octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Rosenblatt J et al. | Caprylic acid and glyceryl trinitrate combination for eradication of biofilm. | 2015 | Antimicrob. Agents Chemother. | pmid:25534725 |
Gourcerol G et al. | Impaired fasting pyloric compliance in gastroparesis and the therapeutic response to pyloric dilatation. | 2015 | Aliment. Pharmacol. Ther. | pmid:25523288 |
Nass R et al. | The level of circulating octanoate does not predict ghrelin O-acyl transferase (GOAT)-mediated acylation of ghrelin during fasting. | 2015 | J. Clin. Endocrinol. Metab. | pmid:25337923 |
Chang P et al. | Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency. | 2015 | J. Pharmacol. Exp. Ther. | pmid:25326131 |
De Preter V et al. | Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. | 2015 | Gut | pmid:24811995 |
Kandula M et al. | Discovery and preclinical development of a novel prodrug conjugate of mesalamine with eicosapentaenoic acid and caprylic acid for the treatment of inflammatory bowel diseases. | 2016 | Int. Immunopharmacol. | pmid:27716592 |
Kateja N et al. | Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow inversion reactor (CFIR). | 2016 | Biotechnol J | pmid:27447837 |
Lemarié F et al. | Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration. | 2016 | Biochim. Biophys. Acta | pmid:27317984 |
Sawatani Y et al. | Sequence-specific DNA binding by long hairpin pyrrole-imidazole polyamides containing an 8-amino-3,6-dioxaoctanoic acid unit. | 2016 | Bioorg. Med. Chem. | pmid:27301681 |
Kubota K et al. | The molecular assembly of the ionic liquid/aliphatic carboxylic acid/aliphatic amine as effective and safety transdermal permeation enhancers. | 2016 | Eur J Pharm Sci | pmid:26965004 |
Nakajima K et al. | Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells. | 2016 | Biomed. Res. | pmid:28003581 |
Hogan S et al. | Eradication of Staphylococcus aureus Catheter-Related Biofilm Infections Using ML:8 and Citrox. | 2016 | Antimicrob. Agents Chemother. | pmid:27458213 |
Lockman KA et al. | Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro. | 2016 | Lipids Health Dis | pmid:27368608 |
Voller B et al. | Dose-escalation study of octanoic acid in patients with essential tremor. | 2016 | J. Clin. Invest. | pmid:26927672 |
Diaz De Rienzo MA et al. | Effect of biosurfactants on Pseudomonas aeruginosa and Staphylococcus aureus biofilms in a BioFlux channel. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26825819 |
Caviglia GP et al. | Gastric emptying and related symptoms in patients treated with buspirone, amitriptyline or clebopride: a "real world" study by 13C-octanoic Acid Breath Test. | 2017 | Minerva Med. | pmid:28707862 |
Khabbush A et al. | Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium-chain triglyceride ketogenic diet. | 2017 | Epilepsia | pmid:28682459 |
Kawai A et al. | Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions. | 2017 | Biochim Biophys Acta Proteins Proteom | pmid:28473296 |
Du J et al. | Molecular basis of P450 OleT: an investigation of substrate binding mechanism and major pathways. | 2017 | J. Comput. Aided Mol. Des. | pmid:28342136 |
Besada-Lombana PB et al. | Engineering Saccharomyces cerevisiae fatty acid composition for increased tolerance to octanoic acid. | 2017 | Biotechnol. Bioeng. | pmid:28294288 |
Lourenço A et al. | Antimicrobial treatments to control Listeria monocytogenes in queso fresco. | 2017 | Food Microbiol. | pmid:28213034 |
Fontaine P et al. | Medium chain length polyhydroxyalkanoates biosynthesis in Pseudomonas putida mt-2 is enhanced by co-metabolism of glycerol/octanoate or fatty acids mixtures. | 2017 | Int. J. Biol. Macromol. | pmid:28174083 |
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Peyser RD et al. | Analysis of cytochrome P450 contribution to evolved plant toxin resistance in Drosophila sechellia. | 2017 | Insect Mol. Biol. | pmid:28703934 |
Hsieh CH et al. | The Enigmatic P450 Decarboxylase OleT Is Capable of, but Evolved To Frustrate, Oxygen Rebound Chemistry. | 2017 | Biochemistry | pmid:28603981 |
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Alva-Murillo N et al. | Sodium Octanoate Modulates the Innate Immune Response of Bovine Mammary Epithelial Cells through the TLR2/P38/JNK/ERK1/2 Pathway: Implications during Staphylococcus aureus Internalization. | 2017 | Front Cell Infect Microbiol | pmid:28361042 |