MeSH term | MeSH ID | Detail |
---|---|---|
Gallstones | D042882 | 3 associated lipids |
Severe Acute Respiratory Syndrome | D045169 | 1 associated lipids |
Drug-Related Side Effects and Adverse Reactions | D064420 | 3 associated lipids |
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Derr RF and Draves K | Methanethiol metabolism in the rat. | 1983 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6407074 |
Bijlsma R and Kerver JW | The effect of DDT on the polymorphism at the G6pd and Pgd loci in Drosophila melanogaster. | 1983 | Genetics | pmid:6404694 |
Reed WD et al. | The effects of insulin and glucagon on ketone-body turnover. | 1984 | Biochem. J. | pmid:6383348 |
Hansford RG | Lipid oxidation by heart mitochondria from young adult and senescent rats. | 1978 | Biochem. J. | pmid:637843 |
Kochel PJ et al. | Effects of noncarbohydrate substrates on protein synthesis in hearts from fed and fasted rats. | 1984 | J. Mol. Cell. Cardiol. | pmid:6374161 |
Bielefeld DR et al. | Altered sensitivity of chronic diabetic rat heart to calcium. | 1983 | Am. J. Physiol. | pmid:6362427 |
Zieve L et al. | Toxicity of a fatty acid and ammonia: interactions with hypoglycemia and Krebs cycle inhibition. | 1983 | J. Lab. Clin. Med. | pmid:6343534 |
Demol P and Sarles H | Action of fatty acids on the exocrine pancreatic secretion of the conscious rat: further evidence for a protein pancreatic inhibitory factor. | 1978 | J. Physiol. (Lond.) | pmid:633115 |
Salesse R and Garnier J | Adenylate cyclase and membrane fluidity. The repressor hypothesis. | 1984 | Mol. Cell. Biochem. | pmid:6323963 |
Nomura T et al. | Effects of octanoate and acetate upon hepatic glycolysis and lipogenesis. | 1983 | Biochim. Biophys. Acta | pmid:6317044 |
Skrede S et al. | Coenzyme A in dog kidneys during hypothermic perfusion. | 1983 | Cryobiology | pmid:6309478 |
Geppert EF and Elstein KH | Short-term regulation of fatty acid synthesis in isolated alveolar type II cells from adult rat lung. Effects of free fatty acids and hormones. | 1983 | Exp. Lung Res. | pmid:6305647 |
Nosek TM and Crosland MB | Calcium-dependent proteolysis in neural tissue is activated at physiologic intracellular Ca2+ levels and inhibited by some anticonvulsants. | 1983 | J. Neurobiol. | pmid:6298363 |
Salesse R et al. | Modulation of adenylate cyclase activity by the physical state of pigeon erythrocyte membrane. 1. Parallel drug-induced changes in the bilayer fluidity and adenylate cyclase activity. | 1982 | Biochemistry | pmid:6282308 |
Seydoux J et al. | Impaired metabolic response to nerve stimulation in brown adipose tissue of hypothyroid rats. | 1982 | Mol. Cell. Endocrinol. | pmid:6276252 |
Assimacopoulos-Jeannet F et al. | Alterations of brown adipose tissue in genetically obese (ob/ob) mice. II. Studies of beta-adrenergic receptors and fatty acid degradation. | 1982 | Endocrinology | pmid:6276135 |
Müller MJ et al. | Effect of thyroid state on ketogenic capacity of the isolated perfused liver of starved rats. | 1981 | Biochim. Biophys. Acta | pmid:6275888 |
Burns AH and Reddy WJ | Effect of ouabain on exogenous substrate oxidation by isolated cardiac myocytes. | 1981 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6267674 |
Kinnula VL and Hassinen I | Effect of chronic hypoxia on hepatic triacylglycerol concentration and mitochondrial fatty acid oxidizing capacity in liver and heart. | 1978 | Acta Physiol. Scand. | pmid:626089 |
Trauner DA | Regional cerebral Na+K+ ATPase activity following octanoate administration. | 1980 | Pediatr. Res. | pmid:6250122 |
Seydoux J et al. | Brown adipose tissue metabolism in streptozotocin-diabetic rats. | 1983 | Endocrinology | pmid:6223804 |
Rabinowitz JL et al. | Sources of serum [14C]-octanoate in cirrhosis of the liver and hepatic encephalopathy. | 1978 | J. Lab. Clin. Med. | pmid:621424 |
Claycomb WC et al. | Culture of the terminally differentiated ventricular cardiac muscle cell. Characterization of exogenous substrate oxidation and the adenylate cyclase system. | 1984 | FEBS Lett. | pmid:6201398 |
Guddat W and Hillger K | A heat polyethylene glycol procedure as an alternative method for plasmafractionation. | 1982 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:6187637 |
Grill V | Nutrient-induced priming of insulin and glucagon secretion. Effects of alpha-ketoisocaproic acid. | 1982 | Endocrinology | pmid:6173206 |
Lemieux G et al. | Relationship between the renal metabolism of glutamine, fatty acids and ketone bodies. | 1977 Oct 23-26 | Curr Probl Clin Biochem | pmid:616372 |
Trimble ME et al. | Fatty acid transport and metabolism in the isolated perfused rat kidney. | 1977 Oct 23-26 | Curr Probl Clin Biochem | pmid:616371 |
Sánchez-Serrano D et al. | Enhancement of ouabain arrhythmias by fatty acids. | 1980 | J. Cardiovasc. Pharmacol. | pmid:6156330 |
Pfadenhauer EH et al. | Identification of the metabolites of erythro-9-(2-hydroxy-3-nonyl)hypoxanthine from laboratory animals. | 1984 May-Jun | Drug Metab. Dispos. | pmid:6145553 |
Rofe AM and Williamson DH | Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia. | 1983 | Biochem. J. | pmid:6135420 |
Henze K et al. | The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts. | 1981 | Biochim. Biophys. Acta | pmid:6118180 |
Baraldi M et al. | Toxins in hepatic encephalopathy: the role of the synergistic effect of ammonia, mercaptans and short chain fatty acids. | 1984 | Arch. Toxicol. Suppl. | pmid:6097201 |
Sundin U et al. | Thyroid-catecholamine interactions in isolated rat brown adipocytes. | 1984 | Metab. Clin. Exp. | pmid:6092828 |
Martin-Sanz P et al. | Long-chain fatty acids and their acyl-CoA esters cause the translocation of phosphatidate phosphohydrolase from the cytosolic to the microsomal fraction of rat liver. | 1984 | FEBS Lett. | pmid:6090213 |
Katoh K and Tsuda T | Effects of acetylcholine and short-chain fatty acids on acinar cells of the exocrine pancreas in sheep. | 1984 | J. Physiol. (Lond.) | pmid:6084059 |
Trauner DA and Huttenlocher PR | Short chain fatty acid-induced central hyperventilation in rabbits. | 1978 | Neurology | pmid:567765 |
Brodersen R and Hansen P | Bilirubin displacing effect of stabilizers added to injectable preparations of human serum albumin. | 1977 | Acta Paediatr Scand | pmid:557276 |
McGarry JD and Foster DW | The regulation of ketogenesis from octanoic acid. The role of the tricarboxylic acid cycle and fatty acid synthesis. | 1971 | J. Biol. Chem. | pmid:5543682 |
Clark SB | The uptake of oleic acid by rat small intestine: a comparison of methodologies. | 1971 | J. Lipid Res. | pmid:5542704 |
Schröder K et al. | [Energy metabolism of the rat renal cortex, as measured by incubation in various substrates]. | 1979 | Acta Biol. Med. Ger. | pmid:543370 |
Skrede S and Slaattelid O | Fatty acid metabolism during hypothermic perfusion of the isolated dog kidney. | 1979 | Scand. J. Clin. Lab. Invest. | pmid:531496 |
Abidov AA et al. | [Strophantin K action on caprylate oxidation in the myocardium]. | 1971 Sep-Oct | Farmakol Toksikol | pmid:5151251 |
Bach A et al. | Octanoate metabolism in the isolated perfused rat liver. II. Comparison with a long chain fatty acid. | 1975 | Arch. Int. Physiol. Biochim. | pmid:50825 |
Valdivia MM et al. | [Effect of octanoic acid on the insulin secretion in response to glucose in vitro (author's transl)]. | 1979 | Rev. Esp. Fisiol. | pmid:504776 |
Paquet RJ et al. | Effects of thiamine deficiency and octanoate administration, in vivo, on gluconeogenesis in rat kidney slices and on amino acid profile in rat liver. | 1972 | Proc. Soc. Exp. Biol. Med. | pmid:5039394 |
Sallee VL et al. | Determination of unidirectional uptake rates for lipids across the intestinal brush border. | 1972 | J. Lipid Res. | pmid:5016300 |
Campillo JE et al. | Effect of oleic and octanoic acids on glucose-induced insulin release in vitro. | 1979 | Diabete Metab | pmid:499632 |
Andersen JM and Dietschy JM | Absolute rates of cholesterol synthesis in extrahepatic tissues measured with 3H-labeled water and 14C-labeled substrates. | 1979 | J. Lipid Res. | pmid:490050 |
Fischer JH et al. | Free fatty acid and glucose metabolism during hypothermic perfusion of canine kidneys. | 1979 | Eur Surg Res | pmid:488147 |
Glick MR et al. | Glucose and octanoate utilization by isolated adult rat heart cells. | 1974 | Life Sci. | pmid:4829540 |