Sugano T et al. Intracellular redox state and control of gluconeogenesis in perfused chicken liver. 1982 J. Biochem. pmid:7118853
Sugano T et al. Stimulation of gluconeogenesis by glucagon and norepinephrine in the perfused chicken liver. 1982 J. Biochem. pmid:7118865
Sugano T et al. Intracellular redox state and stimulation of gluconeogenesis by glucagon and norepinephrine in the perfused rat liver. 1980 J. Biochem. pmid:7358625
Iimura S and Iwahashi H Enhancement by cigarette smoke extract of the radical formation in a reaction mixture of 13-hydroperoxide octadecadienoic acid and ferric ions. 2006 J. Biochem. pmid:16672267
Draye JP and Vamecq J The inhibition by valproic acid of the mitochondrial oxidation of monocarboxylic and omega-hydroxymonocarboxylic acids: possible implications for the metabolism of gamma-aminobutyric acid. 1987 J. Biochem. pmid:3117781
Komura S and Kurahashi K Biosynthesis of polymyxin E by a cell-free enzyme system. IV. Acylation of enzyme-bound L-2,4-diaminobutyric acid. 1985 J. Biochem. pmid:3861608
Iwahashi H et al. The formation of the 7-carboxyheptyl radical from 13-hydroperoxy-9,11-octadecadienoic acid catalyzed by hemoglobin and myoglobin under anaerobic conditions. 2003 J. Biochem. pmid:12801921
Takahashi T et al. Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid. 2009 J. Biochem. pmid:19628676
Kurioka S et al. Purification of fibrinogen using cationic detergent. 1975 J. Biochem. pmid:805129
Nowak-Thompson B et al. 2,5-dialkylresorcinol biosynthesis in Pseudomonas aurantiaca: novel head-to-head condensation of two fatty acid-derived precursors. 2003 J. Bacteriol. pmid:12533461
Jordan SW and Cronan JE The Escherichia coli lipB gene encodes lipoyl (octanoyl)-acyl carrier protein:protein transferase. 2003 J. Bacteriol. pmid:12591875
Iram SH and Cronan JE The beta-oxidation systems of Escherichia coli and Salmonella enterica are not functionally equivalent. 2006 J. Bacteriol. pmid:16385050
Morris TW et al. Lipoic acid metabolism in Escherichia coli: the lplA and lipB genes define redundant pathways for ligation of lipoyl groups to apoprotein. 1995 J. Bacteriol. pmid:8002607
Reed KE and Cronan JE Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes. 1993 J. Bacteriol. pmid:8444795
Hermes FA and Cronan JE Scavenging of cytosolic octanoic acid by mutant LplA lipoate ligases allows growth of Escherichia coli strains lacking the LipB octanoyltransferase of lipoic acid synthesis. 2009 J. Bacteriol. pmid:19684135
Rock CO Opening a new path to lipoic acid. 2009 J. Bacteriol. pmid:19734307
PAYNE WJ and BANNISTER ER EFFECTS OF SODIUM CAPRYLATE ON CANDIDA ALBICANS. II. INFLUENCE OF VARIOUS CONCENTRATIONS ON BIOCHEMICAL CHANGES. 1963 J. Bacteriol. pmid:14066436
ADAMS JN et al. EFFECTS OF SODIUM CAPRYLATE ON CANDIDA ALBICANS. I. INFLUENCE OF CONCENTRATION ON ULTRASTRUCTURE. 1963 J. Bacteriol. pmid:14066435
Fredrickson J et al. The impact of the protein stabilizer octanoic acid on embryonic development and fetal growth in a murine model. 2015 J. Assist. Reprod. Genet. pmid:26342329
Walton ME et al. Octanoate oxidation measured by 13C-NMR spectroscopy in rat skeletal muscle, heart, and liver. 2003 J. Appl. Physiol. pmid:12882988
Montessuit C et al. Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer. 2000 J. Appl. Physiol. pmid:10904042
Thorburn MS et al. Attenuated gastric distress but no benefit to performance with adaptation to octanoate-rich esterified oils in well-trained male cyclists. 2006 J. Appl. Physiol. pmid:16840580
Kim SA and Rhee MS Use of caprylic acid to control pathogens (Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium) in apple juice at mild heat temperature. 2015 J. Appl. Microbiol. pmid:26257401
Bohlscheid JC et al. The influence of nitrogen and biotin interactions on the performance of Saccharomyces in alcoholic fermentations. 2007 J. Appl. Microbiol. pmid:17241344
Cortezzo DE et al. Analysis of the action of compounds that inhibit the germination of spores of Bacillus species. 2004 J. Appl. Microbiol. pmid:15012811
Costello PJ et al. Synthesis of fruity ethyl esters by acyl coenzyme A: alcohol acyltransferase and reverse esterase activities in Oenococcus oeni and Lactobacillus plantarum. 2013 J. Appl. Microbiol. pmid:23216623
Satoh Y et al. Isolation of a thermotolerant bacterium producing medium-chain-length polyhydroxyalkanoate. 2011 J. Appl. Microbiol. pmid:21714837
Grant AC et al. Optimization of in vitro conditions for bovine subcutaneous and intramuscular preadipocyte differentiation. 2008 J. Anim. Sci. pmid:17911240
Theil PK et al. Effects of gestation and transition diets, piglet birth weight, and fasting time on depletion of glycogen pools in liver and 3 muscles of newborn piglets. 2011 J. Anim. Sci. pmid:21278105
Lengi AJ and Corl BA Factors influencing the differentiation of bovine preadipocytes in vitro. 2010 J. Anim. Sci. pmid:20154153
Wieland TM et al. Utilization of medium-chain triglycerides by neonatal pigs: effects of emulsification and dose delivered. 1993 J. Anim. Sci. pmid:8349513
Lepine AJ et al. Effect of colostrum intake on hepatic gluconeogenesis and fatty acid oxidation in the neonatal pig. 1991 J. Anim. Sci. pmid:2066305
Chiang SH et al. Limits of medium-chain and long-chain triacylglycerol utilization by neonatal piglets. 1990 J. Anim. Sci. pmid:2384363
Liu L et al. Quantifying protein-fatty acid interactions using electrospray ionization mass spectrometry. 2011 J. Am. Soc. Mass Spectrom. pmid:21472590
Guan Z Identification and localization of the fatty acid modification in ghrelin by electron capture dissociation. 2002 J. Am. Soc. Mass Spectrom. pmid:12484464
Bender JL et al. Site-isolated luminescent europium complexes with polyester macroligands: metal-centered heteroarm stars and nanoscale assemblies with labile block junctions. 2002 J. Am. Chem. Soc. pmid:12121083
Nicholson CE et al. Unique crystal morphologies of glycine grown from octanoic acid-in-water emulsions. 2006 J. Am. Chem. Soc. pmid:16771468
Tao F and Bernasek SL Two-dimensional self-assembly of a two-component molecular system: formation of an ordered and homogeneous molecular mesh. 2005 J. Am. Chem. Soc. pmid:16159239
Varshney M et al. Pluronic microemulsions as nanoreservoirs for extraction of bupivacaine from normal saline. 2004 J. Am. Chem. Soc. pmid:15099093
Tahara K et al. Two-dimensional porous molecular networks of dehydrobenzo[12]annulene derivatives via alkyl chain interdigitation. 2006 J. Am. Chem. Soc. pmid:17177410
Puigmartí-Luis J et al. Noncovalent control for bottom-up assembly of functional supramolecular wires. 2006 J. Am. Chem. Soc. pmid:17002326
Lu J et al. A molecular mechanism for modulating plasma Zn speciation by fatty acids. 2012 J. Am. Chem. Soc. pmid:22239162
Lucas LH et al. Epitope mapping and competitive binding of HSA drug site II ligands by NMR diffusion measurements. 2004 J. Am. Chem. Soc. pmid:15506793
Fomuso LB et al. Metal-catalyzed oxidation of a structured lipid model emulsion. 2002 J. Agric. Food Chem. pmid:12428969
Henry GE et al. Antioxidant and cyclooxygenase activities of fatty acids found in food. 2002 J. Agric. Food Chem. pmid:11929276
Xu X et al. Synthesis of structured triacylglycerols by lipase-catalyzed acidolysis in a packed bed bioreactor. 2000 J. Agric. Food Chem. pmid:10637041
Coppa M et al. Effect of a hay-based diet or different upland grazing systems on milk volatile compounds. 2011 J. Agric. Food Chem. pmid:21434695
Lee KT et al. Nutritional effects of enzymatically modified soybean oil with caprylic acid versus physical mixture analogue in obese Zucker rats. 2000 J. Agric. Food Chem. pmid:11087541
Vikbjerg AF et al. Monitoring of monooctanoylphosphatidylcholine synthesis by enzymatic acidolysis between soybean phosphatidylcholine and caprylic acid by thin-layer chromatography with a flame ionization detector. 2005 J. Agric. Food Chem. pmid:15884820
Kim BH and Akoh CC Chemical and physical properties of butterfat-vegetable oil blend spread prepared with enzymatically transesterified canola oil and caprylic acid. 2005 J. Agric. Food Chem. pmid:15941341
Lee JE et al. Characterization of fermentative behaviors of lactic acid bacteria in grape wines through 1H NMR- and GC-based metabolic profiling. 2009 J. Agric. Food Chem. pmid:19441818
Gandhi NN and Mukherjee KD Specificity of papaya lipase in esterification with respect to the chemical structure of substrates. 2000 J. Agric. Food Chem. pmid:10691676
Vikbjerg AF et al. Comparative evaluation of the emulsifying properties of phosphatidylcholine after enzymatic acyl modification. 2006 J. Agric. Food Chem. pmid:16637690
Lumor SE and Akoh CC Esterification and hydrolytic activities of Candida rugosa lipase isoform 1 (LIP1) immobilized on celite 545, duolite A7, and sephadex G-25. 2008 J. Agric. Food Chem. pmid:18850711
Kim BH and Akoh CC Characteristics of structured lipid prepared by lipase-catalyzed acidolysis of roasted sesame oil and caprylic acid in a bench-scale continuous packed bed reactor. 2006 J. Agric. Food Chem. pmid:16819927
Cardoso DR et al. Comparison between cachaça and rum using pattern recognition methods. 2004 J. Agric. Food Chem. pmid:15161210
Margolles Cabrales I et al. Influence of Fatty acids on foaming properties of cider. 2003 J. Agric. Food Chem. pmid:14518961
Osborn-Barnes HT and Akoh CC Copper-catalyzed oxidation of a structured lipid-based emulsion containing alpha-tocopherol and citric acid: influence of pH and NaCl. 2003 J. Agric. Food Chem. pmid:14582985
Osborn-Barnes HT and Akoh CC Effects of alpha-tocopherol, beta-carotene, and soy isoflavones on lipid oxidation of structured lipid-based emulsions. 2003 J. Agric. Food Chem. pmid:14582986
Kim BH and Akoh CC Modeling of lipase-catalyzed acidolysis of sesame oil and caprylic Acid by response surface methodology: optimization of reaction conditions by considering both acyl incorporation and migration. 2005 J. Agric. Food Chem. pmid:16190667
Alissandrakis E et al. Comparison of the volatile composition in thyme honeys from several origins in Greece. 2007 J. Agric. Food Chem. pmid:17824662
Karagül-Yüceer Y et al. Aroma-active components of nonfat dry milk. 2001 J. Agric. Food Chem. pmid:11409991
Medina I et al. Effect of lipophilization of hydroxytyrosol on its antioxidant activity in fish oils and fish oil-in-water emulsions. 2009 J. Agric. Food Chem. pmid:19807127
Xu Y et al. Characterization of aroma compounds in apple cider using solvent-assisted flavor evaporation and headspace solid-phase microextraction. 2007 J. Agric. Food Chem. pmid:17355142
Jennings BH and Akoh CC Characterization of a rice bran oil structured lipid. 2009 J. Agric. Food Chem. pmid:19284800
Patel S and Shibamoto T Effect of different strains of Saccharomyces cerevisiae on production of volatiles in Napa Gamay wine and Petite Sirah wine. 2002 J. Agric. Food Chem. pmid:12236692
Sellappan S and Akoh CC Synthesis of structured lipids by transesterification of trilinolein catalyzed by Lipozyme IM60. 2001 J. Agric. Food Chem. pmid:11308369
Coscione AR and Artz WE Vegetable oil stability at elevated temperatures in the presence of ferric stearate and ferrous octanoate. 2005 J. Agric. Food Chem. pmid:15769140
Choi HS Aroma evaluation of an aquatic herb, Changpo (Acorus calamus Var. angustatus Bess), by AEDA and SPME. 2004 J. Agric. Food Chem. pmid:15612802
Vallejo-Cordoba B et al. Tequila volatile characterization and ethyl ester determination by solid phase microextraction gas chromatography/mass spectrometry analysis. 2004 J. Agric. Food Chem. pmid:15373393