octanoic acid

octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.

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Introduction

To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with octanoic acid?

octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with octanoic acid

MeSH term MeSH ID Detail
Insulin Resistance D007333 99 associated lipids
Jaundice, Neonatal D007567 7 associated lipids
Kidney Diseases D007674 29 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Malocclusion D008310 3 associated lipids
Memory Disorders D008569 33 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Obesity D009765 29 associated lipids
Per page 10 20 50 100 | Total 73

PubChem Associated disorders and diseases

What pathways are associated with octanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with octanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with octanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with octanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with octanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with octanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with octanoic acid

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Authors Title Published Journal PubMed Link
Sanaka M et al. Is the time for absorption and oxidation of 13c-octanoate really negligible in the gastric emptying breath test? 2006 Dig. Dis. Sci. pmid:17120146
Punkkinen J et al. Measuring gastric emptying: comparison of 13C-octanoic acid breath test and scintigraphy. 2006 Dig. Dis. Sci. pmid:16534667
Bromer MQ et al. Simultaneous measurement of gastric emptying with a simple muffin meal using [13C]octanoate breath test and scintigraphy in normal subjects and patients with dyspeptic symptoms. 2002 Dig. Dis. Sci. pmid:12141833
Schmidt-Wilcke HA et al. Effect of fatty acids on the stimulated gastric secretion in man. 1975 Digestion pmid:1201821
Toepfer M et al. Noninvasive (13)C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis. 1999 Nov-Dec Digestion pmid:10545728
Minderhoud IM et al. Gastric emptying of a solid meal starts during meal ingestion: combined study using 13C-octanoic acid breath test and Doppler ultrasonography. Absence of a lag phase in 13C-octanoic acid breath test. 2004 Digestion pmid:15297778
Ohkubo Y et al. Presence and properties of acyl coenzyme A synthetase for medium-chain fatty acids in rat intestinal mucosa. 1992 Digestion pmid:1386328
Bluck LJ et al. Bayesian hierarchical methods to interpret the (13)C-octanoic acid breath test for gastric emptying. 2011 Digestion pmid:21042021
Chang P et al. The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. 2012 Dis Model Mech pmid:21876211
Librán-Pérez M et al. Effects of insulin treatment on the response to oleate and octanoate of food intake and fatty acid-sensing systems in rainbow trout. 2015 Domest. Anim. Endocrinol. pmid:26226227
Mohanty AK et al. Etoposide-loaded biodegradable amphiphilic methoxy (poly ethylene glycol) and poly (epsilon caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy. 2010 Drug Deliv pmid:20370380
Choi A et al. Pharmacokinetic characteristics of formulated alendronate transdermal delivery systems in rats and humans. 2010 Drug Deliv pmid:20214414
Matsumoto Y et al. Rectal absorption enhancement of gentamicin in rabbits from hollow type suppositories by sodium salicylate or sodium caprylate. 1989 Drug Des. Deliv. pmid:2490276
Ryu JK and Yoo SD Preparation and evaluation of bicyclol microemulsions for enhanced oral bioavailability. 2012 Drug Dev Ind Pharm pmid:22283588
Karakatsani M et al. The effect of permeation enhancers on the viscosity and the release profile of transdermal hydroxypropyl methylcellulose gel formulations containing diltiazem HCl. 2010 Drug Dev Ind Pharm pmid:20545504
Chen X et al. Preparation and characterization of PEG-modified polyurethane pressure-sensitive adhesives for transdermal drug delivery. 2009 Drug Dev Ind Pharm pmid:19514985
Jung SY et al. Formulation and evaluation of ubidecarenone transdermal delivery systems. 2009 Drug Dev Ind Pharm pmid:19365779
Hossain MA et al. Effect of vehicle systems, pH and enhancers on the permeation of highly lipophilic aripiprazole from Carbopol 971P gel systems across human cadaver skin. 2012 Drug Dev Ind Pharm pmid:22067044
Cho CW et al. Development of the ambroxol gels for enhanced transdermal delivery. 2008 Drug Dev Ind Pharm pmid:18363149
Whang J and Gwak H Effects of amines on percutaneous absorption of alendronate. 2011 Drug Dev Ind Pharm pmid:21126206
Choi JS and Shin SC Preparation and evaluation of pranoprofen gel for percutaneous administration. 2007 Drug Dev Ind Pharm pmid:17192247
Gwak HS et al. Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers. 2004 Drug Dev Ind Pharm pmid:15089053
Cho YA and Gwak HS Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers. 2004 Drug Dev Ind Pharm pmid:15285328
Morris AP et al. Synthesis of haloperidol prodrugs and their hydrolysis by porcine liver esterase. 2008 Drug Metab Lett pmid:19356105
Bjorge SM and Baillie TA Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations. 1991 Jul-Aug Drug Metab. Dispos. pmid:1680661
Pfadenhauer EH et al. Identification of the metabolites of erythro-9-(2-hydroxy-3-nonyl)hypoxanthine from laboratory animals. 1984 May-Jun Drug Metab. Dispos. pmid:6145553
Visarius TM et al. Thiodiglycolic acid is excreted by humans receiving ifosfamide and inhibits mitochondrial function in rats. 1998 Drug Metab. Dispos. pmid:9492379
Kuypers DR et al. The rate of gastric emptying determines the timing but not the extent of oral tacrolimus absorption: simultaneous measurement of drug exposure and gastric emptying by carbon-14-octanoic acid breath test in stable renal allograft recipients. 2004 Drug Metab. Dispos. pmid:15383495
Li C et al. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. 2003 Drug Metab. Dispos. pmid:12756204
Yamamoto A et al. Enhanced permeability of phenylalanyl-glycine (Phe-Gly) across the intestinal membranes by chemical modification with various fatty acids. 2003 Drug Metab. Pharmacokinet. pmid:15618716
Smits NG et al. Development of a flow cytometric immunoassay for recombinant bovine somatotropin-induced antibodies in serum of dairy cows. 2012 Drug Test Anal pmid:21964757
Schenk J et al. [Irrigation treatment of concrements in the common bile duct with octanoate (Capmul 8210) (author's transl)]. 1980 Dtsch. Med. Wochenschr. pmid:7408673
Clifton JG et al. Proteomic characterization of plasma-derived clotting factor VIII-von Willebrand factor concentrates. 2009 Electrophoresis pmid:19768705
Crawford MJ et al. Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast. 2006 EMBO J. pmid:16778769
Lim CT et al. The expression of ghrelin O-acyltransferase (GOAT) in human tissues. 2011 Endocr. J. pmid:21646729
Phillips PS et al. Myotoxic reactions to lipid-lowering therapy are associated with altered oxidation of fatty acids. 2009 Endocrine pmid:19051066
De Vriese C et al. Ghrelin interacts with human plasma lipoproteins. 2007 Endocrinology pmid:17289852
Satou M et al. Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium. 2010 Endocrinology pmid:20685872
Silavin SL et al. Reevaluation of the effects of cytochalasins on steroidogenesis: studies on hamster granulosa cells. 1984 Endocrinology pmid:6592092
Nishi Y et al. Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. 2005 Endocrinology pmid:15677766
Grill V Nutrient-induced priming of insulin and glucagon secretion. Effects of alpha-ketoisocaproic acid. 1982 Endocrinology pmid:6173206
Seydoux J et al. Brown adipose tissue metabolism in streptozotocin-diabetic rats. 1983 Endocrinology pmid:6223804
Assimacopoulos-Jeannet F et al. Alterations of brown adipose tissue in genetically obese (ob/ob) mice. II. Studies of beta-adrenergic receptors and fatty acid degradation. 1982 Endocrinology pmid:6276135
Ferris CF et al. Alcohol and fatty acid stimulation of neurotensin release from rat small intestine. 1985 Endocrinology pmid:3971900
Grill V et al. Multiple abnormalities in insulin responses to nonglucose nutrients in neonatally streptozotocin diabetic rats. 1991 Endocrinology pmid:1706269
Kaiya H et al. Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout. 2003 Endocrinology pmid:12970156
Hamel FG et al. In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters. 2003 Endocrinology pmid:12746301
Schenk J et al. Treatment of choledocholithiasis using the transpapillary perfusion technique. 1980 Endoscopy pmid:7428727
Genser B et al. Within- and between-group regression for improving the robustness of causal claims in cross-sectional analysis. 2015 Environ Health pmid:26159541
Obeso JI et al. The loss of function of PhaC1 is a survival mechanism that counteracts the stress caused by the overproduction of poly-3-hydroxyalkanoates in Pseudomonas putidaΔfadBA. 2015 Environ. Microbiol. pmid:25627209