MeSH term | MeSH ID | Detail |
---|---|---|
Drug-Related Side Effects and Adverse Reactions | D064420 | 3 associated lipids |
REM Sleep Behavior Disorder | D020187 | 1 associated lipids |
Dumping Syndrome | D004377 | 1 associated lipids |
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Roncero C and Goodridge AG | Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. | 1992 | J. Biol. Chem. | pmid:1634532 |
Wanders RJ and Ijlst L | Fatty acid beta-oxidation in leukocytes from control subjects and medium-chain acyl-CoA dehydrogenase deficient patients. | 1992 | Biochim. Biophys. Acta | pmid:1737072 |
Kristev A et al. | Effects of the medium chain octanoic fatty acid on the contractile activity of vascular smooth muscle tissues. | 1992 | Folia Med (Plovdiv) | pmid:1364081 |
Kim CS et al. | Octanoic acid produces accumulation of monoamine acidic metabolites in the brain: interaction with organic anion transport at the choroid plexus. | 1992 | J. Neurochem. | pmid:1372345 |
Prip-Buus C et al. | Evidence for an impaired long-chain fatty acid oxidation and ketogenesis in Fao hepatoma cells. | 1992 | Eur. J. Biochem. | pmid:1356769 |
Stace PB et al. | Cyclic AMP and free fatty acids in the longer-term regulation of pyruvate dehydrogenase kinase in rat soleus muscle. | 1992 | Biochim. Biophys. Acta | pmid:1319745 |
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Boulanger Y et al. | 13C and 1H NMR study of the metabolic degradation of 4-pentenoate in different dog nephron segments. | 1992 | Magn Reson Med | pmid:1435217 |
Hu H et al. | Ethanol and oleate inhibition of alpha-ketoisovalerate and 3-hydroxyisobutyrate metabolism by isolated hepatocytes. | 1992 | Arch. Biochem. Biophys. | pmid:1444452 |
Clore JN et al. | Evidence for dissociation of gluconeogenesis stimulated by non-esterified fatty acids and changes in fructose 2,6-bisphosphate in cultured rat hepatocytes. | 1992 | Biochem. J. | pmid:1445259 |
Nash RA et al. | The possibility of lidocaine ion pair absorption through excised hairless mouse skin. | 1992 | Skin Pharmacol. | pmid:1445706 |
Giron D et al. | Analysis of mono-, di- and triglycerides in pharmaceutical excipients by capillary supercritical fluid chromatography. | 1992 Oct-Dec | J Pharm Biomed Anal | pmid:1298389 |
Hennes MM et al. | Mechanism of free fatty acid effects on hepatocyte insulin receptor binding and processing. | 1993 | Obes. Res. | pmid:16353347 |
SeñarÃs RM et al. | Effects of free fatty acids on somatostatin secretion, content and mRNA levels in cortical and hypothalamic fetal rat neurones in monolayer culture. | 1993 | J. Mol. Endocrinol. | pmid:8097916 |
Alvarez CV et al. | Regulation of prothymosin alpha mRNA levels in rat pituitary tumor cells. | 1993 | Neuroendocrinology | pmid:8232763 |
Adams SH and Odle J | Plasma beta-hydroxybutyrate after octanoate challenge: attenuated ketogenic capacity in neonatal swine. | 1993 | Am. J. Physiol. | pmid:8238444 |
Massolini G et al. | Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases. | 1993 | Biochem. Pharmacol. | pmid:8216380 |
Mitkov D | The role of the octanoic fatty acid in the pathogenesis of the metabolic alkalosis in experimental liver failure. | 1993 | Folia Med (Plovdiv) | pmid:8194797 |
Hulsmann WC et al. | Imminent ischemia in normal and hypertrophic Langendorff rat hearts; effects of fatty acids and superoxide dismutase monitored by NADH surface fluorescence. | 1993 | Biochim. Biophys. Acta | pmid:8318552 |
Geelen MJ and Schmitz MG | The role of citrate in the regulation of hepatic fatty acid synthesis by insulin and glucagon. | 1993 | Horm. Metab. Res. | pmid:7903266 |
Miura S et al. | Increased proliferative response of lymphocytes from intestinal lymph during long chain fatty acid absorption. | 1993 | Immunology | pmid:8436400 |
MartÃn-Requero A et al. | Reciprocal changes in gluconeogenesis and ureagenesis induced by fatty acid oxidation. | 1993 | Metab. Clin. Exp. | pmid:8246772 |
Grolier P and Elcombe CR | In vitro inhibition of carnitine acyltransferase activity in mitochondria from rat and mouse liver by a diethylhexylphthalate metabolite. | 1993 | Biochem. Pharmacol. | pmid:8452557 |
Wieland TM et al. | Utilization of medium-chain triglycerides by neonatal pigs: effects of emulsification and dose delivered. | 1993 | J. Anim. Sci. | pmid:8349513 |
Hoffmann GF et al. | Physiology and pathophysiology of organic acids in cerebrospinal fluid. | 1993 | J. Inherit. Metab. Dis. | pmid:8412012 |
Dieuaide M et al. | Effects of glucose starvation on the oxidation of fatty acids by maize root tip mitochondria and peroxisomes: evidence for mitochondrial fatty acid beta-oxidation and acyl-CoA dehydrogenase activity in a higher plant. | 1993 | Biochem. J. | pmid:8250843 |
Reed KE and Cronan JE | Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes. | 1993 | J. Bacteriol. | pmid:8444795 |
Vandenvelde C et al. | Suppression of the inhibitory effect of denatured albumin on the polymerase chain reaction by sodium octanoate: application to routine clinical detection of hepatitis B virus at its infectivity threshold in serum. | 1993 | J. Virol. Methods | pmid:8514843 |
Morand C et al. | Fatty acids are potent modulators of lactate utilization in isolated hepatocytes from fed rats. | 1993 | Am. J. Physiol. | pmid:8498503 |
Liu MJ and Pollack GM | Pharmacokinetics and pharmacodynamics of valproate analogs in rats. II. Pharmacokinetics of octanoic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid. | 1993 | Biopharm Drug Dispos | pmid:8499583 |
Ghoos YF et al. | Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. | 1993 | Gastroenterology | pmid:8500721 |
Consoli A et al. | Limitations in the use of [2-14C]acetate for measuring gluconeogenesis in vivo. | 1993 | Diabetes | pmid:8482430 |
Hayden MA et al. | Biosynthesis of lipoic acid: characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33-lip9. | 1993 | Biochemistry | pmid:8466915 |
Mabayo RT et al. | Improvement of dietary protein utilisation in chicks by medium chain triglyceride. | 1993 | Br. Poult. Sci. | pmid:8467393 |
Tezikov EB et al. | [Effect of beta-hydroxybutyrate and caprylic acid on function of isolated rat heart in alcoholic intoxication and in the post-intoxication period]. | 1993 May-Jun | Patol Fiziol Eksp Ter | pmid:8058394 |
Tsai CS and al-Kassim LS | Multifunctional activities of pickerel liver alcohol dehydrogenase. | 1993 Sep-Oct | Biochem. Cell Biol. | pmid:8192894 |
Fitzsimmons ME and Anders MW | Fatty acid beta-oxidation-dependent bioactivation of halogenated thiaalkanoic acids in isolated rat hepatocytes. | 1993 Sep-Oct | Chem. Res. Toxicol. | pmid:8292744 |
Morand C et al. | Importance of the modulation of glycolysis in the control of lactate metabolism by fatty acids in isolated hepatocytes from fed rats. | 1994 | Arch. Biochem. Biophys. | pmid:8135535 |
Hayball PJ et al. | Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7894686 |
Zhang Y et al. | Nonhomogeneous labeling of liver extra-mitochondrial acetyl-CoA. Implications for the probing of lipogenic acetyl-CoA via drug acetylation and for the production of acetate by the liver. | 1994 | J. Biol. Chem. | pmid:8157628 |
Herold G et al. | HDL3-mediated cholesterol efflux from cultured enterocytes: the role of apoproteins A-I and A-II. | 1994 | Lipids | pmid:7869853 |
Jensen RG et al. | Fatty acid and positional selectivities of gastric lipase from premature human infants: in vitro studies. | 1994 | Lipids | pmid:8090065 |
Ben Cheikh R et al. | Control of oxidative metabolism in volume-overloaded rat hearts: effects of different lipid substrates. | 1994 | Am. J. Physiol. | pmid:8203607 |
Jensen MM et al. | Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. | 1994 | Ann. Nutr. Metab. | pmid:8067685 |
Morris TW et al. | Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product. | 1994 | J. Biol. Chem. | pmid:8206909 |
Viegas CA et al. | Regulation of the expression of the H(+)-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae. | 1994 | Biochim. Biophys. Acta | pmid:8286419 |
Odle J et al. | Emulsification and fatty acid chain length affect the kinetics of [14C]-medium-chain triacylglycerol utilization by neonatal piglets. | 1994 | J. Nutr. | pmid:8283298 |
Riehle M and Bereiter-Hahn J | Ouabain and digitoxin as modulators of chick embryo cardiomyocyte energy metabolism. | 1994 | Arzneimittelforschung | pmid:7945537 |
Schepkin V et al. | NMR study of lipoic acid binding to bovine serum albumin. | 1994 | Biochem. Mol. Biol. Int. | pmid:7987256 |