Glucosyl sphingosine is a lipid of Sphingolipids (SP) class. Glucosyl sphingosine is associated with abnormalities such as Sphingolipidoses, Globoid cell leukodystrophy, Sandhoff Disease, Tay-Sachs Disease and Fabry Disease. The involved functions are known as Apoptosis, Acetylation, Infiltration, kinase activity and energy pathways. Glucosyl sphingosine often locates in Lysosomal and Protoplasm. The associated genes with Glucosyl sphingosine are MAPT gene, GALC gene, HEXA gene, PICK1 gene and ELF3 gene. The related lipids are lysoganglioside G(M2), Ganglioside GA2, Lysophosphatidylcholines and globotriaosyl lysosphingolipid.
To understand associated biological information of Glucosyl sphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucosyl sphingosine is suspected in Globoid cell leukodystrophy, Sphingolipidoses, Sandhoff Disease, Tay-Sachs Disease, Fabry Disease and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Glucosyl sphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Multiple Myeloma | D009101 | 13 associated lipids |
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Gatt S et al. | Studies on human acid beta-glucosidase and the nature of the molecular defect in type 1 Ashkenazi Gaucher disease. | 1982 | Prog. Clin. Biol. Res. | pmid:6812076 |
| Suzuki K | Glucosylceramide and related compounds in normal tissues and in Gaucher disease. | 1982 | Prog. Clin. Biol. Res. | pmid:7122635 |
| Nilsson O et al. | Glycosphingolipid studies of visceral tissues and brain from type 1 Gaucher disease variants. | 1985 | Clin. Genet. | pmid:3924448 |
| Hara A and Taketomi T | Chemical properties and stereoisomerism of heterogeneous long chain bases in lysosphingolipids by positive ion fast atom bombardment mass spectrometry and carbon-13 NMR spectroscopy. | 1986 | J. Biochem. | pmid:3782058 |
| Igisu H et al. | Inhibition of cytochrome c oxidase and hemolysis caused by lysosphingolipids. | 1988 | Lipids | pmid:2840545 |
| Legler G and Bieberich E | Isolation of a cytosolic beta-glucosidase from calf liver and characterization of its active site with alkyl glucosides and basic glycosyl derivatives. | 1988 | Arch. Biochem. Biophys. | pmid:2963589 |
| Gopalan V et al. | Kinetic analysis of the interaction of alkyl glycosides with two human beta-glucosidases. | 1989 | Biochem. J. | pmid:2508630 |
| Nozawa M et al. | Novel procedure for measuring psychosine derivatives by an HPLC method. | 1992 | J. Neurochem. | pmid:1629732 |
| Atsumi S et al. | Accumulation of tissue glucosylsphingosine in Gaucher-like mouse induced by the glucosylceramidase inhibitor cyclophellitol. | 1993 | Arch. Biochem. Biophys. | pmid:8323295 |