| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
octanoic acid
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
Cross Reference
Introduction
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with octanoic acid?
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with octanoic acid
PubChem Associated disorders and diseases
What pathways are associated with octanoic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with octanoic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with octanoic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with octanoic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with octanoic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with octanoic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with octanoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Marchington DR et al. | Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat cardiac myocytes. | 1990 | Biochem. J. | pmid:2158309 |
| Kragh-Hansen U | Effects of aliphatic fatty acids on the binding of Phenol Red to human serum albumin. | 1981 | Biochem. J. | pmid:7316975 |
| Bauché F et al. | 2-Mercaptoacetate administration depresses the beta-oxidation pathway through an inhibition of long-chain acyl-CoA dehydrogenase activity. | 1981 | Biochem. J. | pmid:7317017 |
| Hansford RG | Lipid oxidation by heart mitochondria from young adult and senescent rats. | 1978 | Biochem. J. | pmid:637843 |
| Ferré P et al. | Relationship between ketogenesis and gluconeogenesis in isolated hepatocytes from newborn rats. | 1981 | Biochem. J. | pmid:7340842 |
| Kasumov T et al. | Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. | 2005 | Biochem. J. | pmid:15773815 |
| Bellringer ME et al. | Sodium valproate inhibits the movement of secretory vesicles in rat hepatocytes. | 1988 | Biochem. J. | pmid:3124828 |
| Buxton DB et al. | Regulatory effects of fatty acids on decarboxylation of leucine and 4-methyl-2-oxopentanoate in the perfused rat heart. | 1984 | Biochem. J. | pmid:6477487 |
| Felix R and Fleisch H | Increase in fatty acid oxidation in calvaria cells cultured with diphosphonates. | 1981 | Biochem. J. | pmid:6458286 |
| Wagenmakers AJ et al. | Increase of the activity state and loss of total activity of the branched-chain 2-oxo acid dehydrogenase in rat diaphragm during incubation. | 1984 | Biochem. J. | pmid:6517861 |
| Lagercrantz C and Larsson T | Comparative studies of the binding of some ligands to human serum albumin non-covalently attached to immobilized Cibacron Blue, or covalently immobilized on Sepharose, by column affinity chromatography. | 1983 | Biochem. J. | pmid:6615442 |
| Ferré P et al. | Development and regulation of ketogenesis in hepatocytes isolated from newborn rats. | 1983 | Biochem. J. | pmid:6626164 |
| Iwahashi H | Some polyphenols inhibit the formation of pentyl radical and octanoic acid radical in the reaction mixture of linoleic acid hydroperoxide with ferrous ions. | 2000 | Biochem. J. | pmid:10677343 |
| Fatania HR et al. | Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n-octanoate. | 1986 | Biochem. J. | pmid:3707545 |
| Strong CR and Dils R | Fatty acid biosynthesis in rabbit mammary gland during pregnancy and early lactation. | 1972 | Biochem. J. | pmid:4643704 |
| Stewart HB et al. | Intermediates in fatty acid oxidation. | 1973 | Biochem. J. | pmid:4722901 |
| Rofe AM and Williamson DH | Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia. | 1983 | Biochem. J. | pmid:6135420 |
| Wilson MB | Control of phosphoenolpyruvate synthesis in guinea-pig mitochondria. | 1973 | Biochem. J. | pmid:4724589 |
| Boveris A and Chance B | The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. | 1973 | Biochem. J. | pmid:4749271 |
| Halestrap AP | The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+. | 1987 | Biochem. J. | pmid:3663110 |
| Even PC et al. | Defective regulation of energy metabolism in mdx-mouse skeletal muscles. | 1994 | Biochem. J. | pmid:7999003 |
| Gavva SR et al. | A 13C isotopomer n.m.r. method for monitoring incomplete beta-oxidation of fatty acids in intact tissue. | 1994 | Biochem. J. | pmid:7980454 |
| Sibille B et al. | The mitochondrial consequences of uncoupling intact cells depend on the nature of the exogenous substrate. | 2001 | Biochem. J. | pmid:11256968 |
| Harwood JL et al. | Fat metabolism in higher plants. Beta-hydroxylation of fatty acids by a soluble preparation from maturing avocado mesocarp. | 1972 | Biochem. J. | pmid:4144293 |
| Reed WD et al. | A double-isotope method for the measurement of ketone-body turnover in the rat. Effect of L-alanine. | 1984 | Biochem. J. | pmid:6721850 |
| Oshino N et al. | The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver. | 1975 | Biochem. J. | pmid:167718 |
| Kragh-Hansen U | Octanoate binding to the indole- and benzodiazepine-binding region of human serum albumin. | 1991 | Biochem. J. | pmid:1996962 |
| Kalbag SS and Palekar AG | Sodium benzoate inhibits fatty acid oxidation in rat liver: effect on ammonia levels. | 1988 | Biochem. Med. Metab. Biol. | pmid:3190922 |
| Schepkin V et al. | NMR study of lipoic acid binding to bovine serum albumin. | 1994 | Biochem. Mol. Biol. Int. | pmid:7987256 |
| GarcÃa-Villafranca J and Castro J | Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. | 2002 | Biochem. Pharmacol. | pmid:12093476 |
| Fulgencio JP et al. | Effect of metformin on fatty acid and glucose metabolism in freshly isolated hepatocytes and on specific gene expression in cultured hepatocytes. | 2001 | Biochem. Pharmacol. | pmid:11448453 |
| Veitch K and Van Hoof F | In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria. | 1990 | Biochem. Pharmacol. | pmid:2242043 |
| Sarnatskaya VV et al. | Effect of protein-bound uraemic toxins on the thermodynamic characteristics of human albumin. | 2002 | Biochem. Pharmacol. | pmid:11960605 |
| Swartzentruber MS and Harris RA | Inhibition of metabolic processes by coenzyme-A-sequestering aromatic acids. Prevention by para-chloro- and para-nitrobenzoic acids. | 1987 | Biochem. Pharmacol. | pmid:3117062 |
| Schudt C and Simon A | Effects of sodium 2-[5-(4-chlorophenyl)pentyl]-oxirane-2-carboxylate (POCA) on carbohydrate and fatty acid metabolism in liver and muscle. | 1984 | Biochem. Pharmacol. | pmid:6437406 |
| el-Aleem SA and Schulz H | Evaluation of inhibitors of fatty acid oxidation in rat myocytes. | 1987 | Biochem. Pharmacol. | pmid:3689454 |
| Deaciuc IV et al. | Studies on the mechanism of action of the hypoglycemic agent, 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304). | 1983 | Biochem. Pharmacol. | pmid:6651864 |
| Olubadewo JO et al. | Effects of 8-N,N-diethylamino-octyl-3,4,5-trimethoxybenzoate (TMB-8) HCl and verapamil on the metabolism of free fatty acid by hepatocytes. | 1988 | Biochem. Pharmacol. | pmid:3358779 |
| Massolini G et al. | Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases. | 1993 | Biochem. Pharmacol. | pmid:8216380 |
| Grolier P and Elcombe CR | In vitro inhibition of carnitine acyltransferase activity in mitochondria from rat and mouse liver by a diethylhexylphthalate metabolite. | 1993 | Biochem. Pharmacol. | pmid:8452557 |
| Haas R et al. | Salicylate-induced loose coupling: protonmotive force measurements. | 1985 | Biochem. Pharmacol. | pmid:3977963 |
| Krahenbuhl S and Brass EP | Inhibition of hepatic propionyl-CoA synthetase activity by organic acids. Reversal of propionate inhibition of pyruvate metabolism. | 1991 Mar 15-Apr 1 | Biochem. Pharmacol. | pmid:2009071 |
| Rozas I et al. | Effects of acute valproate administration on carnitine metabolism in mouse serum and tissues. | 1990 | Biochem. Pharmacol. | pmid:2105093 |
| Thayer WS | Inhibition of mitochondrial fatty acid oxidation in pentenoic acid-induced fatty liver. A possible model for Reye's syndrome. | 1984 | Biochem. Pharmacol. | pmid:6712730 |
| Porter DJ | Binding of 2-acetylpyridine-5-[(2-chloroanilino)thiocarbonyl] thiocarbonohydrazone (BW348U87) to human serum albumin. | 1992 | Biochem. Pharmacol. | pmid:1417962 |
| Ohtsuka Y and Griffith OW | L-carnitine protection in ammonia intoxication. Effect of aminocarnitine on carnitine-dependent metabolism and acute ammonia toxicity. | 1991 | Biochem. Pharmacol. | pmid:2039546 |
| Carrington MJ et al. | Octanoate and palmitate as substrates for ketogenesis by hepatocytes isolated from suckling rabbits. | 1981 | Biochem. Soc. Trans. | pmid:7215663 |
| Littlechild JA et al. | Hyperthermophilic dehydrogenase enzymes. | 2004 | Biochem. Soc. Trans. | pmid:15046583 |
| Priestman DA et al. | Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes. | 1997 | Biochem. Soc. Trans. | pmid:9056999 |
| Sherrington EJ et al. | Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736816 |
| Gandhi NN and Mukherjee KD | Papaya (Carica papaya) lipase with some distinct acyl and alkyl specificities as compared with microbial lipases. | 2000 | Biochem. Soc. Trans. | pmid:11171278 |
| Bhuiyan AK and Pande SV | One-step facile synthesis of radioactive acyl-CoA and acylcarnitines using rat liver outer mitochondrial membrane as the enzyme source. | 1991 | Biochem. Soc. Trans. | pmid:1889559 |
| Clouet P et al. | Mitochondrial respiration on rumenic and linoleic acids. | 2001 | Biochem. Soc. Trans. | pmid:11356175 |
| Zwiebel FM et al. | Role of pyruvate transporter in the regulation of the pyruvate dehydrogenase multienzyme complex in perfused rat liver. | 1982 | Biochemistry | pmid:7074018 |
| Miller JR et al. | Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. | 2000 | Biochemistry | pmid:11106496 |
| Lo YC et al. | Substrate specificities of Escherichia coli thioesterase I/protease I/lysophospholipase L1 are governed by its switch loop movement. | 2005 | Biochemistry | pmid:15697222 |
| Garner CW and Behal FJ | Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups. | 1975 | Biochemistry | pmid:38 |
| Salesse R et al. | Modulation of adenylate cyclase activity by the physical state of pigeon erythrocyte membrane. 1. Parallel drug-induced changes in the bilayer fluidity and adenylate cyclase activity. | 1982 | Biochemistry | pmid:6282308 |
| Pohl J et al. | Long-chain fatty acid uptake into adipocytes depends on lipid raft function. | 2004 | Biochemistry | pmid:15065861 |
| Li W et al. | Reconstitution of the M13 major coat protein and its transmembrane peptide segment on a DNA template. | 2007 | Biochemistry | pmid:17595059 |
| Mao LF et al. | Hepatic beta-oxidation of 3-phenylpropionic acid and the stereospecific dehydration of (R)- and (S)-3-hydroxy-3-phenylpropionyl-CoA by different enoyl-CoA hydratases. | 1994 | Biochemistry | pmid:8136368 |
| Jiang Y et al. | The soluble acyl-acyl carrier protein synthetase of Vibrio harveyi B392 is a member of the medium chain acyl-CoA synthetase family. | 2006 | Biochemistry | pmid:16906759 |
| Hsieh CH et al. | The Enigmatic P450 Decarboxylase OleT Is Capable of, but Evolved To Frustrate, Oxygen Rebound Chemistry. | 2017 | Biochemistry | pmid:28603981 |
| Hayden MA et al. | Biosynthesis of lipoic acid: characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33-lip9. | 1993 | Biochemistry | pmid:8466915 |
| White RH | Stable isotope studies on the biosynthesis of lipoic acid in Escherichia coli. | 1980 | Biochemistry | pmid:6766313 |
| Kawai A et al. | Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions. | 2017 | Biochim Biophys Acta Proteins Proteom | pmid:28473296 |
| Vauhkonen M and Somerharju P | Parinaroyl and pyrenyl phospholipids as probes for the lipid surface layer of human low density lipoproteins. | 1989 | Biochim. Biophys. Acta | pmid:2765542 |
| Sumbilla CM et al. | Comparison of the oxidation of glutamine, glucose, ketone bodies and fatty acids by human diploid fibroblasts. | 1981 | Biochim. Biophys. Acta | pmid:7272339 |
| Einarsson R | The binding of 1-anilino-8-naphthalenesulfonate, heparin, salicylate and caprylate by human antithrombin III. | 1976 | Biochim. Biophys. Acta | pmid:974107 |
| Brass EP and Garrity MJ | Modulation of prostaglandin E2 catabolism and action by fuel substrates in rat hepatocytes. | 1989 | Biochim. Biophys. Acta | pmid:2912505 |
| Lemarié F et al. | Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration. | 2016 | Biochim. Biophys. Acta | pmid:27317984 |
| Bartels PD and Sestoft L | Thyroid hormone-induced changes in gluconeogenesis and ketogenesis in perfused rat liver. | 1980 | Biochim. Biophys. Acta | pmid:7448206 |
| Sundqvist KE et al. | Effect of acetate and octanoate on tricarboxylic acid cycle metabolite disposal during propionate oxidation in the perfused rat heart. | 1984 | Biochim. Biophys. Acta | pmid:6487652 |
| Ayuso MS et al. | Interrelation between gluconeogenesis and hepatic protein synthesis. | 1986 | Biochim. Biophys. Acta | pmid:3015233 |
| Tachibana S et al. | Octanoate reduces very low-density lipoprotein secretion by decreasing the synthesis of apolipoprotein B in primary cultures of chicken hepatocytes. | 2005 | Biochim. Biophys. Acta | pmid:16226916 |
| Dorset DL | Co-solubility of saturated cholesteryl esters: a comparison of calculated and experimental binary phase diagrams. | 1988 | Biochim. Biophys. Acta | pmid:3179332 |
| Arakawa T and Kita Y | Stabilizing effects of caprylate and acetyltryptophanate on heat-induced aggregation of bovine serum albumin. | 2000 | Biochim. Biophys. Acta | pmid:10862953 |
| Merrill AR et al. | Effects of exogenous fatty acids on calcium uptake by brush-border membrane vesicles from rabbit small intestine. | 1986 | Biochim. Biophys. Acta | pmid:3081028 |
| Veerkamp JH et al. | An accurate and sensitive assay of [14C]octanoate oxidation and its application on tissue homogenates and fibroblasts. | 1986 | Biochim. Biophys. Acta | pmid:3081042 |
| Barron JT et al. | Effect of serum albumin on vascular smooth muscle metabolism. | 2000 | Biochim. Biophys. Acta | pmid:10924897 |
| Herold G et al. | Cholesterol synthesis and esterification in cultured intestinal mucosa. Evidence for compartmentation. | 1984 | Biochim. Biophys. Acta | pmid:6567470 |
| Schönfeld P et al. | On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:3196710 |
| Wilson TA et al. | Structured triglycerides containing caprylic (8:0) and oleic (18:1) fatty acids reduce blood cholesterol concentrations and aortic cholesterol accumulation in hamsters. | 2006 | Biochim. Biophys. Acta | pmid:16580874 |
| Gambert S et al. | Regulation of intermediary metabolism in rat cardiac myocyte by extracellular glycerol. | 2005 | Biochim. Biophys. Acta | pmid:16153888 |
| Henze K et al. | The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts. | 1981 | Biochim. Biophys. Acta | pmid:6118180 |
| Müller MJ et al. | Effect of thyroid state on ketogenic capacity of the isolated perfused liver of starved rats. | 1981 | Biochim. Biophys. Acta | pmid:6275888 |
| González-Manchón C et al. | Control of gluconeogenesis: role of fatty acids in the alpha-adrenergic response. | 1988 | Biochim. Biophys. Acta | pmid:3191164 |
| Anraku M et al. | Stabilizing mechanisms in commercial albumin preparations: octanoate and N-acetyl-L-tryptophanate protect human serum albumin against heat and oxidative stress. | 2004 | Biochim. Biophys. Acta | pmid:15450846 |
| Redondo O et al. | Comparative kinetic study of lipases A and B from Candida rugosa in the hydrolysis of lipid p-nitrophenyl esters in mixed micelles with Triton X-100. | 1995 | Biochim. Biophys. Acta | pmid:7827103 |
| Martinelle M and Hult K | Kinetics of acyl transfer reactions in organic media catalysed by Candida antarctica lipase B. | 1995 | Biochim. Biophys. Acta | pmid:7669809 |
| Hulsmann WC et al. | Imminent ischemia in normal and hypertrophic Langendorff rat hearts; effects of fatty acids and superoxide dismutase monitored by NADH surface fluorescence. | 1993 | Biochim. Biophys. Acta | pmid:8318552 |
| Viegas CA et al. | Regulation of the expression of the H(+)-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae. | 1994 | Biochim. Biophys. Acta | pmid:8286419 |
| Murphy MG et al. | Abnormalities in hepatic fatty-acid metabolism in a surfactant/influenza B virus mouse model for acute encephalopathy. | 1996 | Biochim. Biophys. Acta | pmid:8611661 |
| Brandes R et al. | The specificity of triacylglycerol synthesis for medium-chain fatty acids in rat and human adipose preparations. | 1985 | Biochim. Biophys. Acta | pmid:4027259 |
| Thennarasu S et al. | Antimicrobial activity and membrane selective interactions of a synthetic lipopeptide MSI-843. | 2005 | Biochim. Biophys. Acta | pmid:15904663 |
| González-Manchón C et al. | Ca2(+)-fatty acid interaction in the control of hepatic gluconeogenesis. | 1990 | Biochim. Biophys. Acta | pmid:2310772 |
| Salesse R and Garnier J | Effects of drugs on pigeon erythrocyte membrane and asymmetric control or adenylate cyclase by the lipid bilayer. | 1979 | Biochim. Biophys. Acta | pmid:222319 |
| Magliano P et al. | Repercussion of a deficiency in mitochondrial ß-oxidation on the carbon flux of short-chain fatty acids to the peroxisomal ß-oxidation cycle in Aspergillus nidulans. | 2010 | Biochim. Biophys. Acta | pmid:20736083 |
| Shimshoni JA et al. | Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. | 2011 | Biochim. Biophys. Acta | pmid:21184843 |
| Nomura T et al. | Effects of octanoate and acetate upon hepatic glycolysis and lipogenesis. | 1983 | Biochim. Biophys. Acta | pmid:6317044 |