MeSH term | MeSH ID | Detail |
---|---|---|
Drug-Related Side Effects and Adverse Reactions | D064420 | 3 associated lipids |
REM Sleep Behavior Disorder | D020187 | 1 associated lipids |
Dumping Syndrome | D004377 | 1 associated lipids |
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Escapa IF et al. | The polyhydroxyalkanoate metabolism controls carbon and energy spillage in Pseudomonas putida. | 2012 | Environ. Microbiol. | pmid:22225632 |
Walser T et al. | Prospective environmental life cycle assessment of nanosilver T-shirts. | 2011 | Environ. Sci. Technol. | pmid:21506582 |
Hsu HL and Demond AH | Influence of organic acid and organic base interactions on interfacial properties in NAPL--water systems. | 2007 | Environ. Sci. Technol. | pmid:17328200 |
Knight VK et al. | Biotransformation of 3,5-dibromo-4-hydroxybenzonitrile under denitrifying, Fe(III)-reducing, sulfidogenic, and methanogenic conditions. | 2003 | Environ. Toxicol. Chem. | pmid:12627640 |
RodrÃguez A et al. | Synthesis of 2-monoacylglycerols and structured triacylglycerols rich in polyunsaturated fatty acids by enzyme catalyzed reactions. | 2012 | Enzyme Microb. Technol. | pmid:22759534 |
Tao Y et al. | Enhancing trimethylolpropane esters synthesis through lipase immobilized on surface hydrophobic modified support and appropriate substrate feeding methods. | 2014 | Enzyme Microb. Technol. | pmid:24731826 |
Zhang JH et al. | High-throughput screening of B factor saturation mutated Rhizomucor miehei lipase thermostability based on synthetic reaction. | 2012 | Enzyme Microb. Technol. | pmid:22500900 |
Khabbush A et al. | Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium-chain triglyceride ketogenic diet. | 2017 | Epilepsia | pmid:28682459 |
Sutton DG et al. | Validation of the 13C-octanoic acid breath test for measurement of equine gastric emptying rate of solids using radioscintigraphy. | 2003 | Equine Vet. J. | pmid:12553459 |
Wyse CA et al. | Assessment of the rate of solid-phase gastric emptying in ponies by means of the 13C-octanoic acid breath test: a preliminary study. | 2001 | Equine Vet. J. | pmid:11266071 |
Delbende B et al. | 13C-octanoic acid breath test for gastric emptying measurement. | 2000 | Eur J Gastroenterol Hepatol | pmid:10656216 |
Schneider AR et al. | Total body metabolism of 13C-octanoic acid is preserved in patients with non-alcoholic steatohepatitis, but differs between women and men. | 2005 | Eur J Gastroenterol Hepatol | pmid:16215429 |
Gourcerol G et al. | Gastric electrical stimulation in medically refractory nausea and vomiting. | 2007 | Eur J Gastroenterol Hepatol | pmid:17206074 |
Sobczak M | Synthesis and characterization of polyester conjugates of ciprofloxacin. | 2010 | Eur J Med Chem | pmid:20541292 |
Köllner S et al. | Self-emulsifying drug delivery systems: Design of a novel vaginal delivery system for curcumin. | 2017 | Eur J Pharm Biopharm | pmid:28323109 |
Heurtault B et al. | The influence of lipid nanocapsule composition on their size distribution. | 2003 | Eur J Pharm Sci | pmid:12554073 |
Kubota K et al. | The molecular assembly of the ionic liquid/aliphatic carboxylic acid/aliphatic amine as effective and safety transdermal permeation enhancers. | 2016 | Eur J Pharm Sci | pmid:26965004 |
Gschwind HP et al. | Metabolism and disposition of the oral absorption enhancer 14C-radiolabeled 8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC) in healthy postmenopausal women and supplementary investigations in vitro. | 2012 | Eur J Pharm Sci | pmid:22579664 |
Ogungbenro K and Aarons L | A semi-mechanistic gastric emptying pharmacokinetic model for (13)C-octanoic acid: an evaluation using simulation. | 2012 | Eur J Pharm Sci | pmid:22155547 |
Bednarczyk-Cwynar B et al. | The analgesic and anti-inflammatory effect of new oleanolic acid acyloxyimino derivative. | 2012 | Eur J Pharm Sci | pmid:22867936 |
Corson TW et al. | Cell-type specific regulation of calreticulin and Bcl-2 expression by mood stabilizer drugs. | 2004 | Eur Neuropsychopharmacol | pmid:15013030 |
Perri F et al. | 13C-octanoic acid breath test for measuring gastric emptying of solids. | 2005 Sep-Oct | Eur Rev Med Pharmacol Sci | pmid:16457123 |
Usai Satta P et al. | 13C-octanoic acid breath test in functional and organic disease: critical review of literature. | 2005 Sep-Oct | Eur Rev Med Pharmacol Sci | pmid:16457124 |
Bonazzi P et al. | Gastric emptying and intragastric balloon in obese patients. | 2005 Sep-Oct | Eur Rev Med Pharmacol Sci | pmid:16457125 |
Rossi Z et al. | Electrogastrography. | 2005 Sep-Oct | Eur Rev Med Pharmacol Sci | pmid:16457127 |
Bruno G et al. | 13C-octanoic acid breath test to study gastric emptying time. | 2013 | Eur Rev Med Pharmacol Sci | pmid:24443070 |
Nauclér J et al. | Evaluation of kidney viability during hypothermic perfusion or cold storage. | 1984 | Eur Surg Res | pmid:6698069 |
Fischer JH et al. | Free fatty acid and glucose metabolism during hypothermic perfusion of canine kidneys. | 1979 | Eur Surg Res | pmid:488147 |
Scholz R et al. | The effect of fatty acids on the regulation of pyruvate dehydrogenase in perfused rat liver. | 1978 | Eur. J. Biochem. | pmid:658055 |
Sibille B et al. | Octanoate affects 2,4-dinitrophenol uncoupling in intact isolated rat hepatocytes. | 1995 | Eur. J. Biochem. | pmid:7635161 |
von Glutz G and Walter P | Compartmentation of acetyl-coA in rat-liver mitochondria. | 1975 | Eur. J. Biochem. | pmid:1204636 |
Pégorier JP et al. | Octanoate metabolism in isolated hepatocytes and mitochondria from fetal, newborn and adult rabbit. Evidence for a high capacity for octanoate esterification in term fetal liver. | 1989 | Eur. J. Biochem. | pmid:2806250 |
Dirusso CC et al. | Murine FATP alleviates growth and biochemical deficiencies of yeast fat1Delta strains. | 2000 | Eur. J. Biochem. | pmid:10880966 |
Beuers U et al. | Control of ketogenesis in the perfused rat liver by the sympathetic innervation. | 1986 | Eur. J. Biochem. | pmid:3732268 |
Debeer LJ et al. | Effects of octanoate and oleate on energy metabolism in the perfused rat liver. | 1974 | Eur. J. Biochem. | pmid:4434997 |
Handler JA and Thurman RG | Catalase-dependent ethanol oxidation in perfused rat liver. Requirement for fatty-acid-stimulated H2O2 production by peroxisomes. | 1988 | Eur. J. Biochem. | pmid:3416882 |
Agius L and Alberti KG | Regulation of flux through pyruvate dehydrogenase and pyruvate carboxylase in rat hepatocytes. Effects of fatty acids and glucagon. | 1985 | Eur. J. Biochem. | pmid:3932072 |
Fryer LG et al. | The long-term regulation of skeletal muscle pyruvate dehydrogenase kinase by dietary lipid is dependent on fatty acid composition. | 1995 | Eur. J. Biochem. | pmid:7758471 |
Wolf HP and Engel DW | Decrease of fatty acid oxidation, ketogenesis and gluconeogenesis in isolated perfused rat liver by phenylalkyl oxirane carboxylate (B 807-27) due to inhibition of CPT I (EC 2.3.1.21). | 1985 | Eur. J. Biochem. | pmid:4038486 |
Prip-Buus C et al. | Evidence for an impaired long-chain fatty acid oxidation and ketogenesis in Fao hepatoma cells. | 1992 | Eur. J. Biochem. | pmid:1356769 |
Soboll S et al. | Influence of fatty acids on energy metabolism. 2. Kinetics of changes in metabolic rates and changes in subcellular adenine nucleotide contents and pH gradients following addition of octanoate and oleate in perfused rat liver. | 1984 | Eur. J. Biochem. | pmid:6723661 |
Strong P et al. | Aerobic lactate synthesis by cardiac muscle. | 1979 | Eur. J. Biochem. | pmid:230966 |
Scholz R et al. | Influence of fatty acids on energy metabolism. 1. Stimulation of oxygen consumption, ketogenesis and CO2 production following addition of octanoate and oleate in perfused rat liver. | 1984 | Eur. J. Biochem. | pmid:6426957 |
Spydevold O | The effect of octanoate and palmitate on the metabolism of valine in perfused hindquarter of rat. | 1979 | Eur. J. Biochem. | pmid:467425 |
Wanten GJ et al. | Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain-length. | 2002 | Eur. J. Clin. Invest. | pmid:11952815 |
Grattagliano I et al. | 13C-breath tests for clinical investigation of liver mitochondrial function. | 2010 | Eur. J. Clin. Invest. | pmid:20597965 |
Bevington A et al. | Leucine suppresses acid-induced protein wasting in L6 rat muscle cells. | 2001 | Eur. J. Clin. Invest. | pmid:11422399 |
Ghaninia M et al. | Functional classification and central nervous projections of olfactory receptor neurons housed in antennal trichoid sensilla of female yellow fever mosquitoes, Aedes aegypti. | 2007 | Eur. J. Neurosci. | pmid:17880395 |
Ushigome F et al. | Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). | 2001 | Eur. J. Pharmacol. | pmid:11334847 |
Drozak J et al. | The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglycaemic action. | 2008 | Eur. J. Pharmacol. | pmid:18706903 |
Zakaria ZA et al. | Hepatoprotective activity of dried- and fermented-processed virgin coconut oil. | 2011 | Evid Based Complement Alternat Med | pmid:21318140 |
Nisly NL et al. | Dietary supplement polypharmacy: an unrecognized public health problem? | 2010 | Evid Based Complement Alternat Med | pmid:18955288 |
Hasson SS et al. | Neutralisation of Local Haemorrhage Induced by the Saw-Scaled Viper Echis carinatus sochureki Venom Using Ethanolic Extract of Hibiscus aethiopicus L. | 2012 | Evid Based Complement Alternat Med | pmid:22666294 |
Cometto-Muñiz JE and Abraham MH | Structure-activity relationships on the odor detectability of homologous carboxylic acids by humans. | 2010 | Exp Brain Res | pmid:20931179 |
Schiavon FP et al. | Paradoxical increase in liver ketogenesis during long-term insulin-induced hypoglycemia in diabetic rats. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21321320 |
Forest C et al. | A preadipocyte clonal line from mouse brown adipose tissue. Short- and long-term responses to insulin and beta-adrenergics. | 1987 | Exp. Cell Res. | pmid:2877896 |
Geppert EF and Elstein KH | Short-term regulation of fatty acid synthesis in isolated alveolar type II cells from adult rat lung. Effects of free fatty acids and hormones. | 1983 | Exp. Lung Res. | pmid:6305647 |
Vacchina P et al. | Lipoic acid metabolism in Trypanosoma cruzi as putative target for chemotherapy. | 2018 | Exp. Parasitol. | pmid:29409741 |
Laurendeau G and Roy CC | Effect of cholestasis and biliary diversion on the absorption of Na octanoate in the rat. | 1976 | Experientia | pmid:1248600 |
Borbola J et al. | Effects of octanoate on the electrical activity of Purkinje fibres. | 1974 | Experientia | pmid:4824600 |
Agostini C | Effect of sodium octanoate on leucine incorporation into protein of rat liver slices and of Yoshida ascites hepatoma cells. | 1978 | Experientia | pmid:203476 |
Royter M et al. | Thermostable lipases from the extreme thermophilic anaerobic bacteria Thermoanaerobacter thermohydrosulfuricus SOL1 and Caldanaerobacter subterraneus subsp. tengcongensis. | 2009 | Extremophiles | pmid:19579003 |
Levisson M et al. | Carboxylic ester hydrolases from hyperthermophiles. | 2009 | Extremophiles | pmid:19544040 |
Sharma P et al. | Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers. | 2005 Nov-Dec | Farmaco | pmid:16226752 |
Abidova SS and Ovchinnikov IV | [Effect of novodrin on fatty acid oxidation by the myocardial mitochondria of white rats]. | 1983 Jul-Aug | Farmakol Toksikol | pmid:6617836 |
Abidov AA and Isaev EI | [The effect of strophanthin on caprylic acid oxidation in cardiac muscle in adrenaline myocarditis]. | 1973 May-Jun | Farmakol Toksikol | pmid:4788489 |
Abidov AA et al. | [Strophantin K action on caprylate oxidation in the myocardium]. | 1971 Sep-Oct | Farmakol Toksikol | pmid:5151251 |
Erol E et al. | Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice. | 2004 | FASEB J. | pmid:14656998 |
Bu W et al. | Ferritin couples iron and fatty acid metabolism. | 2012 | FASEB J. | pmid:22362897 |
Harmancey R et al. | Decreased long-chain fatty acid oxidation impairs postischemic recovery of the insulin-resistant rat heart. | 2013 | FASEB J. | pmid:23825227 |
Ando Y et al. | Synthesis of acylated SOD derivatives which bind to the biomembrane lipid surface and dismutate extracellular superoxide radicals. | 1988 | FEBS Lett. | pmid:2847946 |
Martin-Sanz P et al. | Long-chain fatty acids and their acyl-CoA esters cause the translocation of phosphatidate phosphohydrolase from the cytosolic to the microsomal fraction of rat liver. | 1984 | FEBS Lett. | pmid:6090213 |
Claycomb WC et al. | Culture of the terminally differentiated ventricular cardiac muscle cell. Characterization of exogenous substrate oxidation and the adenylate cyclase system. | 1984 | FEBS Lett. | pmid:6201398 |
Priestman DA et al. | Pyruvate inhibition of pyruvate dehydrogenase kinase. Effects of progressive starvation and hyperthyroidism in vivo, and of dibutyryl cyclic AMP and fatty acids in cultured cardiac myocytes. | 1996 | FEBS Lett. | pmid:8814284 |
Taylor WM et al. | Effect of depolarizing concentrations of potassium on calcium uptake and metabolism in rat liver. | 1985 | FEBS Lett. | pmid:3979569 |
Plomp PJ et al. | Mechanism of the stimulation of respiration by fatty acids in rat liver. | 1985 | FEBS Lett. | pmid:4065340 |
Welters HJ et al. | Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. | 2004 | FEBS Lett. | pmid:14988006 |
Ruderman NB et al. | Effect of starvation on muscle glucose metabolism: studies with the isolated perfused rat hindquarter. | 1977 | Fed. Proc. | pmid:838085 |
FIELD J and DRYER RL | Effect of sodium caprylate on the thermal stability of the respiratory system in rat brain. | 1947 | Fed. Proc. | pmid:20342637 |
Pepi M et al. | An antarctic psychrotrophic bacterium Halomonas sp. ANT-3b, growing on n-hexadecane, produces a new emulsyfying glycolipid. | 2005 | FEMS Microbiol. Ecol. | pmid:16329937 |
McMahon B and Mayhew SG | Identification and properties of an inducible phenylacyl-CoA dehydrogenase in Pseudomonas putida KT2440. | 2007 | FEMS Microbiol. Lett. | pmid:17559393 |
Yuan MQ et al. | Microbial production of medium-chain-length 3-hydroxyalkanoic acids by recombinant Pseudomonas putida KT2442 harboring genes fadL, fadD and phaZ. | 2008 | FEMS Microbiol. Lett. | pmid:18422622 |
Antonio RV et al. | Analysis of in vivo substrate specificity of the PHA synthase from Ralstonia eutropha: formation of novel copolyesters in recombinant Escherichia coli. | 2000 | FEMS Microbiol. Lett. | pmid:10612741 |
Ayub ND et al. | Impaired polyhydroxybutyrate biosynthesis from glucose in Pseudomonas sp. 14-3 is due to a defective beta-ketothiolase gene. | 2006 | FEMS Microbiol. Lett. | pmid:17020558 |
Tsuge T et al. | Combination of N149S and D171G mutations in Aeromonas caviae polyhydroxyalkanoate synthase and impact on polyhydroxyalkanoate biosynthesis. | 2007 | FEMS Microbiol. Lett. | pmid:18031343 |
Hoffmann N and Rehm BH | Regulation of polyhydroxyalkanoate biosynthesis in Pseudomonas putida and Pseudomonas aeruginosa. | 2004 | FEMS Microbiol. Lett. | pmid:15268931 |
Hang X et al. | PCR cloning of polyhydroxyalkanoate biosynthesis genes from Burkholderia caryophylli and their functional expression in recombinant Escherichia coli. | 2002 | FEMS Microbiol. Lett. | pmid:12023076 |
Jahnke LL and Diggs K | Evidence for the synthesis of the multi-positional isomers of monounsaturated fatty acid in Methylococcus capsusatus by the anaerobic pathway. | 1989 | FEMS Microbiol. Lett. | pmid:11542184 |
Aguedo M et al. | Intracellular pH-dependent efflux of the fluorescent probe pyranine in the yeast Yarrowia lipolytica. | 2001 | FEMS Microbiol. Lett. | pmid:11425473 |
Leonard PH et al. | Variability in protein quality used for embryo culture: embryotoxicity of the stabilizer octanoic acid. | 2013 | Fertil. Steril. | pmid:23602317 |
Guddat W and Hillger K | A heat polyethylene glycol procedure as an alternative method for plasmafractionation. | 1982 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:6187637 |
Mitkov D | The role of the octanoic fatty acid in the pathogenesis of the metabolic alkalosis in experimental liver failure. | 1993 | Folia Med (Plovdiv) | pmid:8194797 |
Kristev A et al. | Effects of the medium chain octanoic fatty acid on the contractile activity of vascular smooth muscle tissues. | 1992 | Folia Med (Plovdiv) | pmid:1364081 |
Mitkov D | Octanoate action on muscular protein catabolism in rats. | 1989 | Folia Med (Plovdiv) | pmid:2490157 |
Skrivanová E and Marounek M | Influence of pH on antimicrobial activity of organic acids against rabbit enteropathogenic strain of Escherichia coli. | 2007 | Folia Microbiol. (Praha) | pmid:17571799 |
Skrivanová E et al. | In vitro effect of C2-C18 fatty acids on Salmonellas. | 2004 | Folia Microbiol. (Praha) | pmid:15227798 |
Marounek M et al. | Susceptibility of Escherichia coli to C2-C18 fatty acids. | 2003 | Folia Microbiol. (Praha) | pmid:15058184 |
Das K and Ghosh M | Structured DAG oil ameliorates renal injury in streptozotocin-induced diabetic rats through inhibition of NF-κB and activation of Nrf2 pathway. | 2017 | Food Chem. Toxicol. | pmid:28025123 |
Traul KA et al. | Review of the toxicologic properties of medium-chain triglycerides. | 2000 | Food Chem. Toxicol. | pmid:10685018 |
Matulka RA et al. | Safety evaluation of a medium- and long-chain triacylglycerol oil produced from medium-chain triacylglycerols and edible vegetable oil. | 2006 | Food Chem. Toxicol. | pmid:16753249 |