Glucosyl sphingosine is a lipid of Sphingolipids (SP) class. Glucosyl sphingosine is associated with abnormalities such as Sphingolipidoses, Globoid cell leukodystrophy, Sandhoff Disease, Tay-Sachs Disease and Fabry Disease. The involved functions are known as Apoptosis, Acetylation, Infiltration, kinase activity and energy pathways. Glucosyl sphingosine often locates in Lysosomal and Protoplasm. The associated genes with Glucosyl sphingosine are MAPT gene, GALC gene, HEXA gene, PICK1 gene and ELF3 gene. The related lipids are lysoganglioside G(M2), Ganglioside GA2, Lysophosphatidylcholines and globotriaosyl lysosphingolipid.
To understand associated biological information of Glucosyl sphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucosyl sphingosine is suspected in Globoid cell leukodystrophy, Sphingolipidoses, Sandhoff Disease, Tay-Sachs Disease, Fabry Disease and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Glucosyl sphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Multiple Myeloma | D009101 | 13 associated lipids |
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mirzaian M et al. | Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard. | 2015 | Blood Cells Mol. Dis. | pmid:25842368 |
| Bischoff A et al. | Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats. | 2001 | Br. J. Pharmacol. | pmid:11309265 |
| Bischoff A et al. | Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. | 2000 | Br. J. Pharmacol. | pmid:10952677 |
| Bischoff A et al. | Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. | 2000 | Br. J. Pharmacol. | pmid:10952678 |
| Angka L et al. | Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells. | 2014 | Cancer Lett. | pmid:24631520 |
| Zehavi U | Synthesis of potentially caged sphingolipids, possible precursors of cellular modulators and second messengers. | 1997 | Chem. Phys. Lipids | pmid:9450322 |
| Fuller M et al. | Rapid, single-phase extraction of glucosylsphingosine from plasma: A universal screening and monitoring tool. | 2015 | Clin. Chim. Acta | pmid:26232157 |
| Auray-Blais C et al. | How well does urinary lyso-Gb3 function as a biomarker in Fabry disease? | 2010 | Clin. Chim. Acta | pmid:20716442 |
| Nilsson O et al. | Glycosphingolipid studies of visceral tissues and brain from type 1 Gaucher disease variants. | 1985 | Clin. Genet. | pmid:3924448 |
| Sun Y et al. | Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. | 2010 | Hum. Mol. Genet. | pmid:20047948 |