MeSH term | MeSH ID | Detail |
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Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
Asthenia | D001247 | 5 associated lipids |
Amyotrophic Lateral Sclerosis | D000690 | 11 associated lipids |
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mao LF et al. | Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid. | 1992 | J. Biol. Chem. | pmid:1737769 |
Noctor TA et al. | Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. | 1992 | J. Chromatogr. | pmid:1400761 |
Roncero C and Goodridge AG | Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. | 1992 | J. Biol. Chem. | pmid:1634532 |
Wanders RJ and Ijlst L | Fatty acid beta-oxidation in leukocytes from control subjects and medium-chain acyl-CoA dehydrogenase deficient patients. | 1992 | Biochim. Biophys. Acta | pmid:1737072 |
Kristev A et al. | Effects of the medium chain octanoic fatty acid on the contractile activity of vascular smooth muscle tissues. | 1992 | Folia Med (Plovdiv) | pmid:1364081 |
Kim CS et al. | Octanoic acid produces accumulation of monoamine acidic metabolites in the brain: interaction with organic anion transport at the choroid plexus. | 1992 | J. Neurochem. | pmid:1372345 |
Prip-Buus C et al. | Evidence for an impaired long-chain fatty acid oxidation and ketogenesis in Fao hepatoma cells. | 1992 | Eur. J. Biochem. | pmid:1356769 |
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Paul HS and Adibi SA | Mechanism of increased conversion of branched chain keto acid dehydrogenase from inactive to active form by a medium chain fatty acid (octanoate) in skeletal muscle. | 1992 | J. Biol. Chem. | pmid:1597456 |
Stace PB et al. | Cyclic AMP and free fatty acids in the longer-term regulation of pyruvate dehydrogenase kinase in rat soleus muscle. | 1992 | Biochim. Biophys. Acta | pmid:1319745 |
Ohkubo Y et al. | Presence and properties of acyl coenzyme A synthetase for medium-chain fatty acids in rat intestinal mucosa. | 1992 | Digestion | pmid:1386328 |
Boulanger Y et al. | 13C and 1H NMR study of the metabolic degradation of 4-pentenoate in different dog nephron segments. | 1992 | Magn Reson Med | pmid:1435217 |
Hu H et al. | Ethanol and oleate inhibition of alpha-ketoisovalerate and 3-hydroxyisobutyrate metabolism by isolated hepatocytes. | 1992 | Arch. Biochem. Biophys. | pmid:1444452 |
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Dawson DA | Additive incidence of developmental malformation for Xenopus embryos exposed to a mixture of ten aliphatic carboxylic acids. | 1991 | Teratology | pmid:1771595 |
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Lepine AJ et al. | Effect of colostrum intake on hepatic gluconeogenesis and fatty acid oxidation in the neonatal pig. | 1991 | J. Anim. Sci. | pmid:2066305 |
Wanders RJ et al. | Octanoate and palmitate beta-oxidation in human leukocytes: implications for the rapid diagnosis of fatty acid beta-oxidation disorders. | 1991 | J. Inherit. Metab. Dis. | pmid:1770782 |
Heales SJ et al. | Rapid diagnosis of medium-chain acyl CoA dehydrogenase deficiency by measurement of cis-4-decenoic acid in plasma. | 1991 | J. Inherit. Metab. Dis. | pmid:1779611 |
Polten BM et al. | [Comparison of protein A purification and combined octanoic acid-ammonium sulfate precipitation for the collection of rabbit immunoglobulin]. | 1991 | Zentralblatt Veterinarmedizin Reihe B | pmid:1789026 |
Sawada T et al. | Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate. | 1991 | Pharm. Res. | pmid:1798671 |
Favre-Bulle O et al. | Bioconversion of n-octane to octanoic acid by a recombinant Escherichia coli cultured in a two-liquid phase bioreactor. | 1991 | Biotechnology (N.Y.) | pmid:1367010 |
Grill V et al. | Multiple abnormalities in insulin responses to nonglucose nutrients in neonatally streptozotocin diabetic rats. | 1991 | Endocrinology | pmid:1706269 |
Viegas CA and Sá-Correia I | Activation of plasma membrane ATPase of Saccharomyces cerevisiae by octanoic acid. | 1991 | J. Gen. Microbiol. | pmid:1827836 |
Bhuiyan AK and Pande SV | One-step facile synthesis of radioactive acyl-CoA and acylcarnitines using rat liver outer mitochondrial membrane as the enzyme source. | 1991 | Biochem. Soc. Trans. | pmid:1889559 |
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Baum G et al. | Clarification of ascites fluid. | 1991 | BioTechniques | pmid:1651092 |
Kihlberg T et al. | Multiple isotopically labeled fatty acids. 1-11C-2,2',3,3'-tetradeutero palmitic and octanoic acid. | 1991 | Acta Radiol Suppl | pmid:1666733 |
Waldenström A et al. | Myocardial disposition of [1-11C]palmitic acid, 2,2',3,3'-tetradeuteropalmitic acid and octanoic acid in the pig. | 1991 | Acta Radiol Suppl | pmid:1666752 |
Kragh-Hansen U | Octanoate binding to the indole- and benzodiazepine-binding region of human serum albumin. | 1991 | Biochem. J. | pmid:1996962 |
Dombrowski GJ and Swiatek KR | Lactate genesis by rat liver and muscle during development. | 1991 | Pediatr. Res. | pmid:1956716 |
Lundblad JL and Seng RL | Inactivation of lipid-enveloped viruses in proteins by caprylate. | 1991 | Vox Sang. | pmid:2031341 |
Ohtsuka Y and Griffith OW | L-carnitine protection in ammonia intoxication. Effect of aminocarnitine on carnitine-dependent metabolism and acute ammonia toxicity. | 1991 | Biochem. Pharmacol. | pmid:2039546 |
Bohnensack R and Fritz S | Stimulation of alanine metabolism by ammonia in the perfused rat liver. Quantitative analysis by means of a mathematical model. | 1991 | Biochim. Biophys. Acta | pmid:2009283 |
Sakamoto A et al. | [A clinical evaluation of reconstruction methods after pancreatoduodenectomy from a view of fat digestion and absorption]. | 1991 | Nihon Geka Gakkai Zasshi | pmid:2014027 |
Pochapsky SS et al. | Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents. | 1990 Jul-Aug | Bioconjug. Chem. | pmid:2096916 |
Kim CS et al. | L-Carnitine prevents mitochondrial damage induced by octanoic acid in the rat choroid plexus. | 1990 | Brain Res. | pmid:1964833 |
Nobes CD et al. | The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes. | 1990 | J. Biol. Chem. | pmid:2376580 |
Perosa F et al. | Purification of human immunoglobulins by sequential precipitation with caprylic acid and ammonium sulphate. | 1990 | J. Immunol. Methods | pmid:2324507 |
Chiang SH et al. | Limits of medium-chain and long-chain triacylglycerol utilization by neonatal piglets. | 1990 | J. Anim. Sci. | pmid:2384363 |
Morton DH and Kelley RI | Diagnosis of medium-chain acyl-coenzyme A dehydrogenase deficiency in the neonatal period by measurement of medium-chain fatty acids in plasma and filter paper blood samples. | 1990 | J. Pediatr. | pmid:2391601 |
González-Manchón C et al. | Ca2(+)-fatty acid interaction in the control of hepatic gluconeogenesis. | 1990 | Biochim. Biophys. Acta | pmid:2310772 |