octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Kingsley-Hickman PB et al. | 31P NMR measurement of mitochondrial uncoupling in isolated rat hearts. | 1990 | J. Biol. Chem. | pmid:2136855 |
Gimeno RE et al. | Characterization of a heart-specific fatty acid transport protein. | 2003 | J. Biol. Chem. | pmid:12556534 |
Krisans SK et al. | Acyl-CoA synthetase in rat liver peroxisomes. Computer-assisted analysis of cell fractionation experiments. | 1980 | J. Biol. Chem. | pmid:7430088 |
Waymack PP et al. | Studies on the activation and inactivation of the branched chain alpha-keto acid dehydrogenase in the perfused rat heart. | 1980 | J. Biol. Chem. | pmid:7430101 |
Deng S et al. | Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver. | 2009 | J. Biol. Chem. | pmid:19666922 |
May ME et al. | Mechanism of the stimulation of branched chain oxoacid oxidation in liver by carnitine. | 1980 | J. Biol. Chem. | pmid:7410370 |
Qahwash IM et al. | Site-specific effects of peptide lipidation on beta-amyloid aggregation and cytotoxicity. | 2007 | J. Biol. Chem. | pmid:17693400 |
Watanabe K et al. | Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. | 2000 | J. Biol. Chem. | pmid:10801788 |
Otto DA | Relationship of the ATP/ADP ratio to the site of octanoate activation. | 1984 | J. Biol. Chem. | pmid:6715356 |
Fulks RM et al. | Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. | 1975 | J. Biol. Chem. | pmid:1141208 |
Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
Jordanova R et al. | The highly abundant protein Ag-lbp55 from Ascaridia galli represents a novel type of lipid-binding proteins. | 2005 | J. Biol. Chem. | pmid:16210327 |
Heaney-Kieras J and King TP | Limited pepsin digestion of human plasma albumin. | 1977 | J. Biol. Chem. | pmid:325004 |
Connolly E and Nedergaard J | Beta-adrenergic modulation of Ca2+ uptake by isolated brown adipocytes. Possible involvement of mitochondria. | 1988 | J. Biol. Chem. | pmid:2839496 |
Roncero C and Goodridge AG | Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. | 1992 | J. Biol. Chem. | pmid:1634532 |
Lysiak W et al. | Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria. | 1986 | J. Biol. Chem. | pmid:3759988 |
Gueguen V et al. | Fatty acid and lipoic acid biosynthesis in higher plant mitochondria. | 2000 | J. Biol. Chem. | pmid:10671542 |
Bian F et al. | Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate. | 2005 | J. Biol. Chem. | pmid:15611129 |
McGarry JD and Foster DW | The regulation of ketogenesis from octanoic acid. The role of the tricarboxylic acid cycle and fatty acid synthesis. | 1971 | J. Biol. Chem. | pmid:5543682 |
Kaiya H et al. | Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. | 2001 | J. Biol. Chem. | pmid:11546772 |
Campbell SE et al. | A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. | 2004 | J. Biol. Chem. | pmid:15161924 |
Lysiak W et al. | Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria. | 1988 | J. Biol. Chem. | pmid:3335535 |
Ishima Y et al. | S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding. | 2008 | J. Biol. Chem. | pmid:18940810 |
Stoddart CA et al. | Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice. | 2008 | J. Biol. Chem. | pmid:18809675 |
Mortimore GE et al. | Modulation of the amino acid control of hepatic protein degradation by caloric deprivation. Two modes of alanine co-regulation. | 1988 | J. Biol. Chem. | pmid:3264284 |
GEYER RP et al. | Metabolism of emulsified trilaurin (-C1400-) and octanoic acid (-C1400-) by rat tissue slices. | 1949 | J. Biol. Chem. | pmid:18139198 |
Stephens JL et al. | Mitochondrial fatty acid synthesis in Trypanosoma brucei. | 2007 | J. Biol. Chem. | pmid:17166831 |
Connolly E et al. | Norepinephrine-induced Na+ influx in brown adipocytes is cyclic AMP-mediated. | 1986 | J. Biol. Chem. | pmid:3021738 |
Morris TW et al. | Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product. | 1994 | J. Biol. Chem. | pmid:8206909 |
Sabbagh E et al. | 3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria. | 1985 | J. Biol. Chem. | pmid:3997873 |
Lai CY and Cronan JE | Beta-ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis. | 2003 | J. Biol. Chem. | pmid:14523010 |
Kawaguchi T et al. | Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. | 2002 | J. Biol. Chem. | pmid:11724780 |
Guy JE et al. | Crystal structure of a class XIB phospholipase A2 (PLA2): rice (oryza sativa) isoform-2 pla2 and an octanoate complex. | 2009 | J. Biol. Chem. | pmid:19457861 |
Fujino T et al. | Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. | 2001 | J. Biol. Chem. | pmid:11470804 |
Strieleman PJ et al. | Fatty acid activation of the reconstituted brown adipose tissue mitochondria uncoupling protein. | 1985 | J. Biol. Chem. | pmid:4055740 |
Abumrad NA et al. | Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. | 1984 | J. Biol. Chem. | pmid:6746632 |
Frederich M and Balschi JA | The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart. | 2002 | J. Biol. Chem. | pmid:11707445 |
KUSUNOSE M et al. | ENZYMATIC OMEGA-OXIDATION OF FATTY ACIDS. I. PRODUCTS OF OCTANOATE, DECONATE, AND LAURATE OXIDATION. | 1964 | J. Biol. Chem. | pmid:14189868 |
Nobes CD et al. | The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes. | 1990 | J. Biol. Chem. | pmid:2376580 |
Vidal H et al. | Vasoactive intestinal peptide stimulates long-chain fatty acid oxidation and inhibits acetyl-coenzyme A carboxylase activity in isolated rat enterocytes. | 1989 | J. Biol. Chem. | pmid:2564395 |
Hiltunen JK et al. | Mitochondrial fatty acid synthesis type II: more than just fatty acids. | 2009 | J. Biol. Chem. | pmid:19028688 |
VESTLING CS and KAUFMAN S | The oxidation of octanoate by normal and leucemic mouse liver homogenates. | 1946 | J. Biol. Chem. | pmid:21001223 |
Hampson RK et al. | Regulation of the glycine cleavage system in the isolated perfused rat liver. | 1984 | J. Biol. Chem. | pmid:6420402 |
Martin JD et al. | Structure and membrane affinity of new amphiphilic siderophores produced by Ochrobactrum sp. SP18. | 2006 | J. Biol. Inorg. Chem. | pmid:16791646 |
Gurvitz A | Identification of the Leishmania major proteins LmjF07.0430, LmjF07.0440, and LmjF27.2440 as components of fatty acid synthase II. | 2009 | J. Biomed. Biotechnol. | pmid:20145708 |
Chen R et al. | Chemiluminescent nanomicelles for imaging hydrogen peroxide and self-therapy in photodynamic therapy. | 2011 | J. Biomed. Biotechnol. | pmid:21765637 |
Mazarro R et al. | Copolymerization of D,L-lactide and glycolide in supercritical carbon dioxide with zinc octoate as catalyst. | 2008 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:17854066 |
Comar JF et al. | Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations. | 2010 | J. Biomed. Sci. | pmid:20055990 |
Chen YJ et al. | Production and characterization of medium-chain-length polyhydroxyalkanoates by Pseudomonas mosselii TO7. | 2014 | J. Biosci. Bioeng. | pmid:24630613 |
Maeda A et al. | Characterization of novel cholesterol esterase from Trichoderma sp. AS59 with high ability to synthesize steryl esters. | 2008 | J. Biosci. Bioeng. | pmid:18499049 |
Furukawa K et al. | Increased ethyl caproate production by inositol limitation in Saccharomyces cerevisiae. | 2003 | J. Biosci. Bioeng. | pmid:16233438 |
Okamoto K et al. | Production of gamma-lactones by the brown-rot basidiomycete Piptoporus soloniensis. | 2002 | J. Biosci. Bioeng. | pmid:16233291 |
Russell RA et al. | Production and use of deuterated polyhydroxyoctanoate in structural studies of PHO inclusions. | 2007 | J. Biotechnol. | pmid:17555837 |
Lomborg CJ et al. | At-line determination of octanoic acid in cultivation broth--an electronic tongue (ET) feasibility study. | 2008 | J. Biotechnol. | pmid:17996321 |
Choi MH et al. | Metabolic relationship between polyhydroxyalkanoic acid and rhamnolipid synthesis in Pseudomonas aeruginosa: comparative ¹³C NMR analysis of the products in wild-type and mutants. | 2011 | J. Biotechnol. | pmid:21029757 |
Vikbjerg AF et al. | Synthesis of structured phospholipids by immobilized phospholipase A2 catalyzed acidolysis. | 2007 | J. Biotechnol. | pmid:17150274 |
Buclin T et al. | Bioavailability and biological efficacy of a new oral formulation of salmon calcitonin in healthy volunteers. | 2002 | J. Bone Miner. Res. | pmid:12162502 |
Sánchez-Serrano D et al. | Enhancement of ouabain arrhythmias by fatty acids. | 1980 | J. Cardiovasc. Pharmacol. | pmid:6156330 |
SMITH JA and DELUCA HF | STRUCTURAL CHANGES IN ISOLATED LIVER MITOCHONDRIA OF RATS DURING ESSENTIAL FATTY ACID DEFICIENCY. | 1964 | J. Cell Biol. | pmid:14154491 |
Stanisz J et al. | Serum factors that stimulate fatty acid oxidation: physiological specificity. | 1986 | J. Cell. Physiol. | pmid:3944194 |
Mori S et al. | Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. | 2003 | J. Cereb. Blood Flow Metab. | pmid:12679720 |
Pierre PS et al. | Differences in volatile profiles of turnip plants subjected to single and dual herbivory above- and belowground. | 2011 | J. Chem. Ecol. | pmid:21448706 |
Vinson SB et al. | Nest liquid resources of several cavity nesting bees in the genus Centris and the identification of a preservative, levulinic acid. | 2006 | J. Chem. Ecol. | pmid:16902822 |
Mukabana WR et al. | A novel synthetic odorant blend for trapping of malaria and other African mosquito species. | 2012 | J. Chem. Ecol. | pmid:22426893 |
Attygalle AB et al. | Defensive chemicals of two species of Trachypachus Motschulski. | 2004 | J. Chem. Ecol. | pmid:15139309 |
Smallegange RC et al. | The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto. | 2009 | J. Chem. Ecol. | pmid:19626371 |
Hall DR et al. | Identification of components of male-produced pheromone of coffee white stemborer, Xylotrechus quadripes. | 2006 | J. Chem. Ecol. | pmid:16525878 |
Suzuki T et al. | Analysis of anal secretions from phlaeothripine thrips. | 2004 | J. Chem. Ecol. | pmid:15112732 |
Wood WF | Volatile components in metatarsal glands of sika deer, Cervus nippon. | 2003 | J. Chem. Ecol. | pmid:14969359 |
Arimoto K et al. | Abnormal 13C-fatty acid breath tests in patients treated with valproic acid. | 1988 | J. Child Neurol. | pmid:3143757 |
Tsaconas C et al. | Gas chromatographic-mass spectrometric assessment of the pharmacokinetics of amineptine and its main metabolite in volunteers with liver impairment. | 1989 | J. Chromatogr. | pmid:2722999 |
Noctor TA et al. | Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. | 1992 | J. Chromatogr. | pmid:1400761 |
Nelis HJ et al. | Chromatographic determination of N-acetyl-DL-tryptophan and octanoic acid in human albumin solutions. | 1985 | J. Chromatogr. | pmid:4055947 |
Abbott FS et al. | Valproic acid analysis in saliva and serum using selected ion monitoring (electron ionization) of the tert.-butyldimethylsilyl derivatives. | 1982 | J. Chromatogr. | pmid:6801067 |
Lee YC and Johnson JH | Determination of sodium caprylate in plasma volume expanders by gas chromatography. | 1986 | J. Chromatogr. | pmid:2426293 |
Simon-Colin C et al. | Development of a three-steps derivatization assay for the localization of double bond in monounsaturated monomers of poly-beta-hydroxyalkanoates by GC-MS. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22717557 |
Endo M et al. | In vitro probe acylcarnitine profiling assay using cultured fibroblasts and electrospray ionization tandem mass spectrometry predicts severity of patients with glutaric aciduria type 2. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20392676 |
Tavares V et al. | Determination of dimenhydrinate in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a relative bioavailability study. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17442639 |
Isidorov VA et al. | Gas chromatographic-mass spectrometric investigation of volatile and extractable compounds of crude royal jelly. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22245368 |
Mu H and Høy CE | Application of atmospheric pressure chemical ionization liquid chromatography-mass spectrometry in identification of lymph triacylglycerols. | 2000 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11087085 |
Kulik W et al. | Improved use of the [13C]octanoic acid breath test as intra-individual parameter to study the effect of a prokinetic drug on gastric emptying in preterm infants with oral feeding intolerance. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11204215 |
Hayball PJ et al. | Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7894686 |
Kanamoto N et al. | Substantial production of ghrelin by a human medullary thyroid carcinoma cell line. | 2001 | J. Clin. Endocrinol. Metab. | pmid:11600575 |
Beglinger S et al. | Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion. | 2010 | J. Clin. Endocrinol. Metab. | pmid:19837920 |
Nass R et al. | The level of circulating octanoate does not predict ghrelin O-acyl transferase (GOAT)-mediated acylation of ghrelin during fasting. | 2015 | J. Clin. Endocrinol. Metab. | pmid:25337923 |
Dickman R et al. | A novel continuous breath test versus scintigraphy for gastric emptying rate measurement. | 2011 | J. Clin. Gastroenterol. | pmid:20495467 |
Demaugre F et al. | Infantile form of carnitine palmitoyltransferase II deficiency with hepatomuscular symptoms and sudden death. Physiopathological approach to carnitine palmitoyltransferase II deficiencies. | 1991 | J. Clin. Invest. | pmid:1999498 |
Tonsgard JH et al. | Binding of straight-chain saturated dicarboxylic acids to albumin. | 1988 | J. Clin. Invest. | pmid:3183053 |
Amendt BA and Rhead WJ | The multiple acyl-coenzyme A dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria. Mitochondrial fatty acid oxidation, acyl-coenzyme A dehydrogenase, and electron transfer flavoprotein activities in fibroblasts. | 1986 | J. Clin. Invest. | pmid:3722376 |
Matsuzaki K et al. | Inhibition of cortical collecting tubule chloride transport by organic acids. | 1988 | J. Clin. Invest. | pmid:3392216 |
Sidossis LS et al. | Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. | 1996 | J. Clin. Invest. | pmid:8941640 |
Zhou YP and Grill VE | Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. | 1994 | J. Clin. Invest. | pmid:8113418 |
Voller B et al. | Dose-escalation study of octanoic acid in patients with essential tremor. | 2016 | J. Clin. Invest. | pmid:26927672 |
Croce A et al. | Effect of infliximab on the glycosylation of IgG of patients with rheumatoid arthritis. | 2007 | J. Clin. Lab. Anal. | pmid:17847113 |
Planelles D et al. | A new, fast, and simple DNA extraction method for HLA and VNTR genotyping by PCR amplification. | 1996 | J. Clin. Lab. Anal. | pmid:8731498 |
Katoh K et al. | Octanoate increases cytosolic Ca2+ concentration and membrane conductance in ovine pancreatic acinar cells. | 1996 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:8923746 |
Du J et al. | Molecular basis of P450 OleT: an investigation of substrate binding mechanism and major pathways. | 2017 | J. Comput. Aided Mol. Des. | pmid:28342136 |
Lord DL et al. | Comparison of capillary pressure relationships of organic liquid-water systems containing an organic acid or base. | 2005 | J. Contam. Hydrol. | pmid:15763355 |
Yonezawa T et al. | Octanoate stimulates cytosolic triacylglycerol accumulation and CD36 mRNA expression but inhibits acetyl coenzyme A carboxylase activity in primary cultured bovine mammary epithelial cells. | 2004 | J. Dairy Res. | pmid:15605705 |
Morrill KM et al. | Estimate of serum immunoglobulin G concentration using refractometry with or without caprylic acid fractionation. | 2013 | J. Dairy Sci. | pmid:23664346 |