| MeSH term | MeSH ID | Detail |
|---|---|---|
| Esophageal Motility Disorders | D015154 | 1 associated lipids |
| Chickenpox | D002644 | 1 associated lipids |
| Severe Acute Respiratory Syndrome | D045169 | 1 associated lipids |
| Chylothorax | D002916 | 1 associated lipids |
| Hepatorenal Syndrome | D006530 | 1 associated lipids |
| Flatulence | D005414 | 1 associated lipids |
| REM Sleep Behavior Disorder | D020187 | 1 associated lipids |
| Snake Bites | D012909 | 1 associated lipids |
| Dumping Syndrome | D004377 | 1 associated lipids |
| Prion Diseases | D017096 | 2 associated lipids |
octanoic acid
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
Cross Reference
Introduction
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with octanoic acid?
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with octanoic acid
PubChem Associated disorders and diseases
What pathways are associated with octanoic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with octanoic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with octanoic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with octanoic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with octanoic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with octanoic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with octanoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shipp DA et al. | Development of fatty acid oxidation in neonatal guinea-pig liver. | 1982 | Biochem. J. | pmid:7165728 |
| Hansford RG | Lipid oxidation by heart mitochondria from young adult and senescent rats. | 1978 | Biochem. J. | pmid:637843 |
| Ferré P et al. | Relationship between ketogenesis and gluconeogenesis in isolated hepatocytes from newborn rats. | 1981 | Biochem. J. | pmid:7340842 |
| Zammit VA | The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-L-carnitine and octanoate by isolated liver mitochondria. | 1980 | Biochem. J. | pmid:7470052 |
| Petcu LG and Plaut GW | NADP-specific isocitrate dehydrogenase in regulation of urea synthesis in rat hepatocytes. | 1980 | Biochem. J. | pmid:7470071 |
| Kasumov T et al. | Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. | 2005 | Biochem. J. | pmid:15773815 |
| Buse MG et al. | Regulation of branched-chain amino acid oxidation in isolated muscles, nerves and aortas of rats. | 1975 | Biochem. J. | pmid:1200982 |
| Blumenthal SA | Inhibition of gluconeogenesis in rat liver by lipoic acid. Evidence for more than one site of action. | 1984 | Biochem. J. | pmid:6430273 |
| Berne C | The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies. | 1975 | Biochem. J. | pmid:776173 |
| Guo W et al. | Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. | 2000 | Biochem. J. | pmid:10880345 |
| Lagercrantz C and Larsson T | Comparative studies of the binding of some ligands to human serum albumin non-covalently attached to immobilized Cibacron Blue, or covalently immobilized on Sepharose, by column affinity chromatography. | 1983 | Biochem. J. | pmid:6615442 |
| Taylor WM et al. | The stimulation of tricarboxylic acid-cycle flux by alpha-adrenergic agonists in perfused rat liver. | 1986 | Biochem. J. | pmid:3082324 |
| Ferré P et al. | Development and regulation of ketogenesis in hepatocytes isolated from newborn rats. | 1983 | Biochem. J. | pmid:6626164 |
| Clouet P et al. | Study of some factors controlling fatty acid oxidation in liver mitochondria of obese Zucker rats. | 1986 | Biochem. J. | pmid:3800970 |
| Bauché F et al. | Inhibition in vitro of acyl-CoA dehydrogenases by 2-mercaptoacetate in rat liver mitochondria. | 1983 | Biochem. J. | pmid:6661181 |
| Pégorier JP et al. | Metabolic fate of non-esterified fatty acids in isolated hepatocytes from newborn and young pigs. Evidence for a limited capacity for oxidation and increased capacity for esterification. | 1983 | Biochem. J. | pmid:6870859 |
| Strong CR and Dils R | Fatty acid biosynthesis in rabbit mammary gland during pregnancy and early lactation. | 1972 | Biochem. J. | pmid:4643704 |
| Foxworthy PS and Eacho PI | Inhibition of hepatic fatty acid oxidation at carnitine palmitoyltransferase I by the peroxisome proliferator 2-hydroxy-3-propyl-4-[6-(tetrazol-5-yl) hexyloxy]acetophenone. | 1988 | Biochem. J. | pmid:3415664 |
| Stewart HB et al. | Intermediates in fatty acid oxidation. | 1973 | Biochem. J. | pmid:4722901 |
| Rofe AM and Williamson DH | Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia. | 1983 | Biochem. J. | pmid:6135420 |
| Wilson MB | Control of phosphoenolpyruvate synthesis in guinea-pig mitochondria. | 1973 | Biochem. J. | pmid:4724589 |
| Boveris A and Chance B | The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. | 1973 | Biochem. J. | pmid:4749271 |
| Watford M et al. | The regulation of glutamine and ketone-body metabolism in the small intestine of the long-term (40-day) streptozotocin-diabetic rat. | 1987 | Biochem. J. | pmid:3473986 |
| Leclercq P et al. | Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats. | 1997 | Biochem. J. | pmid:9230136 |
| Halestrap AP | The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+. | 1987 | Biochem. J. | pmid:3663110 |
| Gavva SR et al. | A 13C isotopomer n.m.r. method for monitoring incomplete beta-oxidation of fatty acids in intact tissue. | 1994 | Biochem. J. | pmid:7980454 |
| Dieuaide M et al. | Effects of glucose starvation on the oxidation of fatty acids by maize root tip mitochondria and peroxisomes: evidence for mitochondrial fatty acid beta-oxidation and acyl-CoA dehydrogenase activity in a higher plant. | 1993 | Biochem. J. | pmid:8250843 |
| Soboll S et al. | Effect of long-chain fatty acyl-CoA on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell. | 1984 | Biochem. J. | pmid:6743276 |
| Harwood JL et al. | Fat metabolism in higher plants. Beta-hydroxylation of fatty acids by a soluble preparation from maturing avocado mesocarp. | 1972 | Biochem. J. | pmid:4144293 |
| Oshino N et al. | The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver. | 1975 | Biochem. J. | pmid:167718 |
| Iwahashi H et al. | Cytochrome c catalyses the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. | 2002 | Biochem. J. | pmid:11742529 |
| Marchington DR et al. | Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat hepatocytes. | 1989 | Biochem. J. | pmid:2539088 |
| Reed WD et al. | The effects of insulin and glucagon on ketone-body turnover. | 1984 | Biochem. J. | pmid:6383348 |
| Clore JN et al. | Evidence for dissociation of gluconeogenesis stimulated by non-esterified fatty acids and changes in fructose 2,6-bisphosphate in cultured rat hepatocytes. | 1992 | Biochem. J. | pmid:1445259 |
| Palabost-Charles L | Selection at the alpha-Gpdh locus in experimental populations of Drosophila melanogaster. | 1982 | Biochem. Genet. | pmid:6810873 |
| Bijlsma R | Polymorphism at the G6pd and 6Pgd loci in Drosophila melanogaster. IV. Genetic factors modifying enzyme activity. | 1980 | Biochem. Genet. | pmid:6781470 |
| Tsai CS and al-Kassim LS | Multifunctional activities of pickerel liver alcohol dehydrogenase. | 1993 Sep-Oct | Biochem. Cell Biol. | pmid:8192894 |
| Tenreiro S et al. | AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11922628 |
| Torres-Guzmán R et al. | Substrate specificity of penicillin acylase from Streptomyces lavendulae. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11855830 |
| Nakajima I et al. | Growth arrest by octanoate is required for porcine preadipocyte differentiation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12963048 |
| Yamato M et al. | Exogenous administration of octanoic acid accelerates octanoylated ghrelin production in the proventriculus of neonatal chicks. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15953586 |
| Ohgusu H et al. | Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19501572 |
| Jones PM et al. | Medium-chain fatty acids undergo elongation before beta-oxidation in fibroblasts. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16750167 |
| Bjorge SM and Baillie TA | Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933498 |
| Maddaiah VT | Ammonium inhibition of fatty acid oxidation in rat liver mitochondria. A possible cause of fatty liver in Reye's syndrome and urea cycle defects. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977937 |
| May JM et al. | Cellular disulfide-reducing capacity: an integrated measure of cell redox capacity. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16650819 |
| Hosoda H et al. | Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. | 2000 | Biochem. Biophys. Res. Commun. | pmid:11162448 |
| Shanado Y et al. | Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15555596 |
| Matsumoto M et al. | Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11549267 |
| Olivieri MC and Botelho LH | Synergistic inhibition of hepatic ketogenesis in the presence of insulin and a cAMP antagonist. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2539126 |
| Suzuki S et al. | Characterization of actions of octanoate on porcine preadipocytes and adipocytes differentiated in vitro. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23376076 |
| Oettl K et al. | An apparent decrease in cholesterol biosynthesis in peroxisomal-defective Chinese hamster ovary cells is related to impaired mitochondrial oxidation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12767923 |
| Lee SM et al. | Prevention of the metabolic effects of 2-tetradecylglycidate by octanoic acid in the genetically diabetic mouse (db/db). | 1985 | Biochem Med | pmid:3994695 |
| Lutz WH et al. | Inhibition of citrulline synthesis by octanoate and its modulation by adenine nucleotides. | 1985 | Biochem Med | pmid:4052056 |
| Böhles H et al. | The influence of i.v. MCT and carnitine on the excretion of dicarboxylic acids. | 1988 | Beitr Infusionther Klin Ernahr | pmid:3132147 |
| Wang Z and Zhang Q | [Study on pulmonary delivery system of salmon calcitonin in rats]. | 2003 | Beijing Da Xue Xue Bao | pmid:12914259 |
| Amlou M et al. | Genetic analysis of Drosophila sechellia specialization: oviposition behavior toward the major aliphatic acids of its host plant. | 1998 | Behav. Genet. | pmid:9926614 |
| Rösen P et al. | Myocardial performance and metabolism in non-ketotic, diabetic rat hearts: myocardial function and metabolism in vivo and in the isolated perfused heart under the influence of insulin and octanoate. | 1986 Nov-Dec | Basic Res. Cardiol. | pmid:3545178 |
| Cave AC et al. | A model of anoxic preconditioning in the isolated rat cardiac myocyte. Importance of adenosine and insulin. | 1996 May-Jun | Basic Res. Cardiol. | pmid:8831940 |
| Mathiesen L et al. | Transport of benzo[alpha]pyrene in the dually perfused human placenta perfusion model: effect of albumin in the perfusion medium. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19508462 |
| Allen PC | Physiological responses of chicken gut tissue to infection with Eimeria acervulina. | 1984 Oct-Dec | Avian Dis. | pmid:6441557 |
| Allen PC | The effect of Eimeria acervulina infection on hearts of young broiler chicks. | 1987 Jul-Sep | Avian Dis. | pmid:3675428 |
| Rücker W et al. | Antiatherosclerotic and antihyperlipidemic effects of octimibate sodium in rabbits. | 1988 | Atherosclerosis | pmid:3348838 |
| Wang X et al. | A self-contained 48-well fatty acid oxidation assay. | 2004 | Assay Drug Dev Technol | pmid:15090211 |
| Amin D et al. | 1-Hydroxy-3-(methylpentylamino)-propylidene-1,1-bisphosphonic acid as a potent inhibitor of squalene synthase. | 1996 | Arzneimittelforschung | pmid:9125274 |
| Riehle M and Bereiter-Hahn J | Ouabain and digitoxin as modulators of chick embryo cardiomyocyte energy metabolism. | 1994 | Arzneimittelforschung | pmid:7945537 |
| Dieterle F et al. | Urinary nucleosides as potential tumor markers evaluated by learning vector quantization. | 2003 | Artif Intell Med | pmid:12927336 |
| Kawamoto T et al. | Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells. | 2011 | Arthritis Res. Ther. | pmid:21426565 |
| Baraldi M et al. | Toxins in hepatic encephalopathy: the role of the synergistic effect of ammonia, mercaptans and short chain fatty acids. | 1984 | Arch. Toxicol. Suppl. | pmid:6097201 |
| Sogorb MA et al. | Hydrolysis of carbaryl by human serum albumin. | 2004 | Arch. Toxicol. | pmid:15235763 |
| Gwak HS et al. | Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin. | 2002 | Arch. Pharm. Res. | pmid:12135116 |
| Kim HW et al. | The effect of vehicles and pressure sensitive adhesives on the percutaneous absorption of quercetin through the hairless mouse skin. | 2004 | Arch. Pharm. Res. | pmid:15357005 |
| Cho CW et al. | Enhanced transdermal absorption and pharmacokinetic evaluation of pranoprofen-ethylene-vinyl acetate matrix containing penetration enhancer in rats. | 2009 | Arch. Pharm. Res. | pmid:19471890 |
| Huang CB et al. | Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. | 2011 | Arch. Oral Biol. | pmid:21333271 |
| Wei P et al. | Characterization of two soil metagenome-derived lipases with high specificity for p-nitrophenyl palmitate. | 2009 | Arch. Microbiol. | pmid:19043691 |
| Morgan-Kiss RM and Cronan JE | The Lactococcus lactis FabF fatty acid synthetic enzyme can functionally replace both the FabB and FabF proteins of Escherichia coli and the FabH protein of Lactococcus lactis. | 2008 | Arch. Microbiol. | pmid:18523755 |
| Sujatha K et al. | Molecular characterization of Pseudomonas sp. LDC-5 involved in accumulation of poly 3-hydroxybutyrate and medium-chain-length poly 3-hydroxyalkanoates. | 2007 | Arch. Microbiol. | pmid:17653530 |
| Cabral MG et al. | Mechanisms underlying the acquisition of resistance to octanoic-acid-induced-death following exposure of Saccharomyces cerevisiae to mild stress imposed by octanoic acid or ethanol. | 2001 | Arch. Microbiol. | pmid:11382226 |
| Sheikh MI et al. | On the mechanism of p-piperidyl and p-benzyl sulfamyl benzoic acids transport by renal tissue. | 1978 | Arch. Int. Physiol. Biochim. | pmid:87158 |
| Bach A et al. | Octanoate metabolism in the isolated perfused rat liver. II. Comparison with a long chain fatty acid. | 1975 | Arch. Int. Physiol. Biochim. | pmid:50825 |
| Buchowicz I et al. | Anti-pseudomonas immunoglobulin. II. Preparation of purified sheep immunoglobulins. | 1981 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:6812541 |
| Cessna AJ and Grover R | Exposure of ground-rig applicators to the herbicide bromoxynil applied as a 1:1 mixture of butyrate and octanoate. | 2002 | Arch. Environ. Contam. Toxicol. | pmid:11910467 |
| Roeder LM et al. | The effects of ketone bodies, bicarbonate, and calcium on hepatic mitochondrial ketogenesis. | 1982 | Arch. Biochem. Biophys. | pmid:7138017 |
| González-Manchón C et al. | Control of hepatic gluconeogenesis: role of fatty acid oxidation. | 1989 | Arch. Biochem. Biophys. | pmid:2712567 |
| Zaleski J and Bryla J | Effects of oleate, palmitate, and octanoate on gluconeogenesis in isolated rabbit liver cells. | 1977 | Arch. Biochem. Biophys. | pmid:921276 |
| Morand C et al. | Importance of the modulation of glycolysis in the control of lactate metabolism by fatty acids in isolated hepatocytes from fed rats. | 1994 | Arch. Biochem. Biophys. | pmid:8135535 |
| BROWN GW et al. | On the unequal conversion of the carboxyl and seventh carbons of octanoate to CO2 by liver slices. | 1954 | Arch. Biochem. Biophys. | pmid:13159319 |
| Almås I et al. | The action of vasopressin and calcium on palmitate metabolism in hepatocytes and isolated mitochondria from rat liver. | 1983 | Arch. Biochem. Biophys. | pmid:6847192 |
| Hu H et al. | Ethanol and oleate inhibition of alpha-ketoisovalerate and 3-hydroxyisobutyrate metabolism by isolated hepatocytes. | 1992 | Arch. Biochem. Biophys. | pmid:1444452 |
| Nagi MN et al. | Biochemical properties of short- and long-chain rat liver microsomal trans-2-enoyl coenzyme A reductase. | 1983 | Arch. Biochem. Biophys. | pmid:6416174 |
| Becker CM and Harris RA | Influence of valproic acid on hepatic carbohydrate and lipid metabolism. | 1983 | Arch. Biochem. Biophys. | pmid:6407400 |
| Jagielski AK et al. | Purinergic regulation of glucose and glutamine synthesis in isolated rabbit kidney-cortex tubules. | 2002 | Arch. Biochem. Biophys. | pmid:12147256 |
| Bach A et al. | Octanoate metabolism in the isolated perfused rat liver. I. Methodology and preliminary results. | 1973 | Arch Sci Physiol (Paris) | pmid:4780669 |
| COHEN R | Four new fungicides for Coccidioides immitis: 1. Sodium caprylate. 2. Ethyl vanillate 3. Fradicin. 4. Thiolutin. | 1951 | Arch Pediatr | pmid:14847786 |
| COHEN R and PERSKY M | Sodium caprylate treatment for thrusii. | 1951 | Arch Pediatr | pmid:14800560 |
| Gumus S et al. | The role of oxidative stress and effect of alpha-lipoic acid in reexpansion pulmonary edema - an experimental study. | 2010 | Arch Med Sci | pmid:22427756 |
| Morimoto K et al. | Effect of medium-chain fatty acid salts on penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas. | 1989 Nov-Dec | Arch Int Pharmacodyn Ther | pmid:2484010 |
| Zentek J et al. | Intestinal concentrations of free and encapsulated dietary medium-chain fatty acids and effects on gastric microbial ecology and bacterial metabolic products in the digestive tract of piglets. | 2012 | Arch Anim Nutr | pmid:22397093 |
| Niewerth H et al. | Synthesis and biotransformation of 2-alkyl-4(1H)-quinolones by recombinant Pseudomonas putida KT2440. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21670979 |
| Liu P et al. | Membrane stress caused by octanoic acid in Saccharomyces cerevisiae. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23435986 |