| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Stomach Diseases | D013272 | 7 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
octanoic acid
octanoic acid is a lipid of Fatty Acyls (FA) class. Octanoic acid is associated with abnormalities such as Ischemia, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, Cardiomyopathies and Obesity. The involved functions are known as Anabolism, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Citric Acid Cycle, Metabolic Inhibition and Excretory function. Octanoic acid often locates in Pore, Protoplasm, Endothelium, Mitochondria and Muscle. The associated genes with octanoic acid are P4HTM gene, CPT1A gene, HADH gene, ACSL1 Gene and CD36 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, Oleates, Palmitates and hexanoic acid.
Cross Reference
Introduction
To understand associated biological information of octanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with octanoic acid?
octanoic acid is suspected in Obesity, Atherosclerosis, Gigantism, Alzheimer's Disease, Neurodegenerative Disorders, Cardiomyopathies and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with octanoic acid
PubChem Associated disorders and diseases
What pathways are associated with octanoic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with octanoic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with octanoic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with octanoic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with octanoic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with octanoic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with octanoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ishii-Iwamoto EL et al. | Effects of norepinephrine on the metabolism of fatty acids with different chain lengths in the perfused rat liver. | 2000 | Mol. Cell. Biochem. | pmid:10821418 |
| Awan MM et al. | Mechanisms whereby glucose deprivation triggers metabolic preconditioning in the isolated rat heart. | 2000 | Mol. Cell. Biochem. | pmid:11055554 |
| Pantazaki AA et al. | Polyhydroxyalkanoate (PHA) biosynthesis in Thermus thermophilus: purification and biochemical properties of PHA synthase. | 2003 | Mol. Cell. Biochem. | pmid:14674696 |
| Abdel-aleem S et al. | Regulation of carbohydrate and fatty acid utilization by L-carnitine during cardiac development and hypoxia. | 1998 | Mol. Cell. Biochem. | pmid:9546635 |
| Scaini G et al. | Toxicity of octanoate and decanoate in rat peripheral tissues: evidence of bioenergetic dysfunction and oxidative damage induction in liver and skeletal muscle. | 2012 | Mol. Cell. Biochem. | pmid:22015654 |
| Leverve X et al. | Oxidative phosphorylation in intact hepatocytes: quantitative characterization of the mechanisms of change in efficiency and cellular consequences. | 1998 | Mol. Cell. Biochem. | pmid:9746312 |
| Elliott KR and Pogson CI | Preparation and characterization of isolated parenchymal cells from guinea pig liver. | 1977 | Mol. Cell. Biochem. | pmid:196181 |
| Tissier C et al. | Substrate dependence of the postischemic cardiomyocyte recovery: dissociation between functional, metabolic and injury markers. | 2005 | Mol. Cell. Biochem. | pmid:16013439 |
| Coort SL et al. | Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake. | 2002 | Mol. Cell. Biochem. | pmid:12479588 |
| Salesse R and Garnier J | Adenylate cyclase and membrane fluidity. The repressor hypothesis. | 1984 | Mol. Cell. Biochem. | pmid:6323963 |
| McNamara BC and Jefcoate CR | Heterogeneous pools of cholesterol side-chain cleavage activity in adrenal mitochondria from ACTH-treated rats: differential responses to different reducing precursors. | 1990 | Mol. Cell. Endocrinol. | pmid:2176627 |
| Seydoux J et al. | Impaired metabolic response to nerve stimulation in brown adipose tissue of hypothyroid rats. | 1982 | Mol. Cell. Endocrinol. | pmid:6276252 |
| Andrade López JM et al. | Genetic basis of octanoic acid resistance in Drosophila sechellia: functional analysis of a fine-mapped region. | 2017 | Mol. Ecol. | pmid:28035709 |
| Gurvitz A | The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2. | 2009 | Mol. Genet. Genomics | pmid:19685079 |
| Velázquez-Arellano A et al. | Functional and metabolic implications of biotin deficiency for the rat heart. | 2008 | Mol. Genet. Metab. | pmid:18824381 |
| Jones PM et al. | Effects of odd-numbered medium-chain fatty acids on the accumulation of long-chain 3-hydroxy-fatty acids in long-chain L-3-hydroxyacyl CoA dehydrogenase and mitochondrial trifunctional protein deficient skin fibroblasts. | 2004 | Mol. Genet. Metab. | pmid:14741189 |
| Bokhout BA et al. | Porcine IgG. Isolation of two IgG-subclasses and anti-IgG class- and subclass-specific antibodies. | 1986 | Mol. Immunol. | pmid:2427943 |
| Guler JL et al. | Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei. | 2008 | Mol. Microbiol. | pmid:18221265 |
| Campbell JW et al. | A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic beta-oxidation pathway. | 2003 | Mol. Microbiol. | pmid:12535077 |
| Ali ST et al. | Octanoylation of the lipoyl domains of the pyruvate dehydrogenase complex in a lipoyl-deficient strain of Escherichia coli. | 1990 | Mol. Microbiol. | pmid:2215217 |
| Kursu VA et al. | Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae. | 2013 | Mol. Microbiol. | pmid:24102902 |
| Montazeri Aliabadi H et al. | Induction of apoptosis by survivin silencing through siRNA delivery in a human breast cancer cell line. | 2011 | Mol. Pharm. | pmid:21838308 |
| Meisner H and Neet K | Competitive binding of long-chain free fatty acids, octanoate, and chlorophenoxyisobutyrate to albumin. | 1978 | Mol. Pharmacol. | pmid:642932 |
| Lohse MJ et al. | Effects of temperature and membrane phase transitions on ligand binding to alpha 2-receptors of human platelets. | 1986 | Mol. Pharmacol. | pmid:3005830 |
| Martin FP et al. | Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. | 2008 | Mol. Syst. Biol. | pmid:18628745 |
| Formisano C et al. | Headspace volatile composition of the flowers of Caralluma europaea N.E.Br. (Apocynaceae). | 2009 | Molecules | pmid:19924088 |
| Sobczak M and Kolodziejski W | Polymerization of cyclic esters initiated by carnitine and tin (II) octoate. | 2009 | Molecules | pmid:19214152 |
| Sobczak M et al. | Synthesis and structural analysis of polyester prodrugs of norfloxacin. | 2008 | Molecules | pmid:18259133 |
| Müller T et al. | Entacapone improves absorption of a coadministered salt in patients with Parkinson's disease. | 2008 | Mov. Disord. | pmid:18546331 |
| Unger MM et al. | Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test. | 2011 | Mov. Disord. | pmid:22147682 |
| Liu S et al. | Biological control of phytopathogenic fungi by fatty acids. | 2008 | Mycopathologia | pmid:18443921 |
| Lord JC and Howard RW | A proposed role for the cuticular fatty amides of Liposcelis bostrychophila (Psocoptera: Liposcelidae) in preventing adhesion of entomopathogenic fungi with dry-conidia. | 2004 | Mycopathologia | pmid:15518350 |
| Andrén-Sandberg A | Pancreatic cancer: chemotherapy and radiotherapy. | 2011 | N Am J Med Sci | pmid:22540056 |
| Guthy E | Enteric-coated fish oil in Crohn's disease. | 1996 | N. Engl. J. Med. | pmid:8927072 |
| Riecken EO | [Structural and functional findings in experimental blind loop syndrome]. | 1984 | Nahrung | pmid:6493325 |
| Shahmoradi B et al. | Modification of neodymium-doped ZnO hybrid nanoparticles under mild hydrothermal conditions. | 2010 | Nanoscale | pmid:20648343 |
| Ma Y et al. | Nanoparticles of Poly(Lactide-Co-Glycolide)-d-a-Tocopheryl Polyethylene Glycol 1000 Succinate Random Copolymer for Cancer Treatment. | 2010 | Nanoscale Res Lett | pmid:20596457 |
| Mei L et al. | A Novel Docetaxel-Loaded Poly (ε-Caprolactone)/Pluronic F68 Nanoparticle Overcoming Multidrug Resistance for Breast Cancer Treatment. | 2009 | Nanoscale Res Lett | pmid:20652101 |
| Liu JH et al. | The fabrication of polycrystalline silver nanowires via self-assembled nanotubes at controlled temperature. | 2009 | Nanotechnology | pmid:19417290 |
| Balaraman E et al. | Catalytic transformation of alcohols to carboxylic acid salts and H2 using water as the oxygen atom source. | 2013 | Nat Chem | pmid:23344447 |
| Andersen JT et al. | Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor. | 2012 | Nat Commun | pmid:22215085 |
| Cordier C et al. | Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries. | 2008 | Nat Prod Rep | pmid:18663392 |
| Chhatre S et al. | Purification of antibodies using the synthetic affinity ligand absorbent MAbsorbent A2P. | 2007 | Nat Protoc | pmid:17641643 |
| Abadi G et al. | Naturally occurring esterification reactions with bryostatin. | 2008 | Nat. Prod. Res. | pmid:18626821 |
| Nazzi F et al. | Octanoic acid confers to royal jelly varroa-repellent properties. | 2009 | Naturwissenschaften | pmid:19050844 |
| Sarnatskaya VV et al. | Extraction of uraemic toxins with activated carbon restores the functional properties of albumin. | 2003 | Nephron Physiol | pmid:14520007 |
| Norenberg MD | The role of astrocytes in hepatic encephalopathy. | 1987 Feb-Apr | Neurochem Pathol | pmid:3306480 |
| Schuck PF et al. | Medium-chain fatty acids accumulating in MCAD deficiency elicit lipid and protein oxidative damage and decrease non-enzymatic antioxidant defenses in rat brain. | 2009 | Neurochem. Int. | pmid:19428797 |
| de Assis DR et al. | Evidence that antioxidants prevent the inhibition of Na+,K(+)-ATPase activity induced by octanoic acid in rat cerebral cortex in vitro. | 2003 | Neurochem. Res. | pmid:12892042 |
| Ninomiya Y and Kayama Y | Inhibition of choline acetyltransferase activity by serum albumin modified with octanoic acid and other fatty acids. | 1998 | Neurochem. Res. | pmid:9804287 |
| Alvarez CV et al. | Regulation of prothymosin alpha mRNA levels in rat pituitary tumor cells. | 1993 | Neuroendocrinology | pmid:8232763 |
| Schoonjans R et al. | The 13C-octanoic acid breath test: validation of a new noninvasive method of measuring gastric emptying in rats. | 2002 | Neurogastroenterol. Motil. | pmid:12061914 |
| van de Casteele M et al. | Oxidative breakdown of octanoic acid is maintained in patients with cirrhosis despite advanced disease. | 2003 | Neurogastroenterol. Motil. | pmid:12680910 |
| Hoffman I and Tack J | Assessment of gastric motor function in childhood functional dyspepsia and obesity. | 2012 | Neurogastroenterol. Motil. | pmid:22103293 |
| Cuomo R et al. | Sweetened carbonated drinks do not alter upper digestive tract physiology in healthy subjects. | 2008 | Neurogastroenterol. Motil. | pmid:18373521 |
| Choung RS et al. | The effect of short-term, low-dose tricyclic and tetracyclic antidepressant treatment on satiation, postnutrient load gastrointestinal symptoms and gastric emptying: a double-blind, randomized, placebo-controlled trial. | 2008 | Neurogastroenterol. Motil. | pmid:18031471 |
| Braden B et al. | Clinical effects of STW 5 (Iberogast) are not based on acceleration of gastric emptying in patients with functional dyspepsia and gastroparesis. | 2009 | Neurogastroenterol. Motil. | pmid:19220753 |
| Verbeke K | Will the 13C-octanoic acid breath test ever replace scintigraphy as the gold standard to assess gastric emptying? | 2009 | Neurogastroenterol. Motil. | pmid:19737258 |
| Qualls-Creekmore E et al. | Time-course of recovery of gastric emptying and motility in rats with experimental spinal cord injury. | 2010 | Neurogastroenterol. Motil. | pmid:19566592 |
| Keller J et al. | Influence of clinical parameters on the results of 13C-octanoic acid breath tests: examination of different mathematical models in a large patient cohort. | 2009 | Neurogastroenterol. Motil. | pmid:19549136 |
| Trauner DA and Huttenlocher PR | Short chain fatty acid-induced central hyperventilation in rabbits. | 1978 | Neurology | pmid:567765 |
| Parker WD et al. | Effects of octanoate on rat brain and liver mitochondria. | 1983 | Neurology | pmid:6684238 |
| Haubenberger D et al. | Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study. | 2013 | Neurology | pmid:23408867 |
| Wlaź P et al. | Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice. | 2012 | Neuropharmacology | pmid:22210332 |
| Randich A et al. | Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity. | 2001 | Neuroreport | pmid:11568645 |
| Ogawa N et al. | The vagal afferent pathway does not play a major role in the induction of satiety by intestinal fatty acid in rats. | 2008 | Neurosci. Lett. | pmid:18248897 |
| Lamas JA et al. | Caprylic acid, a medium chain saturated fatty acid, inhibits the sodium inward current in neuroglioma (NG108-15) cells. | 1995 | Neurosci. Lett. | pmid:8552316 |
| Goetze O et al. | Impaired gastric emptying of a solid test meal in patients with Parkinson's disease using 13C-sodium octanoate breath test. | 2005 | Neurosci. Lett. | pmid:15694254 |
| Señaris RM et al. | Stimulatory effect of free fatty acids on growth hormone releasing hormone secretion by fetal rat neurons in monolayer culture. | 1992 | Neurosci. Lett. | pmid:1542440 |
| Kamata Y et al. | Induction of neurite outgrowth in PC12 cells by the medium-chain fatty acid octanoic acid. | 2007 | Neuroscience | pmid:17434686 |
| Nahab FB et al. | An open-label, single-dose, crossover study of the pharmacokinetics and metabolism of two oral formulations of 1-octanol in patients with essential tremor. | 2011 | Neurotherapeutics | pmid:21594724 |
| Nahab FB et al. | Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor. | 2012 | Neurotherapeutics | pmid:22454323 |
| Ho PW et al. | Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells. | 2010 | Neurotox Res | pmid:19763737 |
| Sakamoto A et al. | [A clinical evaluation of reconstruction methods after pancreatoduodenectomy from a view of fat digestion and absorption]. | 1991 | Nihon Geka Gakkai Zasshi | pmid:2014027 |
| Shimizu H | [Comparative studies on perfused adult and fetal guinea pig liver metabolism before and after anoxia loadings, with special reference to intracellular redox state]. | 1983 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:6875338 |
| Taguchi S | [Acidosis tolerance of fetal metabolism--comparative studies on isolated perfused adult, fetal and neonatal livers]. | 1985 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:4086906 |
| Ishima Y et al. | One-step preparation of S-nitrosated human serum albumin with high biological activities. | 2010 | Nitric Oxide | pmid:20451647 |
| Alves MG et al. | Substrate selection in hearts subjected to ischemia/reperfusion: role of cardioplegic solutions and gender. | 2011 | NMR Biomed | pmid:21274961 |
| Staeffen J et al. | [Hyperoctanoatemia and the hepatic encephalopathy of cirrhosis. 150 dosages in 61 patients (author's transl)]. | 1979 | Nouv Presse Med | pmid:112576 |
| Avenard G et al. | [The prevention of chickenpox in high risk children. Comparison of the effectiveness of specific immunoglobulins and of defibrinated convalescent plasma. 414 cases (author's transl)]. | 1979 | Nouv Presse Med | pmid:221885 |
| Chew CG et al. | Simultaneous 13C/14C dual isotope breath test measurement of gastric emptying of solid and liquid in normal subjects and patients: comparison with scintigraphy. | 2003 | Nucl Med Rev Cent East Eur | pmid:14600930 |
| Kuge Y et al. | [1-11C]octanoate as a potential PET tracer for studying glial functions: PET evaluation in rats and cats. | 1996 | Nucl. Med. Biol. | pmid:9004290 |
| Kawashima H et al. | Development of step-specific PET tracers for studying fatty acid beta-oxidation: biodistribution of [1-(11)C] octanoate analogs in rats and a cat. | 1998 | Nucl. Med. Biol. | pmid:9751421 |
| Yamamura N et al. | Evaluation of [1-11C]octanoate as a new radiopharmaceutical for assessing liver function using positron emission tomography. | 1998 | Nucl. Med. Biol. | pmid:9720664 |
| Xu J et al. | Dual receptor-targeting â¹â¹mTc-labeled Arg-Gly-Asp-conjugated Alpha-Melanocyte stimulating hormone hybrid peptides for human melanoma imaging. | 2015 | Nucl. Med. Biol. | pmid:25577037 |
| Kuge Y et al. | In vitro uptake of [1-14C]Octanoate in brain slices of rats: basic studies for assessing [1-11C]Octanoate as a PET tracer of glial functions. | 2002 | Nucl. Med. Biol. | pmid:11929699 |
| Ashitani J et al. | Effect of octanoic acid-rich formula on plasma ghrelin levels in cachectic patients with chronic respiratory disease. | 2009 | Nutr J | pmid:19527531 |
| Bondia-Pons I et al. | Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread. | 2011 | Nutr J | pmid:22011443 |
| Gallis JL et al. | A metabolic link between mitochondrial ATP synthesis and liver glycogen metabolism: NMR study in rats re-fed with butyrate and/or glucose. | 2011 | Nutr Metab (Lond) | pmid:21676253 |
| Sundaram M and Yao Z | Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. | 2010 | Nutr Metab (Lond) | pmid:20423497 |
| Henderson ST et al. | Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial. | 2009 | Nutr Metab (Lond) | pmid:19664276 |
| Romestaing C et al. | Long term highly saturated fat diet does not induce NASH in Wistar rats. | 2007 | Nutr Metab (Lond) | pmid:17313679 |
| Guo W et al. | Modulation of adipocyte lipogenesis by octanoate: involvement of reactive oxygen species. | 2006 | Nutr Metab (Lond) | pmid:16872526 |
| Seyfried TN and Mukherjee P | Targeting energy metabolism in brain cancer: review and hypothesis. | 2005 | Nutr Metab (Lond) | pmid:16242042 |
| Ling B et al. | D-Lactate altered mitochondrial energy production in rat brain and heart but not liver. | 2012 | Nutr Metab (Lond) | pmid:22296683 |
| Zhu J et al. | The effects of choline on hepatic lipid metabolism, mitochondrial function and antioxidative status in human hepatic C3A cells exposed to excessive energy substrates. | 2014 | Nutrients | pmid:25010553 |
| Han J et al. | Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats. | 2003 | Obes. Res. | pmid:12805394 |
| Hennes MM et al. | Mechanism of free fatty acid effects on hepatocyte insulin receptor binding and processing. | 1993 | Obes. Res. | pmid:16353347 |
| Lei T et al. | Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation. | 2004 | Obes. Res. | pmid:15090627 |
| Hücking K et al. | Deconvolution as a novel approach to analyze moment-to-moment free fatty acid release. | 2007 | Obesity (Silver Spring) | pmid:17925467 |