MeSH term | MeSH ID | Detail |
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Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
Asthenia | D001247 | 5 associated lipids |
Amyotrophic Lateral Sclerosis | D000690 | 11 associated lipids |
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wu G and Thompson JR | Effect of pyruvate, octanoate and glucose on leucine degradation in skeletal muscle from fed and fasted chicks. | 1988 | Int. J. Biochem. | pmid:3371527 |
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Foxworthy PS and Eacho PI | Inhibition of hepatic fatty acid oxidation at carnitine palmitoyltransferase I by the peroxisome proliferator 2-hydroxy-3-propyl-4-[6-(tetrazol-5-yl) hexyloxy]acetophenone. | 1988 | Biochem. J. | pmid:3415664 |
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Jenkins DL and Griffith OW | Antiketogenic and hypoglycemic effects of aminocarnitine and acylaminocarnitines. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3455765 |
Watford M et al. | The regulation of glutamine and ketone-body metabolism in the small intestine of the long-term (40-day) streptozotocin-diabetic rat. | 1987 | Biochem. J. | pmid:3473986 |
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Reik LM et al. | A simple, non-chromatographic purification procedure for monoclonal antibodies. Isolation of monoclonal antibodies against cytochrome P450 isozymes. | 1987 | J. Immunol. Methods | pmid:3598193 |
Cistola DP et al. | Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. I. The filling of individual fatty acid binding sites. | 1987 | J. Biol. Chem. | pmid:3611099 |
Cistola DP et al. | Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. II. Electrostatic interactions in individual fatty acid binding sites. | 1987 | J. Biol. Chem. | pmid:3611100 |
Halestrap AP | The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+. | 1987 | Biochem. J. | pmid:3663110 |
Allen PC | The effect of Eimeria acervulina infection on hearts of young broiler chicks. | 1987 Jul-Sep | Avian Dis. | pmid:3675428 |
Cole SG et al. | Cholesteryl octanoate breath test. Preliminary studies on a new noninvasive test of human pancreatic exocrine function. | 1987 | Gastroenterology | pmid:3678753 |
el-Aleem SA and Schulz H | Evaluation of inhibitors of fatty acid oxidation in rat myocytes. | 1987 | Biochem. Pharmacol. | pmid:3689454 |
Yoshioka M et al. | Malabsorption of long-chain fatty acid in cholera toxin-induced secretory diarrhea. | 1986 | Dig. Dis. Sci. | pmid:3698768 |
Fatania HR et al. | Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n-octanoate. | 1986 | Biochem. J. | pmid:3707545 |
Letko G and Halangk W | Effect of improved hydrogen supply on energy state, ureogenesis and gluconeogenesis in isolated hepatocytes. | 1986 | Biomed. Biochim. Acta | pmid:3707550 |
Okita M et al. | Plasma level of branched chain alpha-amino acids following its alpha-keto acid administration to rats. | 1986 | J. Nutr. Sci. Vitaminol. | pmid:3712111 |
Matsumura T et al. | O2 uptake in periportal and pericentral regions of liver lobule in perfused liver. | 1986 | Am. J. Physiol. | pmid:3717341 |
Amendt BA and Rhead WJ | The multiple acyl-coenzyme A dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria. Mitochondrial fatty acid oxidation, acyl-coenzyme A dehydrogenase, and electron transfer flavoprotein activities in fibroblasts. | 1986 | J. Clin. Invest. | pmid:3722376 |
Beuers U et al. | Control of ketogenesis in the perfused rat liver by the sympathetic innervation. | 1986 | Eur. J. Biochem. | pmid:3732268 |
Spector R | Development and characterization of pantothenic acid transport in brain. | 1986 | J. Neurochem. | pmid:3734794 |
Hulshoff A and Roseboom H | Determination of valproic acid (di-N-propyl acetic acid) in plasma by gas-liquid chromatography with pre-column butylation. | 1979 | Clin. Chim. Acta | pmid:373927 |
Lysiak W et al. | Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria. | 1986 | J. Biol. Chem. | pmid:3759988 |
Higaki K et al. | Effect of medium-chain glycerides (MGK) on the intestinal absorption and the hepatobiliary transport of bromthymol blue. | 1986 | J. Pharmacobio-dyn. | pmid:3761141 |
Nomura T et al. | Effects of vasopressin, angiotensin II and phenylephrine on hepatic ketogenesis and fatty acid synthesis. | 1986 | Jpn. J. Pharmacol. | pmid:3773344 |
Garner CW and Behal FJ | Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups. | 1975 | Biochemistry | pmid:38 |
Clouet P et al. | Study of some factors controlling fatty acid oxidation in liver mitochondria of obese Zucker rats. | 1986 | Biochem. J. | pmid:3800970 |
McKinney MM and Parkinson A | A simple, non-chromatographic procedure to purify immunoglobulins from serum and ascites fluid. | 1987 | J. Immunol. Methods | pmid:3805742 |
Komura S and Kurahashi K | Biosynthesis of polymyxin E by a cell-free enzyme system. IV. Acylation of enzyme-bound L-2,4-diaminobutyric acid. | 1985 | J. Biochem. | pmid:3861608 |
Trauner DA and Garrett RS | Effect of octanoate injection on rat blood-brain barrier. | 1985 Jan-Feb | Pediatr. Neurol. | pmid:3880386 |
Trauner DA and de la Torre JC | Effect of octanoate on blood-brain barrier permeability using L-dopa as a marker. | 1985 Jul-Aug | Pediatr. Neurol. | pmid:3880408 |
Trice JE and Trauner DA | Alterations in serum glucose and hepatic glycogen concentrations during octanoate administration in rabbits. | 1985 Sep-Oct | Pediatr. Neurol. | pmid:3880415 |
Beaufrere B et al. | Apparent decreased oxidation and turnover of leucine during infusion of medium-chain triglycerides. | 1985 | Am. J. Physiol. | pmid:3895976 |
Schmidt FH et al. | A new inhibitor of the long-chain fatty acid transfer across the mitochondrial membrane: 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304). | 1985 | Life Sci. | pmid:3917523 |
Eanes WF et al. | Targeted selection experiments and enzyme polymorphism: negative evidence for octanoate selection at the G6PD locus in Drosophila melanogaster. | 1985 | Genetics | pmid:3918918 |