| MeSH term | MeSH ID | Detail |
|---|---|---|
| Memory Disorders | D008569 | 33 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Starvation | D013217 | 47 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
octanoic acid
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
Cross Reference
Introduction
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with octanoic acid?
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with octanoic acid
PubChem Associated disorders and diseases
What pathways are associated with octanoic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with octanoic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with octanoic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with octanoic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with octanoic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with octanoic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with octanoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shipp DA et al. | Development of fatty acid oxidation in neonatal guinea-pig liver. | 1982 | Biochem. J. | pmid:7165728 |
| Ferré P et al. | Relationship between ketogenesis and gluconeogenesis in isolated hepatocytes from newborn rats. | 1981 | Biochem. J. | pmid:7340842 |
| Zammit VA | The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-L-carnitine and octanoate by isolated liver mitochondria. | 1980 | Biochem. J. | pmid:7470052 |
| Petcu LG and Plaut GW | NADP-specific isocitrate dehydrogenase in regulation of urea synthesis in rat hepatocytes. | 1980 | Biochem. J. | pmid:7470071 |
| Kasumov T et al. | Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. | 2005 | Biochem. J. | pmid:15773815 |
| Buse MG et al. | Regulation of branched-chain amino acid oxidation in isolated muscles, nerves and aortas of rats. | 1975 | Biochem. J. | pmid:1200982 |
| Blumenthal SA | Inhibition of gluconeogenesis in rat liver by lipoic acid. Evidence for more than one site of action. | 1984 | Biochem. J. | pmid:6430273 |
| Bellringer ME et al. | Sodium valproate inhibits the movement of secretory vesicles in rat hepatocytes. | 1988 | Biochem. J. | pmid:3124828 |
| Berne C | The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies. | 1975 | Biochem. J. | pmid:776173 |
| Guo W et al. | Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. | 2000 | Biochem. J. | pmid:10880345 |
| Taylor WM et al. | The stimulation of tricarboxylic acid-cycle flux by alpha-adrenergic agonists in perfused rat liver. | 1986 | Biochem. J. | pmid:3082324 |
| Ferré P et al. | Development and regulation of ketogenesis in hepatocytes isolated from newborn rats. | 1983 | Biochem. J. | pmid:6626164 |
| Clouet P et al. | Study of some factors controlling fatty acid oxidation in liver mitochondria of obese Zucker rats. | 1986 | Biochem. J. | pmid:3800970 |
| Bauché F et al. | Inhibition in vitro of acyl-CoA dehydrogenases by 2-mercaptoacetate in rat liver mitochondria. | 1983 | Biochem. J. | pmid:6661181 |
| Pégorier JP et al. | Metabolic fate of non-esterified fatty acids in isolated hepatocytes from newborn and young pigs. Evidence for a limited capacity for oxidation and increased capacity for esterification. | 1983 | Biochem. J. | pmid:6870859 |
| Foxworthy PS and Eacho PI | Inhibition of hepatic fatty acid oxidation at carnitine palmitoyltransferase I by the peroxisome proliferator 2-hydroxy-3-propyl-4-[6-(tetrazol-5-yl) hexyloxy]acetophenone. | 1988 | Biochem. J. | pmid:3415664 |
| Rofe AM and Williamson DH | Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia. | 1983 | Biochem. J. | pmid:6135420 |
| Wilson MB | Control of phosphoenolpyruvate synthesis in guinea-pig mitochondria. | 1973 | Biochem. J. | pmid:4724589 |
| Boveris A and Chance B | The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. | 1973 | Biochem. J. | pmid:4749271 |
| Watford M et al. | The regulation of glutamine and ketone-body metabolism in the small intestine of the long-term (40-day) streptozotocin-diabetic rat. | 1987 | Biochem. J. | pmid:3473986 |
| Leclercq P et al. | Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats. | 1997 | Biochem. J. | pmid:9230136 |
| Halestrap AP | The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+. | 1987 | Biochem. J. | pmid:3663110 |
| Gavva SR et al. | A 13C isotopomer n.m.r. method for monitoring incomplete beta-oxidation of fatty acids in intact tissue. | 1994 | Biochem. J. | pmid:7980454 |
| Tosh D et al. | Glucagon regulation of gluconeogenesis and ketogenesis in periportal and perivenous rat hepatocytes. Heterogeneity of hormone action and of the mitochondrial redox state. | 1988 | Biochem. J. | pmid:3223900 |
| Dieuaide M et al. | Effects of glucose starvation on the oxidation of fatty acids by maize root tip mitochondria and peroxisomes: evidence for mitochondrial fatty acid beta-oxidation and acyl-CoA dehydrogenase activity in a higher plant. | 1993 | Biochem. J. | pmid:8250843 |
| Lin X et al. | Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets. | 1996 | Biochem. J. | pmid:8761477 |
| Soboll S et al. | Effect of long-chain fatty acyl-CoA on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell. | 1984 | Biochem. J. | pmid:6743276 |
| Ledden DJ et al. | Characterization of fragments of human albumin purified by Cibacron blue F3GA affinity chromatography. | 1982 | Biochem. J. | pmid:6814424 |
| Oshino N et al. | The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver. | 1975 | Biochem. J. | pmid:167718 |
| Iwahashi H et al. | Cytochrome c catalyses the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. | 2002 | Biochem. J. | pmid:11742529 |
| Marchington DR et al. | Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat hepatocytes. | 1989 | Biochem. J. | pmid:2539088 |
| Berger M et al. | Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. | 1976 | Biochem. J. | pmid:136249 |
| Reed WD et al. | The effects of insulin and glucagon on ketone-body turnover. | 1984 | Biochem. J. | pmid:6383348 |
| Kragh-Hansen U | Octanoate binding to the indole- and benzodiazepine-binding region of human serum albumin. | 1991 | Biochem. J. | pmid:1996962 |
| Palabost-Charles L | Selection at the alpha-Gpdh locus in experimental populations of Drosophila melanogaster. | 1982 | Biochem. Genet. | pmid:6810873 |
| Bijlsma R | Polymorphism at the G6pd and 6Pgd loci in Drosophila melanogaster. IV. Genetic factors modifying enzyme activity. | 1980 | Biochem. Genet. | pmid:6781470 |
| Tsai CS and al-Kassim LS | Multifunctional activities of pickerel liver alcohol dehydrogenase. | 1993 Sep-Oct | Biochem. Cell Biol. | pmid:8192894 |
| Tenreiro S et al. | AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11922628 |
| Torres-Guzmán R et al. | Substrate specificity of penicillin acylase from Streptomyces lavendulae. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11855830 |
| Nakajima I et al. | Growth arrest by octanoate is required for porcine preadipocyte differentiation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12963048 |
| Yamato M et al. | Exogenous administration of octanoic acid accelerates octanoylated ghrelin production in the proventriculus of neonatal chicks. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15953586 |
| Ohgusu H et al. | Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19501572 |
| Jones PM et al. | Medium-chain fatty acids undergo elongation before beta-oxidation in fibroblasts. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16750167 |
| Bjorge SM and Baillie TA | Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933498 |
| Maddaiah VT | Ammonium inhibition of fatty acid oxidation in rat liver mitochondria. A possible cause of fatty liver in Reye's syndrome and urea cycle defects. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977937 |
| May JM et al. | Cellular disulfide-reducing capacity: an integrated measure of cell redox capacity. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16650819 |
| Shanado Y et al. | Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15555596 |
| Matsumoto M et al. | Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11549267 |
| Suzuki S et al. | Characterization of actions of octanoate on porcine preadipocytes and adipocytes differentiated in vitro. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23376076 |
| Oettl K et al. | An apparent decrease in cholesterol biosynthesis in peroxisomal-defective Chinese hamster ovary cells is related to impaired mitochondrial oxidation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12767923 |