octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with octanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Shipp DA et al. | Development of fatty acid oxidation in neonatal guinea-pig liver. | 1982 | Biochem. J. | pmid:7165728 |
Ferré P et al. | Relationship between ketogenesis and gluconeogenesis in isolated hepatocytes from newborn rats. | 1981 | Biochem. J. | pmid:7340842 |
Zammit VA | The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-L-carnitine and octanoate by isolated liver mitochondria. | 1980 | Biochem. J. | pmid:7470052 |
Petcu LG and Plaut GW | NADP-specific isocitrate dehydrogenase in regulation of urea synthesis in rat hepatocytes. | 1980 | Biochem. J. | pmid:7470071 |
Kasumov T et al. | Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. | 2005 | Biochem. J. | pmid:15773815 |
Buse MG et al. | Regulation of branched-chain amino acid oxidation in isolated muscles, nerves and aortas of rats. | 1975 | Biochem. J. | pmid:1200982 |
Blumenthal SA | Inhibition of gluconeogenesis in rat liver by lipoic acid. Evidence for more than one site of action. | 1984 | Biochem. J. | pmid:6430273 |
Berne C | The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies. | 1975 | Biochem. J. | pmid:776173 |
Guo W et al. | Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. | 2000 | Biochem. J. | pmid:10880345 |
Taylor WM et al. | The stimulation of tricarboxylic acid-cycle flux by alpha-adrenergic agonists in perfused rat liver. | 1986 | Biochem. J. | pmid:3082324 |
Clouet P et al. | Study of some factors controlling fatty acid oxidation in liver mitochondria of obese Zucker rats. | 1986 | Biochem. J. | pmid:3800970 |
Bauché F et al. | Inhibition in vitro of acyl-CoA dehydrogenases by 2-mercaptoacetate in rat liver mitochondria. | 1983 | Biochem. J. | pmid:6661181 |
Pégorier JP et al. | Metabolic fate of non-esterified fatty acids in isolated hepatocytes from newborn and young pigs. Evidence for a limited capacity for oxidation and increased capacity for esterification. | 1983 | Biochem. J. | pmid:6870859 |
Foxworthy PS and Eacho PI | Inhibition of hepatic fatty acid oxidation at carnitine palmitoyltransferase I by the peroxisome proliferator 2-hydroxy-3-propyl-4-[6-(tetrazol-5-yl) hexyloxy]acetophenone. | 1988 | Biochem. J. | pmid:3415664 |
Watford M et al. | The regulation of glutamine and ketone-body metabolism in the small intestine of the long-term (40-day) streptozotocin-diabetic rat. | 1987 | Biochem. J. | pmid:3473986 |
Leclercq P et al. | Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats. | 1997 | Biochem. J. | pmid:9230136 |
Halestrap AP | The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+. | 1987 | Biochem. J. | pmid:3663110 |
Tosh D et al. | Glucagon regulation of gluconeogenesis and ketogenesis in periportal and perivenous rat hepatocytes. Heterogeneity of hormone action and of the mitochondrial redox state. | 1988 | Biochem. J. | pmid:3223900 |
Dieuaide M et al. | Effects of glucose starvation on the oxidation of fatty acids by maize root tip mitochondria and peroxisomes: evidence for mitochondrial fatty acid beta-oxidation and acyl-CoA dehydrogenase activity in a higher plant. | 1993 | Biochem. J. | pmid:8250843 |
Lin X et al. | Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets. | 1996 | Biochem. J. | pmid:8761477 |
Soboll S et al. | Effect of long-chain fatty acyl-CoA on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell. | 1984 | Biochem. J. | pmid:6743276 |
Ledden DJ et al. | Characterization of fragments of human albumin purified by Cibacron blue F3GA affinity chromatography. | 1982 | Biochem. J. | pmid:6814424 |
Oshino N et al. | The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver. | 1975 | Biochem. J. | pmid:167718 |
Iwahashi H et al. | Cytochrome c catalyses the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. | 2002 | Biochem. J. | pmid:11742529 |
Marchington DR et al. | Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat hepatocytes. | 1989 | Biochem. J. | pmid:2539088 |
Berger M et al. | Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. | 1976 | Biochem. J. | pmid:136249 |
Reed WD et al. | The effects of insulin and glucagon on ketone-body turnover. | 1984 | Biochem. J. | pmid:6383348 |
Kalbag SS and Palekar AG | Sodium benzoate inhibits fatty acid oxidation in rat liver: effect on ammonia levels. | 1988 | Biochem. Med. Metab. Biol. | pmid:3190922 |
Schepkin V et al. | NMR study of lipoic acid binding to bovine serum albumin. | 1994 | Biochem. Mol. Biol. Int. | pmid:7987256 |
GarcÃa-Villafranca J and Castro J | Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. | 2002 | Biochem. Pharmacol. | pmid:12093476 |
Fulgencio JP et al. | Effect of metformin on fatty acid and glucose metabolism in freshly isolated hepatocytes and on specific gene expression in cultured hepatocytes. | 2001 | Biochem. Pharmacol. | pmid:11448453 |
Veitch K and Van Hoof F | In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria. | 1990 | Biochem. Pharmacol. | pmid:2242043 |
Sarnatskaya VV et al. | Effect of protein-bound uraemic toxins on the thermodynamic characteristics of human albumin. | 2002 | Biochem. Pharmacol. | pmid:11960605 |
Swartzentruber MS and Harris RA | Inhibition of metabolic processes by coenzyme-A-sequestering aromatic acids. Prevention by para-chloro- and para-nitrobenzoic acids. | 1987 | Biochem. Pharmacol. | pmid:3117062 |
Schudt C and Simon A | Effects of sodium 2-[5-(4-chlorophenyl)pentyl]-oxirane-2-carboxylate (POCA) on carbohydrate and fatty acid metabolism in liver and muscle. | 1984 | Biochem. Pharmacol. | pmid:6437406 |
el-Aleem SA and Schulz H | Evaluation of inhibitors of fatty acid oxidation in rat myocytes. | 1987 | Biochem. Pharmacol. | pmid:3689454 |
Deaciuc IV et al. | Studies on the mechanism of action of the hypoglycemic agent, 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304). | 1983 | Biochem. Pharmacol. | pmid:6651864 |
Olubadewo JO et al. | Effects of 8-N,N-diethylamino-octyl-3,4,5-trimethoxybenzoate (TMB-8) HCl and verapamil on the metabolism of free fatty acid by hepatocytes. | 1988 | Biochem. Pharmacol. | pmid:3358779 |
Massolini G et al. | Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases. | 1993 | Biochem. Pharmacol. | pmid:8216380 |
Grolier P and Elcombe CR | In vitro inhibition of carnitine acyltransferase activity in mitochondria from rat and mouse liver by a diethylhexylphthalate metabolite. | 1993 | Biochem. Pharmacol. | pmid:8452557 |
Haas R et al. | Salicylate-induced loose coupling: protonmotive force measurements. | 1985 | Biochem. Pharmacol. | pmid:3977963 |
Krahenbuhl S and Brass EP | Inhibition of hepatic propionyl-CoA synthetase activity by organic acids. Reversal of propionate inhibition of pyruvate metabolism. | 1991 Mar 15-Apr 1 | Biochem. Pharmacol. | pmid:2009071 |
Rozas I et al. | Effects of acute valproate administration on carnitine metabolism in mouse serum and tissues. | 1990 | Biochem. Pharmacol. | pmid:2105093 |
Thayer WS | Inhibition of mitochondrial fatty acid oxidation in pentenoic acid-induced fatty liver. A possible model for Reye's syndrome. | 1984 | Biochem. Pharmacol. | pmid:6712730 |
Porter DJ | Binding of 2-acetylpyridine-5-[(2-chloroanilino)thiocarbonyl] thiocarbonohydrazone (BW348U87) to human serum albumin. | 1992 | Biochem. Pharmacol. | pmid:1417962 |
Ohtsuka Y and Griffith OW | L-carnitine protection in ammonia intoxication. Effect of aminocarnitine on carnitine-dependent metabolism and acute ammonia toxicity. | 1991 | Biochem. Pharmacol. | pmid:2039546 |
Carrington MJ et al. | Octanoate and palmitate as substrates for ketogenesis by hepatocytes isolated from suckling rabbits. | 1981 | Biochem. Soc. Trans. | pmid:7215663 |
Littlechild JA et al. | Hyperthermophilic dehydrogenase enzymes. | 2004 | Biochem. Soc. Trans. | pmid:15046583 |
Priestman DA et al. | Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes. | 1997 | Biochem. Soc. Trans. | pmid:9056999 |
Sherrington EJ et al. | Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736816 |
Gandhi NN and Mukherjee KD | Papaya (Carica papaya) lipase with some distinct acyl and alkyl specificities as compared with microbial lipases. | 2000 | Biochem. Soc. Trans. | pmid:11171278 |
Bhuiyan AK and Pande SV | One-step facile synthesis of radioactive acyl-CoA and acylcarnitines using rat liver outer mitochondrial membrane as the enzyme source. | 1991 | Biochem. Soc. Trans. | pmid:1889559 |
Clouet P et al. | Mitochondrial respiration on rumenic and linoleic acids. | 2001 | Biochem. Soc. Trans. | pmid:11356175 |
Zwiebel FM et al. | Role of pyruvate transporter in the regulation of the pyruvate dehydrogenase multienzyme complex in perfused rat liver. | 1982 | Biochemistry | pmid:7074018 |
Miller JR et al. | Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. | 2000 | Biochemistry | pmid:11106496 |
Lo YC et al. | Substrate specificities of Escherichia coli thioesterase I/protease I/lysophospholipase L1 are governed by its switch loop movement. | 2005 | Biochemistry | pmid:15697222 |
Garner CW and Behal FJ | Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups. | 1975 | Biochemistry | pmid:38 |
Salesse R et al. | Modulation of adenylate cyclase activity by the physical state of pigeon erythrocyte membrane. 1. Parallel drug-induced changes in the bilayer fluidity and adenylate cyclase activity. | 1982 | Biochemistry | pmid:6282308 |
Pohl J et al. | Long-chain fatty acid uptake into adipocytes depends on lipid raft function. | 2004 | Biochemistry | pmid:15065861 |
Li W et al. | Reconstitution of the M13 major coat protein and its transmembrane peptide segment on a DNA template. | 2007 | Biochemistry | pmid:17595059 |
Mao LF et al. | Hepatic beta-oxidation of 3-phenylpropionic acid and the stereospecific dehydration of (R)- and (S)-3-hydroxy-3-phenylpropionyl-CoA by different enoyl-CoA hydratases. | 1994 | Biochemistry | pmid:8136368 |
Jiang Y et al. | The soluble acyl-acyl carrier protein synthetase of Vibrio harveyi B392 is a member of the medium chain acyl-CoA synthetase family. | 2006 | Biochemistry | pmid:16906759 |
Hsieh CH et al. | The Enigmatic P450 Decarboxylase OleT Is Capable of, but Evolved To Frustrate, Oxygen Rebound Chemistry. | 2017 | Biochemistry | pmid:28603981 |
Hayden MA et al. | Biosynthesis of lipoic acid: characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33-lip9. | 1993 | Biochemistry | pmid:8466915 |
White RH | Stable isotope studies on the biosynthesis of lipoic acid in Escherichia coli. | 1980 | Biochemistry | pmid:6766313 |
Kawai A et al. | Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions. | 2017 | Biochim Biophys Acta Proteins Proteom | pmid:28473296 |
Vauhkonen M and Somerharju P | Parinaroyl and pyrenyl phospholipids as probes for the lipid surface layer of human low density lipoproteins. | 1989 | Biochim. Biophys. Acta | pmid:2765542 |
Parameswaran M and Arinze IJ | Phosphoenolpyruvate synthesis by fetal guinea-pig liver mitochondria. | 1981 | Biochim. Biophys. Acta | pmid:7225415 |
Mannaerts GP et al. | Hepatic fatty acid oxidation and ketogenesis after clofibrate treatment. | 1978 | Biochim. Biophys. Acta | pmid:656451 |
Lemarié F et al. | Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration. | 2016 | Biochim. Biophys. Acta | pmid:27317984 |
Bartels PD and Sestoft L | Thyroid hormone-induced changes in gluconeogenesis and ketogenesis in perfused rat liver. | 1980 | Biochim. Biophys. Acta | pmid:7448206 |
Dorset DL | Co-solubility of saturated cholesteryl esters: a comparison of calculated and experimental binary phase diagrams. | 1988 | Biochim. Biophys. Acta | pmid:3179332 |
Nieuwenhuizen W et al. | Purification and properties of two lipases from pig adipose tissue. | 1976 | Biochim. Biophys. Acta | pmid:7300 |
MartÃnez Izquierdo JA et al. | Fatty acid-glucose interaction in the control of protein synthesis by isolated rat lung cells. | 1983 | Biochim. Biophys. Acta | pmid:6615881 |
Kohlwein SD and Paltauf F | Uptake of fatty acids by the yeasts, Saccharomyces uvarum and Saccharomycopsis lipolytica. | 1984 | Biochim. Biophys. Acta | pmid:6696936 |
McDonough KH et al. | Effects of oxygen radicals on substrate oxidation by cardiac myocytes. | 1987 | Biochim. Biophys. Acta | pmid:2822138 |
Groot PH and Hülsmann WC | The activation and oxidation of octanoate and palmitate by rat skeletal muscle mitochondria. | 1973 | Biochim. Biophys. Acta | pmid:4741907 |
Barron JT et al. | Oxidation of acetate and octanoate and its relation to glucose metabolism in contracting porcine carotid artery. | 1997 | Biochim. Biophys. Acta | pmid:9452767 |
Wilson TA et al. | Structured triglycerides containing caprylic (8:0) and oleic (18:1) fatty acids reduce blood cholesterol concentrations and aortic cholesterol accumulation in hamsters. | 2006 | Biochim. Biophys. Acta | pmid:16580874 |
Cheng Y and Hauton D | Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase. | 2008 | Biochim. Biophys. Acta | pmid:18722549 |
Henze K et al. | The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts. | 1981 | Biochim. Biophys. Acta | pmid:6118180 |
González-Manchón C et al. | Control of gluconeogenesis: role of fatty acids in the alpha-adrenergic response. | 1988 | Biochim. Biophys. Acta | pmid:3191164 |
Jakobs BS et al. | Beta-oxidation of fatty acids in cultured human skin fibroblasts devoid of the capacity for oxidative phosphorylation. | 1994 | Biochim. Biophys. Acta | pmid:8123680 |
Redondo O et al. | Comparative kinetic study of lipases A and B from Candida rugosa in the hydrolysis of lipid p-nitrophenyl esters in mixed micelles with Triton X-100. | 1995 | Biochim. Biophys. Acta | pmid:7827103 |
Martinelle M and Hult K | Kinetics of acyl transfer reactions in organic media catalysed by Candida antarctica lipase B. | 1995 | Biochim. Biophys. Acta | pmid:7669809 |
Yon JO et al. | Incorporation of extracellular phospholipids and their effect on the growth and lipid metabolism of the Saccharomyces cerevisiae cho1/pss mutant. | 1998 | Biochim. Biophys. Acta | pmid:9767089 |
Kato T et al. | Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11). | 2010 | Biochim. Biophys. Acta | pmid:20398791 |
Noy N and Zakim D | Substrate specificity of fatty-acyl-CoA ligase in liver microsomes. | 1985 | Biochim. Biophys. Acta | pmid:3970953 |
Brandes R et al. | The specificity of triacylglycerol synthesis for medium-chain fatty acids in rat and human adipose preparations. | 1985 | Biochim. Biophys. Acta | pmid:4027259 |
Wanders RJ and Ijlst L | Fatty acid beta-oxidation in leukocytes from control subjects and medium-chain acyl-CoA dehydrogenase deficient patients. | 1992 | Biochim. Biophys. Acta | pmid:1737072 |
Matsuki H et al. | Specific and non-specific binding of long-chain fatty acids to firefly luciferase: cutoff at octanoate. | 1999 | Biochim. Biophys. Acta | pmid:9878713 |
Stace PB et al. | Cyclic AMP and free fatty acids in the longer-term regulation of pyruvate dehydrogenase kinase in rat soleus muscle. | 1992 | Biochim. Biophys. Acta | pmid:1319745 |
Hinson JA and Neal RA | An examination of octanol and octanal metabolism to octanoic acid by horse liver alcohol dehydrogenase. | 1975 | Biochim. Biophys. Acta | pmid:165828 |
Apel CL et al. | Self-assembled vesicles of monocarboxylic acids and alcohols: conditions for stability and for the encapsulation of biopolymers. | 2002 | Biochim. Biophys. Acta | pmid:11825583 |
Zabłocki K et al. | The inhibitory effect of octanoate, palmitate and oleate on glucose formation in rabbit kidney tubules. | 1983 | Biochim. Biophys. Acta | pmid:6838901 |
Evtodienko VY et al. | Effect of the alkyl chain length of monocarboxylic acid on the permeation through bilayer lipid membranes. | 1996 | Biochim. Biophys. Acta | pmid:8664324 |
Latipää PM et al. | Regulation of fatty acid oxidation in heart muscle. Effects of pyruvate and dichloroacetate. | 1983 | Biochim. Biophys. Acta | pmid:6849964 |
el Alaoui-Talibi Z and Moravec J | Carnitine transport and exogenous palmitate oxidation in chronically volume-overloaded rat hearts. | 1989 | Biochim. Biophys. Acta | pmid:2499353 |
Bohnensack R and Fritz S | Stimulation of alanine metabolism by ammonia in the perfused rat liver. Quantitative analysis by means of a mathematical model. | 1991 | Biochim. Biophys. Acta | pmid:2009283 |
Babu E et al. | Role of human organic anion transporter 4 in the transport of ochratoxin A. | 2002 | Biochim. Biophys. Acta | pmid:12063169 |