MeSH term | MeSH ID | Detail |
---|---|---|
Drug-Related Side Effects and Adverse Reactions | D064420 | 3 associated lipids |
REM Sleep Behavior Disorder | D020187 | 1 associated lipids |
Dumping Syndrome | D004377 | 1 associated lipids |
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Shipp DA et al. | Development of fatty acid oxidation in neonatal guinea-pig liver. | 1982 | Biochem. J. | pmid:7165728 |
Ferré P et al. | Relationship between ketogenesis and gluconeogenesis in isolated hepatocytes from newborn rats. | 1981 | Biochem. J. | pmid:7340842 |
Zammit VA | The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-L-carnitine and octanoate by isolated liver mitochondria. | 1980 | Biochem. J. | pmid:7470052 |
Petcu LG and Plaut GW | NADP-specific isocitrate dehydrogenase in regulation of urea synthesis in rat hepatocytes. | 1980 | Biochem. J. | pmid:7470071 |
Kasumov T et al. | Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. | 2005 | Biochem. J. | pmid:15773815 |
Buse MG et al. | Regulation of branched-chain amino acid oxidation in isolated muscles, nerves and aortas of rats. | 1975 | Biochem. J. | pmid:1200982 |
Blumenthal SA | Inhibition of gluconeogenesis in rat liver by lipoic acid. Evidence for more than one site of action. | 1984 | Biochem. J. | pmid:6430273 |
Bellringer ME et al. | Sodium valproate inhibits the movement of secretory vesicles in rat hepatocytes. | 1988 | Biochem. J. | pmid:3124828 |
Guo W et al. | Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. | 2000 | Biochem. J. | pmid:10880345 |
Taylor WM et al. | The stimulation of tricarboxylic acid-cycle flux by alpha-adrenergic agonists in perfused rat liver. | 1986 | Biochem. J. | pmid:3082324 |
Ferré P et al. | Development and regulation of ketogenesis in hepatocytes isolated from newborn rats. | 1983 | Biochem. J. | pmid:6626164 |
Bauché F et al. | Inhibition in vitro of acyl-CoA dehydrogenases by 2-mercaptoacetate in rat liver mitochondria. | 1983 | Biochem. J. | pmid:6661181 |
Pégorier JP et al. | Metabolic fate of non-esterified fatty acids in isolated hepatocytes from newborn and young pigs. Evidence for a limited capacity for oxidation and increased capacity for esterification. | 1983 | Biochem. J. | pmid:6870859 |
Foxworthy PS and Eacho PI | Inhibition of hepatic fatty acid oxidation at carnitine palmitoyltransferase I by the peroxisome proliferator 2-hydroxy-3-propyl-4-[6-(tetrazol-5-yl) hexyloxy]acetophenone. | 1988 | Biochem. J. | pmid:3415664 |
Rofe AM and Williamson DH | Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia. | 1983 | Biochem. J. | pmid:6135420 |
Boveris A and Chance B | The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. | 1973 | Biochem. J. | pmid:4749271 |
Leclercq P et al. | Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats. | 1997 | Biochem. J. | pmid:9230136 |
Halestrap AP | The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+. | 1987 | Biochem. J. | pmid:3663110 |
Tosh D et al. | Glucagon regulation of gluconeogenesis and ketogenesis in periportal and perivenous rat hepatocytes. Heterogeneity of hormone action and of the mitochondrial redox state. | 1988 | Biochem. J. | pmid:3223900 |
Dieuaide M et al. | Effects of glucose starvation on the oxidation of fatty acids by maize root tip mitochondria and peroxisomes: evidence for mitochondrial fatty acid beta-oxidation and acyl-CoA dehydrogenase activity in a higher plant. | 1993 | Biochem. J. | pmid:8250843 |
Soboll S et al. | Effect of long-chain fatty acyl-CoA on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell. | 1984 | Biochem. J. | pmid:6743276 |
Oshino N et al. | The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver. | 1975 | Biochem. J. | pmid:167718 |
Iwahashi H et al. | Cytochrome c catalyses the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. | 2002 | Biochem. J. | pmid:11742529 |
Marchington DR et al. | Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat hepatocytes. | 1989 | Biochem. J. | pmid:2539088 |
Berger M et al. | Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. | 1976 | Biochem. J. | pmid:136249 |
Reed WD et al. | The effects of insulin and glucagon on ketone-body turnover. | 1984 | Biochem. J. | pmid:6383348 |
Kragh-Hansen U | Octanoate binding to the indole- and benzodiazepine-binding region of human serum albumin. | 1991 | Biochem. J. | pmid:1996962 |
Kalbag SS and Palekar AG | Sodium benzoate inhibits fatty acid oxidation in rat liver: effect on ammonia levels. | 1988 | Biochem. Med. Metab. Biol. | pmid:3190922 |
Schepkin V et al. | NMR study of lipoic acid binding to bovine serum albumin. | 1994 | Biochem. Mol. Biol. Int. | pmid:7987256 |
GarcÃa-Villafranca J and Castro J | Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. | 2002 | Biochem. Pharmacol. | pmid:12093476 |
Fulgencio JP et al. | Effect of metformin on fatty acid and glucose metabolism in freshly isolated hepatocytes and on specific gene expression in cultured hepatocytes. | 2001 | Biochem. Pharmacol. | pmid:11448453 |
Veitch K and Van Hoof F | In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria. | 1990 | Biochem. Pharmacol. | pmid:2242043 |
Sarnatskaya VV et al. | Effect of protein-bound uraemic toxins on the thermodynamic characteristics of human albumin. | 2002 | Biochem. Pharmacol. | pmid:11960605 |
Swartzentruber MS and Harris RA | Inhibition of metabolic processes by coenzyme-A-sequestering aromatic acids. Prevention by para-chloro- and para-nitrobenzoic acids. | 1987 | Biochem. Pharmacol. | pmid:3117062 |
Schudt C and Simon A | Effects of sodium 2-[5-(4-chlorophenyl)pentyl]-oxirane-2-carboxylate (POCA) on carbohydrate and fatty acid metabolism in liver and muscle. | 1984 | Biochem. Pharmacol. | pmid:6437406 |
el-Aleem SA and Schulz H | Evaluation of inhibitors of fatty acid oxidation in rat myocytes. | 1987 | Biochem. Pharmacol. | pmid:3689454 |
Deaciuc IV et al. | Studies on the mechanism of action of the hypoglycemic agent, 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304). | 1983 | Biochem. Pharmacol. | pmid:6651864 |
Olubadewo JO et al. | Effects of 8-N,N-diethylamino-octyl-3,4,5-trimethoxybenzoate (TMB-8) HCl and verapamil on the metabolism of free fatty acid by hepatocytes. | 1988 | Biochem. Pharmacol. | pmid:3358779 |
Massolini G et al. | Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases. | 1993 | Biochem. Pharmacol. | pmid:8216380 |
Grolier P and Elcombe CR | In vitro inhibition of carnitine acyltransferase activity in mitochondria from rat and mouse liver by a diethylhexylphthalate metabolite. | 1993 | Biochem. Pharmacol. | pmid:8452557 |
Haas R et al. | Salicylate-induced loose coupling: protonmotive force measurements. | 1985 | Biochem. Pharmacol. | pmid:3977963 |
Krahenbuhl S and Brass EP | Inhibition of hepatic propionyl-CoA synthetase activity by organic acids. Reversal of propionate inhibition of pyruvate metabolism. | 1991 Mar 15-Apr 1 | Biochem. Pharmacol. | pmid:2009071 |
Rozas I et al. | Effects of acute valproate administration on carnitine metabolism in mouse serum and tissues. | 1990 | Biochem. Pharmacol. | pmid:2105093 |
Thayer WS | Inhibition of mitochondrial fatty acid oxidation in pentenoic acid-induced fatty liver. A possible model for Reye's syndrome. | 1984 | Biochem. Pharmacol. | pmid:6712730 |
Porter DJ | Binding of 2-acetylpyridine-5-[(2-chloroanilino)thiocarbonyl] thiocarbonohydrazone (BW348U87) to human serum albumin. | 1992 | Biochem. Pharmacol. | pmid:1417962 |
Ohtsuka Y and Griffith OW | L-carnitine protection in ammonia intoxication. Effect of aminocarnitine on carnitine-dependent metabolism and acute ammonia toxicity. | 1991 | Biochem. Pharmacol. | pmid:2039546 |
Carrington MJ et al. | Octanoate and palmitate as substrates for ketogenesis by hepatocytes isolated from suckling rabbits. | 1981 | Biochem. Soc. Trans. | pmid:7215663 |
Priestman DA et al. | Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes. | 1997 | Biochem. Soc. Trans. | pmid:9056999 |
Sherrington EJ et al. | Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736816 |
Bhuiyan AK and Pande SV | One-step facile synthesis of radioactive acyl-CoA and acylcarnitines using rat liver outer mitochondrial membrane as the enzyme source. | 1991 | Biochem. Soc. Trans. | pmid:1889559 |